ATE147787T1 - Verfahren zur herstellung von polypeptiden in einem zellfreien system - Google Patents
Verfahren zur herstellung von polypeptiden in einem zellfreien systemInfo
- Publication number
- ATE147787T1 ATE147787T1 AT90912892T AT90912892T ATE147787T1 AT E147787 T1 ATE147787 T1 AT E147787T1 AT 90912892 T AT90912892 T AT 90912892T AT 90912892 T AT90912892 T AT 90912892T AT E147787 T1 ATE147787 T1 AT E147787T1
- Authority
- AT
- Austria
- Prior art keywords
- substrates
- cell
- products
- free system
- utp
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 210000004671 cell-free system Anatomy 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000758 substrate Substances 0.000 abstract 4
- 229910019142 PO4 Inorganic materials 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 abstract 2
- 235000011180 diphosphates Nutrition 0.000 abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 2
- 239000010452 phosphate Substances 0.000 abstract 2
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 abstract 1
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/585—Calcitonins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10211—Podoviridae
- C12N2795/10222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU4717700 | 1989-07-31 | ||
| SU4823743 RU1839191C (ru) | 1990-05-29 | 1990-05-29 | Способ получени полипептидов в бесклеточной системе трансл ции |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE147787T1 true ATE147787T1 (de) | 1997-02-15 |
Family
ID=26666213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90912892T ATE147787T1 (de) | 1989-07-31 | 1990-06-14 | Verfahren zur herstellung von polypeptiden in einem zellfreien system |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6399323B1 (de) |
| EP (1) | EP0593757B1 (de) |
| AT (1) | ATE147787T1 (de) |
| CA (1) | CA2064754C (de) |
| DE (1) | DE69029744T2 (de) |
| DK (1) | DK0593757T3 (de) |
| WO (1) | WO1991002076A1 (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2904583B2 (ja) * | 1991-10-11 | 1999-06-14 | プロメガ・コーポレーション | 真核無細胞抽出物中での転写と翻訳の共役 |
| US5665563A (en) * | 1991-10-11 | 1997-09-09 | Promega Corporation | Coupled transcription and translation in eukaryotic cell-free extract |
| AU4930993A (en) * | 1992-09-24 | 1994-04-12 | Public Health Research Institute Of The City Of New York, Inc., The | Coupled replication-translation methods and kits for protein synthesis |
| WO1996014428A1 (en) * | 1994-11-08 | 1996-05-17 | Novagen, Inc. | Method for in vitro protein synthesis |
| US6537776B1 (en) | 1999-06-14 | 2003-03-25 | Diversa Corporation | Synthetic ligation reassembly in directed evolution |
| AU3152797A (en) * | 1996-06-07 | 1998-01-05 | Genentech Inc. | Methods for (in vitro) protein synthesis |
| US5968767A (en) * | 1996-06-07 | 1999-10-19 | Genentech, Inc. | Methods for in vitro protein synthesis |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| RU2148649C1 (ru) * | 1998-03-31 | 2000-05-10 | Институт белка РАН | Способ получения полипептидов в бесклеточной системе (варианты) и устройство для его осуществления |
| RU2169154C2 (ru) * | 1999-03-25 | 2001-06-20 | Институт белка РАН | Способ получения полипептидов в бесклеточной системе |
| DE60042209D1 (de) * | 1999-08-20 | 2009-06-25 | Pasteur Institut | Enzymatische synthese von deoxyribonucleotiden |
| DE10011209A1 (de) | 2000-03-08 | 2001-09-13 | Roche Diagnostics Gmbh | Matrix-Reaktor und Verfahren zur Herstellung von Produkten in diesem Reaktor |
| JP3750020B2 (ja) * | 2000-12-07 | 2006-03-01 | 学校法人慶應義塾 | C末端修飾タンパク質およびその製造方法、ならびに、c末端修飾タンパク質の製造に用いる修飾剤および翻訳テンプレート、ならびに、c末端修飾タンパク質を用いたタンパク質相互作用の検出方法 |
| GB0115841D0 (en) | 2001-06-28 | 2001-08-22 | Medical Res Council | Ligand |
| DE10137792A1 (de) | 2001-08-06 | 2003-02-27 | Erdmann Volker | Verfahren zur Genexpression |
| AU2002333526B2 (en) | 2001-09-10 | 2008-01-17 | Meso Scale Technologies, Llc. | Methods and apparatus for conducting multiple measurements on a sample |
| DK1440083T3 (da) | 2001-10-25 | 2013-03-25 | Medical Res Council | Molekyler |
| US20030162209A1 (en) * | 2001-12-19 | 2003-08-28 | George Martin | PCR based high throughput polypeptide screening |
| US20030119091A1 (en) * | 2001-12-20 | 2003-06-26 | Toru Ezure | Cell-free protein synthesis method and extract solution therefor |
| WO2003064672A1 (fr) * | 2002-01-31 | 2003-08-07 | Yaeta Endo | Extrait cellulaire pour synthese de proteine acellulaire et procede de production de cet extrait |
| WO2003074546A2 (de) | 2002-03-01 | 2003-09-12 | Erdmann Volker A | Streptavidin-bindungspeptid |
| US20060002935A1 (en) | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
| US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| CN101724071A (zh) | 2004-10-08 | 2010-06-09 | 杜门蒂斯有限公司 | 抗肿瘤坏死因子受体1的单域抗体及其使用方法 |
| JP2008532559A (ja) | 2005-03-19 | 2008-08-21 | メディカル リサーチ カウンシル | ウイルス感染の治療及び予防又は治療及び予防の改善 |
| WO2008060448A2 (en) | 2006-11-10 | 2008-05-22 | Massachusetts Institute Of Technology | Small molecule pak inhibitors |
| JP2010043063A (ja) | 2008-05-09 | 2010-02-25 | Agency For Science Technology & Research | 川崎病の診断及び治療 |
| US9309314B2 (en) | 2013-12-03 | 2016-04-12 | Agency For Science, Technology And Research (A*Star) | Polypeptides, nucleic acids and uses thereof |
| WO2020159445A1 (en) | 2019-01-31 | 2020-08-06 | Agency For Science, Technology And Research | Cnx/erp57 inhibitor for use in the treatment or prevention of cancer |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1618761A1 (ru) * | 1987-04-29 | 1991-01-07 | Институт Белка Ан Ссср | Способ получени пептидов и белков в бесклеточной системе трансл ции |
-
1990
- 1990-06-14 US US07/834,523 patent/US6399323B1/en not_active Expired - Lifetime
- 1990-06-14 AT AT90912892T patent/ATE147787T1/de active
- 1990-06-14 EP EP90912892A patent/EP0593757B1/de not_active Expired - Lifetime
- 1990-06-14 DE DE69029744T patent/DE69029744T2/de not_active Expired - Lifetime
- 1990-06-14 DK DK90912892.8T patent/DK0593757T3/da active
- 1990-06-14 WO PCT/SU1990/000151 patent/WO1991002076A1/ru not_active Ceased
- 1990-06-14 CA CA002064754A patent/CA2064754C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2064754C (en) | 1996-06-18 |
| DE69029744D1 (de) | 1997-02-27 |
| CA2064754A1 (en) | 1991-02-01 |
| EP0593757A4 (de) | 1992-05-08 |
| EP0593757B1 (de) | 1997-01-15 |
| DE69029744T2 (de) | 1997-07-10 |
| US6399323B1 (en) | 2002-06-04 |
| DK0593757T3 (da) | 1997-07-07 |
| WO1991002076A1 (en) | 1991-02-21 |
| EP0593757A1 (de) | 1994-04-27 |
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