ATE152711T1 - Substituierte chinolincarboxylsäure - Google Patents
Substituierte chinolincarboxylsäureInfo
- Publication number
- ATE152711T1 ATE152711T1 AT90100839T AT90100839T ATE152711T1 AT E152711 T1 ATE152711 T1 AT E152711T1 AT 90100839 T AT90100839 T AT 90100839T AT 90100839 T AT90100839 T AT 90100839T AT E152711 T1 ATE152711 T1 AT E152711T1
- Authority
- AT
- Austria
- Prior art keywords
- carboxylic acid
- substituted quinolin
- disclosed
- quinolin carboxylic
- substituted
- Prior art date
Links
- LOAUVZALPPNFOQ-UHFFFAOYSA-N quinaldic acid Chemical class C1=CC=CC2=NC(C(=O)O)=CC=C21 LOAUVZALPPNFOQ-UHFFFAOYSA-N 0.000 title abstract 2
- 206010062016 Immunosuppression Diseases 0.000 abstract 1
- 230000002917 arthritic effect Effects 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000006866 deterioration Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000750 progressive effect Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/298,585 US4968702A (en) | 1989-01-17 | 1989-01-17 | Substituted quinolinecarboxylic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE152711T1 true ATE152711T1 (de) | 1997-05-15 |
Family
ID=23151154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90100839T ATE152711T1 (de) | 1989-01-17 | 1990-01-16 | Substituierte chinolincarboxylsäure |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4968702A (de) |
| EP (1) | EP0379145B1 (de) |
| JP (1) | JP3004025B2 (de) |
| KR (1) | KR0140076B1 (de) |
| AT (1) | ATE152711T1 (de) |
| AU (1) | AU624471B2 (de) |
| CA (1) | CA2007740C (de) |
| DE (1) | DE69030632T2 (de) |
| DK (1) | DK0379145T3 (de) |
| ES (1) | ES2100851T3 (de) |
| GR (1) | GR3023585T3 (de) |
| HK (1) | HK1008019A1 (de) |
| IE (1) | IE900169L (de) |
| IL (1) | IL92898A (de) |
| NZ (1) | NZ232111A (de) |
| PH (1) | PH26961A (de) |
| ZA (1) | ZA90299B (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5310732A (en) * | 1986-02-03 | 1994-05-10 | The Scripps Research Institute | 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis |
| TW232013B (de) * | 1992-04-24 | 1994-10-11 | Takeda Pharm Industry Co Ltd | |
| US5409886A (en) * | 1993-02-18 | 1995-04-25 | Mitsui Toatsu Chemicals, Incorporated | 3-pyrroline-2-one derivatives and herbicidal compositions containing same |
| US5393891A (en) * | 1993-06-08 | 1995-02-28 | The Du Pont Merck Pharmaceutical Company | Immunoassay reagents and methods for detecting brequinar and analogs |
| US5428040A (en) * | 1993-08-31 | 1995-06-27 | The Du Pont Merck Pharmaceutical Company | Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents |
| US5453431A (en) * | 1993-10-29 | 1995-09-26 | Gilman; Andrew L. | Use of hydroxychloroquine for treatment of graft-versus-host disease |
| US5578609A (en) * | 1994-03-25 | 1996-11-26 | The Dupont Merck Pharmaceutical Company | 2-carbocyclic and 2-heterocyclic quinoline-4-carboxylic acids and salts thereof useful as immunosuppressive agents |
| US6207679B1 (en) | 1997-06-19 | 2001-03-27 | Sepracor, Inc. | Antimicrobial agents uses and compositions related thereto |
| US6376670B1 (en) | 1997-06-19 | 2002-04-23 | Sepracor Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
| US6103905A (en) * | 1997-06-19 | 2000-08-15 | Sepracor, Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
| US6172084B1 (en) | 1997-06-19 | 2001-01-09 | Sepracor, Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
| WO1999038846A1 (en) * | 1998-01-30 | 1999-08-05 | Procept, Inc. | Immunosuppressive agents |
| AR029489A1 (es) * | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
| AR036873A1 (es) * | 2001-09-07 | 2004-10-13 | Euro Celtique Sa | Piridinas aril sustituidas a, composiciones farmaceuticas y el uso de las mismas para la preparacion de un medicamento |
| AR037233A1 (es) | 2001-09-07 | 2004-11-03 | Euro Celtique Sa | Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento |
| WO2004014377A1 (en) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | 4-hydroxyquinoline derivatives as matrix metalloproteinase inhibitors |
| US7138412B2 (en) | 2003-03-11 | 2006-11-21 | Bristol-Myers Squibb Company | Tetrahydroquinoline derivatives useful as serine protease inhibitors |
| WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
| AU2014209107B2 (en) * | 2013-01-28 | 2018-04-12 | Viamet Pharmaceuticals (NC), Inc. | Metalloenzyme inhibitor compounds |
| EP3071199A2 (de) | 2013-11-22 | 2016-09-28 | Genzyme Corporation | Neuartiges verfahren zur behandlung neurodegenerativer erkrankungen |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE294159C (de) * | ||||
| US2888346A (en) * | 1955-08-22 | 1959-05-26 | Gen Aniline & Film Corp | Ultra-violet absorbing compounds |
| FR2166297A1 (en) * | 1972-01-07 | 1973-08-17 | Rosenberg Eli | 2-(4-isopropylphenyl)quinoline-4-carboxylic acid - as a non-toxic, analgesic agent |
| DE3483704D1 (de) * | 1983-07-22 | 1991-01-17 | Du Pont | Phenylchinolinsaeure und derivate als antitumormittel. |
| US4680299A (en) * | 1984-04-30 | 1987-07-14 | E.I. Du Pont De Nemours And Company | 2-phenyl-4-quinolinecarboxylic acids and pharmaceutical compositions thereof |
| EP0318093A3 (de) * | 1987-11-25 | 1990-12-05 | Merck Frosst Canada Inc. | Diarylchinolindicarbonsäure und ihre Verwendung als Arzneimittel |
-
1989
- 1989-01-17 US US07/298,585 patent/US4968702A/en not_active Expired - Lifetime
- 1989-12-27 IL IL9289889A patent/IL92898A/en unknown
-
1990
- 1990-01-08 PH PH39858A patent/PH26961A/en unknown
- 1990-01-15 NZ NZ232111A patent/NZ232111A/en unknown
- 1990-01-15 CA CA002007740A patent/CA2007740C/en not_active Expired - Lifetime
- 1990-01-16 AT AT90100839T patent/ATE152711T1/de not_active IP Right Cessation
- 1990-01-16 JP JP2004637A patent/JP3004025B2/ja not_active Expired - Fee Related
- 1990-01-16 EP EP90100839A patent/EP0379145B1/de not_active Expired - Lifetime
- 1990-01-16 IE IE900169A patent/IE900169L/xx not_active IP Right Cessation
- 1990-01-16 DK DK90100839.1T patent/DK0379145T3/da active
- 1990-01-16 ZA ZA90299A patent/ZA90299B/xx unknown
- 1990-01-16 AU AU48502/90A patent/AU624471B2/en not_active Ceased
- 1990-01-16 ES ES90100839T patent/ES2100851T3/es not_active Expired - Lifetime
- 1990-01-16 KR KR1019900000643A patent/KR0140076B1/ko not_active Expired - Fee Related
- 1990-01-16 DE DE69030632T patent/DE69030632T2/de not_active Expired - Fee Related
-
1997
- 1997-05-30 GR GR950401502T patent/GR3023585T3/el unknown
-
1998
- 1998-06-27 HK HK98107244A patent/HK1008019A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ232111A (en) | 1992-07-28 |
| US4968702A (en) | 1990-11-06 |
| KR900011733A (ko) | 1990-08-02 |
| JP3004025B2 (ja) | 2000-01-31 |
| GR3023585T3 (en) | 1997-08-29 |
| EP0379145A3 (de) | 1991-07-17 |
| EP0379145A2 (de) | 1990-07-25 |
| AU624471B2 (en) | 1992-06-11 |
| IE900169L (en) | 1990-07-17 |
| IL92898A (en) | 1994-11-28 |
| PH26961A (en) | 1992-12-28 |
| ZA90299B (en) | 1990-10-31 |
| HK1008019A1 (en) | 1999-04-30 |
| KR0140076B1 (ko) | 1998-06-01 |
| CA2007740C (en) | 1999-12-07 |
| DE69030632D1 (de) | 1997-06-12 |
| EP0379145B1 (de) | 1997-05-07 |
| IL92898A0 (en) | 1990-09-17 |
| CA2007740A1 (en) | 1990-07-17 |
| ES2100851T3 (es) | 1997-07-01 |
| JPH02229166A (ja) | 1990-09-11 |
| DE69030632T2 (de) | 1997-10-02 |
| AU4850290A (en) | 1990-07-26 |
| DK0379145T3 (da) | 1997-05-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |