ATE145198T1 - Verfahren zur herstellung eines keton enantiomers - Google Patents

Verfahren zur herstellung eines keton enantiomers

Info

Publication number: ATE145198T1
Authority: AT; Austria
Prior art keywords: cir; dichlorophenyl; isopropyl; butyl; acid ester
Prior art date: 1991-12-13

Application number

AT92920008T

Other languages

English (en)

Inventor

George J Quallich

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-13

Filing date

1992-09-15

Publication date

1996-11-15

1992-09-15 Application filed by Pfizer filed Critical Pfizer

1996-11-15 Application granted granted Critical

1996-11-15 Publication of ATE145198T1 publication Critical patent/ATE145198T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
150000002576 ketones Chemical class 0.000 title 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 6
239000002253 acid Substances 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 abstract 2
150000002148 esters Chemical class 0.000 abstract 2
239000000543 intermediate Substances 0.000 abstract 2
-1 ketobutanoic acid ester Chemical class 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
JGMBHJNMQVKDMW-UHFFFAOYSA-N 4-(3,4-dichlorophenyl)-3,4-dihydro-2h-naphthalen-1-one Chemical compound C1=C(Cl)C(Cl)=CC=C1C1C2=CC=CC=C2C(=O)CC1 JGMBHJNMQVKDMW-UHFFFAOYSA-N 0.000 abstract 1
DPCXOOJTAKKWIC-UHFFFAOYSA-N 4-(3,4-dichlorophenyl)-4-oxobutanoic acid Chemical compound OC(=O)CCC(=O)C1=CC=C(Cl)C(Cl)=C1 DPCXOOJTAKKWIC-UHFFFAOYSA-N 0.000 abstract 1
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
VQTUBCCKSQIDNK-UHFFFAOYSA-N Isobutene Chemical group CC(C)=C VQTUBCCKSQIDNK-UHFFFAOYSA-N 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
235000010290 biphenyl Nutrition 0.000 abstract 1
239000004305 biphenyl Substances 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
239000003638 chemical reducing agent Substances 0.000 abstract 1
238000005859 coupling reaction Methods 0.000 abstract 1
SMBQBQBNOXIFSF-UHFFFAOYSA-N dilithium Chemical compound [Li][Li] SMBQBQBNOXIFSF-UHFFFAOYSA-N 0.000 abstract 1
238000006073 displacement reaction Methods 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000011968 lewis acid catalyst Substances 0.000 abstract 1
125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 1
229950009215 phenylbutanoic acid Drugs 0.000 abstract 1
125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 abstract 1
125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
229960002073 sertraline Drugs 0.000 abstract 1
VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 abstract 1
230000000707 stereoselective effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
- C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT92920008T 1991-12-13 1992-09-15 Verfahren zur herstellung eines keton enantiomers ATE145198T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US80651991A	1991-12-13	1991-12-13

Publications (1)

Publication Number	Publication Date
ATE145198T1 true ATE145198T1 (de)	1996-11-15

Family

ID=25194226

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92920008T ATE145198T1 (de)	1991-12-13	1992-09-15	Verfahren zur herstellung eines keton enantiomers

Country Status (20)

Country	Link
EP (1)	EP0624152B1 (de)
JP (1)	JP2709528B2 (de)
KR (2)	KR940703801A (de)
AT (1)	ATE145198T1 (de)
AU (1)	AU666867B2 (de)
CA (1)	CA2124454C (de)
DE (1)	DE69215235T2 (de)
DK (1)	DK0624152T3 (de)
ES (1)	ES2093848T3 (de)
FI (1)	FI106795B (de)
GR (1)	GR3022028T3 (de)
HU (1)	HU219398B (de)
IL (1)	IL104009A (de)
MX (1)	MX9207178A (de)
NO (1)	NO300729B1 (de)
NZ (2)	NZ245436A (de)
PT (1)	PT101119A (de)
TW (1)	TW226365B (de)
WO (1)	WO1993012062A1 (de)
ZA (1)	ZA929615B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1999046233A1 (en) *	1998-03-09	1999-09-16	Sumika Fine Chemicals Co., Ltd.	Benzyl alcohol derivatives
TR200200110T2 (tr)	1999-07-29	2002-06-21	Ciba Specialty Chemicals Holding Inc.	Sikloheksilidenaminlerin cis-selektif katalitik hidrojenasyonu için süreç

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4839104A (en) *	1987-06-11	1989-06-13	Pfizer, Inc.	Process for preparing sertraline intermediates
US4777288A (en) *	1987-06-11	1988-10-11	Pfizer Inc.	Process for preparing a 4,4-diphenylbutanoic acid derivative
US4921999A (en) *	1988-08-23	1990-05-01	General Electric Company	Method for making tertiary butyl esters

1992
- 1992-09-15 EP EP92920008A patent/EP0624152B1/de not_active Expired - Lifetime
- 1992-09-15 CA CA002124454A patent/CA2124454C/en not_active Expired - Fee Related
- 1992-09-15 ES ES92920008T patent/ES2093848T3/es not_active Expired - Lifetime
- 1992-09-15 DK DK92920008.7T patent/DK0624152T3/da active
- 1992-09-15 HU HU9401763A patent/HU219398B/hu not_active IP Right Cessation
- 1992-09-15 DE DE69215235T patent/DE69215235T2/de not_active Expired - Fee Related
- 1992-09-15 JP JP5510870A patent/JP2709528B2/ja not_active Expired - Fee Related
- 1992-09-15 AU AU25832/92A patent/AU666867B2/en not_active Ceased
- 1992-09-15 AT AT92920008T patent/ATE145198T1/de not_active IP Right Cessation
- 1992-09-15 KR KR1019940702007A patent/KR940703801A/ko not_active Withdrawn
- 1992-09-15 WO PCT/US1992/007654 patent/WO1993012062A1/en not_active Ceased
- 1992-09-23 TW TW081107522A patent/TW226365B/zh active
- 1992-12-07 IL IL104009A patent/IL104009A/en not_active IP Right Cessation
- 1992-12-11 PT PT101119A patent/PT101119A/pt not_active Application Discontinuation
- 1992-12-11 MX MX9207178A patent/MX9207178A/es unknown
- 1992-12-11 NZ NZ245436A patent/NZ245436A/en unknown
- 1992-12-11 NZ NZ270859A patent/NZ270859A/en unknown
- 1992-12-11 ZA ZA929615A patent/ZA929615B/xx unknown
1994
- 1994-06-10 NO NO942184A patent/NO300729B1/no unknown
- 1994-06-10 FI FI942767A patent/FI106795B/fi active
- 1994-06-11 KR KR94702007A patent/KR0136961B1/ko not_active Expired - Fee Related
1996
- 1996-12-13 GR GR960403449T patent/GR3022028T3/el unknown

Also Published As

Publication number	Publication date
WO1993012062A1 (en)	1993-06-24
DE69215235D1 (de)	1996-12-19
NO942184D0 (no)	1994-06-10
HU219398B (hu)	2001-04-28
NZ270859A (en)	1996-01-26
JPH07502504A (ja)	1995-03-16
FI942767A7 (fi)	1994-06-10
NO300729B1 (no)	1997-07-14
CA2124454A1 (en)	1993-06-24
MX9207178A (es)	1993-07-01
EP0624152A1 (de)	1994-11-17
NO942184L (de)	1994-06-10
NZ245436A (en)	1996-01-26
GR3022028T3 (en)	1997-03-31
FI106795B (fi)	2001-04-12
CA2124454C (en)	1997-08-26
JP2709528B2 (ja)	1998-02-04
ZA929615B (en)	1994-06-13
TW226365B (de)	1994-07-11
DE69215235T2 (de)	1997-03-06
EP0624152B1 (de)	1996-11-13
PT101119A (pt)	1994-02-28
KR940703801A (ko)	1994-12-12
IL104009A (en)	1998-02-22
FI942767A0 (fi)	1994-06-10
HUT67623A (en)	1995-04-28
KR0136961B1 (en)	1998-04-25
ES2093848T3 (es)	1997-01-01
DK0624152T3 (da)	1996-12-30
HU9401763D0 (en)	1994-09-28
AU2583292A (en)	1993-07-19
IL104009A0 (en)	1993-05-13
AU666867B2 (en)	1996-02-29

Legal Events

Date	Code	Title	Description
2008-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
Hoffmann et al.	1989	Stereoselective synthesis of alcohols, XXXI: Stereoselective C C bond formation using chiral Z‐pentenylboronates
Shono et al.	1981	Electroorganic chemistry. 46. A new carbon-carbon bond forming reaction at the. alpha.-position of amines utilizing anodic oxidation as a key step
US4943635A (en)	1990-07-24	Enantioselective reduction of ketones
EP0158255A2 (de)	1985-10-16	Optisch wirksame Ketale, Verfahren zu deren Herstellung und deren Verwendung in der Synthese von alpha-Arylalkansäuren
Barnhart et al.	1995	Homogeneous Catalysis. Mechanism of Diastereoselective Hydroacylation of 3-Substituted-4-pentenals using Chiral Rhodium Catalysts
Kim et al.	1993	Stereocontrolled catalytic asymmetric reduction of ketones with oxazaborolidines derived from new chiral amino alcohols
KR20000064735A (ko)	2000-11-06	R-α-프로필-피페로닐 아민 및 그의 유사체의 신규 비대칭 합성 방법
US5399722A (en)	1995-03-21	Process for preparing tert-butyl (3R,5S)-6-hydroxy-3,5--O--isopropylidene-3,5-dihydroxyhexanoate
KR19980701432A (ko)	1998-05-15	레보부피바카인 및 관련된 피페리딘카르복스아닐리드 마취제 제조시 사용하기 위한 라세미화 방법(racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents)
US5196607A (en)	1993-03-23	Process for preparing ketone enantiomer
DE69215235D1 (de)	1996-12-19	Verfahren zur herstellung eines keton enantiomers
DE3862434D1 (de)	1991-05-23	Verfahren zur herstellung eines 4,4-diphenylbutansaeurederivats.
DE69406553D1 (de)	1997-12-04	Verfahren zur herstellung von chiralen tetralonen
Cao et al.	2008	Regio-and diastereoselective conjugate addition of Grignard reagents to aryl substituted α, β-unsaturated carbonyl compounds derived from Oppolzer's sultam
US6177589B1 (en)	2001-01-23	Epoxides, process for their preparation and their use for the preparation of perfuming ingredients
ITMI990364A1 (it)	2000-08-23	Processo per la produzione di paroxetina
Johnson et al.	1973	Microbial oxygenation of dialkylbenzenes (I)
KR100884558B1 (ko)	2009-02-19	고수율 및 고 광학순도의 광학활성 아미드의 제조방법
EP0528694B1 (de)	1997-04-09	Verfahren zur Herstellung von optisch aktiven 3-substituierten-2-Norbornanonen und deren Zwischenprodukte
JPH0641440B2 (ja)	1994-06-01	トランス−β−ベンゾイルアクリル酸エステルの製造法
JP3651009B2 (ja)	2005-05-25	β−スルホキシ−γ−シリルアルコール及びその製造法
US6111125A (en)	2000-08-29	Preparation of (1R,4S)-4-hydroxy-1,2,2-trimethylcyclopentyl methyl ketone and derivatives and stereoisomers of this compound
US20040147756A1 (en)	2004-07-29	Optically active fluorine-containing compounds and processes for their production
ATE319722T1 (de)	2006-03-15	Verfahren zur herstellung von vitamin-d analogen
JP2838529B2 (ja)	1998-12-16	新規な光学活性化合物