ATE153346T1 - Oxidationsresistente analoga des thrombomodulins - Google Patents

Oxidationsresistente analoga des thrombomodulins

Info

Publication number
ATE153346T1
ATE153346T1 AT91908593T AT91908593T ATE153346T1 AT E153346 T1 ATE153346 T1 AT E153346T1 AT 91908593 T AT91908593 T AT 91908593T AT 91908593 T AT91908593 T AT 91908593T AT E153346 T1 ATE153346 T1 AT E153346T1
Authority
AT
Austria
Prior art keywords
thrombomodulin
analogs
oxidation
resistant analogues
soluble
Prior art date
Application number
AT91908593T
Other languages
English (en)
Inventor
Charles B Glaser
Michael John Morser
David Richard Light
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of ATE153346T1 publication Critical patent/ATE153346T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Semiconductor Integrated Circuits (AREA)
  • Semiconductor Memories (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • External Artificial Organs (AREA)
  • Paints Or Removers (AREA)
AT91908593T 1990-04-09 1991-04-09 Oxidationsresistente analoga des thrombomodulins ATE153346T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/506,325 US5256770A (en) 1990-04-09 1990-04-09 Oxidation resistant thrombomodulin analogs

Publications (1)

Publication Number Publication Date
ATE153346T1 true ATE153346T1 (de) 1997-06-15

Family

ID=24014143

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91908593T ATE153346T1 (de) 1990-04-09 1991-04-09 Oxidationsresistente analoga des thrombomodulins

Country Status (11)

Country Link
US (1) US5256770A (de)
EP (1) EP0527821B1 (de)
JP (1) JP3051995B2 (de)
AT (1) ATE153346T1 (de)
AU (1) AU650880B2 (de)
CA (1) CA2077691C (de)
DE (1) DE69126205T2 (de)
DK (1) DK0527821T3 (de)
ES (1) ES2103810T3 (de)
GR (1) GR3024099T3 (de)
WO (1) WO1991015514A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2046906A1 (en) * 1989-02-17 1990-08-18 Michael J. Morser Soluble analogs of thrombomodulin
US6063763A (en) * 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
AU643306B2 (en) * 1990-06-27 1993-11-11 Mochida Pharmaceutical Co., Ltd. Anticoagulant polypeptides
AU8723391A (en) * 1990-08-15 1992-03-17 Schering Aktiengesellschaft Superior thrombomodulin analogs for pharmaceutical use
JP3442774B2 (ja) * 1991-07-01 2003-09-02 バーレックス ラボラトリーズ，インコーポレイティド 新規な突然変異誘発法および組成物
CA2129370A1 (en) * 1992-02-05 1993-08-19 David Richard Light Protease-resistant thrombomodulin analogs
DE4323754C1 (de) * 1993-07-15 1994-12-01 Gruenenthal Gmbh Bifunktionelle Urokinasevarianten mit verbesserten fibrinolytischen Eigenschaften und thrombinhemmender Wirkung
US5585095A (en) * 1993-09-14 1996-12-17 Regents Of The University Of Minnesota Method to enhance thrombomodulin APC generation using cationic proteins
DE4440892A1 (de) * 1994-11-17 1996-05-23 Gruenenthal Gmbh Proteine mit fibrinolytischen und gerinnungshemmenden Eigenschaften
JP4949558B2 (ja) * 1999-03-23 2012-06-13 ハイバーネーション・セラピューティクス・グローバル・リミテッド 臓器の停止、保護、及び保存
US6632791B1 (en) 2000-06-21 2003-10-14 Schering Aktiengesellschaft Thrombomodulin analogs for pharmaceutical use
US20020111296A1 (en) * 2000-08-31 2002-08-15 Festoff Barry W. Thrombomodulin analogs for use in recovery of spinal cord injury
US6706068B2 (en) 2002-04-23 2004-03-16 Bret A. Ferree Artificial disc replacements with natural kinematics
US7579000B2 (en) 2002-05-01 2009-08-25 Bayer Schering Pharma Ag Tissue factor targeted antibodies as anticoagulants
HK1080372A1 (zh) * 2002-05-01 2006-04-28 Schering Aktiengesellschaft 作为抗凝剂的新型组织因子目标抗体
AUPS312602A0 (en) * 2002-06-21 2002-07-18 James Cook University Organ arrest, protection, preservation and recovery
WO2004056180A1 (en) * 2002-12-23 2004-07-08 Global Cardiac Solutions Pty Ltd Organ preconditioning, arrest, protection, preservation and recovery (1)
US7833978B2 (en) 2004-02-20 2010-11-16 Emory University Thrombomodulin derivatives and conjugates
WO2006005362A1 (en) * 2004-07-13 2006-01-19 Paion Deutschland Gmbh Production of mammalian proteins in plant cells
JP2008523083A (ja) * 2004-12-08 2008-07-03 イムノメディクス， インコーポレイテッド 炎症性疾患および免疫調節不全疾患、感染性疾患、病的血管新生およびがんの免疫療法および検出のための方法および組成物
WO2006129849A1 (ja) * 2005-06-03 2006-12-07 Mochida Pharmaceutical Co., Ltd. 抗ｃｄ１４抗体融合蛋白質
JP2009538834A (ja) 2006-05-29 2009-11-12 ハイバーネイション セラピューティクス リミテッド 組織維持の改善
AU2007278754B2 (en) 2006-07-25 2014-11-13 Hibernation Therapeutics, A Kf Llc Trauma therapy
US8541236B2 (en) * 2006-12-08 2013-09-24 University Of Washington Mutant apolipoprotein A-1 polypeptide with increased resistance to oxidation and reactive carbonyls
AU2008222595B2 (en) 2007-03-02 2014-03-27 Hibernation Therapeutics, A Kf Llc Transplants
AU2008280836A1 (en) * 2007-07-25 2009-01-29 Hibernation Therapeutics, A Kf Llc Improved organ protection, preservation and recovery
EP2120049A1 (de) 2008-05-14 2009-11-18 PAION Deutschland GmbH Lösliches Thrombomodulin als Biomarker bei Therapien mit Gerinnungshemmern
US8241861B1 (en) 2008-07-08 2012-08-14 Insilicos, Llc Methods and compositions for diagnosis or prognosis of cardiovascular disease
JP2012529445A (ja) 2009-06-12 2012-11-22 パイオン ドイチュラント ゲーエムベーハー 線溶亢進を伴う凝固障害の処置
JP2013531651A (ja) 2010-06-14 2013-08-08 パイオン ドイチュラント ゲーエムベーハー 線溶亢進を伴う凝固障害の処置
EP2600891B1 (de) 2010-08-05 2018-01-17 Council of Scientific & Industrial Research Proteinfusionskonstrukte mit thrombolyse- und gerinnungshemmenden eigenschaften
WO2014020183A1 (de) 2012-08-03 2014-02-06 Ici Immunochemical Intelligence Gmbh In-vitro-assay zur diagnose von störungen der hämostase
AU2014292826A1 (en) 2013-07-17 2016-02-04 Hibernation Therapeutics, A Kf Llc A method for treating infection, sepsis and injury

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4752585A (en) * 1985-12-17 1988-06-21 Cetus Corporation Oxidation-resistant muteins
WO1988005053A1 (fr) * 1987-01-08 1988-07-14 Asahi Kasei Kogyo Kabushiki Kaisha Peptide servant a accelerer l'activation de la proteine c avec de la thrombine
US4835260A (en) * 1987-03-20 1989-05-30 Genetics Institute, Inc. Erythropoietin composition
US4912207A (en) * 1987-05-06 1990-03-27 Washington University DNA clone of human thrombomodulin and portions thereof
DE3824595A1 (de) * 1988-07-19 1990-01-25 Buechler B Set Ag Palette

Also Published As

Publication number Publication date
EP0527821B1 (de) 1997-05-21
US5256770A (en) 1993-10-26
DE69126205T2 (de) 1998-08-20
AU7778491A (en) 1991-10-30
CA2077691A1 (en) 1991-10-10
WO1991015514A1 (en) 1991-10-17
EP0527821A4 (en) 1993-05-05
EP0527821A1 (de) 1993-02-24
DE69126205D1 (en) 1997-06-26
JPH05508150A (ja) 1993-11-18
DK0527821T3 (da) 1997-12-15
AU650880B2 (en) 1994-07-07
GR3024099T3 (en) 1997-10-31
ES2103810T3 (es) 1997-10-01
JP3051995B2 (ja) 2000-06-12
CA2077691C (en) 2001-11-20

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee