ATE142269T1 - Gentherapie unter verwendung von genschmelzen für genetische und erworbene störungen - Google Patents

Gentherapie unter verwendung von genschmelzen für genetische und erworbene störungen

Info

Publication number
ATE142269T1
ATE142269T1 AT89907509T AT89907509T ATE142269T1 AT E142269 T1 ATE142269 T1 AT E142269T1 AT 89907509 T AT89907509 T AT 89907509T AT 89907509 T AT89907509 T AT 89907509T AT E142269 T1 ATE142269 T1 AT E142269T1
Authority
AT
Austria
Prior art keywords
gene
genetic
melts
acquired disorders
gene therapy
Prior art date
Application number
AT89907509T
Other languages
English (en)
Inventor
Ira H Pastan
Michael M Gottesman
Ursula A Germann
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health filed Critical Us Health
Application granted granted Critical
Publication of ATE142269T1 publication Critical patent/ATE142269T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AT89907509T 1988-06-03 1989-06-05 Gentherapie unter verwendung von genschmelzen für genetische und erworbene störungen ATE142269T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20278388A 1988-06-03 1988-06-03

Publications (1)

Publication Number Publication Date
ATE142269T1 true ATE142269T1 (de) 1996-09-15

Family

ID=22751243

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89907509T ATE142269T1 (de) 1988-06-03 1989-06-05 Gentherapie unter verwendung von genschmelzen für genetische und erworbene störungen

Country Status (8)

Country Link
EP (1) EP0420911B1 (de)
JP (1) JP2949440B2 (de)
AT (1) ATE142269T1 (de)
AU (1) AU634162B2 (de)
CA (1) CA1339654C (de)
DE (1) DE68927104T2 (de)
IL (1) IL90514A (de)
WO (1) WO1989012109A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03504560A (ja) * 1988-10-21 1991-10-09 アメリカ合衆国 多薬剤耐性を試験するためのトランスジェニック動物
US5858784A (en) * 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
US5756353A (en) * 1991-12-17 1998-05-26 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol-and liposome-based delivery
US6627615B1 (en) 1991-12-17 2003-09-30 The Regents Of The University Of California Methods and compositions for in vivo gene therapy
US6806084B1 (en) 1992-06-04 2004-10-19 The Regents Of The University Of California Methods for compositions for in vivo gene delivery
EP0646178A1 (de) * 1992-06-04 1995-04-05 The Regents Of The University Of California Expression kassette mit im säugetier wirt funktionnellen regulator sequenzen
DE4238778C2 (de) * 1992-11-12 1995-11-02 Max Delbrueck Centrum Vektor zur Expression von therapeutisch relevanten Genen
US5968735A (en) * 1992-11-12 1999-10-19 Max Delbruck-Centrum Fur Molekular Medizin Berlin Vector for the expression of therapy-relevant genes
US6344445B1 (en) 1995-10-19 2002-02-05 Cantab Pharmaceutical Research Limited Herpes virus vectors and their uses
GB2333527B (en) * 1996-10-29 2001-05-02 Oxford Biomedica Ltd Therapeutic gene
GB9622500D0 (en) 1996-10-29 1997-01-08 Oxford Biomedica Ltd Therapeutic gene
US6924123B2 (en) 1996-10-29 2005-08-02 Oxford Biomedica (Uk) Limited Lentiviral LTR-deleted vector
EP4056686A1 (de) 2012-09-11 2022-09-14 Corning Incorporated Verbrauchbare kryokonservierte zellen mit vorübergehender überexpression von gen(en), die für wirkstofftransporterprotein(e) und/oder wirkstoffmetabolisierende enzym(e) codieren

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE55244B1 (en) * 1982-05-25 1990-07-18 Lilly Co Eli Cloning vectors for expression of exogenous protein
DE3715033A1 (de) * 1987-05-06 1988-11-17 Hoechst Ag Verfahren zur isolierung von fusionsproteinen
JPH03504560A (ja) * 1988-10-21 1991-10-09 アメリカ合衆国 多薬剤耐性を試験するためのトランスジェニック動物
JP3193999B2 (ja) * 1989-06-23 2001-07-30 アメリカ合衆国 非選択性遺伝子の同定可能な発現のための能率的方法

Also Published As

Publication number Publication date
JPH03505818A (ja) 1991-12-19
EP0420911A4 (en) 1991-11-13
AU634162B2 (en) 1993-02-18
DE68927104T2 (de) 1997-03-06
AU3778889A (en) 1990-01-05
WO1989012109A1 (en) 1989-12-14
DE68927104D1 (de) 1996-10-10
JP2949440B2 (ja) 1999-09-13
EP0420911B1 (de) 1996-09-04
CA1339654C (en) 1998-02-03
IL90514A (en) 1995-10-31
EP0420911A1 (de) 1991-04-10

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time