ATE141927T1 - Dipeptide-analoge von aspertam und verfahren zur deren herstellung, sowie eine neue herstellung von aspertam - Google Patents

Dipeptide-analoge von aspertam und verfahren zur deren herstellung, sowie eine neue herstellung von aspertam

Info

Publication number: ATE141927T1
Authority: AT; Austria
Prior art keywords: aspertame; het; substd; opt; production
Prior art date: 1985-10-21

Application number

AT93110704T

Other languages

English (en)

Inventor

Alan Bruce Chmurny

Akiva Tuvia Gross

Robert Joe Kupper

Richard Paul Woodbury

Rowena Lisa Roberts

Original Assignee

Hampshire Chemical Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-10-21

Filing date

1986-10-21

Publication date

1996-09-15

1985-10-21 Priority claimed from US06/789,595 external-priority patent/US4710583A/en

1986-10-21 Application filed by Hampshire Chemical Corp filed Critical Hampshire Chemical Corp

1996-09-15 Application granted granted Critical

1996-09-15 Publication of ATE141927T1 publication Critical patent/ATE141927T1/de

Links

108010016626 Dipeptides Proteins 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001413 amino acids Chemical group 0.000 abstract 2
101100496169 Arabidopsis thaliana CLH1 gene Proteins 0.000 abstract 1
229910014033 C-OH Inorganic materials 0.000 abstract 1
229910014570 C—OH Inorganic materials 0.000 abstract 1
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
101100044057 Mesocricetus auratus SYCP3 gene Proteins 0.000 abstract 1
101100080600 Schizosaccharomyces pombe (strain 972 / ATCC 24843) nse6 gene Proteins 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
101150111293 cor-1 gene Proteins 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
101150009274 nhr-1 gene Proteins 0.000 abstract 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

AT93110704T 1985-10-21 1986-10-21 Dipeptide-analoge von aspertam und verfahren zur deren herstellung, sowie eine neue herstellung von aspertam ATE141927T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US78959385A	1985-10-21	1985-10-21
US06/789,595 US4710583A (en)	1985-10-21	1985-10-21	Dipeptides and process

Publications (1)

Publication Number	Publication Date
ATE141927T1 true ATE141927T1 (de)	1996-09-15

Family

ID=27120931

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93110704T ATE141927T1 (de)	1985-10-21	1986-10-21	Dipeptide-analoge von aspertam und verfahren zur deren herstellung, sowie eine neue herstellung von aspertam

Country Status (5)

Country	Link
EP (2)	EP0574028B1 (de)
AT (1)	ATE141927T1 (de)
DE (2)	DE3689817T2 (de)
ES (2)	ES2090789T3 (de)
NZ (1)	NZ217813A (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5102792A (en) *	1987-08-13	1992-04-07	W. R. Grace & Co.-Conn.	Selective production of L-serine derivative isomers
DE3738908A1 (de) *	1987-11-17	1989-05-24	Hoechst Ag	Verfahren zur enzymatischen peptidsynthese mit mindestens einer nicht-proteinogenen aminosaeure sowie die neuen, bei der synthese anfallenden peptide
DK163435C (da) *	1988-08-12	1992-07-20	Carlsberg Biotechnology Ltd	Fremgangsmaade til enzymatisk fremstilling af dipeptider og derivater deraf
EP0628634A3 (de) *	1993-05-25	1995-09-06	Lilly Co Eli	Verfahren zur Herstellung von Serin-Hydromethyltransferase.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3475403A (en) *	1967-01-20	1969-10-28	Searle & Co	Aspartic acid containing dipeptide lower alkyl esters
JPS543952B2 (de)	1973-03-22	1979-02-28
US4086136A (en) *	1975-10-23	1978-04-25	(Zaidanhojin) Sagami Chemical Research Center	Process for producing a peptide using a serine or thiol proteinase
JPS55135595A (en) *	1979-04-03	1980-10-22	Toyo Soda Mfg Co Ltd	Preparation of dipeptide
ATE9995T1 (de) *	1981-07-10	1984-11-15	Pfizer Inc.	Verzweigte amide von l-aspartyl-daminos[uredipeptiden und deren verbindungen.
HU187215B (en)	1983-01-26	1985-11-28	Egyt Gyogyszervegyeszeti Gyar	Method for producing pharmaceutical product of high actor content and prolonged effect
HU190864B (en)	1983-12-08	1986-11-28	Alkaloida Vegyeszeti Gyar	Process for production of phenil-alanin derivatives
IT1175926B (it) *	1984-01-13	1987-08-12	Debi Derivati Biologici	Procedimento per la preparazione dell'estere metilico di alfa-l-aspartil-l-fenilalanina

1986
- 1986-10-06 NZ NZ217813A patent/NZ217813A/xx unknown
- 1986-10-21 ES ES93110704T patent/ES2090789T3/es not_active Expired - Lifetime
- 1986-10-21 DE DE3689817T patent/DE3689817T2/de not_active Expired - Fee Related
- 1986-10-21 DE DE3650564T patent/DE3650564T2/de not_active Expired - Fee Related
- 1986-10-21 EP EP93110704A patent/EP0574028B1/de not_active Expired - Lifetime
- 1986-10-21 AT AT93110704T patent/ATE141927T1/de not_active IP Right Cessation
- 1986-10-21 ES ES86308176T patent/ES2056046T3/es not_active Expired - Lifetime
- 1986-10-21 EP EP86308176A patent/EP0220923B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE3689817D1 (de)	1994-06-01
EP0220923A2 (de)	1987-05-06
EP0220923A3 (en)	1989-01-11
ES2090789T3 (es)	1996-10-16
DE3650564D1 (de)	1996-10-02
AU6429486A (en)	1987-04-30
AU607123B2 (en)	1991-02-28
ES2056046T3 (es)	1994-10-01
EP0574028A1 (de)	1993-12-15
EP0220923B1 (de)	1994-04-27
NZ217813A (en)	1991-01-29
DE3689817T2 (de)	1994-12-08
EP0574028B1 (de)	1996-08-28
DE3650564T2 (de)	1997-01-16

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Legal Events

Date	Code	Title	Description
1997-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties