ATE154614T1 - Heparinderivate und verfahren zu deren herstellung - Google Patents

Heparinderivate und verfahren zu deren herstellung

Info

Publication number: ATE154614T1
Authority: AT; Austria
Prior art keywords: heparin; show; derivatives; equal; standard
Prior art date: 1991-04-18

Application number

AT92908867T

Other languages

English (en)

Inventor

Christer Mattsson

Carl-Magnus Svahn

Michael Weber

Original Assignee

Pharmacia & Upjohn Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-18

Filing date

1992-04-14

Publication date

1997-07-15

1992-04-14 Application filed by Pharmacia & Upjohn Ab filed Critical Pharmacia & Upjohn Ab

1997-07-15 Application granted granted Critical

1997-07-15 Publication of ATE154614T1 publication Critical patent/ATE154614T1/de

Links

HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title abstract 8
238000004519 manufacturing process Methods 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
229960002897 heparin Drugs 0.000 abstract 5
229920000669 heparin Polymers 0.000 abstract 5
241000283690 Bos taurus Species 0.000 abstract 2
229940064551 bovine heparin Drugs 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
239000002628 heparin derivative Substances 0.000 abstract 2
229940045627 porcine heparin Drugs 0.000 abstract 2
241000282472 Canis lupus familiaris Species 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
238000003556 assay Methods 0.000 abstract 1
230000000740 bleeding effect Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000001990 intravenous administration Methods 0.000 abstract 1
208000031225 myocardial ischemia Diseases 0.000 abstract 1
230000014508 negative regulation of coagulation Effects 0.000 abstract 1
230000010412 perfusion Effects 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1
208000019553 vascular disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Polymers & Plastics (AREA)
Materials Engineering (AREA)
Biochemistry (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

AT92908867T 1991-04-18 1992-04-14 Heparinderivate und verfahren zu deren herstellung ATE154614T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE9101155A SE9101155D0 (sv)	1991-04-18	1991-04-18	Novel heparin derivatives

Publications (1)

Publication Number	Publication Date
ATE154614T1 true ATE154614T1 (de)	1997-07-15

Family

ID=20382487

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92908867T ATE154614T1 (de)	1991-04-18	1992-04-14	Heparinderivate und verfahren zu deren herstellung

Country Status (12)

Country	Link
US (2)	US6150342A (de)
EP (1)	EP0536363B1 (de)
JP (1)	JP3278676B2 (de)
AT (1)	ATE154614T1 (de)
AU (1)	AU642626B2 (de)
CA (1)	CA2084301C (de)
DE (1)	DE69220442T2 (de)
DK (1)	DK0536363T3 (de)
ES (1)	ES2104909T3 (de)
GR (1)	GR3024757T3 (de)
SE (1)	SE9101155D0 (de)
WO (1)	WO1992018545A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5696100A (en) *	1992-12-22	1997-12-09	Glycomed Incorporated	Method for controlling O-desulfation of heparin and compositions produced thereby
US5296471A (en) *	1992-12-22	1994-03-22	Glycomed Incorporated	Method for controlling o-desulfation of heparin and compositions produced thereby
AU2435795A (en) *	1994-05-06	1995-11-29	Glycomed Incorporated	O-desulfated heparin derivatives, methods of making and uses thereof
DE69621528T2 (de) *	1995-02-07	2003-01-16	Shiseido Co. Ltd., Tokio/Tokyo	Anti-inflamatorische agenzien
US6001820A (en) *	1995-03-31	1999-12-14	Hamilton Civic Hospitals Research Development Inc.	Compositions and methods for inhibiting thrombogenesis
US5763427A (en) *	1995-03-31	1998-06-09	Hamilton Civic Hospitals Research Development Inc.	Compositions and methods for inhibiting thrombogenesis
US5744457A (en) *	1995-03-31	1998-04-28	Hamilton Civic Hospitals Research Development Inc.	Compositions and methods for inhibiting thrombogenesis
US5767269A (en) *	1996-10-01	1998-06-16	Hamilton Civic Hospitals Research Development Inc.	Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
DE69931038T2 (de) *	1998-02-26	2006-11-23	Seikagaku Corp.	Neue polysaccharidderivate, verfahren zu ihrer herstellung und medizinische zusammensetzungen die diese als aktives bestandteil enthalten
CZ20014665A3 (cs) *	1999-06-30	2002-05-15	Hamilton Civic Hospitals Research Development, Inc	Prostředek s obsahem heparinu se střední molekulovou hmotností
US7608246B2 (en) *	2005-09-02	2009-10-27	The Brigham And Women's Hospital, Inc.	Apolipoprotein E as an adjuvant for lipid antigens
US8592393B2 (en)	2007-11-02	2013-11-26	Momenta Pharmaceuticals, Inc.	Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
ES2567079T3 (es)	2007-11-02	2016-04-19	Momenta Pharmaceuticals, Inc.	Composiciones de polisacáridos que no son anticoagulantes
US8569262B2 (en)	2007-11-02	2013-10-29	Momenta Pharmaceuticals, Inc.	Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
US9387256B2 (en)	2010-04-16	2016-07-12	Momenta Pharmaceuticals, Inc.	Tissue targeting
WO2011159770A2 (en)	2010-06-17	2011-12-22	Momenta Pharmaceuticals, Inc.	Methods and compositions for modulating hair growth
US10016449B2 (en)	2013-05-28	2018-07-10	Momenta Pharmaceuticals, Inc.	Pharmaceutical compositions
GB2515315A (en) *	2013-06-19	2014-12-24	Dilafor Ab	New Processes
WO2022015794A1 (en)	2020-07-14	2022-01-20	Optimvia, Llc	Methods for synthesizing non-anticoagulant heparan sulfate
WO2025106117A1 (en) *	2023-11-17	2025-05-22	Glycos Biomedical Ltd.	Medium molecular weight heparin

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1136620A (en) *	1979-01-08	1982-11-30	Ulf P.F. Lindahl	Heparin fragments having selective anticoagulation activity
IL61201A (en) *	1979-10-05	1984-09-30	Choay Sa	Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
US4948881A (en) *	1982-12-28	1990-08-14	Sanofi	Process for the depolymerization and sulfation of polysaccharides
FR2538404B1 (de) *	1982-12-28	1985-08-23	Anic Spa
US4745098A (en) *	1984-02-24	1988-05-17	The Regents Of The University Of California	Compositions and method for improving wound healing
FR2584728B1 (fr) *	1985-07-12	1987-11-20	Choay Sa	Procede de sulfatation de glycosaminoglycanes et de leurs fragments
FR2614026B1 (fr) *	1987-04-16	1992-04-17	Sanofi Sa	Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
SE8702254D0 (sv) *	1987-05-29	1987-05-29	Kabivitrum Ab	Novel heparin derivatives
DE3744119A1 (de) *	1987-12-24	1989-07-06	Basf Ag	Verwendung von polysulfatierten heparinen
IT1237518B (it) *	1989-11-24	1993-06-08	Renato Conti	Eparine supersolfatate

1991
- 1991-04-18 SE SE9101155A patent/SE9101155D0/xx unknown
1992
- 1992-04-14 AU AU16463/92A patent/AU642626B2/en not_active Ceased
- 1992-04-14 DK DK92908867.2T patent/DK0536363T3/da active
- 1992-04-14 CA CA002084301A patent/CA2084301C/en not_active Expired - Fee Related
- 1992-04-14 EP EP92908867A patent/EP0536363B1/de not_active Expired - Lifetime
- 1992-04-14 ES ES92908867T patent/ES2104909T3/es not_active Expired - Lifetime
- 1992-04-14 DE DE69220442T patent/DE69220442T2/de not_active Expired - Fee Related
- 1992-04-14 AT AT92908867T patent/ATE154614T1/de not_active IP Right Cessation
- 1992-04-14 JP JP50809992A patent/JP3278676B2/ja not_active Expired - Fee Related
- 1992-04-14 US US07/949,551 patent/US6150342A/en not_active Expired - Fee Related
- 1992-04-14 WO PCT/SE1992/000243 patent/WO1992018545A1/en not_active Ceased
1995
- 1995-05-10 US US08/438,933 patent/US6326476B1/en not_active Expired - Fee Related
1997
- 1997-09-17 GR GR970402402T patent/GR3024757T3/el unknown

Also Published As

Publication number	Publication date
GR3024757T3 (en)	1997-12-31
AU642626B2 (en)	1993-10-21
US6150342A (en)	2000-11-21
JP3278676B2 (ja)	2002-04-30
ES2104909T3 (es)	1997-10-16
DE69220442D1 (de)	1997-07-24
AU1646392A (en)	1992-11-17
US6326476B1 (en)	2001-12-04
WO1992018545A1 (en)	1992-10-29
DK0536363T3 (da)	1998-01-26
CA2084301C (en)	2005-10-25
EP0536363B1 (de)	1997-06-18
CA2084301A1 (en)	1992-10-19
SE9101155D0 (sv)	1991-04-18
JPH05508184A (ja)	1993-11-18
DE69220442T2 (de)	1998-01-29
EP0536363A1 (de)	1993-04-14

Similar Documents

Publication	Publication Date	Title
DE69220442D1 (de)	1997-07-24	Heparinderivate und verfahren zu deren herstellung
DE69905258T2 (de)	2003-11-06	Verwendung einer zusammensetzung mit heparin als nicht-thrombogenes oberflächenbeschichtungsmittel zur prophylaxe von arterienthrobosen
ATE87319T1 (de)	1993-04-15	Inklusionskomplexe von 7-isopropoxy-isoflavon mit cyclodextrinen, verfahren zu deren herstellung und diese inklusionskomplexe enthaltende pharmazeutische praeparate.
ATE131176T1 (de)	1995-12-15	Sulfatierte polysaccharide, antikoagulierungs- und antikomplementärmittel, hergestellt aus fukanen aus braunen algen, und verfahren zu deren herstellung.
ATE161273T1 (de)	1998-01-15	Polysaccharidderivate von heparin, heparansulfate, ihre fraktionen und fragmente, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, welche diese enthalten
DE69005394D1 (de)	1994-02-03	Zusammensetzungen welche komplexe von hyaluronsäure enthalten und verfahren zu deren herstellung.
DE3486341T2 (de)	1995-05-04	Derivate von Dextran mit antikoagulierenden und antikomplementären Eigenschaften, ihre Herstellung und ihre biologischen Anwendungen.
DE3772221D1 (de)	1991-09-26	Suessware und verfahren zur herstellung derselben.
ES2021905A6 (es)	1991-11-16	Procedimiento para la preparacion de fracciones de sulfato de dermatano.
DE3785726T2 (de)	1993-09-23	Verfahren zur kontrollierten depolymerisierung von polysacchariden.
EP0700684A2 (de)	1996-03-13	Zusammensetzungen, enthaltend Prothrombinkomplex-Konzentrat und wenigstens eine weitere Komponente das die Blutgerrinnung fördert, als Gegenmittel für Blut-Anticoagulanzien
RU2216548C2 (ru)	2003-11-20	Смесь линейных олигосахаридов, полученная из дерматансульфата, фармацевтическая композиция, обладающая антитромботическим действием, и способ лечения
DE69025691D1 (de)	1996-04-11	Einschlusskomplexe mit Silybinin, ihre Herstellung und pharmazeutische Präparate, die diese enthalten
DE3787996D1 (de)	1993-12-09	Heparine, frei von E.D.T.A., Fraktionen und Fragmente von Heparin, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, welche diese enthalten.
ATE83237T1 (de)	1992-12-15	Pyridinderivate und verfahren zu ihrer herstellung.
KR930012023A (ko)	1993-07-20	환원된 형태의 비글리코실화 재조합 인체 il2의 안정화된 제약 조성물 및 그의 제조방법
EP0700682A2 (de)	1996-03-13	Arzneimittel, enthaltend Prothrombin zur Antagonisierung von Blut-Anticoagulanzien
EP0320785A3 (de)	1990-07-11	Peptide mit beeinflussender Wirkung auf die Hypophyse von Säugern
ATE112276T1 (de)	1994-10-15	Aryl-chinolyl-substituierte 1,4-dihydropyridin- dicarbonsäurederivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln.
EP0164587A3 (de)	1986-03-19	Nifedipinpräparate und Verfahren zu ihrer Herstellung
JP2002532431A (ja)	2002-10-02	低分子量ヘパリンの新規な治療的応用
DE413248T1 (de)	1993-06-09	Substanzen mit heparinaehnlicher struktur und verfahren zur herstellung.
SE8306792D0 (sv)	1983-12-08	Neues terapeutisches preparat enthaltend hydrierte ergotalkaloide und heparin
ATE24715T1 (de)	1987-01-15	Cycloaliphatische aminosulfonsaeurederivate, verfahren zu deren herstellung und arzneimittel zur bekaempfung von herz- und gefaesskrankheiten.
EP0252299A3 (de)	1990-04-11	Verwendung von 12-Amino-pyridazino [4',5' : 3,4] pyrrolo[2,1-a] isochinolinen zur Herstellung von cardio- und neuroprotektiven Mitteln

Legal Events

Date	Code	Title	Description
1997-12-15	UEP	Publication of translation of european patent specification
2010-01-15	REN	Ceased due to non-payment of the annual fee