ATE144523T1 - Glykosylierte arzneimittel-vorstufen, verfahren zu ihrer herstellung und ihre verwendungen - Google Patents

Glykosylierte arzneimittel-vorstufen, verfahren zu ihrer herstellung und ihre verwendungen

Info

Publication number
ATE144523T1
ATE144523T1 AT92401218T AT92401218T ATE144523T1 AT E144523 T1 ATE144523 T1 AT E144523T1 AT 92401218 T AT92401218 T AT 92401218T AT 92401218 T AT92401218 T AT 92401218T AT E144523 T1 ATE144523 T1 AT E144523T1
Authority
AT
Austria
Prior art keywords
production
glycosylated products
glycosylated
prodrugs
products
Prior art date
Application number
AT92401218T
Other languages
English (en)
Inventor
Jean-Claude Jacquesy
Jean-Pierre Gesson
Claude Monneret
Martine Mondon
Brigitte Renoux
Jean-Claude Florent
Michel Koch
Francois Tillequin
Hans Harald Sedlacek
Manfred Gerken
Cenek Kolar
Gilbert Gaudel
Klaus Bosslet
Joerg Czech
Dieter Hoffman
Gerhard Seeman
Hans-Ulrich Schorlemmer
Gerhard Dickneite
Original Assignee
Hoechst Sa Lab
Behringwerke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Sa Lab, Behringwerke Ag filed Critical Hoechst Sa Lab
Application granted granted Critical
Publication of ATE144523T1 publication Critical patent/ATE144523T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
AT92401218T 1991-04-30 1992-04-29 Glykosylierte arzneimittel-vorstufen, verfahren zu ihrer herstellung und ihre verwendungen ATE144523T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9105326A FR2676058B1 (fr) 1991-04-30 1991-04-30 Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers.

Publications (1)

Publication Number Publication Date
ATE144523T1 true ATE144523T1 (de) 1996-11-15

Family

ID=9412404

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92401218T ATE144523T1 (de) 1991-04-30 1992-04-29 Glykosylierte arzneimittel-vorstufen, verfahren zu ihrer herstellung und ihre verwendungen

Country Status (15)

Country Link
US (1) US5561119A (de)
EP (1) EP0511917B1 (de)
JP (1) JP3053646B2 (de)
KR (1) KR100254113B1 (de)
AT (1) ATE144523T1 (de)
AU (1) AU673138B2 (de)
CA (1) CA2109304C (de)
DE (1) DE69214712T2 (de)
DK (1) DK0511917T3 (de)
ES (1) ES2096735T3 (de)
FR (1) FR2676058B1 (de)
GR (1) GR3022344T3 (de)
IE (1) IE921369A1 (de)
UA (1) UA56981C2 (de)
WO (1) WO1992019639A1 (de)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610299B1 (en) * 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) * 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
DE4236237A1 (de) * 1992-10-27 1994-04-28 Behringwerke Ag Prodrugs, ihre Herstellung und Verwendung als Arzneimittel
EP0647450A1 (de) * 1993-09-09 1995-04-12 BEHRINGWERKE Aktiengesellschaft Verbesserte Prodrogen für Enzym-vermittelten-Aktivierungen
DK0648503T3 (da) * 1993-09-22 2000-10-02 Hoechst Ag Pro-prodrugs, deres fremstilling og anvendelse
FR2712888B1 (fr) * 1993-11-23 1996-02-09 Bioeurope Utilisation de alpha-D-alkylglucopyranosides et esters de ceux-ci pour la préparation de prodrogues capables de traverser la barrière hématoencéphalique, prodrogues obtenues et précurseurs de celles-ci.
DE4417865A1 (de) * 1994-05-20 1995-11-23 Behringwerke Ag Kombination von Tumornekrose-induzierenden Substanzen mit Substanzen, die durch Nekrosen aktiviert werden, zur selektiven Tumortherapie
US5525606A (en) 1994-08-01 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines
DE19512484A1 (de) 1995-04-04 1996-10-17 Bayer Ag Kohlenhydratmodifizierte Cytostatika
PT751144E (pt) * 1995-06-27 2004-12-31 Pharmachemie Bv Novos pro-farmacos antraciclinicos, metodo para preparacao e tambem a sua utilizacao em quimioterapia selectiva
EP0795334B1 (de) * 1996-03-12 2006-02-01 Sanofi-Aventis Deutschland GmbH Neuartige Prodrugs für die Therapie von Tumoren und entzündlichen Erkrankungen
DE19617851A1 (de) 1996-05-03 1997-11-13 Hoechst Ag Nukleinsäurekonstrukte mit Genen kodierend für Transportsignale
GB2318471A (en) * 1996-10-18 1998-04-22 Stc Submarine Systems Ltd Semiconductor laser amplifiers for transient suppression in optical wavelength division multiplex networks
DE19720312A1 (de) * 1997-05-15 1998-11-19 Hoechst Ag Zubereitung mit erhöhter in vivo Verträglichkeit
DE19751587A1 (de) 1997-11-21 1999-07-29 Hoechst Marion Roussel De Gmbh Onkogen- oder virusgesteuerte Expressionssysteme
WO1999030727A1 (en) 1997-12-17 1999-06-24 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
US6180095B1 (en) 1997-12-17 2001-01-30 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
US6624142B2 (en) 1997-12-30 2003-09-23 Enzon, Inc. Trimethyl lock based tetrapartate prodrugs
US5965119A (en) 1997-12-30 1999-10-12 Enzon, Inc. Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
US6962702B2 (en) 1998-06-22 2005-11-08 Immunomedics Inc. Production and use of novel peptide-based agents for use with bi-specific antibodies
US6214330B1 (en) 1998-07-13 2001-04-10 Enzon, Inc. Coumarin and related aromatic-based polymeric prodrugs
US6043367A (en) * 1998-09-30 2000-03-28 Roffler; Steve Proactive antitumor compounds
US6413507B1 (en) 1999-12-23 2002-07-02 Shearwater Corporation Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
US7220824B1 (en) 2000-08-28 2007-05-22 Bayer Aktiengesellschaft Integrin-mediated drug targeting
US7829074B2 (en) * 2001-10-18 2010-11-09 Nektar Therapeutics Hydroxypatite-targeting poly(ethylene glycol) and related polymers
US6436386B1 (en) 2000-11-14 2002-08-20 Shearwater Corporation Hydroxyapatite-targeting poly (ethylene glycol) and related polymers
EP1219634A1 (de) * 2000-12-27 2002-07-03 Bayer Aktiengesellschaft Glycokonjugate von Cytostatika mit einem geeigneten spaltbaren Peptidlinker
ATE378342T1 (de) * 2001-02-20 2007-11-15 Enzon Inc Terminal verzweigte, polymere linker und diese enthaltende polymere konjugate
EP1238678A1 (de) 2001-03-08 2002-09-11 Bayer Aktiengesellschaft Enzymaktivierte cytostatische Prodrugverbindungen mit Integrin Liganden
US7629309B2 (en) 2002-05-29 2009-12-08 Zystor Therapeutics, Inc. Targeted therapeutic proteins
US7560424B2 (en) 2001-04-30 2009-07-14 Zystor Therapeutics, Inc. Targeted therapeutic proteins
CN1649600A (zh) 2002-02-28 2005-08-03 A&D生物科学公司 氟西汀及类似物的糖醛酰胺、苷和原酸酯苷及其应用
WO2003079980A2 (en) * 2002-03-19 2003-10-02 A & D Bioscience, Inc. Caboxylic acid glycuronides, glycosamides and glycosides of quinolones, penicillins, analogs, and uses thereof
WO2003086475A1 (en) * 2002-04-12 2003-10-23 A & D Bioscience, Inc. Conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents, and uses thereof
CA2484891A1 (en) * 2002-05-07 2003-11-20 A & D Bioscience, Inc. Conjugates comprising central nervous system active drug
US20050215487A1 (en) * 2002-06-27 2005-09-29 Holick Michael F Conjugates comprising an nsaid and a sugar and uses thereof
KR20120068769A (ko) 2002-07-15 2012-06-27 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 음이온성 인지질 및 아미노인지질에 결합하는 선택된 항체 및 치료하는데 있어서 이의 용도
US20040152769A1 (en) * 2002-11-09 2004-08-05 Ekwuribe Nnochiri Nkem Modified carbamate-containing prodrugs and methods of synthesizing same
DE10256982A1 (de) * 2002-12-05 2004-06-24 Schering Ag Neue Effektor-Konjugate, Verfahren zu Ihrer Herstellung und Ihre Pharmazeutische Verwendung
US7902338B2 (en) 2003-07-31 2011-03-08 Immunomedics, Inc. Anti-CD19 antibodies
CA2534639C (en) 2003-07-31 2013-07-30 Immunomedics, Inc. Anti-cd19 antibodies
AU2005282562A1 (en) * 2004-09-08 2006-03-16 Government Of The United States Of America Represented By The Secretary, Department Of Health And Human Services Beta-glucuronidase cleavable prodrugs of O6-alkylguanine-DNA alkyltransferase inactivators
US7825096B2 (en) * 2004-09-08 2010-11-02 The United States Of America As Represented By The Department Of Health And Human Services O6-alkylguanine-DNA alkyltransferase inactivators and beta-glucuronidase cleavable prodrugs
DK3248613T3 (da) 2005-07-18 2022-03-14 Seagen Inc Beta-glucuronid-lægemiddel-linkerkonjugater
US20070185135A1 (en) * 2005-12-30 2007-08-09 Pharmaessentia Corp. Drug-Polymer Conjugates
WO2008153394A2 (en) * 2007-06-14 2008-12-18 Academisch Medisch Centrum Novel anti-inflammatory pro-drugs
JP5404624B2 (ja) * 2007-08-01 2014-02-05 カウンスィル オブ サイエンティフィック アンド インダストリアル リサーチ 選択的な抗腫瘍薬として有用なピロロ［２，１−ｃ］［１，４］ベンゾジアゼピン−グリコシドプロドラッグ
US8440787B2 (en) * 2007-10-23 2013-05-14 Nektar Therapeutics Hydroxyapatite-targeting multiarm polymers and conjugates made therefrom
CA2705152C (en) 2007-11-09 2016-10-11 Peregrine Pharmaceuticals, Inc. Anti-vegf antibody compositions and methods
EP2098533A1 (de) * 2008-03-07 2009-09-09 Pharmachemie B.V. Ester aus Glucuronid-Prodrugs von Anthracyclinen und Verfahren zu deren Herstellung und Verwendung bei der tumorselektiven Chemotherapie
JP5627571B2 (ja) 2008-05-07 2014-11-19 バイオマリン ファーマシューティカル インコーポレイテッド リソソーム標的化ペプチドおよびその使用
US20100316639A1 (en) 2009-06-16 2010-12-16 Genentech, Inc. Biomarkers for igf-1r inhibitor therapy
EP3679942A1 (de) 2009-06-17 2020-07-15 BioMarin Pharmaceutical Inc. Formulierungen für lysosomale enzyme
FR2960153B1 (fr) 2010-05-20 2012-08-17 Centre Nat Rech Scient Nouveaux bras autoreactifs et prodrogues les comprenant
US9023813B2 (en) * 2011-04-13 2015-05-05 NuTek Pharma Ltd. Synthesis and use of glycoside derivatives of propofol
US8962577B2 (en) 2012-03-16 2015-02-24 The Johns Hopkins University Controlled release formulations for the delivery of HIF-1 inhibitors
CN109843919A (zh) 2016-03-25 2019-06-04 西雅图基因公司 用于制备聚乙二醇化的药物-接头及其中间体的方法
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
RS61795B1 (sr) 2017-02-08 2021-06-30 Adc Therapeutics Sa Konjugati pirolobenzodiazepin antitela
KR102648564B1 (ko) 2017-03-24 2024-03-19 씨젠 인크. 글루쿠로니드 약물-링커의 제조 공정 및 그 중간물
CN110582505B (zh) 2017-04-18 2021-04-02 免疫医疗有限公司 吡咯并苯并二氮杂*缀合物
KR102270107B1 (ko) 2017-08-18 2021-06-30 메디뮨 리미티드 피롤로벤조디아제핀 컨쥬게이트
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
EA202191244A1 (ru) 2018-11-05 2021-10-11 Байер Фарма Акциенгезельшафт Новые цитостатические конъюгаты с лигандами интегрина
CN113631560B (zh) 2019-03-15 2025-02-18 麦迪穆有限责任公司 氮杂环丁烷并苯并二氮杂䓬二聚体和用于治疗癌症的包含它们的缀合物
KR102258299B1 (ko) * 2019-03-21 2021-05-28 고려대학교 산학협력단 대장암 선택적 항암 치료진단제
WO2021056270A1 (en) * 2019-09-25 2021-04-01 Peking University Senolytic prodrugs and methods of use thereof
CN114341148B (zh) * 2019-09-25 2024-01-09 北京大学 抗衰老和抗炎前药及其使用方法
WO2021057840A1 (en) * 2019-09-25 2021-04-01 Peking University Senolytic and antiinflammatory prodrugs and methods of use thereof
WO2023057812A1 (en) 2021-10-04 2023-04-13 Vincerx Pharma Gmbh Compounds, pharmaceutical compositions, and methods for the treatment, prevention, or management of hyperproliferative disorder
WO2023057813A1 (en) 2021-10-04 2023-04-13 Vincerx Pharma Gmbh Compounds, pharmaceutical compositions, and methods for the treatment, prevention, or management of hyperproliferative disorders
WO2023057814A1 (en) 2021-10-04 2023-04-13 Vincerx Pharma Gmbh Compounds, pharmaceutical compositions, and methods for the treatment, prevention, or management of hyperproliferative disorders

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4035566A (en) * 1975-09-25 1977-07-12 Sidney Farber Cancer Institute, Inc. N-trifluoroacetyladriamycin-14-alkanoates and therapeutic compositions containing same
WO1981001145A1 (en) * 1979-10-18 1981-04-30 Univ Illinois Hydrolytic enzyme-activatible pro-drugs
GB8705477D0 (en) * 1987-03-09 1987-04-15 Carlton Med Prod Drug delivery systems
US4975278A (en) * 1988-02-26 1990-12-04 Bristol-Myers Company Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
US4952394A (en) * 1987-11-23 1990-08-28 Bristol-Myers Company Drug-monoclonal antibody conjugates
JP3273608B2 (ja) * 1989-01-23 2002-04-08 アクゾ・エヌ・ヴエー 治療薬の部位特異的インビボ活性化
DE3924655A1 (de) * 1989-07-26 1991-01-31 Behringwerke Ag Anthracyclin-derivate
JPH075572B2 (ja) * 1989-08-18 1995-01-25 積水化学工業株式会社 ２―［２―（２―ヒドロキシフェニル）ビニルピラジンおよびその製造法
DE3935016A1 (de) * 1989-10-20 1991-04-25 Behringwerke Ag Glycosyl-etoposid-prodrugs, verfahren zu ihrer herstellung und ihre anwendung in kombination mit funktionalisiertem tumorspezifischen enzym-konjugaten

Also Published As

Publication number Publication date
IE921369A1 (en) 1992-11-04
CA2109304A1 (en) 1992-10-31
CA2109304C (en) 2002-01-15
FR2676058A1 (fr) 1992-11-06
US5561119A (en) 1996-10-01
EP0511917A1 (de) 1992-11-04
KR100254113B1 (ko) 2000-04-15
DK0511917T3 (da) 1997-04-01
DE69214712D1 (de) 1996-11-28
HK1008020A1 (en) 1999-04-30
JP3053646B2 (ja) 2000-06-19
UA56981C2 (uk) 2003-06-16
AU673138B2 (en) 1996-10-31
JPH06506687A (ja) 1994-07-28
GR3022344T3 (en) 1997-04-30
WO1992019639A1 (fr) 1992-11-12
AU1778892A (en) 1992-12-21
DE69214712T2 (de) 1997-05-07
ES2096735T3 (es) 1997-03-16
EP0511917B1 (de) 1996-10-23
FR2676058B1 (fr) 1994-02-25

Similar Documents

Publication Publication Date Title
ATE144523T1 (de) Glykosylierte arzneimittel-vorstufen, verfahren zu ihrer herstellung und ihre verwendungen
HUT59558A (en) New 5-chloro-quinoline-8-oxy-alkane-carboxylic acid derivatives, process for producing and utilizing them as antidotum
IL115790A0 (en) Pharmaceutical compositions containing boronic ester and acid compounds and methods for the preparation thereof
ATA195588A (de) Epipodophyllotoxinglucosid-4'-phosphat-derivate deren herstellung, sowie pharmazeutische zusammensetzungen hierzu
EP0409427A3 (en) Catheter apparatus, and compositions useful for producing same
CA2083179A1 (en) Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use
HUT60784A (en) Process for producing n,o-sulfated heparosanes and pharmaceutical compositions comprising such compounds
KR960701211A (ko) 암 백신을 제조하는 방법(process for preparing cancer vaccines)
HU913213D0 (en) Substituted 2-mercapto-nicotineacid derivatives, process for their production, and the anti-endoparasitic compositions containing them
HUT66234A (en) Process to prepare 4,13-dioxabicyclo(8.2.1)-tridecenon-derivatives and pharmaceutical compositions containing them
KR0156686B1 (en) Pharmaceutical composition comprising aryl-substituted rhodanine derivatives
DE69107031D1 (de) Thexyl-trialkoxysilane, Verfahren zur Herstellung und deren Verwendung.
AU1413788A (en) Dihydropyridinamides process for their preparation, and their use in medicaments
EP0331092A3 (en) Alpha-amino-carboxylic-acid derivatives, their preparation and use
EP0527704A3 (en) Dyestuffs, process for their preparation and the use thereof
EP0234348A3 (en) N-glycosyl amide derivatives, method for their preparation and their use as medicaments
FI930238A7 (fi) N-5-suojatut 2,5-diamino-4,6-diklooripyrimidiinit ja menetelmä niiden valmistamiseksi
PT87563A (pt) Process for the preparation of vinylcephalosporins useful as medicaments
FI933506A7 (fi) Bisyklopolyatsamakrosyklokarboksyylihappokomplekseja, niiden konjugaat teja, menetelmä niiden valmistamiseksi ja käyttö varjoaineina
EP0473267A3 (en) Acylaminopyridinecarboxamides, process for their preparation and their use as fungicides
FI915025A7 (fi) 8-atsabisyklo(3,2,1)oktyylialkyylitiatsolidinoneja, menetelmä niiden valmistamiseksi ja niiden käyttö lääkeaineina
DE69103388D1 (de) Thexyl-(C1-C4)alkyl-dialkoxysilane, Verfahren zur Herstellung und deren Verwendung.
FI952462L (fi) Menetelmä 1,3-oksatsolidin-5-karboksyylihapon valmistamiseksi
PT88294A (pt) Processo para a preparacao de derivados de fenantridina
IL104062A0 (en) Bicyclopolyazamacrocyclophosphonic acid complexes,their conjugates,processes for their preparation,and use as radiopharmaceuticals

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EEIH Change in the person of patent owner