ATE157986T1 - Peptid-synthese an fester phase - Google Patents

Peptid-synthese an fester phase

Info

Publication number
ATE157986T1
ATE157986T1 AT92305340T AT92305340T ATE157986T1 AT E157986 T1 ATE157986 T1 AT E157986T1 AT 92305340 T AT92305340 T AT 92305340T AT 92305340 T AT92305340 T AT 92305340T AT E157986 T1 ATE157986 T1 AT E157986T1
Authority
AT
Austria
Prior art keywords
peptide
amino acid
synthesis
solid support
aza
Prior art date
Application number
AT92305340T
Other languages
English (en)
Inventor
Ronald Cotton
Michael Brian Giles
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Application granted granted Critical
Publication of ATE157986T1 publication Critical patent/ATE157986T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT92305340T 1991-06-14 1992-06-11 Peptid-synthese an fester phase ATE157986T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919112825A GB9112825D0 (en) 1991-06-14 1991-06-14 Process for making peptides

Publications (1)

Publication Number Publication Date
ATE157986T1 true ATE157986T1 (de) 1997-09-15

Family

ID=10696665

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92305340T ATE157986T1 (de) 1991-06-14 1992-06-11 Peptid-synthese an fester phase

Country Status (10)

Country Link
US (1) US5602231A (de)
EP (1) EP0518655B1 (de)
JP (1) JP3249178B2 (de)
AT (1) ATE157986T1 (de)
AU (1) AU667035B2 (de)
CA (1) CA2069724C (de)
DE (1) DE69222091T2 (de)
ES (1) ES2106831T3 (de)
GB (1) GB9112825D0 (de)
NO (1) NO303390B1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9319776D0 (en) * 1993-09-24 1993-11-10 Medical Res Council Azapeptide synthesis
DE69519182T2 (de) * 1994-03-17 2001-05-17 Fujirebio Inc., Tokio/Tokyo Azapeptid-Derivate
ES2154590B1 (es) 1999-05-20 2001-11-01 Lipotec Sa Procedimiento de sintesis de peptidos en fase solida
JP2006501150A (ja) * 2002-05-03 2006-01-12 アベシア・リミテッド ペプチド合成のためのプロセス
PT1737889E (pt) 2004-10-19 2010-12-13 Lonza Ag Método para síntese de péptidos em fase sólida
ES2336826T3 (es) 2005-05-03 2010-04-16 Novetide, Ltd. Procedimientos para la produccion de un peptido que presenta una amida c-terminal.
WO2008044890A1 (en) * 2006-10-12 2008-04-17 Dong Kook Pharm. Co., Ltd A method for preparing peptides using by solid phase synthesis
KR101046846B1 (ko) 2006-10-12 2011-07-06 동국제약 주식회사 고체상 합성법을 이용한 펩타이드의 제조방법
WO2010141276A1 (en) * 2009-06-03 2010-12-09 Mallinckrodt Inc. Solid phase peptide synthesis process for the production of goserelin
CN102690329B (zh) * 2011-03-25 2014-06-04 杭州九源基因工程有限公司 一种戈舍瑞林多肽的纯化生产方法
CN102190709A (zh) * 2011-03-31 2011-09-21 厦门博欣生物技术有限公司 促黄体生成素释放激素衍生物的合成方法
CN102746383A (zh) * 2011-04-21 2012-10-24 杭州九源基因工程有限公司 一种戈舍瑞林的合成方法
US10450343B2 (en) 2013-03-21 2019-10-22 Sanofi-Aventis Deutschland Gmbh Synthesis of cyclic imide containing peptide products
CA2907454C (en) 2013-03-21 2021-05-04 Sanofi-Aventis Deutschland Gmbh Synthesis of hydantoin containing peptide products
KR20170014624A (ko) * 2015-07-30 2017-02-08 주식회사 대웅제약 Tdm-621의 제조방법
CN105884865A (zh) * 2016-05-18 2016-08-24 江苏开元药业有限公司 一种戈舍瑞林的合成方法
CN106589072B (zh) * 2016-12-22 2020-08-18 江苏诺泰澳赛诺生物制药股份有限公司 一种戈舍瑞林的合成法
JP2020505379A (ja) 2017-01-20 2020-02-20 イミューン システム レギュレェイション ホールディング エービー 新規化合物（イムノレリン）
JP2020505378A (ja) 2017-01-20 2020-02-20 イミューン システム レギュレェイション ホールディング エービー 新規化合物（イムノヘリン−細胞内感染）
US11883461B2 (en) 2019-05-09 2024-01-30 The Feinstein Institutes For Medical Research HMGB1 antagonist treatment of severe sepsis
WO2020227592A1 (en) 2019-05-09 2020-11-12 The Feinstein Institutes For Medical Research Thiosemicarbazates and uses thereof
EP3965792A4 (de) 2019-05-09 2023-01-18 The Feinstein Institutes for Medical Research Hmgb1-antagonist
IL287499B2 (en) 2019-05-09 2025-11-01 Feinstein Institutes For Medical Research Compounds for use in synthesis of peptidomimetics
KR20210104460A (ko) * 2020-02-17 2021-08-25 주식회사 아이바이오코리아 고체상 합성법을 이용한 펩타이드의 제조 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5116666A (de) * 1974-07-30 1976-02-10 Shionogi Seiyaku Kk
HU187503B (en) * 1983-03-29 1986-01-28 Magyar Tudomanyos Akademia,Hu Process for preparing gonadoliberine derivatives containing beta-aspartyl group
DE3523365A1 (de) * 1985-06-29 1987-01-08 Behringwerke Ag Verbrueckungsreagenz, verfahren zu seiner herstellung und seine anwendung
TW295589B (de) * 1990-08-30 1997-01-11 Hoechst Ag

Also Published As

Publication number Publication date
EP0518655A3 (en) 1993-05-05
NO922319L (no) 1992-12-15
ES2106831T3 (es) 1997-11-16
EP0518655B1 (de) 1997-09-10
NO922319D0 (no) 1992-06-12
CA2069724C (en) 2003-07-29
CA2069724A1 (en) 1992-12-15
EP0518655A2 (de) 1992-12-16
GB9112825D0 (en) 1991-07-31
DE69222091D1 (de) 1997-10-16
JP3249178B2 (ja) 2002-01-21
DE69222091T2 (de) 1998-01-29
AU1704092A (en) 1992-12-17
AU667035B2 (en) 1996-03-07
JPH05170791A (ja) 1993-07-09
NO303390B1 (no) 1998-07-06
US5602231A (en) 1997-02-11

Similar Documents

Publication Publication Date Title
ATE157986T1 (de) Peptid-synthese an fester phase
CA1241643A (en) Peptides affecting the immune regulation and a process for their preparation
Li et al. Direct preparation of peptide thioesters using an Fmoc solid-phase method
Carpino et al. (Fluoren-9-ylmethoxy) carbonyl (Fmoc) amino acid chlorides. Synthesis, characterization, and application to the rapid synthesis of short peptide segments
Pozdnev Activation of carboxylic acids by pyrocarbonates. Application of di-tert-butyl pyrocarbonate as condensing reagent in the synthesis of amides of protected amino acids and peptides
US4261886A (en) Peptides having thymopoietin-like activity
US5827821A (en) Conformationally stabilized cell adhesion peptides
CA2036997C (en) Leu3a binding peptides
KR840009069A (ko) 향정신성 펩티드류의 제조 방법
US5510460A (en) Peptide process
US4397842A (en) Peptides having thymopoietin-like activity
Swistok et al. A convenient preparation of C-terminal peptide alcohols by solid phase synthesis
JPH06510281A (ja) ペプチドアミドの製造
Asahina et al. One Step Synthesis of Fmoc-Aminoacyl-N-alkylcysteine via the Ugi Four-Component Condensation Reaction
Bonora et al. Structural aspects of small peptides. Synthesis and characterization of protected homo‐oligomers derived from l‐alanine
IE58407B1 (en) Peptides
US4258151A (en) Pentapeptide modified resin
Schwartz et al. Insulin analog possessing higher in vitro biological activity than receptor binding affinity.[21-Proline-B] insulin
YAJIMA et al. Studies on peptides. XXIII. Total synthesis of monkey β-melanocyte-stimulating hormone
US4258152A (en) Pentapeptide modified resin
KR910004867B1 (ko) 펩티드의 제조방법
Yajima et al. Studies on Peptides. XIV. Synthesis of Lysyl-S-benzylcysteinylalanylglutaminyl-S-benzyl-cysteinylhistidine, a Peptide related to Horse Heart Cytochrome C.
Katakai et al. Synthesis of oligopeptides having alternate L-leucyl and L-methionyl residues
Miura et al. Synthesis of a Fragment (Pentapeptide) of E. Coli Acyl Carrier Protein Apoprotein
Naidenova et al. Synthesis of N-methylamides of Nα-acetylated oligolysines

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee