ATE143605T1 - Dual-funktionnierende excipient für metalchelate- kontrastmitteln - Google Patents

Dual-funktionnierende excipient für metalchelate- kontrastmitteln

Info

Publication number
ATE143605T1
ATE143605T1 AT91106575T AT91106575T ATE143605T1 AT E143605 T1 ATE143605 T1 AT E143605T1 AT 91106575 T AT91106575 T AT 91106575T AT 91106575 T AT91106575 T AT 91106575T AT E143605 T1 ATE143605 T1 AT E143605T1
Authority
AT
Austria
Prior art keywords
contrast agents
metalchelate
dual
excipient
functioning excipient
Prior art date
Application number
AT91106575T
Other languages
English (en)
Inventor
C Allen Chang
Krishan Kumar
Michael F Tweedle
Original Assignee
Bracco Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24047292&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE143605(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bracco Int Bv filed Critical Bracco Int Bv
Application granted granted Critical
Publication of ATE143605T1 publication Critical patent/ATE143605T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT91106575T 1990-04-25 1991-04-24 Dual-funktionnierende excipient für metalchelate- kontrastmitteln ATE143605T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51446890A 1990-04-25 1990-04-25

Publications (1)

Publication Number Publication Date
ATE143605T1 true ATE143605T1 (de) 1996-10-15

Family

ID=24047292

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91106575T ATE143605T1 (de) 1990-04-25 1991-04-24 Dual-funktionnierende excipient für metalchelate- kontrastmitteln

Country Status (8)

Country Link
EP (1) EP0454078B1 (de)
JP (1) JP3153260B2 (de)
AT (1) ATE143605T1 (de)
CA (1) CA2039399C (de)
DE (1) DE69122422T2 (de)
DK (1) DK0454078T3 (de)
ES (1) ES2092522T3 (de)
GR (1) GR3021928T3 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4115789A1 (de) * 1991-05-10 1992-11-12 Schering Ag Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
GB9321595D0 (en) * 1993-10-20 1993-12-08 Nycomed Imaging As Contrast agents
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
TW319763B (de) 1995-02-01 1997-11-11 Epix Medical Inc
DE19719033C1 (de) * 1997-04-29 1999-01-28 Schering Ag Ionenpaare, Verfahren zu ihrer Herstellung und ihre Verwendung als Kontrastmittel
US6559330B1 (en) 1999-09-09 2003-05-06 Schering Aktiengesellschaft Calcium complex of [[(4r)-4-[bis{carboxy-.kappa.o)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.o)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.n6,.kappa.n9,.kappa.011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents
US20090208421A1 (en) 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents
KR101142730B1 (ko) * 2009-03-16 2012-05-04 가천의과학대학교 산학협력단 상자성-이노시톨 포스페이트 복합체를 이용한 자기공명영상용 조영제
KR102231121B1 (ko) * 2013-04-26 2021-03-23 게르브 조영제 제형 및 이와 관련된 제조 방법
EP3101012A1 (de) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft Neue gadoliniumchelat-verbindung zur verwendung in der magnetresonanzbildgebung
RU2755181C2 (ru) 2016-11-28 2021-09-14 Байер Фарма Акциенгезельшафт Новые хелатные соединения гадолиния с высокой релаксивностью для применения в магнитно-резонансной визуализации
WO2020084504A1 (en) * 2018-10-24 2020-04-30 Biophore India Pharmaceuticals Pvt. Ltd Novel process for the preparation of macrocyclic chelant 2,2',2''-(10-(2-hydroxypropyl)-1,4,7,10-tetra azacyclododecane-1,4,7-triyl) triacetic acid and it's complexes with paramagnetic metal ions
IL321215B2 (en) 2018-11-23 2026-05-01 Bayer Ag Contrast media formulation and process for its preparation
JP7582053B2 (ja) 2021-04-30 2024-11-13 Ｉ－Ｐｅｘ株式会社 コネクタ及びコネクタシステム
JP7537355B2 (ja) 2021-04-30 2024-08-21 Ｉ－Ｐｅｘ株式会社 コネクタ及び組立方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3772785D1 (de) * 1986-01-23 1991-10-17 Squibb & Sons Inc 1-substituiertes-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecan und analoga.
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
DE3640708C2 (de) * 1986-11-28 1995-05-18 Schering Ag Verbesserte metallhaltige Pharmazeutika
DE3854717T3 (de) * 1987-06-30 1999-04-15 Mallinckrodt, Inc. (N.D.Ges.Des Staates Delaware), St. Louis, Mo. Verfahren zur erhöhung der sicherheit von metall-ligandchelaten als röntgenstrahlen-kontrastmittel.

Also Published As

Publication number Publication date
CA2039399C (en) 2000-09-05
DK0454078T3 (da) 1996-11-18
ES2092522T3 (es) 1996-12-01
EP0454078B1 (de) 1996-10-02
JP3153260B2 (ja) 2001-04-03
JPH04225925A (ja) 1992-08-14
DE69122422T2 (de) 1997-02-13
EP0454078A3 (en) 1991-11-13
DE69122422D1 (de) 1996-11-07
EP0454078A2 (de) 1991-10-30
CA2039399A1 (en) 1991-10-26
GR3021928T3 (en) 1997-03-31

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time