ATE158506T1 - Okulare hypotensive 2-dekarboxyl-2-aminoalkyl- prostaglandine - Google Patents

Okulare hypotensive 2-dekarboxyl-2-aminoalkyl- prostaglandine

Info

Publication number: ATE158506T1
Authority: AT; Austria
Prior art keywords: decarboxyl; aminoalkyl; prostaglandins; occular; hypotensive
Prior art date: 1990-11-09

Application number

AT92900219T

Other languages

English (en)

Inventor

Ming Fai Chan

David Frederick Woodward

Original Assignee

Allergan Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-09

Filing date

1991-10-30

Publication date

1997-10-15

1991-10-30 Application filed by Allergan Inc filed Critical Allergan Inc

1997-10-15 Application granted granted Critical

1997-10-15 Publication of ATE158506T1 publication Critical patent/ATE158506T1/de

Links

208000001953 Hypotension Diseases 0.000 title abstract 2
208000021822 hypotensive Diseases 0.000 title abstract 2
230000001077 hypotensive effect Effects 0.000 title abstract 2
229940094443 oxytocics prostaglandins Drugs 0.000 title abstract 2
150000003180 prostaglandins Chemical class 0.000 title abstract 2
208000010412 Glaucoma Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Ophthalmology & Optometry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Geophysics And Detection Of Objects (AREA)
Feedback Control In General (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)

AT92900219T 1990-11-09 1991-10-30 Okulare hypotensive 2-dekarboxyl-2-aminoalkyl- prostaglandine ATE158506T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/611,029 US5270049A (en)	1990-11-09	1990-11-09	2-decarboxyl-2-aminoalkyl-prostaglandins as ocular hypotensives

Publications (1)

Publication Number	Publication Date
ATE158506T1 true ATE158506T1 (de)	1997-10-15

Family

ID=24447325

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92900219T ATE158506T1 (de)	1990-11-09	1991-10-30	Okulare hypotensive 2-dekarboxyl-2-aminoalkyl- prostaglandine

Country Status (15)

Country	Link
US (1)	US5270049A (de)
EP (1)	EP0556296B1 (de)
JP (1)	JP3488456B2 (de)
AT (1)	ATE158506T1 (de)
AU (1)	AU656752B2 (de)
BR (1)	BR9107071A (de)
CA (1)	CA2095430A1 (de)
DE (1)	DE69127755T2 (de)
ES (1)	ES2107522T3 (de)
HU (1)	HUT70500A (de)
IE (1)	IE913906A1 (de)
IL (1)	IL99975A (de)
NZ (1)	NZ240502A (de)
WO (1)	WO1992008465A2 (de)
ZA (1)	ZA918869B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5288754A (en) *	1992-02-04	1994-02-22	Allergan, Inc.	Polar C-1 esters of prostaglandins
US5834498A (en) *	1992-09-21	1998-11-10	Allergan	Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5688819A (en) *	1992-09-21	1997-11-18	Allergan	Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5972991A (en)	1992-09-21	1999-10-26	Allergan	Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5352708A (en) *	1992-09-21	1994-10-04	Allergan, Inc.	Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5328933A (en) *	1992-10-28	1994-07-12	Allergan, Inc.	Cyclopentane heptenylnitro and heptanylnitro-2-aliphatic or aryl aliphatic derivatives and homologues
US6124353A (en) *	1992-11-12	2000-09-26	Allergan Sales, Inc.	Method of treating ocular hypertension with 8-epi prostaglandins
US5545665A (en)	1993-12-28	1996-08-13	Allergan	Cyclopentane(ene) heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents
US5698733A (en) *	1994-09-30	1997-12-16	Alcon Laboratories, Inc.	Use of 9-deoxy prostaglandin derivatives to treat glaucoma
WO1998021180A1 (en)	1995-06-07	1998-05-22	Alcon Laboratories, Inc.	Conformationally rigid aryl- or heteroaryl prostaglandins for use in glaucoma therapy
US6066671A (en)	1997-12-19	2000-05-23	Alcon Laboratories, Inc.	Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides
US6646001B2 (en)	1997-12-19	2003-11-11	Alcon Manufacturing, Ltd.	Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension
US6096783A (en) *	1998-12-15	2000-08-01	Alcon Laboratories, Inc.	Cyclobutane prostaglandin analogues as ocular hypotensive agents
US6211226B1 (en)	1998-12-17	2001-04-03	Alcon Laboratories, Inc.	11-Aza prostaglandins for the treatment of glaucoma and ocular hypertension
US6160013A (en) *	1998-12-17	2000-12-12	Alcon Laboratories, Inc.	14-aza prostaglandins for the treatment of glaucoma and ocular hypertension
US20090148527A1 (en) *	2007-12-07	2009-06-11	Robinson Michael R	Intraocular formulation
US9241918B2 (en)	2005-03-16	2016-01-26	Allergan, Inc.	Enhanced bimatoprost ophthalmic solution
US7851504B2 (en)	2005-03-16	2010-12-14	Allergan, Inc.	Enhanced bimatoprost ophthalmic solution
US9522153B2 (en)	2009-12-22	2016-12-20	Allergan, Inc.	Compositions and methods for lowering intraocular pressure

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4081478A (en) *	1975-12-29	1978-03-28	The Upjohn Company	2-Decarboxy-2-amino-methyl-PGF.sub.α compounds
US4599353A (en) *	1982-05-03	1986-07-08	The Trustees Of Columbia University In The City Of New York	Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma
EP0242580B1 (de) *	1986-03-13	1993-04-28	The Trustees Of Columbia University In The City Of New York	Verwendung von A-, B- und C-Prostaglandinen und deren Derivaten zur Behandlung von Augen-Hypertension und Glaukom
US4883819A (en) *	1986-07-31	1989-11-28	The Trustees Of Columbia University In The City Of New York	Use of A, B and C prostaglandins and derivatives thereof to treat ocular hypertension and glaucoma
US4824857A (en) *	1986-05-16	1989-04-25	Yasumasa Goh	Use of prostaglandin D2 -active substances
US4952581A (en) *	1987-04-03	1990-08-28	The Trustees Of Columbia University In The City Of New York	Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocular pressure
ES2052735T3 (es) *	1987-09-18	1994-07-16	R Tech Ueno Ltd	Un metodo para producir un agente hipotensor ocular.
US4927846A (en) *	1988-11-23	1990-05-22	Allergan, Inc.	Intraocular pressure reducing 1,11-lactone prostaglandins
US4994274A (en) *	1989-07-27	1991-02-19	Allergan, Inc.	Intraocular pressure reducing 11,15-diacyl prostaglandins and method of using
US5011856A (en) *	1990-03-12	1991-04-30	Allergan, Inc.	Use of prostaglandin F3 α as an ocular hypotensive agent
US5238961A (en) *	1990-06-14	1993-08-24	Allergan, Inc.	Pgf 1-alcohols and their use as ocular hypotensives

1990
- 1990-11-09 US US07/611,029 patent/US5270049A/en not_active Expired - Lifetime
1991
- 1991-10-30 BR BR919107071A patent/BR9107071A/pt not_active Application Discontinuation
- 1991-10-30 HU HU9301327A patent/HUT70500A/hu active IP Right Revival
- 1991-10-30 AU AU90414/91A patent/AU656752B2/en not_active Ceased
- 1991-10-30 DE DE69127755T patent/DE69127755T2/de not_active Expired - Fee Related
- 1991-10-30 ES ES92900219T patent/ES2107522T3/es not_active Expired - Lifetime
- 1991-10-30 JP JP50084392A patent/JP3488456B2/ja not_active Expired - Fee Related
- 1991-10-30 EP EP92900219A patent/EP0556296B1/de not_active Expired - Lifetime
- 1991-10-30 AT AT92900219T patent/ATE158506T1/de not_active IP Right Cessation
- 1991-10-30 WO PCT/US1991/007982 patent/WO1992008465A2/en not_active Ceased
- 1991-10-30 CA CA002095430A patent/CA2095430A1/en not_active Abandoned
- 1991-11-06 IL IL9997591A patent/IL99975A/en active IP Right Grant
- 1991-11-07 NZ NZ240502A patent/NZ240502A/en unknown
- 1991-11-08 ZA ZA918869A patent/ZA918869B/xx unknown
- 1991-11-08 IE IE390691A patent/IE913906A1/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
US5270049A (en)	1993-12-14
CA2095430A1 (en)	1992-05-10
IE913906A1 (en)	1992-05-20
JPH06501482A (ja)	1994-02-17
IL99975A (en)	1996-05-14
DE69127755T2 (de)	1998-04-30
EP0556296B1 (de)	1997-09-24
BR9107071A (pt)	1993-09-21
IL99975A0 (en)	1992-08-18
EP0556296A1 (de)	1993-08-25
HUT70500A (en)	1995-10-30
WO1992008465A2 (en)	1992-05-29
JP3488456B2 (ja)	2004-01-19
AU9041491A (en)	1992-06-11
ZA918869B (en)	1992-07-29
WO1992008465A3 (en)	1992-10-15
NZ240502A (en)	1995-07-26
HU9301327D0 (en)	1993-09-28
DE69127755D1 (de)	1997-10-30
ES2107522T3 (es)	1997-12-01
AU656752B2 (en)	1995-02-16

Legal Events

Date	Code	Title	Description
1998-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE158506T1 (de)	1997-10-15	Okulare hypotensive 2-dekarboxyl-2-aminoalkyl- prostaglandine
ES2138691T3 (es)	2000-01-16	Procedimiento para la obtencion de derivados de n-acil-5-fluorocitidina.
NO912630L (no)	1992-01-06	Fremgangsmaate for fremstilling av nye 2,6-dialkyl-4-silyl-fenoler som antiarteriosklerotiske midler
ES2145318T3 (es)	2000-07-01	Imidazo(4,5-c)quinolin-aminas.
ATE269290T1 (de)	2004-07-15	Benzoylderivate
MX9100628A (es)	1994-02-28	Compuestos peptidomimeticos de borolisina y procedimiento para su preparacion.
NO914092D0 (no)	1991-10-17	Fremgangsmaate for fremstilling av mercaptoacetylamidderivater
ES2174298T3 (es)	2002-11-01	Derivados de aminotiazol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
MX9403915A (es)	1995-01-31	Derivados de n-alquiltio de pliamina como agentes radioprotectores.
NO930035L (no)	1993-01-07	Eksitatoriske aminosyreantagonister
IS4367A (is)	1996-09-30	CCK eða gastrín temprandi 5-heterósýklísk-1,5-bensódíazepín
ES2079872T3 (es)	1996-01-16	Derivados hipotensores oculares de la 2-descarboxil-2-aciltioalquilprostaglandina.
FI892222A0 (fi)	1989-05-09	Peptidalkoholer med antikoagulantverkan.
ATE164763T1 (de)	1998-04-15	Okulare hypotensive homo-prostaglandinderivate
FI901277A0 (fi)	1990-03-14	2,5,6,7-tetranor-4,8-inter-m-fenylen pg1z-derivativ.
ES2072936T3 (es)	1995-08-01	Derivados de pradimicin-amida.
WO1992010473A3 (en)	1992-08-20	2-decarboxyl-2-alkoxyalkyl prostaglandins as ocular hypotensives
NO921317D0 (no)	1992-04-03	Antimetastatisk virkende midler
GR1001309B (el)	1993-08-31	Μεθοδος παρασκευης παραγωγου ενωσεως της διχλωροανιλινης.
ES512921A0 (es)	1983-03-01	"procedimiento de preparacion de derivados de etanolamina".
NO911585L (no)	1991-10-24	Fremgangsmaate for fremstilling av optisk aktive isomerer av 6-substituerte purinylpiperazinderivater.
BE860603A (fr)	1978-05-08	Derives de l'oxadiazole-1,2,4 utilisables comme azureurs optiques
ES2019841A6 (es)	1991-07-01	Procedimiento para preparar derivados de tieno-triazolo-diazepina.