ATE147390T1 - Verfahren zur herstellung von 3',4'- anhydrovinblastin - Google Patents

Verfahren zur herstellung von 3',4'- anhydrovinblastin

Info

Publication number: ATE147390T1
Authority: AT; Austria
Prior art keywords: producing; anhydrovinblastin; anhydrovinblastine; reacting; catharanthine
Prior art date: 1988-08-11

Application number

AT93108543T

Other languages

English (en)

Inventor

Hiroaki Tan

Naoya Sakamoto

Eiichirou Hata

Takeshi Ishitoku

Noriaki Kihara

Original Assignee

Mitsui Petrochemical Ind

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-11

Filing date

1989-08-09

Publication date

1997-01-15

1988-08-11 Priority claimed from JP63198898A external-priority patent/JP2582131B2/ja

1988-08-11 Priority claimed from JP63198897A external-priority patent/JP2564618B2/ja

1989-08-09 Application filed by Mitsui Petrochemical Ind filed Critical Mitsui Petrochemical Ind

1997-01-15 Application granted granted Critical

1997-01-15 Publication of ATE147390T1 publication Critical patent/ATE147390T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
FFRFGVHNKJYNOV-DOVUUNBWSA-N 3',4'-Anhydrovinblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C=C(C2)CC)N2CCC2=C1NC1=CC=CC=C21 FFRFGVHNKJYNOV-DOVUUNBWSA-N 0.000 abstract 2
GKWYINOZGDHWRA-UHFFFAOYSA-N catharanthine Natural products C1C(CC)(O)CC(CC2C(=O)OC)CN1CCC1=C2NC2=CC=CC=C12 GKWYINOZGDHWRA-UHFFFAOYSA-N 0.000 abstract 2
WVTGEXAIVZDLCR-UHFFFAOYSA-N Vindoline Natural products CC1C2CN3CCCC14CCC5Nc6ccccc6C25C34 WVTGEXAIVZDLCR-UHFFFAOYSA-N 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
229940041181 antineoplastic drug Drugs 0.000 abstract 1
CMKFQVZJOWHHDV-DYHNYNMBSA-N catharanthine Chemical compound C([C@@H]1C=C([C@@H]2[C@@]3(C1)C(=O)OC)CC)N2CCC1=C3NC2=CC=CC=C12 CMKFQVZJOWHHDV-DYHNYNMBSA-N 0.000 abstract 1
239000007795 chemical reaction product Substances 0.000 abstract 1
239000003638 chemical reducing agent Substances 0.000 abstract 1
230000000415 inactivating effect Effects 0.000 abstract 1
CXBGOBGJHGGWIE-IYJDUVQVSA-N vindoline Chemical compound CN([C@H]1[C@](O)([C@@H]2OC(C)=O)C(=O)OC)C3=CC(OC)=CC=C3[C@]11CCN3CC=C[C@]2(CC)[C@@H]13 CXBGOBGJHGGWIE-IYJDUVQVSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G5/00—Alkaloids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT93108543T 1988-08-11 1989-08-09 Verfahren zur herstellung von 3',4'- anhydrovinblastin ATE147390T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP63198898A JP2582131B2 (ja)	1988-08-11	1988-08-11	二量体アルカロイドの製造方法
JP63198897A JP2564618B2 (ja)	1988-08-11	1988-08-11	３’，４’−アンヒドロビンブラスチンの製造方法

Publications (1)

Publication Number	Publication Date
ATE147390T1 true ATE147390T1 (de)	1997-01-15

Family

ID=26511236

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93108543T ATE147390T1 (de)	1988-08-11	1989-08-09	Verfahren zur herstellung von 3',4'- anhydrovinblastin

Country Status (6)

Country	Link
US (1)	US5037977A (de)
EP (2)	EP0354778B1 (de)
KR (1)	KR920001138B1 (de)
AT (1)	ATE147390T1 (de)
CA (1)	CA1334588C (de)
DE (2)	DE68913855T2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5432279A (en) *	1989-03-04	1995-07-11	Mitsui Petrochemical Industries, Inc.	Process for the preparation of binary indole alkaloids
US20030162803A1 (en) *	1997-03-04	2003-08-28	Bruce Schmidt	Anhydrovinblastine for the treatment of cancer
CA2219095A1 (en) *	1997-03-04	1998-09-04	Bruce Schmidt	Anhydrovinblastine for the treatment of cervical and lung cancer
AU783029B2 (en) *	1997-03-04	2005-09-15	University Of British Columbia, The	Anhydrovinblastine for the treatment of cervical and lung cancer
US6049419A (en)	1998-01-13	2000-04-11	3M Innovative Properties Co	Multilayer infrared reflecting optical body
FR2779146B1 (fr) *	1998-06-02	2002-01-18	Roowin	Nouveaux derives de vinca-alcaloides et procedes de preparation
FR2822830B1 (fr) *	2001-03-30	2003-06-06	Commissariat Energie Atomique	Procede de reduction de la leurosine en anhydrovinblastine
CN103936769B (zh) *	2014-04-30	2016-10-05	淮海工学院	一种制备高光学纯脱水长春碱的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2296418B1 (de) *	1974-12-30	1978-07-21	Anvar
US4279817A (en) *	1975-05-30	1981-07-21	The United States Of America As Represented By The Department Of Health & Human Services	Method for producing dimer alkaloids
FR2544319B1 (fr) *	1983-04-14	1985-08-09	Fabre Sa Pierre	Procede de preparation de l'anhydrovinblastine
US4778885A (en) *	1986-09-18	1988-10-18	Allelix Inc.	Production of alkaloid dimers using ferric ion
CA1341261C (en) *	1987-01-22	2001-06-26	James P. Kutney	Process for the synthesis of 3',4'-anhydrovinblastine, vinblastine and vincristine

1989
- 1989-08-08 US US07/390,903 patent/US5037977A/en not_active Expired - Fee Related
- 1989-08-09 EP EP89308089A patent/EP0354778B1/de not_active Expired - Lifetime
- 1989-08-09 EP EP93108543A patent/EP0569043B1/de not_active Expired - Lifetime
- 1989-08-09 DE DE68913855T patent/DE68913855T2/de not_active Expired - Fee Related
- 1989-08-09 DE DE68927649T patent/DE68927649T2/de not_active Expired - Fee Related
- 1989-08-09 AT AT93108543T patent/ATE147390T1/de not_active IP Right Cessation
- 1989-08-10 KR KR1019890011386A patent/KR920001138B1/ko not_active Expired
- 1989-08-10 CA CA000607984A patent/CA1334588C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR920001138B1 (ko)	1992-02-06
EP0569043B1 (de)	1997-01-08
CA1334588C (en)	1995-02-28
EP0354778A2 (de)	1990-02-14
US5037977A (en)	1991-08-06
EP0354778A3 (de)	1991-04-17
KR900003188A (ko)	1990-03-26
DE68927649D1 (de)	1997-02-20
DE68913855T2 (de)	1995-02-02
EP0569043A1 (de)	1993-11-10
EP0354778B1 (de)	1994-03-16
DE68913855D1 (de)	1994-04-21
DE68927649T2 (de)	1997-06-19

Similar Documents

Publication	Publication Date	Title
ATE121088T1 (de)	1995-04-15	Verfahren zur herstellung von imidazo(4,5- c>chinolin-4-aminen.
ATE259374T1 (de)	2004-02-15	Verfahren zur herstellung von isoguanosin und 2'- derivaten davon
DE3887625D1 (de)	1994-03-17	Verfahren zur Herstellung von 1,1,1-Trifluorodichlorethan und von 1,1,1,2-Tetrafluorchlorethan.
DE3863170D1 (de)	1991-07-11	Mesophasenpech zur herstellung von kohlenstoffkoerpern und verfahren zur herstellung derselben.
ATE161013T1 (de)	1997-12-15	Verfahren zum reinigen von 20 cs)-camptothecin
DE69427955D1 (de)	2001-09-20	Verfahren zur Herstellung von 2,2-Difluorketensilylacetalen und alpha,alpha-Difluor-beta -Silyloxy-1,3-Dioxolan-4-Propansäureestern
DE68927649D1 (de)	1997-02-20	Verfahren zur Herstellung von 3',4'-Anhydrovinblastin
HUT45564A (en)	1988-07-28	Process for producing hirudine variants
ATE181549T1 (de)	1999-07-15	Verfahren zur herstellung von (s)-3-amino-1- substituiert-pirrolidine
DE69428845D1 (de)	2001-12-06	Verfahren zur Herstellung von Sende-Empfängern
DE68908576D1 (de)	1993-09-30	Verfahren zur Herstellung von Aktivkohle.
DE59209957D1 (de)	2002-07-04	Verfahren zur Herstellung von mono-N-substituierten Tetraazamakrocyclen
DE69403550D1 (de)	1997-07-10	Vorrichtung zur Herstellung von gebohrten Nadelrohlingen
DE69314445D1 (de)	1997-11-13	Verfahren zur Herstellung von Wasserstoffperoxyd
DE59303465D1 (de)	1996-09-26	Verfahren zur Reaktivierung eines bei der Herstellung von 1,1,1,2,3,3,3-Heptafluorpropan (R 227) eingesetzten Aktivkohle-Katalysators
DE69321885D1 (de)	1998-12-10	Verfahren zur fermentativen Herstellung von 10-Hydroxy-C18-Carbonsäure und Gamma-Dodekalaktonderivaten
DE59309380D1 (de)	1999-03-25	Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsäure
ATA112388A (de)	1989-08-15	Verfahren zur herstellung von 5-chlor-3chlorsulfonyl-2-thiophencarbonsaeureestern
NO903338D0 (no)	1990-07-27	Fremgangsmaate for mikrobiologisk fremstilling av l-carnitin.
EP0292806A3 (en)	1990-10-17	Substituted vinyl cephalosporins, process for their preparation and their use as medicines
DE59010812D1 (de)	1998-04-23	Verfahren zur Herstellung von 2-Acylamino-6-halogen-purin aus 2,9-Diacylguanin
DE3785537D1 (de)	1993-05-27	Mikroorganismus und verfahren zur herstellung von oxydationsverbindungen mit diesem mikroorganismus.
DE69326050D1 (de)	1999-09-23	Verfahren zur Herstellung von 0,0'-Diacylweinsäureanhydrid und Verfahren zur Herstellung von 0,0'-Diacylweinsäure
DE68908843D1 (de)	1993-10-07	Verfahren zur Herstellung von 4,6-Dimethyl-7-hydroxynonan-3-on.
DE4294717T1 (de)	1994-01-13	Verfahren zur Herstellung von medizinischen Beuteln

Legal Events

Date	Code	Title	Description
1997-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties