ATE150005T1 - Verbesserte ioversol-synthese - Google Patents

Verbesserte ioversol-synthese

Info

Publication number: ATE150005T1
Authority: AT; Austria
Prior art keywords: ioversol; synthesis; improved; acetoxyacetamido; diacetoxypropyl
Prior art date: 1992-05-15

Application number

AT93911018T

Other languages

English (en)

Inventor

Allan R Bailey

Shard S Sathe

Andre T Spears

Richard C Wisneski

Mills T Kneller

Original Assignee

Mallinckrodt Medical Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-05-15

Filing date

1993-05-03

Publication date

1997-03-15

1993-05-03 Application filed by Mallinckrodt Medical Inc filed Critical Mallinckrodt Medical Inc

1997-03-15 Application granted granted Critical

1997-03-15 Publication of ATE150005T1 publication Critical patent/ATE150005T1/de

Links

AMDBBAQNWSUWGN-UHFFFAOYSA-N Ioversol Chemical compound OCCN(C(=O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I AMDBBAQNWSUWGN-UHFFFAOYSA-N 0.000 title abstract 2
229960004537 ioversol Drugs 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
IAUBOTXWQGTRKW-UHFFFAOYSA-N [n-acetyl-3,5-bis(2,3-diacetyloxypropylcarbamoyl)-2,4,6-triiodoanilino] 4-acetyloxybutanoate Chemical compound CC(=O)OCCCC(=O)ON(C(C)=O)C1=C(I)C(C(=O)NCC(COC(C)=O)OC(C)=O)=C(I)C(C(=O)NCC(COC(C)=O)OC(C)=O)=C1I IAUBOTXWQGTRKW-UHFFFAOYSA-N 0.000 abstract 1
239000012535 impurity Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT93911018T 1992-05-15 1993-05-03 Verbesserte ioversol-synthese ATE150005T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US88376092A	1992-05-15	1992-05-15

Publications (1)

Publication Number	Publication Date
ATE150005T1 true ATE150005T1 (de)	1997-03-15

Family

ID=25383289

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93911018T ATE150005T1 (de)	1992-05-15	1993-05-03	Verbesserte ioversol-synthese

Country Status (9)

Country	Link
US (1)	US5489708A (de)
EP (1)	EP0640067B1 (de)
JP (1)	JPH07506835A (de)
AT (1)	ATE150005T1 (de)
AU (1)	AU4230893A (de)
CA (1)	CA2134653A1 (de)
DE (1)	DE69308839T2 (de)
ES (1)	ES2102031T3 (de)
WO (1)	WO1993023365A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69308839T2 (de) *	1992-05-15	1997-07-24	Mallinckrodt Medical Inc	Verbesserte ioversol-synthese
TWI288654B (en) *	2001-05-17	2007-10-21	Ind Tech Res Inst	Process for the purification of water-soluble non-ionic contrast agents
US7959211B2 (en) *	2008-08-25	2011-06-14	Control Solutions LLC	Sensor installations for motorized vehicle doors
US7938376B2 (en) *	2008-08-22	2011-05-10	Control Solutions LLC	Mounting clips and sensor installations for motorized vehicle doors
FR3084668A1 (fr)	2018-08-02	2020-02-07	Guerbet	Procede de preparation monotope de composes organo-iodes intermediaires a la synthese du ioversol
CN115160174A (zh) *	2022-07-09	2022-10-11	浙江海洲制药有限公司	一种碘佛醇的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US503587A (en) *		1893-08-22		Process of making smokeless explosives
US5035877A (en) *	1985-08-09	1991-07-30	Cook Imaging Corporation	Non-ionic contrast media from ionic contrast media
DE3739098A1 (de) *	1987-11-16	1989-05-24	Schering Ag	Neue substituierte dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6- trijod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel
US5043152A (en) *	1988-06-02	1991-08-27	Guerbet S.A.	Novel iodinated non-ionic triiodobenzene compounds and contrast media containing them
US4997983A (en) *	1990-01-31	1991-03-05	Mallinckrodt, Inc.	Process for production of ioversol
US5019371A (en) *	1990-11-21	1991-05-28	Mallinckrodt Medical, Inc.	Novel x-ray contrast agents, compositions and methods
DE69308839T2 (de) *	1992-05-15	1997-07-24	Mallinckrodt Medical Inc	Verbesserte ioversol-synthese

1993
- 1993-05-03 DE DE69308839T patent/DE69308839T2/de not_active Expired - Fee Related
- 1993-05-03 AT AT93911018T patent/ATE150005T1/de not_active IP Right Cessation
- 1993-05-03 ES ES93911018T patent/ES2102031T3/es not_active Expired - Lifetime
- 1993-05-03 CA CA002134653A patent/CA2134653A1/en not_active Abandoned
- 1993-05-03 EP EP93911018A patent/EP0640067B1/de not_active Expired - Lifetime
- 1993-05-03 WO PCT/US1993/004174 patent/WO1993023365A1/en not_active Ceased
- 1993-05-03 AU AU42308/93A patent/AU4230893A/en not_active Abandoned
- 1993-05-03 JP JP5520279A patent/JPH07506835A/ja active Pending
- 1993-12-01 US US08/161,181 patent/US5489708A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ES2102031T3 (es)	1997-07-16
WO1993023365A1 (en)	1993-11-25
EP0640067A4 (de)	1995-05-31
CA2134653A1 (en)	1993-11-25
DE69308839D1 (de)	1997-04-17
JPH07506835A (ja)	1995-07-27
DE69308839T2 (de)	1997-07-24
EP0640067B1 (de)	1997-03-12
EP0640067A1 (de)	1995-03-01
US5489708A (en)	1996-02-06
AU4230893A (en)	1993-12-13

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Legal Events

Date	Code	Title	Description
1997-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties