ATE156805T1 - Derivate von iodierten aromatischen säuren und ihre verwendung als röntgenkontrastmittel - Google Patents

Derivate von iodierten aromatischen säuren und ihre verwendung als röntgenkontrastmittel

Info

Publication number
ATE156805T1
ATE156805T1 AT93203302T AT93203302T ATE156805T1 AT E156805 T1 ATE156805 T1 AT E156805T1 AT 93203302 T AT93203302 T AT 93203302T AT 93203302 T AT93203302 T AT 93203302T AT E156805 T1 ATE156805 T1 AT E156805T1
Authority
AT
Austria
Prior art keywords
alkyl
contrast agents
fluoroalkyl
aryloxy
coo
Prior art date
Application number
AT93203302T
Other languages
English (en)
Inventor
Edward R Bacon
Carl R Illig
Baldev Singh
Original Assignee
Nanosystems Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanosystems Llc filed Critical Nanosystems Llc
Application granted granted Critical
Publication of ATE156805T1 publication Critical patent/ATE156805T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/88—Carboxylic acid amides having nitrogen atoms of carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/55—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and esterified hydroxy groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT93203302T 1992-12-14 1993-11-26 Derivate von iodierten aromatischen säuren und ihre verwendung als röntgenkontrastmittel ATE156805T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US99030692A 1992-12-14 1992-12-14

Publications (1)

Publication Number Publication Date
ATE156805T1 true ATE156805T1 (de) 1997-08-15

Family

ID=25536008

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93203302T ATE156805T1 (de) 1992-12-14 1993-11-26 Derivate von iodierten aromatischen säuren und ihre verwendung als röntgenkontrastmittel

Country Status (18)

Country Link
US (1) US5384107A (de)
EP (1) EP0603923B1 (de)
JP (1) JPH06228068A (de)
KR (1) KR940014288A (de)
AT (1) ATE156805T1 (de)
AU (1) AU670458B2 (de)
CA (1) CA2102269A1 (de)
CZ (1) CZ271193A3 (de)
DE (1) DE69313088T2 (de)
ES (1) ES2105088T3 (de)
FI (1) FI935307A7 (de)
HU (1) HUT66332A (de)
IL (1) IL107795A (de)
MX (1) MX9306937A (de)
MY (1) MY141505A (de)
NO (1) NO934316L (de)
NZ (1) NZ250063A (de)
SK (1) SK141793A3 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527926A (en) * 1990-11-26 1996-06-18 Bracco International B.V. Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
IT1256248B (it) * 1992-12-24 1995-11-29 Bracco Spa Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x
US5316755A (en) * 1993-02-02 1994-05-31 Sterling Winthrop Inc. Compositions of iodophenoxy alkanes and iodophenyl ethers for visualization of the gastrointestinal tract
NO940115D0 (no) * 1994-01-13 1994-01-13 Nycomed Imaging As Kontrastmidler for roentgen- og magnettomografisk avbildning
FI963299L (fi) * 1994-02-25 1996-08-23 Nycomed Imaging As Röntgenvarjoainekoostumukset, jotka sisältävät selluloosajohdannaisia
US5488133A (en) * 1994-03-10 1996-01-30 Eastman Kodak Company Iodinated aroyloxy ketones
HUT76304A (en) * 1994-04-21 1997-07-28 Nycomed Imaging As X-ray contrast compositions containing pharmaceutically acceptable clays for examination of gastrointestinal tract
NL9400762A (nl) * 1994-05-09 1995-12-01 T G Wiersma Vaginaal contrastmiddel voor röntgendiagnostisch onderzoek en werkwijze voor de bereiding ervan.
GB9419206D0 (en) * 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media
GB9419203D0 (en) * 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media
UA72189C2 (uk) 1997-11-17 2005-02-15 Янссен Фармацевтика Н.В. Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
EP1450863A4 (de) * 2001-11-07 2009-01-07 Imcor Pharmaceutical Company Verfahren für die bilddarstellung von gefässen mit nanoteilchenförmigen kontrastmitteln
US20040076586A1 (en) * 2002-03-28 2004-04-22 Reinhard Koening Compositions and methods for delivering pharmaceutically active agents using nanoparticulates
AU2016278040B2 (en) * 2015-06-16 2019-07-04 Nanophagix LLC Drug delivery and imaging chemical conjugate, formulations and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL239757A (de) * 1958-06-03
US3144479A (en) * 1958-08-07 1964-08-11 Chemie Linz Ag New iodine-containing benzoic acid esters
NL7102816A (de) * 1970-03-12 1971-09-14
US4018783A (en) * 1970-09-09 1977-04-19 Beecham Group Limited Esters of metrizoic acid
GB8900376D0 (en) * 1989-01-09 1989-03-08 Nycomed As Iodinated esters
US5330739A (en) * 1992-12-04 1994-07-19 Sterling Winthrop Inc. Iodinated benzoyl acetals and ketals for x-ray imaging

Also Published As

Publication number Publication date
JPH06228068A (ja) 1994-08-16
EP0603923A1 (de) 1994-06-29
FI935307L (fi) 1994-06-15
ES2105088T3 (es) 1997-10-16
US5384107A (en) 1995-01-24
IL107795A0 (en) 1994-02-27
SK141793A3 (en) 1994-07-06
NZ250063A (en) 1996-03-26
CZ271193A3 (en) 1995-09-13
HUT66332A (en) 1994-11-28
DE69313088D1 (de) 1997-09-18
DE69313088T2 (de) 1998-01-29
IL107795A (en) 1997-09-30
NO934316L (no) 1994-06-15
MX9306937A (es) 1994-06-30
NO934316D0 (no) 1993-11-29
FI935307A0 (fi) 1993-11-29
FI935307A7 (fi) 1994-06-15
CA2102269A1 (en) 1994-06-15
EP0603923B1 (de) 1997-08-13
MY141505A (en) 2010-05-14
KR940014288A (ko) 1994-07-18
AU5046793A (en) 1994-06-23
HU9303559D0 (en) 1994-04-28
AU670458B2 (en) 1996-07-18

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