ATE153500T1 - Verfahren zur inhibierung der fibrose - Google Patents

Verfahren zur inhibierung der fibrose

Info

Publication number: ATE153500T1
Authority: AT; Austria
Prior art keywords: formula; fibrosis; alkyl; hydrogen; compound
Prior art date: 1991-04-01

Application number

AT92917284T

Other languages

English (en)

Inventor

Saood Murad

Sheldon R Pinnell

Original Assignee

Univ Duke

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-01

Filing date

1992-03-31

Publication date

1997-06-15

1992-03-31 Application filed by Univ Duke filed Critical Univ Duke

1997-06-15 Application granted granted Critical

1997-06-15 Publication of ATE153500T1 publication Critical patent/ATE153500T1/de

Links

206010016654 Fibrosis Diseases 0.000 title abstract 3
230000004761 fibrosis Effects 0.000 title abstract 3
230000002401 inhibitory effect Effects 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
WARCRYXKINZHGQ-UHFFFAOYSA-N benzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1 WARCRYXKINZHGQ-UHFFFAOYSA-N 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
-1 hydroxy, amino Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Diabetes (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Mechanical Treatment Of Semiconductor (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
Saccharide Compounds (AREA)

AT92917284T 1991-04-01 1992-03-31 Verfahren zur inhibierung der fibrose ATE153500T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US67847291A	1991-04-01	1991-04-01

Publications (1)

Publication Number	Publication Date
ATE153500T1 true ATE153500T1 (de)	1997-06-15

Family

ID=24722926

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92917284T ATE153500T1 (de)	1991-04-01	1992-03-31	Verfahren zur inhibierung der fibrose

Country Status (11)

Country	Link
US (2)	US5374660A (de)
EP (1)	EP0581904B1 (de)
JP (1)	JPH06506471A (de)
AT (1)	ATE153500T1 (de)
AU (1)	AU652644B2 (de)
CA (1)	CA2107371A1 (de)
DE (1)	DE69220050T2 (de)
DK (1)	DK0581904T3 (de)
ES (1)	ES2104938T3 (de)
GR (1)	GR3024548T3 (de)
WO (1)	WO1992017065A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2107371A1 (en) *	1991-04-01	1992-10-02	Saood Murad	Method of inhibiting fibrosis
US5645839A (en) *	1995-06-07	1997-07-08	Trustees Of Boston University	Combined use of angiotensin inhibitors and nitric oxide stimulators to treat fibrosis
US6117445A (en) *	1998-01-28	2000-09-12	Link Technology Inc.	Methods for the prevention and treatment of fibrosis and sclerosis
DK2712617T3 (en)	2004-03-12	2017-02-13	Intercept Pharmaceuticals Inc	Treatment of fibrosis with Fxr ligands.
AT509045B1 (de)	2010-01-29	2011-06-15	Planta Naturstoffe Vertriebsges M B H	Verbindungen zur behandlung von asthma bronchiale
EP2953948B1 (de)	2013-02-07	2017-09-27	Scifluor Life Sciences, Inc	Fluorierte integrin-antagonisten
AU2016219906B2 (en)	2015-02-19	2020-10-01	Scifluor Life Sciences, Inc.	Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof
KR20170141757A (ko)	2015-04-30	2017-12-26	사이플루어 라이프 사이언시즈, 인크	테트라하이드로나프티리디닐 프로피온산 유도체 및 이의 용도
US10118929B2 (en)	2016-04-27	2018-11-06	Scifluor Life Sciences, Inc.	Nonanoic and decanoic acid derivatives and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB828344A (en) *	1957-01-30	1960-02-17	Ici Ltd	Veterinary compositions containing acid hydrazides
JPS5119135A (en) *	1974-08-05	1976-02-16	Itsuo Takeshita	Kohakusenzaino seiho
US4321273A (en) *	1978-03-01	1982-03-23	Ryuichi Sato	Germanium-containing organic polymer and its use in the treatment of pulmonary fibrosis
US4382941A (en) *	1980-11-26	1983-05-10	Sicardi Susana M	Bishydrazide quaternary salts and pharmaceutical compositions thereof
HU207051B (en) *	1987-12-30	1993-03-01	Chinoin Gyogyszer Es Vegyeszet	Process for producing 4-chloro-3-sulfamoylbenzoic acid hydrazides and pharmaceutical compositions comprising such compounds
CA2107371A1 (en) *	1991-04-01	1992-10-02	Saood Murad	Method of inhibiting fibrosis

1992
- 1992-03-31 CA CA002107371A patent/CA2107371A1/en not_active Abandoned
- 1992-03-31 EP EP92917284A patent/EP0581904B1/de not_active Expired - Lifetime
- 1992-03-31 AT AT92917284T patent/ATE153500T1/de not_active IP Right Cessation
- 1992-03-31 DK DK92917284.9T patent/DK0581904T3/da active
- 1992-03-31 JP JP4510233A patent/JPH06506471A/ja active Pending
- 1992-03-31 WO PCT/US1992/002618 patent/WO1992017065A2/en not_active Ceased
- 1992-03-31 DE DE69220050T patent/DE69220050T2/de not_active Expired - Fee Related
- 1992-03-31 AU AU18763/92A patent/AU652644B2/en not_active Ceased
- 1992-03-31 ES ES92917284T patent/ES2104938T3/es not_active Expired - Lifetime
1993
- 1993-02-16 US US08/017,795 patent/US5374660A/en not_active Expired - Lifetime
1994
- 1994-12-07 US US08/351,484 patent/US5571846A/en not_active Expired - Fee Related
1997
- 1997-08-27 GR GR970402158T patent/GR3024548T3/el unknown

Also Published As

Publication number	Publication date
EP0581904B1 (de)	1997-05-28
CA2107371A1 (en)	1992-10-02
EP0581904A1 (de)	1994-02-09
DK0581904T3 (da)	1997-12-29
DE69220050D1 (de)	1997-07-03
DE69220050T2 (de)	1998-01-22
AU1876392A (en)	1992-11-02
GR3024548T3 (en)	1997-12-31
ES2104938T3 (es)	1997-10-16
WO1992017065A3 (en)	1992-11-26
AU652644B2 (en)	1994-09-01
EP0581904A4 (en)	1994-05-25
WO1992017065A2 (en)	1992-10-15
US5374660A (en)	1994-12-20
JPH06506471A (ja)	1994-07-21
US5571846A (en)	1996-11-05

Legal Events

Date	Code	Title	Description
1998-01-15	UEP	Publication of translation of european patent specification
2000-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
TW255881B (de)	1995-09-01
DE69727956D1 (de)	2004-04-08	Pharmazeutische zubereitungen zur verminderung von atmungsdepressionen
KR890005124A (ko)	1989-05-11	세펨 화합물 및 이의 제조방법
KR870005973A (ko)	1987-07-08	항염증성 및 진통성의 활성을 갖는 벤조산 및 벤조산 에스테르의 유도체
ES8701228A1 (es)	1986-11-16	Un metodo para producir una propioxantina
DE69220050D1 (de)	1997-07-03	Verfahren zur inhibierung der fibrose
GB9108629D0 (en)	1991-06-12	Heterocyclic pharmaceutical compounds,preparation and use
ATE161178T1 (de)	1998-01-15	Pyrazolpyridine für die behandlung der anämie
HUP0001773A2 (hu)	2000-11-28	Szubsztituált tetrahidropiridinszármazékok, eljárás előállításukra, továbbá a vegyületeket tartalmazó gyógyászati készítmények
ES2005042A6 (es)	1989-02-16	Procedimiento de preparar derivados de aminoacidos que tienen actividad sobre el sistema nervioso central.
NO950177L (no)	1995-01-17	Farmakologisk aktive erivater
ES8500899A1 (es)	1984-11-01	Procedimiento para preparar derivados de amidas de los acidos mercaptoacetico y 3-mercaptopropionico
ZA916977B (en)	1992-06-24	Pharmaceutical compositions for use in treating aids
IL105122A0 (en)	1993-07-08	Benzimidazole derivative for use as an anti-irritant
ES487971A1 (es)	1980-08-01	Procedimiento para la preparacion de nuevos derivados de p-cloroacetofenona oxima con actividad analgesica
KR890005123A (ko)	1989-05-11	세펨 화합물 및 이의 제조방법
EP0285356A3 (de)	1989-05-31	Dopamin-beta-hydroxylase-Hemmer