ATE147073T1 - Hydantoin-derivate - Google Patents

Hydantoin-derivate

Info

Publication number: ATE147073T1
Authority: AT; Austria
Prior art keywords: group; hydantoin derivatives; optionally protected; solvates; toxic salts
Prior art date: 1988-08-24

Application number

AT89115635T

Other languages

English (en)

Inventor

Ei Mochida

Kimihiro Murakami

Kazuo Kato

Katsuaki Kato

Jun Okuda

Ichitomo Miwa

Original Assignee

Mochida Pharm Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-24

Filing date

1989-08-24

Publication date

1997-01-15

1988-08-24 Priority claimed from US07/235,557 external-priority patent/US4914099A/en

1989-08-24 Application filed by Mochida Pharm Co Ltd filed Critical Mochida Pharm Co Ltd

1997-01-15 Application granted granted Critical

1997-01-15 Publication of ATE147073T1 publication Critical patent/ATE147073T1/de

Links

229940053195 antiepileptics hydantoin derivative Drugs 0.000 title abstract 5
WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical class O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 title 1
150000001469 hydantoins Chemical class 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 2
231100000252 nontoxic Toxicity 0.000 abstract 2
230000003000 nontoxic effect Effects 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
239000012453 solvate Substances 0.000 abstract 2
239000003288 aldose reductase inhibitor Substances 0.000 abstract 1
229940090865 aldose reductase inhibitors used in diabetes Drugs 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/70—Sulfur atoms
- C07D277/76—Sulfur atoms attached to a second hetero atom
- C07D277/80—Sulfur atoms attached to a second hetero atom to a nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/64—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/14—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 6 and unsubstituted in position 7
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT89115635T 1988-08-24 1989-08-24 Hydantoin-derivate ATE147073T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/235,557 US4914099A (en)	1987-08-28	1988-08-24	Hydantoin derivatives as aldose reductase inhibitors
JP4342289		1989-02-25

Publications (1)

Publication Number	Publication Date
ATE147073T1 true ATE147073T1 (de)	1997-01-15

Family

ID=26383180

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89115635T ATE147073T1 (de)	1988-08-24	1989-08-24	Hydantoin-derivate

Country Status (11)

Country	Link
EP (1)	EP0355827B1 (de)
AT (1)	ATE147073T1 (de)
AU (2)	AU623676B2 (de)
CA (1)	CA1338866C (de)
DE (1)	DE68927599T2 (de)
DK (1)	DK100190A (de)
ES (1)	ES2098222T3 (de)
FI (1)	FI902028A7 (de)
GR (1)	GR3022223T3 (de)
NO (1)	NO176478C (de)
WO (1)	WO1990002126A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5202339A (en) *	1987-08-28	1993-04-13	Mochida Pharmaceutical Co., Ltd.	Hydantoin derivatives
US5004751A (en) *	1987-08-28	1991-04-02	Mochida Pharmaceutical Co., Ltd.	Hydantoin derivatives
JP2673381B2 (ja) *	1990-02-23	1997-11-05	持田製薬株式会社	糖尿病前症治療剤および／または脂質低下剤
DE4426245A1 (de)	1994-07-23	1996-02-22	Gruenenthal Gmbh	1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
EP0853620A1 (de) *	1995-10-04	1998-07-22	Fmc Corporation	Heterocyclisch substituierte benzisoxazole und benzisoxazolidinone als herbizide
WO1998007719A1 (en) *	1996-08-22	1998-02-26	Dong Wha Pharm. Ind. Co., Ltd.	Arylsulfonylimidazolone derivatives as an antitumor agent
AU2001264616A1 (en) *	2000-05-17	2001-11-26	Cor Therapeutics, Inc.	Methods for producing amino substituted chromanes and intermediates therefor
GB2435825A (en) *	2006-03-09	2007-09-12	Esteve Labor Dr	Benzimidazole-2- & pyrido[d]imidazole-2- sulphonamide derivatives for treatment of disorders mediated via 5-HT6 receptors, eg those related to food intake
US9487485B2 (en)	2013-02-28	2016-11-08	Takeda Pharmaceutical Company Limited	Method for producing sulfonyl chloride compound

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3384643A (en) *	1965-02-17	1968-05-21	Upjohn Co	1-hydrocarbylsulfonyl-2, 2-dichloro (ordialkoxy)-4, 5-imidazolidine diones
US3534022A (en) *	1966-02-17	1970-10-13	Dainippon Pharmaceutical Co	1-sulfonyl-5,5-disubstituted hydantoins and processes for preparation thereof
WO1986001107A1 (en) *	1984-08-14	1986-02-27	Pfizer Inc.	Tetracyclic spiro-hydantoin aldose reductase inhibitors, compositions and methods of making
US4666931A (en) *	1984-12-29	1987-05-19	Kaken Pharmaceutical Co., Ltd.	Benzofuran derivatives useful in treating diabetic complications
US4575507A (en) *	1985-05-29	1986-03-11	Pfizer Inc.	Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use
US4743611A (en) *	1986-07-02	1988-05-10	American Home Products Corp.	Naphthalenylsulfonylimidazolidinediones and their thioxo analogs useful as aldose reductase inhibitors
JP2764262B2 (ja) *	1987-08-28	1998-06-11	持田製薬株式会社	ヒダントイン誘導体及びそれを有効成分とする医薬組成物

1989
- 1989-08-22 WO PCT/JP1989/000851 patent/WO1990002126A1/en not_active Ceased
- 1989-08-22 FI FI902028A patent/FI902028A7/fi not_active Application Discontinuation
- 1989-08-22 AU AU40647/89A patent/AU623676B2/en not_active Ceased
- 1989-08-23 CA CA000609100A patent/CA1338866C/en not_active Expired - Fee Related
- 1989-08-24 EP EP89115635A patent/EP0355827B1/de not_active Expired - Lifetime
- 1989-08-24 DE DE68927599T patent/DE68927599T2/de not_active Expired - Fee Related
- 1989-08-24 ES ES89115635T patent/ES2098222T3/es not_active Expired - Lifetime
- 1989-08-24 AT AT89115635T patent/ATE147073T1/de not_active IP Right Cessation
1990
- 1990-04-23 NO NO901789A patent/NO176478C/no unknown
- 1990-04-23 DK DK100190A patent/DK100190A/da not_active Application Discontinuation
1992
- 1992-08-21 AU AU21225/92A patent/AU646967B2/en not_active Ceased
1997
- 1997-01-03 GR GR960403684T patent/GR3022223T3/el unknown

Also Published As

Publication number	Publication date
EP0355827A2 (de)	1990-02-28
FI902028A0 (fi)	1990-04-23
EP0355827B1 (de)	1997-01-02
DE68927599T2 (de)	1997-05-15
AU2122592A (en)	1992-10-15
GR3022223T3 (en)	1997-04-30
DK100190A (da)	1990-06-14
ES2098222T3 (es)	1997-05-01
DE68927599D1 (de)	1997-02-13
AU4064789A (en)	1990-03-23
FI902028A7 (fi)	1990-04-23
NO901789D0 (no)	1990-04-23
WO1990002126A1 (en)	1990-03-08
AU646967B2 (en)	1994-03-10
EP0355827A3 (de)	1990-03-21
AU623676B2 (en)	1992-05-21
DK100190D0 (da)	1990-04-23
CA1338866C (en)	1997-01-21
NO901789L (no)	1990-04-23
NO176478B (no)	1995-01-02
NO176478C (no)	1995-04-12

Legal Events

Date	Code	Title	Description
1997-08-15	UEP	Publication of translation of european patent specification
2000-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
NZ507144A (en)	2002-10-25	Benzamide derivatives useful for the treatment of diseases mediated by cytokines
DK0418845T3 (da)	1995-09-18	Pyrazolderivater, fremgangsmåder til fremstilling deraf og farmaceutisk præparat omfattende samme
DE69942801D1 (de)	2010-11-11	Heterozyklische indolderivate und mono- oder diazaindol-derivate
DK0528337T3 (da)	2000-03-27	Thiazolylbenzofuranderivater, fremgangsmåde til fremstilling deraf og farmaceutiske præparater, der indeholder disse forbin
AU643310B2 (en)	1993-11-11	Isoxazole derivatives
DE68927599D1 (de)	1997-02-13	Hydantoin-Derivate
AU5795694A (en)	1994-09-29	New bicyclic nitrogen compounds, process for preparing them and pharmaceutical compositions containing them
DE60330758D1 (de)	2010-02-11	Bestimmte pharmazeutisch wertvolle substituierte aminoalkyl-heterocyclen
ATE402151T1 (de)	2008-08-15	2-(arylphenyl)amino-imidazolin-derivate
DK1135387T3 (da)	2002-11-25	3-(heterocyclyl)-benzoylpyrazol-derivater
IL84300A (en)	1991-11-21	Herbicidal compositions containing 1-(2-(hetero)-arylsulphonylcarbanoyl)-2-pyrazoline derivatives,certain such novel compounds and their preparation
AU2003251172A1 (en)	2004-06-18	1,2,4-triazole derivative, method for preparing the same, and pharmaceutical composition containing the same
KR940018362A (ko)	1994-08-16	니코틴산 유도체
MXPA01011888A (es)	2002-06-21	Derivados de tetrazolinona.
DE69208384D1 (de)	1996-03-28	Fungizide Furanonderivate
GB0427491D0 (en)	2005-01-19	Process and compounds