ATE147281T1 - Produktinformation in chromatographischem effluenten durch differenzbildung - Google Patents

Produktinformation in chromatographischem effluenten durch differenzbildung

Info

Publication number
ATE147281T1
ATE147281T1 AT92910887T AT92910887T ATE147281T1 AT E147281 T1 ATE147281 T1 AT E147281T1 AT 92910887 T AT92910887 T AT 92910887T AT 92910887 T AT92910887 T AT 92910887T AT E147281 T1 ATE147281 T1 AT E147281T1
Authority
AT
Austria
Prior art keywords
product information
difference formation
chromatographic effluents
effluents
chromatographic
Prior art date
Application number
AT92910887T
Other languages
English (en)
Inventor
Noubar B Afeyan
Fred E Regnier
Original Assignee
Perseptive Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perseptive Biosystems Inc filed Critical Perseptive Biosystems Inc
Application granted granted Critical
Publication of ATE147281T1 publication Critical patent/ATE147281T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G01N30/14—Preparation by elimination of some components
    • G01N2030/143—Preparation by elimination of some components selective absorption
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G01N30/52—Physical parameters
    • G01N2030/524—Physical parameters structural properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N2030/621—Detectors specially adapted therefor signal-to-noise ratio
    • G01N2030/625—Detectors specially adapted therefor signal-to-noise ratio by measuring reference material, e.g. carrier without sample
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/80—Fraction collectors
    • G01N30/82—Automatic means therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Fats And Perfumes (AREA)
  • External Artificial Organs (AREA)
  • Processing Of Solid Wastes (AREA)
  • Detergent Compositions (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT92910887T 1991-03-28 1992-03-20 Produktinformation in chromatographischem effluenten durch differenzbildung ATE147281T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67687291A 1991-03-28 1991-03-28

Publications (1)

Publication Number Publication Date
ATE147281T1 true ATE147281T1 (de) 1997-01-15

Family

ID=24716390

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92910887T ATE147281T1 (de) 1991-03-28 1992-03-20 Produktinformation in chromatographischem effluenten durch differenzbildung

Country Status (8)

Country Link
US (1) US5234586A (de)
EP (1) EP0533909B1 (de)
JP (1) JP3175941B2 (de)
AT (1) ATE147281T1 (de)
AU (1) AU647929B2 (de)
CA (1) CA2083820A1 (de)
DE (1) DE69216520T2 (de)
WO (1) WO1992017259A1 (de)

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US5935522A (en) * 1990-06-04 1999-08-10 University Of Utah Research Foundation On-line DNA analysis system with rapid thermal cycling
US7273749B1 (en) 1990-06-04 2007-09-25 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US5228960A (en) * 1992-07-17 1993-07-20 Beckman Instruments, Inc. Analysis of samples by capillary electrophoretic immunosubtraction
US5316630A (en) * 1993-03-30 1994-05-31 Dionex Corporation Methods for chromatography analysis
US5491096A (en) * 1993-12-27 1996-02-13 Eli Lilly And Company Antigen detection with affinity chromatography and parallel processing a control
EP0704053A1 (de) * 1994-04-13 1996-04-03 Beckman Instruments, Inc. Analyse von analyten in biologischen flüssigkeiten
AU6160896A (en) * 1995-06-07 1996-12-30 Life Technologies, Inc. On line detection of a desired solute in an effluent stream using fluorescence spectroscopy
US5783397A (en) * 1995-12-11 1998-07-21 Northeastern University Screening natural samples for new therapeutic compounds using capillary electrophoresis
JP4540754B2 (ja) * 1996-06-04 2010-09-08 ユニバーシティ オブ ユタ リサーチ ファウンデーション Ｐｃｒ中のハイブリダイゼーションのモニタリング
US5837135A (en) * 1996-07-09 1998-11-17 Agency Of Industrial Science And Technology Chromatography and related apparatus system
US5938932A (en) * 1997-11-14 1999-08-17 Pharmacopeia, Inc. High-throughput method and apparatus for identifying, quantitating and determining the purity of chemical compounds in mixtures
US6299747B1 (en) 1997-12-17 2001-10-09 Cetek Corporation Capillary electrophoretic methods to detect new biologically active compounds in complex biological material
AU2199099A (en) * 1997-12-31 1999-07-19 Genentech Inc. Real-time monitoring of an analyte by chromatography using an on-line assay
US6136197A (en) * 1998-05-27 2000-10-24 Battelle Memorial Institute Systems for column-based separations, methods of forming packed columns, and methods of purifying sample components
US6077438A (en) 1998-12-22 2000-06-20 Combichem, Inc. Automated on-line evaporation light scattering detection to quantify isolated fluid sample compounds in microtiter plate format
DE19914358C2 (de) * 1999-03-30 2001-05-17 Agilent Technologies Inc Vorrichtung und Verfahren zur Bereitstellung von Volumenströmen von Flüssigkeiten in Kapillaren
AU4450900A (en) 1999-04-23 2000-11-10 Advanced Bioanalytical Services, Inc. High-throughput parallel liquid chromatography system
WO2001004622A1 (en) * 1999-07-13 2001-01-18 The Dow Chemical Company Method for chemical analysis of biological material
US6106710A (en) * 1999-09-10 2000-08-22 Agilent Technologies, Inc. Fraction collection delay calibration for liquid chromatography
DE19945351C2 (de) * 1999-09-22 2002-04-18 Lohmann Therapie Syst Lts Verfahren zum Auffinden und zur Isolierung pharmakologisch wirksamer Verbindungen aus Substanzgemischen
US6767467B2 (en) * 2000-07-06 2004-07-27 Agilent Technologies, Inc. Fraction collection delay calibration for liquid chromatography
US6402946B1 (en) * 2000-10-26 2002-06-11 Bruker Analytik Gmbh Device for feeding a chromatography flow
DE60130353T2 (de) * 2000-11-02 2008-05-29 Gene Bio-Application Ltd. Gel für elektrophorese
US7691645B2 (en) * 2001-01-09 2010-04-06 Agilent Technologies, Inc. Immunosubtraction method
US20020186263A1 (en) * 2001-06-07 2002-12-12 Nanostream, Inc. Microfluidic fraction collectors
US6813929B2 (en) 2002-08-01 2004-11-09 Dionex Corporation Method and apparatus for monitoring fluid flow
US7332087B2 (en) * 2003-11-26 2008-02-19 Waters Investments Limited Flow sensing apparatus used to monitor/provide feedback to a split flow pumping system
US7186336B2 (en) * 2003-11-26 2007-03-06 Waters Investments Limited Flow sensing apparatus
US7204264B2 (en) * 2004-04-21 2007-04-17 Waters Investments Ltd. High pressure capillary micro-fluidic valve device and a method of fabricating same
US8877051B2 (en) * 2006-07-21 2014-11-04 Waters Technologies Corporation Time delay for sample collection in chromatography systems
JP2010540965A (ja) * 2007-12-05 2010-12-24 オールテック・アソシエイツ・インコーポレーテッド サンプルの画分を収集しサンプルを分析するための方法および装置
WO2009152291A1 (en) * 2008-06-11 2009-12-17 Argonide Corporation Chromatrography device with a stationary phase including a nano alumina medium
JP5653930B2 (ja) 2008-12-04 2015-01-14 オールテック・アソシエイツ・インコーポレーテッド 流体のアリコットサンプルを移動させるための方法および装置
WO2010068276A1 (en) 2008-12-10 2010-06-17 Alltech Associates Inc. Chromatography systems and system components
US8314934B2 (en) 2009-09-01 2012-11-20 Alltech Associates, Inc. Methods and apparatus for analyzing samples and collecting sample fractions
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US11287403B2 (en) * 2016-01-07 2022-03-29 Board Of Regents, The University Of Texas System Ion chromatography system and methods utilizing a weak acid or weak base extraction device
US11478524B1 (en) * 2017-07-31 2022-10-25 University Of South Florida Methods and compositions for modulating complex mixtures by selective deletion chromatography

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Also Published As

Publication number Publication date
JP3175941B2 (ja) 2001-06-11
DE69216520T2 (de) 1997-04-24
US5234586A (en) 1993-08-10
AU647929B2 (en) 1994-03-31
EP0533909A4 (en) 1993-06-30
CA2083820A1 (en) 1992-09-29
WO1992017259A1 (en) 1992-10-15
DE69216520D1 (de) 1997-02-20
EP0533909A1 (de) 1993-03-31
JPH06500402A (ja) 1994-01-13
EP0533909B1 (de) 1997-01-08
AU1768292A (en) 1992-11-02

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