ATE153037T1 - Quartäre vernetzte allylammoniumpolymere, ihre herstellung und verwendung - Google Patents

Quartäre vernetzte allylammoniumpolymere, ihre herstellung und verwendung

Info

Publication number: ATE153037T1
Authority: AT; Austria
Prior art keywords: linked; cross; allylammonium; quarternary; polymers
Prior art date: 1990-12-07

Application number

AT92900351T

Other languages

English (en)

Inventor

Fergus Mctaggart

Denis Pemberton

Graham John Smith

Original Assignee

Zeneca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-07

Filing date

1991-12-06

Publication date

1997-05-15

1990-12-07 Priority claimed from GB909026616A external-priority patent/GB9026616D0/en

1991-05-10 Priority claimed from GB919110180A external-priority patent/GB9110180D0/en

1991-12-06 Application filed by Zeneca Ltd filed Critical Zeneca Ltd

1997-05-15 Application granted granted Critical

1997-05-15 Publication of ATE153037T1 publication Critical patent/ATE153037T1/de

Links

VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical compound NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 title 1
229920000642 polymer Polymers 0.000 title 1
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
238000004519 manufacturing process Methods 0.000 abstract 2
230000036470 plasma concentration Effects 0.000 abstract 2
239000002861 polymer material Substances 0.000 abstract 2
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
102000007330 LDL Lipoproteins Human genes 0.000 abstract 1
108010007622 LDL Lipoproteins Proteins 0.000 abstract 1
235000012000 cholesterol Nutrition 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
WGYKZJWCGVVSQN-UHFFFAOYSA-O propan-1-aminium Chemical group CCC[NH3+] WGYKZJWCGVVSQN-UHFFFAOYSA-O 0.000 abstract 1
208000019553 vascular disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
- C08F226/02—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/02—Alkylation

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Inorganic Insulating Materials (AREA)
Organic Insulating Materials (AREA)

AT92900351T 1990-12-07 1991-12-06 Quartäre vernetzte allylammoniumpolymere, ihre herstellung und verwendung ATE153037T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB909026616A GB9026616D0 (en)	1990-12-07	1990-12-07	Nitrogen derivatives
GB919110180A GB9110180D0 (en)	1991-05-10	1991-05-10	Nitrogen derivatives

Publications (1)

Publication Number	Publication Date
ATE153037T1 true ATE153037T1 (de)	1997-05-15

Family

ID=26298074

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92900351T ATE153037T1 (de)	1990-12-07	1991-12-06	Quartäre vernetzte allylammoniumpolymere, ihre herstellung und verwendung

Country Status (15)

Country	Link
US (2)	US5462730A (de)
EP (1)	EP0513300B1 (de)
KR (1)	KR927003663A (de)
AT (1)	ATE153037T1 (de)
AU (1)	AU640845B2 (de)
CA (1)	CA2056862A1 (de)
DE (1)	DE69126126T2 (de)
FI (1)	FI104324B1 (de)
HU (1)	HUT64370A (de)
IE (1)	IE914179A1 (de)
IL (1)	IL100253A (de)
NZ (1)	NZ240844A (de)
PL (1)	PL295641A1 (de)
PT (1)	PT99715B (de)
WO (1)	WO1992010522A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5487888A (en)	1993-05-20	1996-01-30	Geltex, Inc.	Iron-binding polymers for oral administration
US5929184A (en) *	1993-06-02	1999-07-27	Geltex Pharmaceuticals, Inc.	Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants
US5624963A (en) *	1993-06-02	1997-04-29	Geltex Pharmaceuticals, Inc.	Process for removing bile salts from a patient and compositions therefor
US5618530A (en) *	1994-06-10	1997-04-08	Geltex Pharmaceuticals, Inc.	Hydrophobic amine polymer sequestrant and method of cholesterol depletion
US5607669A (en) *	1994-06-10	1997-03-04	Geltex Pharmaceuticals, Inc.	Amine polymer sequestrant and method of cholesterol depletion
US5900475A (en) *	1994-06-10	1999-05-04	Geltex Pharmaceuticals, Inc.	Hydrophobic sequestrant for cholesterol depletion
US5703188A (en) *	1993-06-02	1997-12-30	Geltex Pharmaceuticals, Inc.	Process for removing bile salts from a patient and compositions therefor
US6129910A (en) *	1993-06-02	2000-10-10	Geltex Pharmaceuticals, Inc.	Water-insoluble noncrosslinked bile acid sequestrants
US5667775A (en)	1993-08-11	1997-09-16	Geltex Pharmaceuticals, Inc.	Phosphate-binding polymers for oral administration
US5496545A (en) *	1993-08-11	1996-03-05	Geltex Pharmaceuticals, Inc.	Phosphate-binding polymers for oral administration
TW474813B (en) *	1994-06-10	2002-02-01	Geltex Pharma Inc	Alkylated composition for removing bile salts from a patient
US6203785B1 (en) *	1996-12-30	2001-03-20	Geltex Pharmaceuticals, Inc.	Poly(diallylamine)-based bile acid sequestrants
US5925379A (en) *	1997-03-27	1999-07-20	Geltex Pharmaceuticals, Inc.	Interpenetrating polymer networks for sequestration of bile acids
US6423754B1 (en) *	1997-06-18	2002-07-23	Geltex Pharmaceuticals, Inc.	Method for treating hypercholesterolemia with polyallylamine polymers
US6726905B1 (en)	1997-11-05	2004-04-27	Genzyme Corporation	Poly (diallylamines)-based phosphate binders
US6083497A (en)	1997-11-05	2000-07-04	Geltex Pharmaceuticals, Inc.	Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
WO2000063259A1 (en)	1999-04-16	2000-10-26	Abbott Laboratories	Process for producing cross-linked polyallylamine hydrochloride
US6733780B1 (en)	1999-10-19	2004-05-11	Genzyme Corporation	Direct compression polymer tablet core
AU2002232955A1 (en) *	2000-11-20	2002-05-27	Dow Global Technologies Inc.	In vivo use of water absorbent polymers
EP1847271A3 (de) *	2000-11-20	2008-08-06	Sorbent Therapeutics, Inc.	Wasser-absorbierende Polymere und ihre Verwendung als Arzneimittel
AT409630B (de) *	2000-12-13	2002-09-25	Dsm Fine Chem Austria Gmbh	Alkylierung von n-bzw. amino- oder ammoniumgruppen haltigen, vernetzten polymeren
EP1379259A1 (de) *	2001-04-18	2004-01-14	Genzyme Corporation	Verfahren zur behandlung von syndrom x mit aliphatischen polyaminen
AU2002252632B2 (en) *	2001-04-18	2004-09-23	Genzyme Corporation	Low salt forms of polyallylamine
EP1584633B1 (de) *	2003-04-01	2010-10-20	Nitto Boseki Co., Ltd.	Modifiziertes polyallylamin und herstellungsverfahren dafür
US8192758B2 (en)	2004-03-30	2012-06-05	Relypsa, Inc.	Ion binding compositions
US7854924B2 (en)	2004-03-30	2010-12-21	Relypsa, Inc.	Methods and compositions for treatment of ion imbalances
BRPI0509331B8 (pt)	2004-03-30	2021-05-25	Ilypsa Inc	uso de uma composição de ligação de sódio
US7556799B2 (en)	2004-03-30	2009-07-07	Relypsa, Inc.	Ion binding polymers and uses thereof
US8282960B2 (en)	2004-03-30	2012-10-09	Relypsa, Inc.	Ion binding compositions
US7429394B2 (en)	2004-03-30	2008-09-30	Relypsa, Inc.	Ion binding compositions
US7985418B2 (en)	2004-11-01	2011-07-26	Genzyme Corporation	Aliphatic amine polymer salts for tableting
WO2006072054A1 (en) *	2004-12-30	2006-07-06	Genzyme Corporation	Zinc-containing treatments for hyperphosphatemia
US8986669B2 (en)	2005-09-02	2015-03-24	Genzyme Corporation	Method for removing phosphate and polymer used therefore
EP3000460A1 (de)	2005-09-15	2016-03-30	Genzyme Corporation	Beutelformulierung für aminpolymere
CA2624112A1 (en)	2005-09-30	2007-04-05	Ilypsa, Inc.	Methods for preparing core-shell composites having cross-linked shells and core-shell composites resulting therefrom
GB2446077B (en)	2005-09-30	2010-10-13	Ilypsa Inc	Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal
WO2008005217A2 (en) *	2006-07-05	2008-01-10	Genzyme Corporation	Iron(ii)-containing treatments for hyperphosphatemia
EP2066293A2 (de)	2006-09-29	2009-06-10	Genzyme Corporation	Amid-dendrimer-zusammensetzungen
US8163799B2 (en)	2006-12-14	2012-04-24	Genzyme Corporation	Amido-amine polymer compositions
US8337824B2 (en)	2008-08-22	2012-12-25	Relypsa, Inc.	Linear polyol stabilized polyfluoroacrylate compositions
JP6475624B2 (ja)	2012-10-08	2019-02-27	レリプサ，インコーポレイテッド	高血圧症及び高カリウム血症を治療するためのカリウム結合剤
MA41202A (fr)	2014-12-18	2017-10-24	Genzyme Corp	Copolymères polydiallymine réticulé pour le traitement du diabète de type 2

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU509755B2 (en) *	1976-12-13	1980-05-22	Commonwealth Scientific And Industrial Research Organisation	Basic ion exchange resins
US4759923A (en) *	1987-06-25	1988-07-26	Hercules Incorporated	Process for lowering serum cholesterol using poly(diallylmethylamine) derivatives
KR890014100A (ko) *	1988-03-24	1989-10-21	우에하라 아끼라	콜레스테롤 강하제
GB8829835D0 (en) *	1988-12-21	1989-02-15	Smith Kline French Lab	Compounds
GB8911719D0 (en) *	1989-05-22	1989-07-05	Smith Kline French Lab	Compounds
GB8928278D0 (en) *	1989-12-14	1990-02-21	Smith Kline French Lab	Compounds

1991
- 1991-12-02 IE IE417991A patent/IE914179A1/en unknown
- 1991-12-03 NZ NZ240844A patent/NZ240844A/en unknown
- 1991-12-03 CA CA002056862A patent/CA2056862A1/en not_active Abandoned
- 1991-12-05 IL IL10025391A patent/IL100253A/en not_active IP Right Cessation
- 1991-12-06 AT AT92900351T patent/ATE153037T1/de not_active IP Right Cessation
- 1991-12-06 AU AU90466/91A patent/AU640845B2/en not_active Ceased
- 1991-12-06 EP EP92900351A patent/EP0513300B1/de not_active Expired - Lifetime
- 1991-12-06 HU HU9202460A patent/HUT64370A/hu unknown
- 1991-12-06 DE DE69126126T patent/DE69126126T2/de not_active Expired - Fee Related
- 1991-12-06 KR KR1019920701890A patent/KR927003663A/ko not_active Withdrawn
- 1991-12-06 PT PT99715A patent/PT99715B/pt not_active IP Right Cessation
- 1991-12-06 PL PL29564191A patent/PL295641A1/xx unknown
- 1991-12-06 WO PCT/GB1991/002168 patent/WO1992010522A1/en not_active Ceased
1992
- 1992-07-31 FI FI923476A patent/FI104324B1/fi active
1994
- 1994-06-01 US US08/252,521 patent/US5462730A/en not_active Expired - Fee Related
1995
- 1995-06-05 US US08/465,006 patent/US5589166A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69126126T2 (de)	1997-08-28
HU9202460D0 (en)	1992-10-28
FI104324B (fi)	1999-12-31
EP0513300A1 (de)	1992-11-19
PL295641A1 (en)	1993-08-09
PT99715B (pt)	1999-05-31
IL100253A (en)	1995-11-27
HUT64370A (en)	1993-12-28
CA2056862A1 (en)	1992-06-08
AU9046691A (en)	1992-07-08
FI923476A0 (fi)	1992-07-31
FI923476L (fi)	1992-07-31
PT99715A (pt)	1992-10-30
EP0513300B1 (de)	1997-05-14
IL100253A0 (en)	1992-09-06
FI104324B1 (fi)	1999-12-31
US5589166A (en)	1996-12-31
NZ240844A (en)	1993-12-23
DE69126126D1 (de)	1997-06-19
IE914179A1 (en)	1992-06-17
KR927003663A (ko)	1992-12-18
AU640845B2 (en)	1993-09-02
WO1992010522A1 (en)	1992-06-25
US5462730A (en)	1995-10-31

Legal Events

Date	Code	Title	Description
1997-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE153037T1 (de)	1997-05-15	Quartäre vernetzte allylammoniumpolymere, ihre herstellung und verwendung
DE69417550D1 (de)	1999-05-06	Blutfilter und methode zu dessen herstellung
ES2148733T3 (es)	2000-10-16	Grupos carboxi o tetrazol conteniendo dialquilo-eteres.
ATE85225T1 (de)	1993-02-15	Chirurgisches biokompositmaterial und dessen herstellung.
DE59305882D1 (de)	1997-04-24	Mitogenfreie substanz, deren herstellung sowie verwendung
NO20011292L (no)	2001-05-14	Polymerer
DE69019180D1 (de)	1995-06-14	Organopolysiloxan-Polyharnstoff Blockcopolymer und Methode zu seiner Herstellung.
DE69010210D1 (de)	1994-07-28	Kieselsäuresole, verfahren zur herstellung von kieselsäuresolen sowie verwendung der sole.
DE68924799D1 (de)	1995-12-21	Verfahren zur Herstellung von Perfluoropolyethern von kontrollierbarem Molekulargewicht, welche Perfluoralkyl- oder Perfluorchloralky-Endgruppen enthalten.
DE69523654D1 (de)	2001-12-13	Verwendung von Ascorbyl-gamma-Linolenat und von Ascorbyl-dihomo-gamma-linolenat zur Behandlung von Asthma, Krebs, kardiovaskulären und inflammatorischen Erkrankungen
ATE17363T1 (de)	1986-01-15	Verfahren zur herstellung von hochelastischen schaeumen und alkoxysilicium-verbindung(en) als schaumstabilisatoren hierfuer.
DE69635305D1 (de)	2006-03-02	Verwendung eines anti-interleukin-9 antikörpers zur herstellung eines medikamentes zur behandlung von asthma
MX9101958A (es)	1992-07-08	Inhibidores de acat de urea de aminosulfonilo
NO832092L (no)	1983-12-12	Fremgangsmaate ved fremstilling av et heparinfragment
ATE126709T1 (de)	1995-09-15	Hämoverträgliches verbundmaterial.
EP0674905A3 (de)	1995-12-06	Bacterin zur Behandlung von Necrophorum-Krankheiten und Verfahren zur Herstellung.
NO923091L (no)	1992-10-01	Kvaternaere tverrbundne allylammoniumpolymerer, deres fremstilling og anvendelse
DE3785555D1 (de)	1993-05-27	Verwendung von guaifenesin zur behandlung urologischer beschwerden.
ATE305052T1 (de)	2005-10-15	Drogen untersuchungssystem
DE59103673D1 (de)	1995-01-12	Spezielle Dihydroxydiphenylbicycloalkane, ihre Herstellung und ihre Verwendung zur Herstellung von hochmolekularen Polycarbonaten.
IL143279A0 (en)	2002-04-21	Novel therapeutic application of low molecular weight heparin
ATE101667T1 (de)	1994-03-15	Nichtgewebtes, faseriges, nichtelastisches material und verfahren zu dessen herstellung.
DE69113773D1 (de)	1995-11-16	Verwendung von 3-aryl-5-alkylthio-4H-1,2,4-triazolen zur Behandlung von Überreflexen infolge von Rückenmarkstrauma.
DE59006217D1 (de)	1994-07-28	Nicht wirkstoffretardierender Pressling, Verfahren zu dessen Herstellung und Verwendung von Polyhydroxybuttersäure zur Herstellung eines solchen Presslings.
DE59403201D1 (de)	1997-07-24	Verfahren zur herstellung von wässrigen polymerdispersionen, nach diesem verfahren hergestellte wässrige polymerdispersionen und verwendung dieser polymerdispersionen