ATE150650T1 - Stabile zusammensetzung die ein enalapril-salz enthält, verfahren zu ihrer herstellung und ihre verwendung - Google Patents

Stabile zusammensetzung die ein enalapril-salz enthält, verfahren zu ihrer herstellung und ihre verwendung

Info

Publication number: ATE150650T1
Authority: AT; Austria
Prior art keywords: sodium; preparation; composition containing; chem; formula
Prior art date: 1991-11-25

Application number

AT92119896T

Other languages

English (en)

Inventor

Marjo Merslavic

Jozica Razen

Ales Rotar

Original Assignee

Krka Tovarna Zdravil

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-11-25

Filing date

1992-11-23

Publication date

1997-04-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25555813&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE150650(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-11-23 Application filed by Krka Tovarna Zdravil filed Critical Krka Tovarna Zdravil

1997-04-15 Application granted granted Critical

1997-04-15 Publication of ATE150650T1 publication Critical patent/ATE150650T1/de

Links

GBXSMTUPTTWBMN-XIRDDKMYSA-N enalapril Chemical class C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 GBXSMTUPTTWBMN-XIRDDKMYSA-N 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 2
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 2
239000000654 additive Substances 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
238000011065 in-situ storage Methods 0.000 abstract 1
229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
229910000029 sodium carbonate Inorganic materials 0.000 abstract 1
150000003388 sodium compounds Chemical class 0.000 abstract 1
FTTHROYWFRGKST-BDURURIASA-M sodium;(2s)-1-[(2s)-2-[[(2s)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylate Chemical class [Na+].C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C([O-])=O)CC1=CC=CC=C1 FTTHROYWFRGKST-BDURURIASA-M 0.000 abstract 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/556—Angiotensin converting enzyme inhibitors

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Vascular Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

AT92119896T 1991-11-25 1992-11-23 Stabile zusammensetzung die ein enalapril-salz enthält, verfahren zu ihrer herstellung und ihre verwendung ATE150650T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
YU184291A YU48602B (sh)	1991-11-25	1991-11-25	Postupak za dobijanje stabilne formulacije soli enalaprila

Publications (1)

Publication Number	Publication Date
ATE150650T1 true ATE150650T1 (de)	1997-04-15

Family

ID=25555813

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92119896T ATE150650T1 (de)	1991-11-25	1992-11-23	Stabile zusammensetzung die ein enalapril-salz enthält, verfahren zu ihrer herstellung und ihre verwendung

Country Status (11)

Country	Link
US (1)	US5350582A (de)
EP (1)	EP0545194B1 (de)
AT (1)	ATE150650T1 (de)
CA (1)	CA2083683C (de)
DE (1)	DE69218557T2 (de)
DK (1)	DK0545194T3 (de)
ES (1)	ES2101004T3 (de)
GR (1)	GR3023655T3 (de)
HR (1)	HRP921482B1 (de)
SI (1)	SI9111842A (de)
YU (1)	YU48602B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5562921A (en) *	1994-07-15	1996-10-08	Sherman; Bernard C.	Stable solid pharmaceutical compositions containing enalapril maleate
US5573780A (en) *	1995-08-04	1996-11-12	Apotex Usa Inc.	Stable solid formulation of enalapril salt and process for preparation thereof
GB9521781D0 (en) *	1995-10-24	1996-01-03	Merck Sharp & Dohme	Therapeutic agents
RU2140261C1 (ru) *	1997-04-03	1999-10-27	Открытое акционерное общество "АЙ СИ ЭН Лексредства"	Твердая лекарственная форма на основе малеата эналаприла
ES2125198B1 (es) *	1997-05-13	1999-11-16	Vita Invest Sa	Asociacion a dosis fija de un inhibidor de la enzima convertidora de angiotensina y de un antagonista de los canales de calcio, procedimiento para su preparacion y su utilizacion para el tratamiento de enfermees cardiovasculares.
CZ293008B6 (cs) *	1998-07-21	2004-01-14	Kaneka Corporation	Způsob krystalizace soli kyseliny maleinové s N-(1(S)-ethoxykarbonyl-3-fenylpropyl)-L-alanyl-L-prolinem
NZ333206A (en)	1998-12-08	2000-07-28	Bernard Charles Sherman	Solid pharmaceutical compositions comprising a stable magnesium salt of quinapril that acts as a ACE (Angiotensin Converting Enzyme) inhibitor
US6637359B1 (en) *	1998-12-15	2003-10-28	Maritrans Inc.	System and method for internally fitting a new inner hull to an existing outer hull to form a rebuilt double hull vessel
US6555551B1 (en)	1999-08-31	2003-04-29	Mutual Pharmaceutical Co., Inc.	Stable formulations of ACE inhibitors, and methods for preparation thereof
US20040157911A1 (en) *	1999-08-31	2004-08-12	Spiridon Spireas	Storage-stable and bio-stable formulations of ace inhibitors, and methods for preparation thereof
US20030225124A1 (en) *	1999-08-31	2003-12-04	Spiridon Spireas	Stable formulations of ACE inhibitors, and methods for preparation thereof
US6764694B1 (en) *	1999-08-31	2004-07-20	Mutual Pharmaceutical Co., Inc.	Stable formulations of ACE inhibitors, and methods for preparation thereof
HU226950B1 (en) *	1999-11-03	2010-03-29	Richter Gedeon Nyrt	The magnesium salt of enalapril and antihypertensive pharmaceutical composition containing it
US20030215526A1 (en) *	2002-03-08	2003-11-20	Scott Stofik	Stable formulations of angiotensin converting enzyme (ACE) inhibitors
HRP20161602T1 (hr) *	2004-03-29	2016-12-30	Les Laboratoires Servier	Postupak priprave čvrstog farmaceutskog pripravka
SI21800A (sl) *	2004-05-14	2005-12-31	Krka, Tovarna Zdravil, D.D., Novo Mesto	Nov postopek sinteze perindoprila
HRP20140476T1 (hr)	2005-11-17	2014-07-18	Silverstone Pharma Est.	Stabilni oblik amorfnih soli perindoprila, postupak njihove pripreme, posebno industrijske pripreme i njihova uporaba u lijeäśenju hipertenzije
SI23149A (sl)	2009-09-21	2011-03-31	Silverstone Pharma	Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni
EA027787B1 (ru) †	2010-06-23	2017-09-29	Крка, Товарна Здравил, Д.Д., Ново Место	Пероральные лекарственные формы, содержащие лерканидипин и эналаприл и их фармацевтически приемлемые соли
WO2012085249A2 (en)	2010-12-24	2012-06-28	Krka, D.D., Novo Mesto	Homogenous pharmaceutical oral dosage forms comprising lercanidipine and enalapril or their pharmaceutically acceptable salts
US8986939B1 (en)	2013-08-28	2015-03-24	Psychemedics Corporation	Integrity testing of hair samples
US20170165315A1 (en)	2014-07-31	2017-06-15	Pharmathen S.A.	Orodispersible film composition comprising enalapril for the treatment of hypertension in a pediatric population

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4830853A (en) *	1986-10-20	1989-05-16	Warner-Lambert Company	Drug compositions stabilized against oxidation
US4743450A (en) *	1987-02-24	1988-05-10	Warner-Lambert Company	Stabilized compositions
EP0391462A1 (de) *	1989-04-05	1990-10-10	Janssen Pharmaceutica N.V.	Ketanserin enthaltende synergistische Zusammensetzungen

1991
- 1991-11-25 SI SI9111842A patent/SI9111842A/sl unknown
- 1991-11-25 YU YU184291A patent/YU48602B/sh unknown
1992
- 1992-11-23 ES ES92119896T patent/ES2101004T3/es not_active Expired - Lifetime
- 1992-11-23 EP EP92119896A patent/EP0545194B1/de not_active Expired - Lifetime
- 1992-11-23 DE DE69218557T patent/DE69218557T2/de not_active Expired - Lifetime
- 1992-11-23 AT AT92119896T patent/ATE150650T1/de not_active IP Right Cessation
- 1992-11-23 DK DK92119896.6T patent/DK0545194T3/da active
- 1992-11-24 CA CA002083683A patent/CA2083683C/en not_active Expired - Fee Related
- 1992-11-24 US US07/980,956 patent/US5350582A/en not_active Expired - Fee Related
- 1992-12-30 HR HRP-1842/91A patent/HRP921482B1/xx not_active IP Right Cessation
1997
- 1997-06-04 GR GR970401299T patent/GR3023655T3/el unknown

Also Published As

Publication number	Publication date
HRP921482B1 (en)	2000-04-30
DK0545194T3 (da)	1997-07-28
HRP921482A2 (en)	1996-12-31
YU48602B (sh)	1998-12-23
CA2083683C (en)	2000-09-05
ES2101004T3 (es)	1997-07-01
YU184291A (sh)	1994-04-05
CA2083683A1 (en)	1993-05-26
DE69218557D1 (de)	1997-04-30
SI9111842A (sl)	1998-04-30
US5350582A (en)	1994-09-27
EP0545194B1 (de)	1997-03-26
DE69218557T2 (de)	1997-11-13
GR3023655T3 (en)	1997-09-30
EP0545194A1 (de)	1993-06-09

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Legal Events

Date	Code	Title	Description
1997-11-15	UEP	Publication of translation of european patent specification
2003-08-15	REN	Ceased due to non-payment of the annual fee