ATE146474T1 - Imidazoindolizinderivate mit angiotensin-ii hemmwirkung - Google Patents

Imidazoindolizinderivate mit angiotensin-ii hemmwirkung

Info

Publication number: ATE146474T1
Authority: AT; Austria
Prior art keywords: imidazoindolizine; angiotensin; substituted; inhibiting effect; derivatives
Prior art date: 1991-09-10

Application number

AT92114987T

Other languages

English (en)

Inventor

Yasushi Honma

Yasuo Sekine

Sumihiro Nomura

Kazuaki Naito

Hiroshi Narita

Original Assignee

Tanabe Seiyaku Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-10

Filing date

1992-09-02

Publication date

1997-01-15

1992-09-02 Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co

1997-01-15 Application granted granted Critical

1997-01-15 Publication of ATE146474T1 publication Critical patent/ATE146474T1/de

Links

ZTJVDMYOVFOUDV-UHFFFAOYSA-N 5h-imidazo[4,5-g]indolizine Chemical class C1C=C2N=CN=C2C2=CC=CN12 ZTJVDMYOVFOUDV-UHFFFAOYSA-N 0.000 title abstract 3
102000005862 Angiotensin II Human genes 0.000 title abstract 2
101800000733 Angiotensin-2 Proteins 0.000 title abstract 2
CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 title abstract 2
229950006323 angiotensin ii Drugs 0.000 title abstract 2
230000002401 inhibitory effect Effects 0.000 title abstract 2
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
206010020772 Hypertension Diseases 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
125000002915 carbonyl group Chemical class [*:2]C([*:1])=O 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)

AT92114987T 1991-09-10 1992-09-02 Imidazoindolizinderivate mit angiotensin-ii hemmwirkung ATE146474T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP30856091		1991-09-10
JP5304492		1992-01-27

Publications (1)

Publication Number	Publication Date
ATE146474T1 true ATE146474T1 (de)	1997-01-15

Family

ID=26393753

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92114987T ATE146474T1 (de)	1991-09-10	1992-09-02	Imidazoindolizinderivate mit angiotensin-ii hemmwirkung

Country Status (16)

Country	Link
US (1)	US5268377A (de)
EP (1)	EP0531876B1 (de)
JP (1)	JP2590797B2 (de)
KR (1)	KR0168457B1 (de)
AT (1)	ATE146474T1 (de)
AU (1)	AU644539B2 (de)
CA (1)	CA2077420C (de)
DE (1)	DE69216013T2 (de)
DK (1)	DK0531876T3 (de)
ES (1)	ES2098403T3 (de)
FI (1)	FI98369C (de)
GR (1)	GR3022106T3 (de)
ID (1)	ID902B (de)
IL (1)	IL103021A (de)
MY (1)	MY129927A (de)
SG (1)	SG42962A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH06271576A (ja) *	1993-03-19	1994-09-27	Upjohn Co:The	イミダゾール誘導体の製法
FR2712592B1 (fr) *	1993-11-17	1995-12-22	Adir	Nouveaux dérivés tricycliques azotés, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2008151257A2 (en)	2007-06-04	2008-12-11	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2627848T3 (es)	2008-06-04	2017-07-31	Synergy Pharmaceuticals Inc.	Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
ES2624828T3 (es)	2008-07-16	2017-07-17	Synergy Pharmaceuticals Inc.	Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
EP2968439A2 (de)	2013-03-15	2016-01-20	Synergy Pharmaceuticals Inc.	Zusammensetzungen zur behandlung von magen-darm-störungen
US9708367B2 (en)	2013-03-15	2017-07-18	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase and their uses
PL3004138T3 (pl)	2013-06-05	2024-07-29	Bausch Health Ireland Limited	Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie
BR112018077075A2 (pt)	2016-06-29	2019-04-30	Universite De Montreal	heterociclos de biarilmetila

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU1047148A1 (ru) *	1981-03-30	1986-12-23	Институт физико-органической химии и углехимии АН УССР	Бензилиденпроизводные имидазо-[4,5-L]-индолизинов,обладающие бактериостатической и фунгистатической активностью
US4686226A (en) *	1985-09-03	1987-08-11	Merck & Co., Inc.	Substituted benzo[b]furo- and benzo[b]thieno quinolizines
US4812462A (en) *	1986-04-01	1989-03-14	Warner-Lambert Company	4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity
US4816463A (en) *	1986-04-01	1989-03-28	Warner-Lambert Company	Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive activity
CA1334092C (en) *	1986-07-11	1995-01-24	David John Carini	Angiotensin ii receptor blocking imidazoles
DE3928177A1 (de) *	1989-04-08	1991-02-28	Thomae Gmbh Dr K	Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
IL96019A0 (en) *	1989-10-31	1991-07-18	Fujisawa Pharmaceutical Co	Imidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same

1992
- 1992-09-02 AT AT92114987T patent/ATE146474T1/de not_active IP Right Cessation
- 1992-09-02 IL IL10302192A patent/IL103021A/en not_active IP Right Cessation
- 1992-09-02 CA CA002077420A patent/CA2077420C/en not_active Expired - Fee Related
- 1992-09-02 SG SG1996001486A patent/SG42962A1/en unknown
- 1992-09-02 AU AU22056/92A patent/AU644539B2/en not_active Ceased
- 1992-09-02 DE DE69216013T patent/DE69216013T2/de not_active Expired - Fee Related
- 1992-09-02 ES ES92114987T patent/ES2098403T3/es not_active Expired - Lifetime
- 1992-09-02 DK DK92114987.8T patent/DK0531876T3/da active
- 1992-09-02 EP EP92114987A patent/EP0531876B1/de not_active Expired - Lifetime
- 1992-09-03 US US07/939,652 patent/US5268377A/en not_active Expired - Fee Related
- 1992-09-07 MY MYPI92001597A patent/MY129927A/en unknown
- 1992-09-08 KR KR1019920016409A patent/KR0168457B1/ko not_active Expired - Fee Related
- 1992-09-08 JP JP4239080A patent/JP2590797B2/ja not_active Expired - Lifetime
- 1992-09-10 ID IDP469892A patent/ID902B/id unknown
- 1992-09-10 FI FI924043A patent/FI98369C/fi active
1996
- 1996-12-19 GR GR960403177T patent/GR3022106T3/el unknown

Also Published As

Publication number	Publication date
JPH05279365A (ja)	1993-10-26
FI98369C (fi)	1997-06-10
DE69216013D1 (de)	1997-01-30
ID902B (id)	1996-09-09
KR930006024A (ko)	1993-04-20
CA2077420A1 (en)	1993-03-11
EP0531876A2 (de)	1993-03-17
US5268377A (en)	1993-12-07
FI924043A0 (fi)	1992-09-10
AU2205692A (en)	1993-03-11
JP2590797B2 (ja)	1997-03-12
FI924043L (fi)	1993-03-11
DE69216013T2 (de)	1997-05-07
IL103021A0 (en)	1993-02-21
ES2098403T3 (es)	1997-05-01
MY129927A (en)	2007-05-31
SG42962A1 (en)	1997-10-17
EP0531876A3 (de)	1993-05-05
DK0531876T3 (de)	1997-02-17
CA2077420C (en)	1998-08-25
AU644539B2 (en)	1993-12-09
EP0531876B1 (de)	1996-12-18
KR0168457B1 (ko)	1999-01-15
FI98369B (fi)	1997-02-28
GR3022106T3 (en)	1997-03-31
IL103021A (en)	1996-10-16

Legal Events

Date	Code	Title	Description
1997-07-15	UEP	Publication of translation of european patent specification
2000-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
GB9625045D0 (en)	1997-01-22	Parasiticidal compounds
NZ514873A (en)	2004-05-28	4,5,6,7-tetrahydroindazole derivatives as antitumor agents
AU644539B2 (en)	1993-12-09	Imidazoindolizine derivatives and process for preparation thereof
ES2187561T3 (es)	2003-06-16	Derivados heterobiciclicos.
GEP20074124B (en)	2007-06-11	Azaindole kinase inhibitors
WO2001038324A3 (en)	2002-05-10	Imidazole derivatives and their use as raf kinase inhibitors
MXPA05012415A (es)	2006-02-13	Inhibidores de glutamina fructosa-3-fosfato amidotransferasa (gfat).
AU2001293233A1 (en)	2002-03-13	Aza heterocyclic derivatives and their therapeutic use
DK0716649T3 (da)	1999-02-08	5-Arylindolderivater
NO20055655L (no)	2006-01-31	Anvendelse av azetidinkarboksamidderivater i terapi
CA2117643A1 (en)	1993-09-16	Indole Derivatives
NO944371D0 (no)	1994-11-16	Kjemisk forbindelse med blodplateaggregeringsinhiberende virkning
DE69108067D1 (de)	1995-04-20	Thiazolidin-Derivate mit antihypertensiver Aktivität und deren therapeutische Anwendung.
CS743389A3 (en)	1992-03-18	Amino(methyl)phenyl derivatives, process for their preparation and use
DE69916066D1 (de)	2004-05-06	Neue benzoxazole mit pde-hemmender wirkung
AU615385B2 (en)	1991-09-26	Heterocyclicgaunidines as 5ht antagonists
NZ337271A (en)	2001-01-26	4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-one derivatives and their use as dopamine autoreceptor (D2) agonists