ATE149T1 - 2-(N-(2'-CHLORO-4'-METHYLTHIENYL-3')-N-(CYCLOPROPYL-METHYL)-AMINO)-IMIDAZOLINE-(2), ITS ACID ADDITION SALTS, MEDICINAL PRODUCT CONTAINING THIS AND PROCESS FOR ITS PREPARATION. - Google Patents

2-(N-(2'-CHLORO-4'-METHYLTHIENYL-3')-N-(CYCLOPROPYL-METHYL)-AMINO)-IMIDAZOLINE-(2), ITS ACID ADDITION SALTS, MEDICINAL PRODUCT CONTAINING THIS AND PROCESS FOR ITS PREPARATION.

Info

Publication number
ATE149T1
ATE149T1 AT79101859T AT79101859T ATE149T1 AT E149 T1 ATE149 T1 AT E149T1 AT 79101859 T AT79101859 T AT 79101859T AT 79101859 T AT79101859 T AT 79101859T AT E149 T1 ATE149 T1 AT E149T1
Authority
AT
Austria
Prior art keywords
methyl
imidazoline
cyclopropyl
chloro
amino
Prior art date
Application number
AT79101859T
Other languages
German (de)
Inventor
Helmut Dr. Staehle
Herbert Dr. Koeppe
Werner Dr. Kummer
Walter Prof. Dr. Kobinger
Christian Dr. Lillie
Ludwig Dr. Pichler
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Application granted granted Critical
Publication of ATE149T1 publication Critical patent/ATE149T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

2-[N-(Cyclopropyl-methyl)-N-(2'-chloro-4'-methyl-thienyl-3')-amino]-2- imidazoline and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds are useful as bradycardiacs.
AT79101859T 1978-07-10 1979-06-11 2-(N-(2'-CHLORO-4'-METHYLTHIENYL-3')-N-(CYCLOPROPYL-METHYL)-AMINO)-IMIDAZOLINE-(2), ITS ACID ADDITION SALTS, MEDICINAL PRODUCT CONTAINING THIS AND PROCESS FOR ITS PREPARATION. ATE149T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782830279 DE2830279A1 (en) 1978-07-10 1978-07-10 2-CORNER CLAMP ON N- (2'-CHLOR-4'-METHYL-THIENYL-3 ') - N- (CYCLOPROPYLMETHYL) - AMINO CORNER CLAMP ON-IMIDAZOLINE- (2), THE ACID ADDITION SALTS THAT IT INCLUDES HIS PRODUCTION
EP79101859A EP0007007B1 (en) 1978-07-10 1979-06-11 2-(n-(2'chloro-4'-methyl-thienyl-3')-n-(cyclopropylmethyl)-amino) imidazoline (2), its acid addition salts, pharmaceutical preparations containing them and process for their preparation

Publications (1)

Publication Number Publication Date
ATE149T1 true ATE149T1 (en) 1981-09-15

Family

ID=6043997

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79101859T ATE149T1 (en) 1978-07-10 1979-06-11 2-(N-(2'-CHLORO-4'-METHYLTHIENYL-3')-N-(CYCLOPROPYL-METHYL)-AMINO)-IMIDAZOLINE-(2), ITS ACID ADDITION SALTS, MEDICINAL PRODUCT CONTAINING THIS AND PROCESS FOR ITS PREPARATION.

Country Status (5)

Country Link
US (1) US4215133A (en)
EP (1) EP0007007B1 (en)
JP (1) JPS5513285A (en)
AT (1) ATE149T1 (en)
DE (2) DE2830279A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2951601A1 (en) * 1979-12-21 1981-07-02 C.H. Boehringer Sohn, 6507 Ingelheim NEW SUBSTITUTED 2-PHENYLAMINOIMIDAZOLINE (2), THE ACID ADDITION SALTS THEREOF, THE MEDICINAL PRODUCTS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION THEREOF
GB8304593D0 (en) * 1983-02-18 1983-03-23 Beecham Group Plc Amidines
DE10224892A1 (en) * 2002-06-04 2003-12-18 Aventis Pharma Gmbh Substituted thiophenes, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them
US7049333B2 (en) * 2002-06-04 2006-05-23 Sanofi-Aventis Deutschland Gmbh Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3746724A (en) * 1970-04-13 1973-07-17 Ciba Geigy Corp 3-guanidinoalkyl-thiophenes
DE2308883C3 (en) * 1973-02-23 1978-05-24 C.H. Boehringer Sohn, 6507 Ingelheim 2-Phenylamino-thienylmethyl-imidazoline- (2), process for the preparation of the same and medicaments containing them
DE2636732A1 (en) * 1976-08-14 1978-02-16 Boehringer Sohn Ingelheim NEW SUBSTITUTED 2-PHENYLAMINO IMIDAZOLINE (2), THE ACID ADDITION SALTS THEREOF, THE MEDICINAL PRODUCTS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION THEREOF

Also Published As

Publication number Publication date
EP0007007A1 (en) 1980-01-23
EP0007007B1 (en) 1981-08-12
DE2960627D1 (en) 1981-11-12
US4215133A (en) 1980-07-29
DE2830279A1 (en) 1980-01-31
JPS5513285A (en) 1980-01-30

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