ATE152724T1 - Synthetische verwandlung von bryostatin 2 in bryostatin 1 - Google Patents

Synthetische verwandlung von bryostatin 2 in bryostatin 1

Info

Publication number
ATE152724T1
ATE152724T1 AT91311568T AT91311568T ATE152724T1 AT E152724 T1 ATE152724 T1 AT E152724T1 AT 91311568 T AT91311568 T AT 91311568T AT 91311568 T AT91311568 T AT 91311568T AT E152724 T1 ATE152724 T1 AT E152724T1
Authority
AT
Austria
Prior art keywords
bryostatin
synthetic conversion
synthetic
conversion
converted
Prior art date
Application number
AT91311568T
Other languages
English (en)
Inventor
George R Pettit
Original Assignee
Univ Arizona
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Arizona filed Critical Univ Arizona
Application granted granted Critical
Publication of ATE152724T1 publication Critical patent/ATE152724T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • External Artificial Organs (AREA)
  • Auxiliary Devices For Music (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
AT91311568T 1990-12-31 1991-12-12 Synthetische verwandlung von bryostatin 2 in bryostatin 1 ATE152724T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/636,212 US5072004A (en) 1990-12-31 1990-12-31 Synthetic conversion of bryostatin 2 into bryostatin 1

Publications (1)

Publication Number Publication Date
ATE152724T1 true ATE152724T1 (de) 1997-05-15

Family

ID=24550938

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91311568T ATE152724T1 (de) 1990-12-31 1991-12-12 Synthetische verwandlung von bryostatin 2 in bryostatin 1

Country Status (10)

Country Link
US (1) US5072004A (de)
EP (1) EP0496160B1 (de)
JP (1) JP3225318B2 (de)
AT (1) ATE152724T1 (de)
CA (1) CA2057441C (de)
DE (1) DE69126011T2 (de)
DK (1) DK0496160T3 (de)
ES (1) ES2103788T3 (de)
GR (1) GR3023990T3 (de)
MX (1) MX9102830A (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7256286B2 (en) * 1999-11-30 2007-08-14 The Board Of Trustees Of The Leland Stanford Junior University Bryostatin analogues, synthetic methods and uses
WO2002087423A2 (en) * 2001-05-02 2002-11-07 Blanchette Rockefeller Neurosciences Institute Carbonic anhydrase activators for enhancing learning and memory
US20080004332A1 (en) * 2002-03-07 2008-01-03 Alkon Daniel L Methods for alzheimer's disease treatment and cognitive enhancement
US6825229B2 (en) 2002-03-07 2004-11-30 Blanchette Rockefeller Neurosciences Institute Methods for Alzheimer's Disease treatment and cognitive enhancement
US20050065205A1 (en) * 2002-03-07 2005-03-24 Daniel Alkon Methods for Alzheimer's disease treatment and cognitive enhance
TW201207390A (en) * 2004-05-18 2012-02-16 Brni Neurosciences Inst Method for screening agent for antidepressant activity
US20070054890A1 (en) * 2005-07-29 2007-03-08 Alkon Daniel L Protein synthesis required for long-term memory is induced by PKC activation on days preceding associative learning
US7754465B2 (en) * 2006-04-27 2010-07-13 James A Papp Decontamination of biological agents
EP2762136A1 (de) 2006-07-28 2014-08-06 Blanchette Rockefeller Neurosciences, Institute Verfahren zur Stimulierung von Zellwachstum, synaptischer Umformung und Verfestigung des Langzeitgedächtnisses
CN101848726A (zh) 2007-02-09 2010-09-29 布朗歇特洛克菲勒神经科学研究所 苔藓抑素、苔藓抑素类似物和其它相关物质对头部创伤引起的记忆缺陷和脑损伤的疗效
ES2528033T3 (es) 2007-02-09 2015-02-03 Blanchette Rockefeller Neurosciences Institute Efectos terapéuticos de las briostatinas sobre la alteración de la memoria inducida por isquemia/accidente vascular cerebral y lesiones cerebrales
EP2590642B1 (de) 2010-07-08 2018-03-14 Daniel L. Alkon Pkc-aktivatoren und antikoagulans für einen therapieplan zur behandlung von apoplexie
JP6062362B2 (ja) 2010-08-19 2017-01-18 ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート Ｐｋｃ活性化剤を使用した、異常な樹状突起棘に関連した認知障害の治療
WO2013071282A1 (en) 2011-11-13 2013-05-16 Blanchette Rockefeller Neurosciences Institute Pkc activators and combinations thereof
US20180030095A1 (en) 2015-02-13 2018-02-01 George Robert Pettit Silstatin compounds
US20180217163A1 (en) 2015-05-11 2018-08-02 Daniel L. Alkon Treatment of neurodegenerative conditions using pkc activators after determining the presence of the apoe4 allele
WO2019094709A1 (en) 2017-11-09 2019-05-16 Pettit George R Betulastatin compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4560774A (en) * 1982-11-17 1985-12-24 Arizona State University Macrocyclic lactones
US4611066A (en) * 1984-08-10 1986-09-09 Arizona State University Bryostatins 4 to 8
US4833257A (en) * 1986-07-28 1989-05-23 Arizona Board Of Regents Compositions of matter and methods of using same

Also Published As

Publication number Publication date
JP3225318B2 (ja) 2001-11-05
CA2057441A1 (en) 1992-07-01
EP0496160B1 (de) 1997-05-07
DE69126011D1 (de) 1997-06-12
CA2057441C (en) 2002-06-11
DE69126011T2 (de) 1997-09-25
JPH0867683A (ja) 1996-03-12
ES2103788T3 (es) 1997-10-01
MX9102830A (es) 1992-06-01
DK0496160T3 (da) 1997-07-28
GR3023990T3 (en) 1997-10-31
EP0496160A1 (de) 1992-07-29
US5072004A (en) 1991-12-10

Similar Documents

Publication Publication Date Title
DE69126011D1 (de) Synthetische Verwandlung von Bryostatin 2 in Bryostatin 1
AU580122B2 (en) Block polyesters and like compounds useful as soil release agents in detergent compositions
ES2055131T3 (es) Resinas de poliester disipables en agua y revestimientos preparados a partir de ellas.
MX174467B (es) 1,4,7-triscarboximetil-1,4,7,10-tetraazaciclodo decano substituido en 1 y compuestos analogos
OA07021A (fr) Procédé d'inclusion de micro-organismes du groupe des mycorhizes et des actinorhizes.
ATE156008T1 (de) Reinigungszusammensetzung
ATE102196T1 (de) Glykosidase-inhibitor salbostatin, verfahren zu seiner herstellung und seine verwendung.
FR2599049B1 (fr) Procede de fabrication d'un feuillard en zircaloy 2 ou zircaloy 4 partiellement recristallise et feuillard obtenu
IT8622864A1 (it) Procedimento per migliorare la tingibilita' di manufatti tessili tessuti o non tessuti
ATE144238T1 (de) Verwendung von pilzmyzel als bodenhilfsstoff
FR2601021B2 (fr) Fraction immunogene active a l'egard des bilharzioses, sa preparation, compositions immunisantes la contenant
FI894003A7 (fi) Kalsiumsulfaatin käyttö orgaanisen jätteen fermentoimisen parantamisek si
EP0631616A4 (de) Enterococcus enthaltene fettsäuremikrosphären zur erhöhung und verbesserung der qualität des körpers.
NZ221106A (en) Imidazolyl- and 1,2,4-triazolyl- dioxanes and dioxolanes and use as plant fungicides
FR2630128B1 (fr) Boites de culture simultanee de micro-organismes aerobies et anaerobies
EP0326545A4 (en) Alteration of plant response to microorganisms
DE3787499D1 (de) Herstellung eines Plasminogenaktivators.
DK0452085T3 (da) Fremgangsmåde til fremstilling af methylaminer
FR2553562B1 (fr) Generateur d'un produit radioactif ou toxique utilisable notamment comme generateur d'iode radioactif
FR2614680B1 (fr) Absorbeur-stockeur souple d'energie solaire
Thingstad Environmental contaminants in some adult Larus fuscus fuscus from Tarya, an islet on the coast of Soer-Troendelag.
FI884293A0 (fi) Foerfarande foer foerhindrande av tillvaext av mikroorganismer i vattenhaltig vaetska.
KR900700417A (ko) 유기폐기물의 발효의 개량을 위한 황산칼슘의 사용
Spourdalakis The contradictions of the short march to power; the origin and development of the Panhellenic Socialist Movement 1974-1984.
SE8604979D0 (sv) "relip" = rehabilitering lett i position

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee