ATE155691T1 - Rhenium- und technetiumkomplexe mit einer hypoxie lokalisierenden gruppe - Google Patents

Rhenium- und technetiumkomplexe mit einer hypoxie lokalisierenden gruppe

Info

Publication number
ATE155691T1
ATE155691T1 AT92309922T AT92309922T ATE155691T1 AT E155691 T1 ATE155691 T1 AT E155691T1 AT 92309922 T AT92309922 T AT 92309922T AT 92309922 T AT92309922 T AT 92309922T AT E155691 T1 ATE155691 T1 AT E155691T1
Authority
AT
Austria
Prior art keywords
aryl
alkyl
coor3
hydrogen
groups
Prior art date
Application number
AT92309922T
Other languages
English (en)
Inventor
Karen Linder
Kondareddiar Ramalingam
John P Pirro
Adrian D Nunn
Rocco Richard J Di
David P Nowotnik
William L Rumsey
Original Assignee
Bracco Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Int Bv filed Critical Bracco Int Bv
Application granted granted Critical
Publication of ATE155691T1 publication Critical patent/ATE155691T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0474Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0497Organic compounds conjugates with a carrier being an organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32Oximes
    • C07C251/34Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32Oximes
    • C07C251/34Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/36Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/38Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91Nitro radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00Preparations for testing in vivo
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
AT92309922T 1991-10-29 1992-10-29 Rhenium- und technetiumkomplexe mit einer hypoxie lokalisierenden gruppe ATE155691T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78448691A 1991-10-29 1991-10-29
CN93103893A CN1093084A (zh) 1991-10-29 1993-03-31 包含缺氧定位部分的铼和锝络合物

Publications (1)

Publication Number Publication Date
ATE155691T1 true ATE155691T1 (de) 1997-08-15

Family

ID=36809246

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92309922T ATE155691T1 (de) 1991-10-29 1992-10-29 Rhenium- und technetiumkomplexe mit einer hypoxie lokalisierenden gruppe

Country Status (18)

Country Link
EP (1) EP0544412B1 (de)
JP (1) JP3385048B2 (de)
CN (2) CN1071928A (de)
AT (1) ATE155691T1 (de)
AU (1) AU662361B2 (de)
CA (1) CA2081637C (de)
DE (1) DE69221084T2 (de)
DK (1) DK0544412T3 (de)
ES (1) ES2104848T3 (de)
FI (1) FI924914A7 (de)
GR (1) GR3024895T3 (de)
HU (1) HUT74804A (de)
IL (1) IL103353A (de)
MX (1) MX9206070A (de)
NO (1) NO304466B1 (de)
NZ (1) NZ244613A (de)
PL (1) PL296409A1 (de)
ZA (1) ZA927692B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5808091A (en) 1991-10-29 1998-09-15 Bracco International B.V. Rhenium and technetium complexes containing a hypoxia localizing moiety
US5608110A (en) * 1993-06-15 1997-03-04 Bracco International B.V. Heteroatom-bearing ligands and metal complexes thereof
CA2168652A1 (en) * 1993-08-04 1995-02-16 Colin Mill Archer Radiometal complexes that localise in hypoxic tissue
IL111592A0 (en) * 1993-12-14 1995-01-24 Bracco Int Bv Stable multilayer lyophile
ES2114735T3 (es) * 1994-01-12 1998-06-01 Bracco Int Bv Ligandos y complejos metalicos de los mismos.
US5700825A (en) * 1995-03-31 1997-12-23 Florida State University Radiosensitizing diamines and their pharmaceutical preparations
US6060604A (en) * 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
DE69830057T2 (de) 1997-01-21 2006-06-29 Ge Healthcare Ltd., Little Chalfont MARKIERTE FAKTOR XIIIa SUBSTRATE
WO1998033935A1 (en) * 1997-01-31 1998-08-06 The University Of Alberta Method for detecting exogenous gene expression
US8562945B2 (en) 2008-01-09 2013-10-22 Molecular Insight Pharmaceuticals, Inc. Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
RU2498798C2 (ru) 2008-01-09 2013-11-20 Моликьюлар Инсайт Фармасьютикалз, Инк. Ингибиторы карбоангидразы iх
AU2010260195B2 (en) 2009-06-15 2014-11-20 Molecular Insight Pharmaceuticals, Inc. Process for production of heterodimers of glutamic acid
CA2775397A1 (en) * 2009-09-28 2011-03-31 University Of Kentucky Research Foundation Thiol-containing compounds for the removal of elements from contaminated milieu and methods of use
EP2800471A4 (de) 2012-01-06 2015-11-04 Molecular Insight Pharm Inc Metallkomplexe von poly(carboxyl)aminhaltigen liganden mit einer affinität für carboanhydrase ix
EP3939972A1 (de) 2013-01-14 2022-01-19 Molecular Insight Pharmaceuticals, Inc. Triazinbasierte radiopharmazeutika und strahlungsbildgebungsmittel
CN111372940A (zh) * 2017-09-19 2020-07-03 阿尔伯塔大学理事会 生物还原活化的化合物、其前药、放射性药物、组合物及其在包括癌症在内的低氧疾病的多模式治疗控制中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2093451B (en) * 1981-02-24 1984-10-31 May & Baker Ltd Nitroimidazole derivatives
US4615876A (en) * 1983-04-25 1986-10-07 Curators Of The University Of Missouri Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides
US4638051A (en) * 1984-04-30 1987-01-20 The Johns Hopkins University Brain imaging radiopharmaceuticals
DE3687467T2 (de) * 1985-03-11 1993-04-29 Amersham Int Plc Komplexe von technetium-99m mit propylen-amin-oximen.
WO1989010759A1 (en) * 1988-04-29 1989-11-16 Mallinckrodt, Inc. Diaminedithiol chelating agents for radiopharmaceuticals
US4988496A (en) * 1988-05-31 1991-01-29 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
US4925650A (en) * 1988-11-16 1990-05-15 Mallinckrodt, Inc. Technetium -99m complex for examining the renal function
US4986979A (en) * 1989-03-14 1991-01-22 Neorx Corporation Imaging tissue sites of inflammation
DE3930674A1 (de) * 1989-09-11 1991-03-21 Diagnostikforschung Inst Bifunktionelle chelatbildner zur komplexierung von tc- und re-isotopen, verfahren zu ihrer herstellung und darstellung von konjugaten daraus sowie deren verwendung in diagnostik und therapie

Also Published As

Publication number Publication date
CA2081637A1 (en) 1993-12-15
MX9206070A (es) 1993-04-01
EP0544412B1 (de) 1997-07-23
IL103353A0 (en) 1993-03-15
NZ244613A (en) 1996-05-28
NO924157L (no) 1993-04-30
EP0544412A3 (en) 1993-08-25
CN1071928A (zh) 1993-05-12
ES2104848T3 (es) 1997-10-16
AU2737392A (en) 1993-05-06
DK0544412T3 (da) 1998-03-02
GR3024895T3 (en) 1998-01-30
NO304466B1 (no) 1998-12-21
FI924914L (fi) 1993-04-30
CN1093084A (zh) 1994-10-05
ZA927692B (en) 1993-04-15
DE69221084D1 (de) 1997-08-28
HUT74804A (en) 1997-02-28
FI924914A0 (fi) 1992-10-29
JPH05239046A (ja) 1993-09-17
IL103353A (en) 1999-01-26
HU9203389D0 (en) 1993-01-28
EP0544412A2 (de) 1993-06-02
DE69221084T2 (de) 1998-02-26
PL296409A1 (en) 1993-11-29
CA2081637C (en) 2000-05-16
NO924157D0 (no) 1992-10-28
JP3385048B2 (ja) 2003-03-10
FI924914A7 (fi) 1993-04-30
AU662361B2 (en) 1995-08-31

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