ATE156265T1 - Methode zur photometrischen (in vitro) bestimmung des gehaltes eines analyts in einer probe - Google Patents

Methode zur photometrischen (in vitro) bestimmung des gehaltes eines analyts in einer probe

Info

Publication number
ATE156265T1
ATE156265T1 AT92920833T AT92920833T ATE156265T1 AT E156265 T1 ATE156265 T1 AT E156265T1 AT 92920833 T AT92920833 T AT 92920833T AT 92920833 T AT92920833 T AT 92920833T AT E156265 T1 ATE156265 T1 AT E156265T1
Authority
AT
Austria
Prior art keywords
radiation
measuring chamber
analyte
pct
path length
Prior art date
Application number
AT92920833T
Other languages
English (en)
Inventor
Peter Aage Frischauf
Original Assignee
Radiometer Medical As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Radiometer Medical As filed Critical Radiometer Medical As
Application granted granted Critical
Publication of ATE156265T1 publication Critical patent/ATE156265T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/036—Cuvette constructions transformable, modifiable
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0364—Cuvette constructions flexible, compressible
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N2021/3129—Determining multicomponents by multiwavelength light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1048—General features of the devices using the transfer device for another function
    • G01N2035/1062—General features of the devices using the transfer device for another function for testing the liquid while it is in the transfer device
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/066—Modifiable path; multiple paths in one sample
    • G01N2201/0662—Comparing measurements on two or more paths in one sample

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Optical Measuring Cells (AREA)
  • Paper (AREA)
AT92920833T 1991-09-19 1992-09-17 Methode zur photometrischen (in vitro) bestimmung des gehaltes eines analyts in einer probe ATE156265T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK161391A DK167942B1 (da) 1991-09-19 1991-09-19 Fremgangsmaade, apparat og maalekammerenhed ved fotometrisk in vitro bestemmelse af indholdet af en analyt i en proeve ved maaling direkte paa proeven

Publications (1)

Publication Number Publication Date
ATE156265T1 true ATE156265T1 (de) 1997-08-15

Family

ID=8106547

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92920833T ATE156265T1 (de) 1991-09-19 1992-09-17 Methode zur photometrischen (in vitro) bestimmung des gehaltes eines analyts in einer probe

Country Status (8)

Country Link
US (1) US5371020A (de)
EP (1) EP0605598B1 (de)
JP (1) JP2978565B2 (de)
AT (1) ATE156265T1 (de)
AU (1) AU2671692A (de)
DE (1) DE69221306T2 (de)
DK (2) DK167942B1 (de)
WO (1) WO1993006456A1 (de)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5351686A (en) * 1990-10-06 1994-10-04 In-Line Diagnostics Corporation Disposable extracorporeal conduit for blood constituent monitoring
US6246894B1 (en) 1993-02-01 2001-06-12 In-Line Diagnostics Corporation System and method for measuring blood urea nitrogen, blood osmolarity, plasma free hemoglobin and tissue water content
US6725072B2 (en) 1990-10-06 2004-04-20 Hema Metrics, Inc. Sensor for transcutaneous measurement of vascular access blood flow
US5550630A (en) * 1993-03-19 1996-08-27 The United States Of America As Represented By The Secretary Of Agriculture Spectrophotometric method for structural analysis of organic compounds, polymers, nucleotides and peptides
DE4405375C2 (de) * 1994-02-19 1996-07-25 Fritz Nerbe Nachfolger Juergen Mikrotiterplatte
AT400639B (de) * 1994-07-18 1996-02-26 Avl Verbrennungskraft Messtech Verfahren zur bestimmung der konzentration c eines in einer trägersubstanz homogen verteilten absorbens
US5510621A (en) * 1994-10-03 1996-04-23 Optical Solutions, Inc. Apparatus and method for measuring components in a bag
DE19520446A1 (de) * 1995-06-03 1996-12-05 Boehringer Mannheim Gmbh Probenträger für die Infrarot-Transmissionsspektroskopie
US6605471B1 (en) 1996-05-30 2003-08-12 Radiometer Medical A/S Method and system for determining at least one parameter of at least one sample of a physiological liquid, a holder and a test device
KR100253914B1 (ko) * 1997-12-20 2000-04-15 윤덕용 광투과경로길이조절이가능한밀폐형온라인측정장치
US6804543B2 (en) 1998-02-05 2004-10-12 Hema Metrics, Inc. Sensor for transcutaneous measurement of vascular access blood flow
US6246474B1 (en) * 1998-04-29 2001-06-12 Particle Measuring Systems, Inc. Method and apparatus for measurement of particle size distribution in substantially opaque slurries
ATE246352T1 (de) 1998-05-13 2003-08-15 Bayer Ag Durchflussküvette zur spektroskopischen untersuchung einer probe
NZ511560A (en) 1998-11-05 2002-11-26 Chemometec As A method for the assessment of particles and a system and a device for use in the method
US6458326B1 (en) 1999-11-24 2002-10-01 Home Diagnostics, Inc. Protective test strip platform
US6746407B2 (en) 2000-12-29 2004-06-08 Hema Metrics, Inc. Method of measuring transcutaneous access blood flow
US6541266B2 (en) 2001-02-28 2003-04-01 Home Diagnostics, Inc. Method for determining concentration of an analyte in a test strip
US6562625B2 (en) 2001-02-28 2003-05-13 Home Diagnostics, Inc. Distinguishing test types through spectral analysis
US6525330B2 (en) 2001-02-28 2003-02-25 Home Diagnostics, Inc. Method of strip insertion detection
US7016087B2 (en) * 2001-08-08 2006-03-21 Becton Dickinson And Company Photon efficient scanner
US6678542B2 (en) * 2001-08-16 2004-01-13 Optiscan Biomedical Corp. Calibrator configured for use with noninvasive analyte-concentration monitor and employing traditional measurements
FR2829286B1 (fr) * 2001-09-03 2008-04-04 Ge Med Sys Global Tech Co Llc Dispositif et procede d'emission de rayons x
US7050157B2 (en) * 2001-11-08 2006-05-23 Optiscan Biomedical Corp. Reagent-less whole-blood glucose meter
US7061593B2 (en) * 2001-11-08 2006-06-13 Optiscan Biomedical Corp. Device and method for in vitro determination of analyte concentrations within body fluids
US6989891B2 (en) * 2001-11-08 2006-01-24 Optiscan Biomedical Corporation Device and method for in vitro determination of analyte concentrations within body fluids
US6958809B2 (en) 2001-11-08 2005-10-25 Optiscan Biomedical Corporation Reagent-less whole-blood glucose meter
GB0223546D0 (en) * 2002-10-10 2002-11-20 Council Cent Lab Res Councils Sample cell
US6983177B2 (en) * 2003-01-06 2006-01-03 Optiscan Biomedical Corporation Layered spectroscopic sample element with microporous membrane
US20040132168A1 (en) * 2003-01-06 2004-07-08 Peter Rule Sample element for reagentless whole blood glucose meter
US20040131088A1 (en) * 2003-01-08 2004-07-08 Adtran, Inc. Shared T1/E1 signaling bit processor
WO2004091387A2 (en) * 2003-04-15 2004-10-28 Optiscan Biomedical Corporation Dual measurement analyte detection system
AU2004230531A1 (en) * 2003-04-15 2004-10-28 Optiscan Biomedical Corporation Sample element qualification
US20050106749A1 (en) * 2003-04-15 2005-05-19 Braig James R. Sample element for use in material analysis
US20050037384A1 (en) * 2003-04-15 2005-02-17 Braig James R. Analyte detection system
US7271912B2 (en) * 2003-04-15 2007-09-18 Optiscan Biomedical Corporation Method of determining analyte concentration in a sample using infrared transmission data
US20050038674A1 (en) * 2003-04-15 2005-02-17 Braig James R. System and method for managing a chronic medical condition
CA2542897A1 (en) 2003-10-30 2005-05-12 Bayer Healthcare Llc Optical cuvette with platform-and-well construction
EP1956359A1 (de) * 2003-10-30 2008-08-13 Bayer Healthcare, LLC Formate für die optische Analyse sowie Verfahren zur Herstellung davon
CA2563425A1 (en) * 2004-04-19 2005-10-27 Trojan Technologies Inc. Optical radiation sensor system and method for measuring radiation transmittance of a fluid
US20050264815A1 (en) * 2004-05-07 2005-12-01 Mark Wechsler Sample element with fringing-reduction capabilities
US7763454B2 (en) 2004-07-09 2010-07-27 Church & Dwight Co., Inc. Electronic analyte assaying device
US20060030790A1 (en) * 2004-08-06 2006-02-09 Braig James R Sample element with barrier material and vacuum
WO2006058741A1 (en) * 2004-12-02 2006-06-08 Foss Analytical A/S Spectrophotometer
DE102004059704B4 (de) * 2004-12-10 2012-07-05 Scieva Gmbh Spektroskopischer Nachweis anorganischer, organischer oder biologischer Stoffe
US20060194325A1 (en) 2005-02-14 2006-08-31 Gable Jennifer H Fluid handling cassette with a fluid control interface
US7722537B2 (en) * 2005-02-14 2010-05-25 Optiscan Biomedical Corp. Method and apparatus for detection of multiple analytes
US8251907B2 (en) 2005-02-14 2012-08-28 Optiscan Biomedical Corporation System and method for determining a treatment dose for a patient
US20070030482A1 (en) * 2005-08-08 2007-02-08 Zhenghua Ji Spectrophotometer with adjustable light pathlength
US9561001B2 (en) 2005-10-06 2017-02-07 Optiscan Biomedical Corporation Fluid handling cassette system for body fluid analyzer
DE102006038271A1 (de) * 2006-08-11 2008-02-14 Senslab-Gesellschaft Zur Entwicklung Und Herstellung Bioelektrochemischer Sensoren Mbh Sensorvorrichtung mit strukturierter Durchflusszelle
DE102007019695B4 (de) * 2007-04-24 2009-08-13 Analytik Jena Ag Küvette für die optische Analyse kleiner Volumina
US8597190B2 (en) 2007-05-18 2013-12-03 Optiscan Biomedical Corporation Monitoring systems and methods with fast initialization
EP2257783B1 (de) * 2008-03-21 2014-02-26 Eppendorf Ag Küvette und verfahren zur optischen untersuchung kleiner flüssigkeitsmengen
DE102008027085B4 (de) * 2008-06-05 2010-07-15 Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V. Vorrichtung zur Analyse einer flüssigen Probe sowie Verfahren zur Analytbestimmung in einem Dialysat mit einer solchen Vorrichtung
US7961310B1 (en) * 2008-07-09 2011-06-14 Durasens, LLC Transmission liquid flow cell with increased internal flow rates
US9370324B2 (en) 2008-11-05 2016-06-21 Fresenius Medical Care Holdings, Inc. Hemodialysis patient data acquisition, management and analysis system
US10475529B2 (en) 2011-07-19 2019-11-12 Optiscan Biomedical Corporation Method and apparatus for analyte measurements using calibration sets
WO2011011462A1 (en) 2009-07-20 2011-01-27 Optiscan Biomedical Corporation Adjustable connector and dead space reduction
US9554742B2 (en) 2009-07-20 2017-01-31 Optiscan Biomedical Corporation Fluid analysis system
EP2580589B1 (de) 2010-06-09 2016-08-31 Optiscan Biomedical Corporation Messung von analyten in einer flüssigkeitsprobe aus einem patienten
US8517968B2 (en) 2011-02-25 2013-08-27 Fresenius Medical Care Holdings, Inc. Shrouded sensor clip assembly and blood chamber for an optical blood monitoring system
US8333724B2 (en) 2010-09-07 2012-12-18 Fresenius Medical Care Holdings, Inc. Low flow optical blood chamber
US9194792B2 (en) * 2010-09-07 2015-11-24 Fresenius Medical Care Holdings, Inc. Blood chamber for an optical blood monitoring system
US8743354B2 (en) 2010-09-07 2014-06-03 Fresenius Medical Care Holdings, Inc. Shrouded sensor clip assembly and blood chamber for an optical blood monitoring system
MX347286B (es) 2010-11-17 2017-04-21 Fresenius Medical Care Holdings Inc Ensamble de sujetador de sensor para un sistema de monitoreo óptico.
US9173988B2 (en) 2010-11-17 2015-11-03 Fresenius Medical Care Holdings, Inc. Sensor clip assembly for an optical monitoring system
DE102011013002C5 (de) * 2011-03-04 2020-12-17 Optek-Danulat Gmbh Durchströmbare Messzelle
WO2013006716A1 (en) 2011-07-06 2013-01-10 Optiscan Biomedical Corporation Sample cell for fluid analysis system
USD725261S1 (en) 2012-02-24 2015-03-24 Fresenius Medical Care Holdings, Inc. Blood flow chamber
EP2936118B1 (de) * 2012-12-20 2023-06-21 Radiometer Medical ApS Vorrichtung zum nachweis der konzentration einer komponente in einer probe
CN105229448B (zh) * 2013-04-18 2017-11-21 尼普洛株式会社 流体浓度测定装置
EP3208585B1 (de) * 2013-05-27 2019-11-27 GasPorOx AB System und verfahren zur bestimmung einer konzentration eines gases in einem behälter
DE102013011495A1 (de) * 2013-07-02 2015-01-08 Laser- Und Medizin-Technologie Gmbh, Berlin Verfahren zur Ermittlung der Konzentration eines Stoffes in einem verformbaren Behälter
USD799031S1 (en) 2015-09-09 2017-10-03 Fresenius Medical Care Holdings, Inc. Blood flow chamber with directional arrow
EP3199937A1 (de) * 2016-01-28 2017-08-02 Minitüb GmbH Zählfach und verfahren zur probenanalyse
ES2923758T3 (es) * 2016-02-04 2022-09-30 Nova Biomedical Corp Sistema y procedimiento para la medición de la absorbancia óptica de sangre entera
JP2019510987A (ja) * 2016-04-08 2019-04-18 ヴェリフィ リミテッド 分光測光法のための試料容器
WO2018196937A1 (en) * 2017-04-28 2018-11-01 Q-Interline A/S A sampling pipette and cuvette, a method of carrying out spectroscopy and a device
US11022548B2 (en) 2017-05-02 2021-06-01 Ping Lin Sample holder for use in infrared spectroscopy
EP4143294A4 (de) 2020-04-28 2025-01-08 Siemens Healthcare Diagnostics, Inc. Vorrichtungen und verfahren zur akustophoretischen lyse

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3740156A (en) * 1971-08-11 1973-06-19 Exxon Research Engineering Co Photometric analyzer sampling cell
US3810695A (en) * 1972-12-14 1974-05-14 Gam Rad Fluid analyzer with variable light path
US4509522A (en) * 1981-12-15 1985-04-09 The United States Of America As Represented By The Secretary Of The Navy Infrared optical measurement of blood gas concentrations and fiber optic catheter
GB2160646B (en) * 1984-05-18 1988-05-05 Univ London Method for determining the concentration of a gas
DK282085D0 (da) * 1985-06-21 1985-06-21 Radiometer As Fremgangsmaade og apparat til bestemmelse af blodkomponenter
US4762798A (en) * 1985-12-31 1988-08-09 Marshall Diagnostics, Inc. Device and method for determining a characteristic of a fluid sample
US4800886A (en) * 1986-07-14 1989-01-31 C. R. Bard, Inc. Sensor for measuring the concentration of a gaseous component in a fluid by absorption
US4873993A (en) * 1986-07-22 1989-10-17 Personal Diagnostics, Inc. Cuvette
US4786171A (en) * 1986-07-29 1988-11-22 Guided Wave, Inc. Spectral analysis apparatus and method
US5149503A (en) * 1987-07-24 1992-09-22 Terumo Kabushiki Kaisha Apparatus for measuring hemoglobin concentration and oxygen saturation thereof
DK163194C (da) * 1988-12-22 1992-06-22 Radiometer As Fremgangsmaade ved fotometrisk in vitro bestemmelse af en blodgasparameter i en blodproeve
DE3838371A1 (de) * 1988-11-11 1990-05-17 Hench Automatik App Masch Messzelle zur spektralanalyse von stroemenden medien, insbesondere kunststoffschmelzen
ATE80225T1 (de) * 1989-05-23 1992-09-15 Biosensors Technology Inc Verfahren zur bestimmung mittels strahlungsabsorption von substanzen in absorbierenden und streuenden matrixmaterialien.
US4980551A (en) * 1990-01-05 1990-12-25 National Research Council Canada Conseil National De Recherches Canada Non-pressure-dependancy infrared absorption spectra recording, sample cell
US5168367A (en) * 1991-01-16 1992-12-01 Rourke Patrick E O Variable path length spectrophotometric probe

Also Published As

Publication number Publication date
JPH07500904A (ja) 1995-01-26
EP0605598B1 (de) 1997-07-30
US5371020A (en) 1994-12-06
JP2978565B2 (ja) 1999-11-15
DE69221306T2 (de) 1998-01-08
DK161391D0 (da) 1991-09-19
DK0605598T3 (da) 1997-12-29
WO1993006456A1 (en) 1993-04-01
DK167942B1 (da) 1994-01-03
DE69221306D1 (de) 1997-09-04
EP0605598A1 (de) 1994-07-13
DK161391A (da) 1993-03-20
AU2671692A (en) 1993-04-27

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