ATE154801T1 - Chinoline enthaltende ketosäure als leukotrien- antagonisten - Google Patents

Chinoline enthaltende ketosäure als leukotrien- antagonisten

Info

Publication number
ATE154801T1
ATE154801T1 AT92301393T AT92301393T ATE154801T1 AT E154801 T1 ATE154801 T1 AT E154801T1 AT 92301393 T AT92301393 T AT 92301393T AT 92301393 T AT92301393 T AT 92301393T AT E154801 T1 ATE154801 T1 AT E154801T1
Authority
AT
Austria
Prior art keywords
antagonists
leucotrien
acid containing
keto acid
quinolines
Prior art date
Application number
AT92301393T
Other languages
English (en)
Inventor
Michel L Belley
Original Assignee
Merck Frosst Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc
Application granted granted Critical
Publication of ATE154801T1 publication Critical patent/ATE154801T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
AT92301393T 1991-02-21 1992-02-20 Chinoline enthaltende ketosäure als leukotrien- antagonisten ATE154801T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65893191A 1991-02-21 1991-02-21

Publications (1)

Publication Number Publication Date
ATE154801T1 true ATE154801T1 (de) 1997-07-15

Family

ID=24643302

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92301393T ATE154801T1 (de) 1991-02-21 1992-02-20 Chinoline enthaltende ketosäure als leukotrien- antagonisten

Country Status (17)

Country Link
EP (1) EP0500360B1 (de)
JP (1) JPH0788361B2 (de)
KR (1) KR920016423A (de)
CN (1) CN1065062A (de)
AT (1) ATE154801T1 (de)
AU (1) AU648385B2 (de)
CA (1) CA2061675C (de)
CS (1) CS47192A3 (de)
DE (1) DE69220517T2 (de)
ES (1) ES2104821T3 (de)
FI (1) FI920734A7 (de)
HU (1) HU9200552D0 (de)
IE (1) IE920499A1 (de)
IL (1) IL100985A0 (de)
MX (1) MX9200714A (de)
NO (1) NO920681L (de)
ZA (1) ZA921232B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270324A (en) * 1992-04-10 1993-12-14 Merck Frosst Canada, Inc. Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists
GB9216768D0 (en) * 1992-08-07 1992-09-23 Leo Pharm Prod Ltd Chemical compounds
EP0830133A1 (de) * 1995-04-28 1998-03-25 Takeda Chemical Industries, Ltd. Therapeutische zusammensetzung für arthritis
WO1998008820A1 (en) * 1996-08-26 1998-03-05 Yamanouchi Pharmaceutical Co., Ltd. Benzenesulfone compounds and salts thereof
PT1037627E (pt) * 1998-07-14 2001-11-30 Alcon Lab Inc Utilizacao do acido 11-(3-dimetilaminopropilideno)-6,11-dihidrodibenz¬b,e|oxepin-2-acetico e seus sais derivados farmaceuticamente aceitaveis para a producao de um medicamento para o tratamento de doencas inflamatorias oftalmicas nao-alergicas e para a prebencao da neovascularizacao ocular
MXPA06012220A (es) 2004-04-21 2007-07-18 Teva Pharma Procesos para preparar sodio de montelukast.
ITMI20050247A1 (it) * 2005-02-18 2006-08-19 Chemi Spa Processo per la preparazione di montelukast
WO2006131782A1 (en) * 2005-06-07 2006-12-14 Glade Organics Private Limited Process for the manufacture of methyl-2-(3-(2-(7-chloro-2-quinolinyl-ethenyl)-phenyl)-3-oxopropyl) benzoate
US7812168B2 (en) 2005-07-05 2010-10-12 Teva Pharmaceutical Industries Ltd. Purification of montelukast
CN101365683A (zh) * 2005-11-18 2009-02-11 斯索恩有限公司 制备孟鲁司特及其中间体的方法
AR057909A1 (es) * 2005-11-18 2007-12-26 Synthon Bv Proceso para preparar montelukast y compuestos relacionados, que utiliza un compuesto intermediario derivado de un ester sulfonico.
EP2059509A2 (de) * 2006-09-15 2009-05-20 Cipla Limited Verfahren zur herstellung von montelukast, und zwischenprodukte dafür
ES2320077B1 (es) * 2007-07-31 2010-02-26 Moehs Iberica, S.L. Proceso de preparacion de un antagonista de leucotrienos y de un intermedio del mismo.
CN101851196B (zh) * 2010-05-28 2011-07-27 中国科学院昆明植物研究所 2-(1h)喹啉酮衍生物,其药物组合物及其制备方法和用途
KR20140108627A (ko) * 2011-07-26 2014-09-12 썬 파마 어드밴스트 리서치 컴패니 리미티드 퀴놀린-, 퀸옥살린 또는 벤조티아졸계 시스테이닐 류코트리엔 길항물질 (ltc4)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE59889B1 (en) * 1986-02-14 1994-04-20 Merck Frosst Canada Inc 2-substituted quinoline dioic acids
EP0318093A3 (de) * 1987-11-25 1990-12-05 Merck Frosst Canada Inc. Diarylchinolindicarbonsäure und ihre Verwendung als Arzneimittel
EP0349062A1 (de) * 1988-06-27 1990-01-03 Merck Frosst Canada Inc. Chinolinetheralkansäuren
NZ233752A (en) * 1989-05-24 1993-05-26 Merck Frosst Canada Inc Substituted quinoline derivatives, preparation and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
KR920016423A (ko) 1992-09-24
NO920681L (no) 1992-08-24
IE920499A1 (en) 1992-08-26
FI920734L (fi) 1992-08-22
CA2061675C (en) 2002-12-17
ES2104821T3 (es) 1997-10-16
CN1065062A (zh) 1992-10-07
CS47192A3 (en) 1992-10-14
HU9200552D0 (en) 1992-05-28
JPH0525135A (ja) 1993-02-02
MX9200714A (es) 1992-10-01
EP0500360B1 (de) 1997-06-25
DE69220517D1 (de) 1997-07-31
FI920734A7 (fi) 1992-08-22
CA2061675A1 (en) 1992-08-22
DE69220517T2 (de) 1997-12-18
NO920681D0 (no) 1992-02-20
JPH0788361B2 (ja) 1995-09-27
EP0500360A1 (de) 1992-08-26
AU648385B2 (en) 1994-04-21
ZA921232B (en) 1992-10-28
IL100985A0 (en) 1992-11-15
FI920734A0 (fi) 1992-02-20
AU1111992A (en) 1992-08-27

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee