ATE152725T1 - Silylierte acetylcholinesterase inhibitoren - Google Patents

Silylierte acetylcholinesterase inhibitoren

Info

Publication number
ATE152725T1
ATE152725T1 AT94908615T AT94908615T ATE152725T1 AT E152725 T1 ATE152725 T1 AT E152725T1 AT 94908615 T AT94908615 T AT 94908615T AT 94908615 T AT94908615 T AT 94908615T AT E152725 T1 ATE152725 T1 AT E152725T1
Authority
AT
Austria
Prior art keywords
silylated
acetylcholinesterase inhibitors
compounds
methods
acetylcholinesterase
Prior art date
Application number
AT94908615T
Other languages
English (en)
Inventor
Jean-Noel Collard
Jean-Marie Hornsperger
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of ATE152725T1 publication Critical patent/ATE152725T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AT94908615T 1993-02-16 1994-01-25 Silylierte acetylcholinesterase inhibitoren ATE152725T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93400385A EP0611769A1 (de) 1993-02-16 1993-02-16 Silytierte acetylcholinesterase Inhibitoren

Publications (1)

Publication Number Publication Date
ATE152725T1 true ATE152725T1 (de) 1997-05-15

Family

ID=8214682

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94908615T ATE152725T1 (de) 1993-02-16 1994-01-25 Silylierte acetylcholinesterase inhibitoren

Country Status (19)

Country Link
EP (2) EP0611769A1 (de)
JP (1) JP3516955B2 (de)
KR (1) KR100336547B1 (de)
CN (1) CN1043575C (de)
AT (1) ATE152725T1 (de)
AU (1) AU672885B2 (de)
CA (1) CA2154870C (de)
DE (1) DE69403068T2 (de)
DK (1) DK0684951T3 (de)
ES (1) ES2104358T3 (de)
FI (1) FI111461B (de)
GR (1) GR3024151T3 (de)
HU (1) HUT72736A (de)
IL (1) IL108623A0 (de)
MX (1) MX9401175A (de)
NO (1) NO305517B1 (de)
NZ (1) NZ262247A (de)
WO (1) WO1994019356A1 (de)
ZA (1) ZA94925B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0627400A1 (de) * 1993-06-04 1994-12-07 Merrell Dow Pharmaceuticals Inc. Aromatische Inhibitoren von Acetylcholinesterase
CN100431539C (zh) * 2004-01-12 2008-11-12 和泓生物技术（上海）有限公司 乙酰胆碱酯酶抑制剂在制备治疗帕金森病药物中的应用
US8278345B2 (en) 2006-11-09 2012-10-02 Probiodrug Ag Inhibitors of glutaminyl cyclase
ATE554085T1 (de) 2006-11-30 2012-05-15 Probiodrug Ag Neue inhibitoren von glutaminylcyclase
JP5930573B2 (ja) 2007-03-01 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤の新規使用
EP2142514B1 (de) 2007-04-18 2014-12-24 Probiodrug AG Thioharnstoffderivate als glutaminylcyclaseinhibitoren
JP5934645B2 (ja) 2009-09-11 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
AU2011215870B2 (en) 2010-02-09 2016-01-28 The Johns Hopkins University Methods and compositions for improving cognitive function
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
NZ602312A (en) 2010-03-10 2014-02-28 Probiodrug Ag Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
EP2686313B1 (de) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazolderivate als glutaminylcyclase-hemmer
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
JP6433482B2 (ja) 2013-03-15 2018-12-05 エージンバイオ， インコーポレイテッド 認知機能を改善するための方法および組成物
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
WO2016191288A1 (en) 2015-05-22 2016-12-01 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa
CN112047973B (zh) * 2019-06-06 2022-11-18 上海科技大学 一种大麻素类化合物，其制备方法、组合物和用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0403713A1 (de) * 1989-06-22 1990-12-27 Merrell Dow Pharmaceuticals Inc. Acetylcholinesterase-Inhibitoren

Also Published As

Publication number Publication date
DK0684951T3 (da) 1997-05-26
WO1994019356A1 (en) 1994-09-01
FI953851L (fi) 1995-08-15
JPH08507059A (ja) 1996-07-30
NO305517B1 (no) 1999-06-14
KR960701068A (ko) 1996-02-24
KR100336547B1 (ko) 2002-11-02
CN1043575C (zh) 1999-06-09
JP3516955B2 (ja) 2004-04-05
DE69403068D1 (en) 1997-06-12
EP0684951B1 (de) 1997-05-07
NO953201D0 (no) 1995-08-15
HUT72736A (en) 1996-05-28
ES2104358T3 (es) 1997-10-01
AU672885B2 (en) 1996-10-17
CA2154870A1 (en) 1994-09-01
FI111461B (fi) 2003-07-31
EP0684951A1 (de) 1995-12-06
FI953851A0 (fi) 1995-08-15
EP0611769A1 (de) 1994-08-24
ZA94925B (en) 1994-08-25
NZ262247A (en) 1996-01-26
CA2154870C (en) 1998-10-27
NO953201L (no) 1995-08-15
MX9401175A (es) 1994-08-31
DE69403068T2 (de) 1997-12-11
IL108623A0 (en) 1994-05-30
CN1117733A (zh) 1996-02-28
GR3024151T3 (en) 1997-10-31
AU6164194A (en) 1994-09-14

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Legal Events

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UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner