ATE158176T1 - Ein guanidinothiazol und antazida enthaltende arzneimittel - Google Patents
Ein guanidinothiazol und antazida enthaltende arzneimittelInfo
- Publication number
- ATE158176T1 ATE158176T1 AT93309611T AT93309611T ATE158176T1 AT E158176 T1 ATE158176 T1 AT E158176T1 AT 93309611 T AT93309611 T AT 93309611T AT 93309611 T AT93309611 T AT 93309611T AT E158176 T1 ATE158176 T1 AT E158176T1
- Authority
- AT
- Austria
- Prior art keywords
- guanidinothiazole
- antacids
- product containing
- medicinal product
- antacid
- Prior art date
Links
- 229940069428 antacid Drugs 0.000 title abstract 4
- 239000003159 antacid agent Substances 0.000 title abstract 4
- 150000008326 guanidinothiazoles Chemical class 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 3
- 230000001458 anti-acid effect Effects 0.000 abstract 3
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 230000004888 barrier function Effects 0.000 abstract 1
- -1 guanidinothiazole compound Chemical class 0.000 abstract 1
- 239000006186 oral dosage form Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/12—Magnesium silicate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/08—Oxides; Hydroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/245—Bismuth; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98392392A | 1992-12-01 | 1992-12-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE158176T1 true ATE158176T1 (de) | 1997-10-15 |
Family
ID=25530183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93309611T ATE158176T1 (de) | 1992-12-01 | 1993-12-01 | Ein guanidinothiazol und antazida enthaltende arzneimittel |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5817340A (de) |
| EP (1) | EP0600725B1 (de) |
| AT (1) | ATE158176T1 (de) |
| BR (1) | BR1100490A (de) |
| CA (1) | CA2110313C (de) |
| DE (1) | DE69313983T2 (de) |
| DK (1) | DK0600725T3 (de) |
| ES (1) | ES2108234T3 (de) |
| GR (1) | GR1002397B (de) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR1002332B (el) * | 1992-05-21 | 1996-05-16 | Mcneil-Ppc Inc. | Νεες φαρμακευτικες συνθεσεις που περιεχουν σιμεθεικονη. |
| DE4444052A1 (de) * | 1994-12-10 | 1996-06-13 | Rhone Poulenc Rorer Gmbh | Pharmazeutische, oral anwendbare Zubereitung |
| EP0867191A4 (de) * | 1995-11-27 | 2000-01-05 | Yamanouchi Pharma Co Ltd | Medikamentenzusammensetzung |
| SE9600071D0 (sv) † | 1996-01-08 | 1996-01-08 | Astra Ab | New oral formulation of two active ingredients I |
| ES2274550T3 (es) * | 1996-10-04 | 2007-05-16 | MERCK & CO., INC. | Procedimientos y composiciones para prevenir y tratar ardor de estomago. |
| US5989588A (en) * | 1996-10-04 | 1999-11-23 | Merck & Co., Inc. | Methods and compositions for preventing and treating heartburn |
| JP3001440B2 (ja) * | 1996-11-25 | 2000-01-24 | 日本電気通信システム株式会社 | 仮想lan方式 |
| GB9720061D0 (en) * | 1997-09-19 | 1997-11-19 | Crosfield Joseph & Sons | Metal compounds as phosphate binders |
| CA2305179A1 (en) * | 1997-09-30 | 1999-04-08 | Daiichi Pharmaceutical Co., Ltd. | Oral administration preparation |
| US6232351B1 (en) * | 1998-05-22 | 2001-05-15 | Amway Corporation | Co-processed botanical plant composition |
| WO2000025754A2 (en) * | 1998-11-04 | 2000-05-11 | Mcneil-Ppc, Inc. | Solid oral dosage forms containing alginic acid and famotidine |
| US6270807B1 (en) | 1999-03-02 | 2001-08-07 | L. Perrigo Company | Taste-masked pharmaceutical composition |
| US6793942B2 (en) | 2000-02-23 | 2004-09-21 | Bioselect Innovations, Inc. | Composition and method for treating the effects of diseases and maladies |
| US6787164B2 (en) | 2000-02-23 | 2004-09-07 | Bioselect Innovations, Inc. | Composition and method for treating the effects of diseases and maladies |
| US6841544B2 (en) * | 2000-02-23 | 2005-01-11 | Bioselect Innovations, Inc. | Composition and method for treating the effects of diseases and maladies |
| US6759062B2 (en) | 2000-02-23 | 2004-07-06 | Bioselect Innovations, Inc. | Composition and method for treating the effects of diseases and maladies |
| US6551617B1 (en) * | 2000-04-20 | 2003-04-22 | Bristol-Myers Squibb Company | Taste masking coating composition |
| RU2179022C1 (ru) * | 2001-04-19 | 2002-02-10 | Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" | Фармацевтическая противоязвенная композиция и способ ее получения |
| US8206741B2 (en) | 2001-06-01 | 2012-06-26 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
| US7101573B2 (en) * | 2001-09-28 | 2006-09-05 | Mcneil-Pcc, Inc. | Simethicone solid oral dosage form |
| US7049435B2 (en) | 2002-03-08 | 2006-05-23 | Tate & Lyle Public Limited Company | Extractive methods for purifying sucralose |
| US6998480B2 (en) | 2002-03-08 | 2006-02-14 | Tate & Lyle Public Limited Company | Process for improving sucralose purity and yield |
| US20030203027A1 (en) * | 2002-04-26 | 2003-10-30 | Ethicon, Inc. | Coating technique for deposition of drug substance on a substrate |
| US6663892B1 (en) * | 2002-08-19 | 2003-12-16 | L. Perrigo Company | Multiple portion tablet |
| US7838031B2 (en) | 2004-05-21 | 2010-11-23 | Lawrence Solomon | Method of administering a partial dose using a segmented pharmaceutical tablet |
| ES2385832T3 (es) * | 2004-05-21 | 2012-08-01 | Accu-Break Technologies, Inc. | Comprimidos farmacéuticos que presentan un segmento relativamente inactivo |
| US7713547B2 (en) | 2004-05-21 | 2010-05-11 | Accu-Break Pharmaceuticals, Inc. | Method of administering a partial dose of a segmented pharmaceutical tablet |
| US7318935B2 (en) * | 2004-05-21 | 2008-01-15 | Accu-Break Technologies, Inc. | Pharmaceutical tablets with active and inactive segments |
| US7780985B2 (en) * | 2005-07-12 | 2010-08-24 | Accu-Break Technologies, Inc. | Tablets having a printed separation mark to guide breaking |
| US7329418B2 (en) * | 2004-05-21 | 2008-02-12 | Accu Break Technologies, Inc. | Pharmaceutical tablets having height greater than width |
| US7622137B2 (en) * | 2004-05-21 | 2009-11-24 | Accu-Break Technologies, Inc. | Dosage forms contained within a capsule or sachet |
| KR100714616B1 (ko) * | 2005-06-23 | 2007-05-07 | 삼성전기주식회사 | 지수 함수 발생기 및 이를 이용한 가변 이득 증폭기 |
| CN100493499C (zh) * | 2005-10-14 | 2009-06-03 | 四川泰华堂制药有限公司 | 制备复方法莫替丁咀嚼片的方法 |
| WO2007058660A1 (en) * | 2005-11-18 | 2007-05-24 | Accu-Break Technologies, Inc. | Segmented pharmaceutical dosage forms |
| US7351853B2 (en) * | 2006-01-23 | 2008-04-01 | Albion Advanced Nutrition | Method of manufacturing a granular mineral composition |
| MY157620A (en) | 2006-01-31 | 2016-06-30 | Cytochroma Dev Inc | A granular material of a solid water-soluble mixed metal compound capable of binding phosphate |
| US7776831B2 (en) | 2006-02-01 | 2010-08-17 | Weg Stuart L | Use of antifungal compositions to treat upper gastrointestinal conditions |
| US20070237815A1 (en) * | 2006-04-06 | 2007-10-11 | Lawrence Solomon | Dosage forms and methods comprising amlodipine and chlorthalidone |
| GB0714670D0 (en) * | 2007-07-27 | 2007-09-05 | Ineos Healthcare Ltd | Use |
| GB0720220D0 (en) * | 2007-10-16 | 2007-11-28 | Ineos Healthcare Ltd | Compound |
| US8436156B2 (en) * | 2008-01-04 | 2013-05-07 | Tate & Lyle Technology Limited | Method for the production of sucralose |
| WO2009095210A1 (en) * | 2008-01-31 | 2009-08-06 | Bayer Consumer Care Ag | Composition comprising an antacid and a h2-antagonists |
| WO2009117317A1 (en) * | 2008-03-20 | 2009-09-24 | Tate & Lyle Technology Ltd | Removal of acids from tertiary amide solvents |
| US8436157B2 (en) * | 2008-03-26 | 2013-05-07 | Tate & Lyle Technology Limited | Method for the production of sucralose |
| US20090259036A1 (en) * | 2008-04-03 | 2009-10-15 | Tate & Lyle Technology Limited | Extraction of less polar impurities from sucralose containing aqueous feed streams |
| EP2260049B1 (de) * | 2008-04-03 | 2013-02-27 | Tate & Lyle Technology Limited | Wirkung der kohlenhydratkonzentrierung auf die sucraloseextraktionseffizienz |
| AR071134A1 (es) * | 2008-04-03 | 2010-05-26 | Tate & Lyle Technology Ltd | Cristalizacion de sucralosa a partir de chorros que contienen sucralosa |
| US8497367B2 (en) * | 2008-04-03 | 2013-07-30 | Tate & Lyle Technology Limited | Sucralose purification process |
| AU2009290712A1 (en) * | 2008-09-09 | 2010-03-18 | Astrazeneca Ab | Method for delivering a pharmaceutical composition to patient in need thereof |
| US8058296B2 (en) * | 2008-11-25 | 2011-11-15 | Richard Tokunaga | Treatment and prevention of deleterious effects associated with alcohol consumption |
| WO2010078542A1 (en) * | 2009-01-05 | 2010-07-08 | Mcneil-Ppc, Inc. | Three layer tablet containing cetirizine, pseudoephedrine, and naproxen |
| WO2010078541A1 (en) * | 2009-01-05 | 2010-07-08 | Mcneil-Ppc, Inc. | Tablet containing coated particles of cetirizine, pseudoephedrine, and/or naproxen |
| WO2010078543A1 (en) * | 2009-01-05 | 2010-07-08 | Mcneil-Ppc, Inc. | Tablet containing cetirizine pseudoephedrine, and naproxen containing a barrier layer |
| GB2469158B (en) | 2009-03-31 | 2011-09-28 | Peter J Seaberg | Base-assisted formation of tin-sucrose adducts |
| CA2764963C (en) | 2009-06-25 | 2016-11-01 | Astrazeneca Ab | Method for treating a patient at risk for developing an nsaid-associated ulcer |
| GB0913525D0 (en) | 2009-08-03 | 2009-09-16 | Ineos Healthcare Ltd | Method |
| GB2474310B (en) | 2009-10-12 | 2012-02-29 | Tate & Lyle Technology Ltd | Process for the production of sucrose-6-ester |
| GB2474311B (en) | 2009-10-12 | 2012-10-17 | Tate & Lyle Technology Ltd | Low temperature, single solvent process for the production of sucrose-6-ester |
| GB201001779D0 (en) | 2010-02-04 | 2010-03-24 | Ineos Healthcare Ltd | Composition |
| GB201110520D0 (en) | 2011-05-10 | 2011-08-03 | Tate & Lyle Technology Ltd | Extraction of carboxylic acids with tin compounds |
| BR112014016085A8 (pt) | 2011-12-28 | 2017-07-04 | Pozen Inc | composições aprimoradas e métodos para distribuição de omeprazol mais ácido acetilsalicílico |
| CN104906057B (zh) * | 2015-05-29 | 2018-03-02 | 西南药业股份有限公司 | 法莫替丁钙镁微丸型咀嚼片的制备方法及其产品 |
| CN104971073B (zh) * | 2015-05-29 | 2018-01-12 | 西南药业股份有限公司 | 法莫替丁钙镁咀嚼片的制备方法及其产品 |
| WO2017091166A1 (en) | 2015-11-26 | 2017-06-01 | Pharmacti̇ve İlaç San. Ve Ti̇c. A.Ş. | Stable pharmaceutical compositions and process for their preparation |
| WO2017106812A1 (en) | 2015-12-19 | 2017-06-22 | First Time Us Generics Llc | Soft-chew tablet pharmaceutical formulations |
| US20190022013A1 (en) | 2015-12-19 | 2019-01-24 | First Time Us Generics Llc | Soft-chew tablet pharmaceutical formulations |
| CN112020350A (zh) * | 2018-04-27 | 2020-12-01 | 强生消费者公司 | 液体口服药物剂型 |
| EP3610860A1 (de) * | 2018-08-15 | 2020-02-19 | Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen | Zusammensetzung aus kohlendioxidabsorptionsmittel oder -adsorptionsmittel, wobei die besagte zusammensetzung eine aus silikonkautschuk und cellulose ausgewählte polymerbeschichtung enthält |
| US11141375B2 (en) | 2018-10-18 | 2021-10-12 | Johnson & Johnson Consumer Inc. | Soft chewable dosage form |
| MA55857A (fr) | 2019-05-06 | 2022-03-16 | Ferrer Int | Formes posologiques solides pharmaceutiques ou nutraceutiques multicouches comprenant des dérivés de pyrimidine et/ou de purine et des vitamines b, leur préparation et leurs utilisations |
| KR102484953B1 (ko) * | 2020-06-25 | 2023-01-06 | 주식회사 인트로바이오파마 | 파모티딘, 수산화마그네슘, 및 침강탄산칼슘을 유효성분으로 하는 위장질환 치료용 필름코팅정제 |
| CN112294841A (zh) * | 2020-10-21 | 2021-02-02 | 北京鑫开元医药科技有限公司 | 一种法莫替丁枸橼酸铋钾复方组合物、制备方法及其应用 |
| AU2022244333A1 (en) | 2021-03-24 | 2023-11-09 | Kenvue Brands Llc | A pharmaceutical composition comprising famotidine |
| CN115792063B (zh) * | 2022-12-21 | 2025-04-04 | 珠海润都制药股份有限公司 | 一种奥美沙坦酯氢氯噻嗪片有关物质检验方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3048526A (en) * | 1958-08-04 | 1962-08-07 | Wander Company | Medicinal tablet |
| FR2236483B1 (de) * | 1973-07-12 | 1976-11-12 | Choay Sa | |
| US4198390A (en) * | 1979-01-31 | 1980-04-15 | Rider Joseph A | Simethicone antacid tablet |
| JPS6056143B2 (ja) * | 1979-08-02 | 1985-12-09 | 山之内製薬株式会社 | アミジン誘導体ならびにその製造法 |
| DE3710462A1 (de) * | 1987-03-30 | 1988-10-13 | Heumann Pharma Gmbh & Co | Pharmazeutische zubereitung zur behandlung von erkrankungen des magen-darm-traktes |
| KR960011236B1 (ko) * | 1987-05-08 | 1996-08-21 | 스미스 클라인 앤드 프렌취 라보라토리스 리미티드 | 제약학적 조성물 및 고체 제형 |
| EP0294933B1 (de) * | 1987-05-08 | 1992-03-11 | Smith Kline & French Laboratories Limited | Pharmazeutische Zusammensetzungen |
| DK469989D0 (da) * | 1989-09-22 | 1989-09-22 | Bukh Meditec | Farmaceutisk praeparat |
| US5075114A (en) * | 1990-05-23 | 1991-12-24 | Mcneil-Ppc, Inc. | Taste masking and sustained release coatings for pharmaceuticals |
| CA2085873A1 (en) * | 1990-06-22 | 1991-12-23 | Adrian Francis Davis | Treatment |
| US5260072A (en) * | 1990-08-30 | 1993-11-09 | Mcneil-Ppc, Inc. | Rotogranulations and taste masking coatings for preparation of chewable pharmaceutical tablets |
| CA2052679C (en) * | 1990-08-30 | 1997-12-02 | Edward J. Roche | Rotogranulations and taste masking coatings for preparation of chewable pharmaceutical tablets |
| US5229137A (en) * | 1992-05-06 | 1993-07-20 | Brigham And Women's Hospital, Inc. | Methods and pharmaceutical compositions for treating episodic heartburn |
-
1993
- 1993-11-30 CA CA002110313A patent/CA2110313C/en not_active Expired - Lifetime
- 1993-12-01 ES ES93309611T patent/ES2108234T3/es not_active Expired - Lifetime
- 1993-12-01 AT AT93309611T patent/ATE158176T1/de not_active IP Right Cessation
- 1993-12-01 DE DE69313983T patent/DE69313983T2/de not_active Expired - Lifetime
- 1993-12-01 EP EP93309611A patent/EP0600725B1/de not_active Expired - Lifetime
- 1993-12-01 GR GR930100475A patent/GR1002397B/el not_active IP Right Cessation
- 1993-12-01 DK DK93309611.7T patent/DK0600725T3/da active
-
1996
- 1996-11-25 US US08/756,080 patent/US5817340A/en not_active Expired - Lifetime
-
1997
- 1997-05-13 BR BR1100490-8A patent/BR1100490A/pt active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP0600725A1 (de) | 1994-06-08 |
| US5817340A (en) | 1998-10-06 |
| BR1100490A (pt) | 2000-06-13 |
| DE69313983D1 (de) | 1997-10-23 |
| GR930100475A (el) | 1994-08-31 |
| CA2110313A1 (en) | 1994-06-02 |
| GR1002397B (el) | 1996-07-12 |
| EP0600725B1 (de) | 1997-09-17 |
| DE69313983T2 (de) | 1998-02-19 |
| DK0600725T3 (da) | 1998-03-16 |
| CA2110313C (en) | 2004-10-26 |
| ES2108234T3 (es) | 1997-12-16 |
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