ATE145210T1 - Neue bis-platinkomplexe als chemotherapeutisches mittel - Google Patents

Neue bis-platinkomplexe als chemotherapeutisches mittel

Info

Publication number: ATE145210T1
Authority: AT; Austria
Prior art keywords: complexes; platinum; sulfoxide; carboxylate; substituted
Prior art date: 1989-09-01

Application number

AT90913955T

Other languages

English (en)

Inventor

Nicholas Farrell

Original Assignee

Univ Vermont

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-01

Filing date

1990-09-04

Publication date

1996-11-15

1990-09-04 Application filed by Univ Vermont filed Critical Univ Vermont

1996-11-15 Application granted granted Critical

1996-11-15 Publication of ATE145210T1 publication Critical patent/ATE145210T1/de

Links

239000002246 antineoplastic agent Substances 0.000 title 1
229940127089 cytotoxic agent Drugs 0.000 title 1
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 7
150000007942 carboxylates Chemical class 0.000 abstract 3
239000003446 ligand Substances 0.000 abstract 3
229910052697 platinum Inorganic materials 0.000 abstract 3
150000003462 sulfoxides Chemical class 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
229910002651 NO3 Inorganic materials 0.000 abstract 2
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 2
XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 2
229910019142 PO4 Inorganic materials 0.000 abstract 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
150000001805 chlorine compounds Chemical group 0.000 abstract 1
150000004985 diamines Chemical class 0.000 abstract 1
150000004820 halides Chemical class 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
239000010452 phosphate Substances 0.000 abstract 1
229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
150000003057 platinum Chemical class 0.000 abstract 1
229920000768 polyamine Polymers 0.000 abstract 1
150000003141 primary amines Chemical class 0.000 abstract 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
150000003335 secondary amines Chemical class 0.000 abstract 1
229910021653 sulphate ion Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Control Of Throttle Valves Provided In The Intake System Or In The Exhaust System (AREA)
Electrically Driven Valve-Operating Means (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT90913955T 1989-09-01 1990-09-04 Neue bis-platinkomplexe als chemotherapeutisches mittel ATE145210T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/401,919 US5107007A (en)	1989-09-01	1989-09-01	Bis-platinum complexes as chemotherapeutic agents

Publications (1)

Publication Number	Publication Date
ATE145210T1 true ATE145210T1 (de)	1996-11-15

Family

ID=23589786

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90913955T ATE145210T1 (de)	1989-09-01	1990-09-04	Neue bis-platinkomplexe als chemotherapeutisches mittel

Country Status (9)

Country	Link
US (1)	US5107007A (de)
EP (1)	EP0489850B1 (de)
JP (2)	JP3142866B2 (de)
AT (1)	ATE145210T1 (de)
AU (1)	AU645266B2 (de)
CA (1)	CA2065271C (de)
DE (1)	DE69029138T2 (de)
ES (1)	ES2094758T3 (de)
WO (1)	WO1991003482A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5206400A (en) *	1986-07-07	1993-04-27	Ohio State University	Diastereomeric mono- and di-substituted diamino cyclohexane compounds and the method of preparation thereof
US5380897A (en) *	1993-05-25	1995-01-10	Hoeschele; James D.	Tri(platinum) complexes
US5409915A (en) *	1993-09-14	1995-04-25	The University Of Vermont And State Agricultural College	Bis-platinum (IV) complexes as chemotherapeutic agents
IT1273391B (it) *	1994-03-31	1997-07-08	Boehringer Mannheim Italia	Platino complessi cationici trinucleari ad attivita' antitumorale e composizioni farmaceutiche che li contengono
EP0897389B1 (de) *	1996-03-11	2002-07-03	Yoshinori Kidani	Binukleare platinkomplexe, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die diese komplexe enthalten
ZA976422B (en) *	1996-07-22	1998-01-22	Boehringer Mannheim Italia	New bis-platinum complexes with polymethylene derivatives as ligands having antitumor activity.
ZA976421B (en) *	1996-07-22	1998-01-22	Boehringer Mannheim Italia	New bis-platinum complexes with polyamine ligands as antitumor agents.
EP0870770A1 (de) *	1997-04-10	1998-10-14	Kreatech Biotechnology B.V.	Trans-Platinverbindung, ein diese enthaltender, diagnostischer Kit, und ein Verfahren zur Markierung von bioorganischen Molekülen
WO1998045304A1 (en) *	1997-04-10	1998-10-15	Kreatech Biotechnology B.V.	Trans-platinum compound, and diagnostic kit
SE9703396D0 (sv)	1997-09-19	1997-09-19	Lincoln	Binuclear complex
US6130245A (en) *	1998-10-26	2000-10-10	Unitech Pharmaceuticals, Inc.	Dinuclear platinum complexes as cisplatin analogs for cancer treatment
US6001872A (en) *	1999-03-05	1999-12-14	Virginia Commonwealth University	Water soluble transplatinum complexes with anti-cancer activity and method of using same
US6310047B1 (en) *	1999-08-24	2001-10-30	Virginia Commonwealth University	High affinity DNA binding compounds as adjuvants in antisense technology
JP2001148485A (ja)	1999-09-06	2001-05-29	Seiko Epson Corp	半導体装置
US7160908B2 (en) *	2003-03-04	2007-01-09	Unitech Pharmaceuticals, Inc.	Dynamic anticancer platinum compounds
JP5449769B2 (ja) *	2005-06-30	2014-03-19	バイオニューメリック・ファーマスーティカルズ・インコーポレイテッド	モノニトリル含有リガンドを有する白金錯体
ATE488507T1 (de) *	2005-06-30	2010-12-15	Bionumerik Pharmaceuticals Inc	Platinanaloga mit monoazolligand
ITMI20052449A1 (it) *	2005-12-22	2007-06-23	Cell Therapeutics Europe Srl	Nuovi bis-platino complessi ad attivita' antitumorale
US10384935B2 (en) *	2008-07-07	2019-08-20	Northwestern University	Functionalization of carbon nanotubes with metallic moieties
WO2010087976A2 (en) *	2009-01-31	2010-08-05	Igf Oncology, Llc	Anti-cancer protein-platinum conjugates
WO2011085772A1 (en)	2010-01-15	2011-07-21	Basf Se	"process for the dmc-catalyzed preparation of polyols"
JP6831796B2 (ja) *	2015-12-22	2021-02-17	日本化薬株式会社	スルホキシド誘導体配位白金（ｉｉ）錯体の高分子結合体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4560782A (en) *	1982-11-19	1985-12-24	Research Corporation	Anti-tumor diplatinum coordination compounds
US4533502A (en) *	1983-02-22	1985-08-06	Rochon Fernande D	Platinum (II) compounds and their preparation
US4565884A (en) *	1983-05-10	1986-01-21	Andrulis Research Corporation	Bis-platinum complexes as antitumor agents
DE3432320A1 (de) *	1984-09-03	1986-03-13	Behringwerke Ag, 3550 Marburg	Cis-platin-komplexe mit einem pentaerythritderivat als liganden, verfahren zu ihrer herstellung und diese verbindungen enthaltendes pharmazeutisches mittel
US4797393A (en) *	1986-07-25	1989-01-10	University Of Vermont And State Agricultural College	Bis-platinum complexes as chemotherapeutic agents
EP0396588A1 (de) *	1987-12-18	1990-11-14	Boehringer Mannheim Italia S.P.A.	Aminoanthracendion-bis-platin-komplexe, verwendbar als antitumormittel

1989
- 1989-09-01 US US07/401,919 patent/US5107007A/en not_active Expired - Lifetime
1990
- 1990-09-04 EP EP90913955A patent/EP0489850B1/de not_active Expired - Lifetime
- 1990-09-04 AT AT90913955T patent/ATE145210T1/de not_active IP Right Cessation
- 1990-09-04 ES ES90913955T patent/ES2094758T3/es not_active Expired - Lifetime
- 1990-09-04 WO PCT/US1990/004966 patent/WO1991003482A1/en not_active Ceased
- 1990-09-04 JP JP02513023A patent/JP3142866B2/ja not_active Expired - Lifetime
- 1990-09-04 AU AU64050/90A patent/AU645266B2/en not_active Expired
- 1990-09-04 DE DE69029138T patent/DE69029138T2/de not_active Expired - Lifetime
- 1990-09-04 CA CA002065271A patent/CA2065271C/en not_active Expired - Lifetime
1999
- 1999-05-06 JP JP12559699A patent/JP3200421B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU6405090A (en)	1991-04-08
JPH05500218A (ja)	1993-01-21
DE69029138D1 (de)	1996-12-19
JP3200421B2 (ja)	2001-08-20
EP0489850B1 (de)	1996-11-13
WO1991003482A1 (en)	1991-03-21
ES2094758T3 (es)	1997-02-01
JP2000001496A (ja)	2000-01-07
JP3142866B2 (ja)	2001-03-07
US5107007A (en)	1992-04-21
EP0489850A1 (de)	1992-06-17
DE69029138T2 (de)	1997-03-06
CA2065271A1 (en)	1991-03-02
EP0489850A4 (en)	1992-11-04
CA2065271C (en)	1996-02-20
AU645266B2 (en)	1994-01-13

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Legal Events

Date	Code	Title	Description
1997-04-15	UEP	Publication of translation of european patent specification
2010-12-15	EELA	Cancelled due to lapse of time