ATE159022T1 - Ecteinascidine 736 und 722 - Google Patents

Ecteinascidine 736 und 722

Info

Publication number: ATE159022T1
Authority: AT; Austria
Prior art keywords: tetrahydro; ecteinascidine; ecteinascidins; isoquinolines; carboline
Prior art date: 1990-11-30

Application number

AT92904206T

Other languages

English (en)

Inventor

Kenneth Rinehart

Ryuichi Sakai

Original Assignee

Univ Illinois

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-30

Filing date

1991-11-27

Publication date

1997-10-15

1991-11-27 Application filed by Univ Illinois filed Critical Univ Illinois

1997-10-15 Application granted granted Critical

1997-10-15 Publication of ATE159022T1 publication Critical patent/ATE159022T1/de

Links

PKVRCIRHQMSYJX-AIFWHQITSA-N trabectedin Chemical compound C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](O)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 PKVRCIRHQMSYJX-AIFWHQITSA-N 0.000 title 1
229960000977 trabectedin Drugs 0.000 title 1
SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract 1
241000798369 Ecteinascidia turbinata Species 0.000 abstract 1
208000001382 Experimental Melanoma Diseases 0.000 abstract 1
208000006552 Lewis Lung Carcinoma Diseases 0.000 abstract 1
206010025323 Lymphomas Diseases 0.000 abstract 1
241000699670 Mus sp. Species 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
150000003526 tetrahydroisoquinolines Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
External Artificial Organs (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT92904206T 1990-11-30 1991-11-27 Ecteinascidine 736 und 722 ATE159022T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/620,427 US5149804A (en)	1990-11-30	1990-11-30	Ecteinascidins 736 and 722

Publications (1)

Publication Number	Publication Date
ATE159022T1 true ATE159022T1 (de)	1997-10-15

Family

ID=24485894

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92904206T ATE159022T1 (de)	1990-11-30	1991-11-27	Ecteinascidine 736 und 722

Country Status (10)

Country	Link
US (1)	US5149804A (de)
EP (1)	EP0559838B1 (de)
JP (1)	JP3098029B2 (de)
AT (1)	ATE159022T1 (de)
AU (1)	AU650829B2 (de)
DE (1)	DE69127905T2 (de)
DK (1)	DK0559838T3 (de)
ES (1)	ES2111631T3 (de)
GR (1)	GR3025837T3 (de)
WO (1)	WO1992009607A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5478932A (en) *	1993-12-02	1995-12-26	The Board Of Trustees Of The University Of Illinois	Ecteinascidins
US20040059112A1 (en) *	1994-02-18	2004-03-25	Rinehart Kenneth L.	Ecteinascidins
US5721362A (en) *	1996-09-18	1998-02-24	President And Fellows Of Harvard College	Process for producing ecteinascidin compounds
CA2301693A1 (en) *	1997-09-19	1999-04-01	Klaus Unsicker	Cytokines having neurotrophic activity
BR9909488B1 (pt) *	1998-04-06	2011-02-08		ecteinascidinas semi-sintéticas e composição farmacêutica.
CA2331593C (en) *	1998-05-11	2008-08-05	Pharma Mar, S.A.	Metabolites of ecteinascidin 743
MY164077A (en) *	1999-05-13	2017-11-30	Pharma Mar Sa	Compositions and uses of et743 for treating cancer
AR035842A1 (es) *	1999-05-14	2004-07-21	Pharma Mar Sa	Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
US7919493B2 (en) *	2000-04-12	2011-04-05	Pharma Mar, S.A.	Anititumoral ecteinascidin derivatives
WO2001077115A1 (en) *	2000-04-12	2001-10-18	Pharma Mar, S.A.	Antitumoral ecteinascidin derivatives
MXPA02011319A (es) *	2000-05-15	2003-06-06	Pharma Mar Sa	Analogos antitumorales de ecteinascidina 743.
US7420051B2 (en) *	2000-05-15	2008-09-02	Pharma Mar, S.A.	Synthetic process for the manufacture of an ecteinaschidin compound
BR0115162A (pt) *	2000-11-06	2003-10-21	Pharma Mar Sa	Tratamentos antitumorais eficazes
GB0117402D0 (en) *	2001-07-17	2001-09-05	Pharma Mar Sa	New antitumoral derivatives of et-743
GB0119243D0 (en) *	2001-08-07	2001-10-03	Pharma Mar Sa	Antitumoral analogs of ET-743
GB0202544D0 (en) *	2002-02-04	2002-03-20	Pharma Mar Sa	The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) *	2003-05-29	2003-07-02	Pharma Mar Sau	Treatment
GB0324201D0 (en) *	2003-10-15	2003-11-19	Pharma Mar Sau	Improved antitumoral combinations
HRP20080598T3 (en) *	2003-11-13	2009-01-31	Pharma Mar	Combination of et-743 with 5-fluorouracil pro-drugs for the treatment of cancer
GB0326486D0 (en) *	2003-11-14	2003-12-17	Pharma Mar Sau	Combination treatment
AU2004291037A1 (en) *	2003-11-14	2005-06-02	Pharma Mar, S.A.	Combination therapy comprising the use of ET-743 and paclitaxel for treating cancer
WO2006005602A2 (en) *	2004-07-09	2006-01-19	Pharma Mar, S.A.	Use of ecteinascidin in the treatment of cancer in patients with low level of brca1
AU2005288696A1 (en) *	2004-09-28	2006-04-06	Pharma Mar S.A., Sociedad Unipersonal	Ecteinascidin compounds as anti -inflammatory agents
EP1827500B1 (de) *	2004-10-26	2009-05-06	Pharma Mar S.A., Sociedad Unipersonal	Pegyliertes liposomales doxorubicin in kombination mit ecteinescidin 743
ATE368461T1 (de)	2004-10-29	2007-08-15	Pharma Mar Sa	Zusammensetzungen enthaltend ecteinascidin und einen disaccharide
GB0522082D0 (en) *	2005-10-31	2005-12-07	Pharma Mar Sa	Formulations
US20100267732A1 (en) *	2007-10-19	2010-10-21	Pharma Mar, S.A.	Prognostic Molecular Markers for ET-743 Treatment
RS54648B1 (sr)	2010-11-12	2016-08-31	Pharma Mar S.A.	Kombinovana terapija sa antitumorskim alkaloidom
KR102491180B1 (ko)	2017-04-27	2023-01-20	파르마 마르 에스.에이.	항종양 화합물
PE20252386A1 (es)	2019-11-21	2025-10-10	Pharma Mar Sa	Metodo de tratamiento del cancer de pulmon de celulas pequenas con formulaciones de lurbinectedina
CN115427081B (zh)	2020-04-21	2025-12-09	法马马有限公司	药物抗体共轭物

1990
- 1990-11-30 US US07/620,427 patent/US5149804A/en not_active Expired - Lifetime
1991
- 1991-11-27 EP EP92904206A patent/EP0559838B1/de not_active Expired - Lifetime
- 1991-11-27 JP JP04504283A patent/JP3098029B2/ja not_active Expired - Fee Related
- 1991-11-27 AU AU91764/91A patent/AU650829B2/en not_active Expired
- 1991-11-27 DK DK92904206.7T patent/DK0559838T3/da active
- 1991-11-27 AT AT92904206T patent/ATE159022T1/de not_active IP Right Cessation
- 1991-11-27 WO PCT/US1991/008988 patent/WO1992009607A1/en not_active Ceased
- 1991-11-27 DE DE69127905T patent/DE69127905T2/de not_active Expired - Lifetime
- 1991-11-27 ES ES92904206T patent/ES2111631T3/es not_active Expired - Lifetime
1998
- 1998-01-07 GR GR980400013T patent/GR3025837T3/el unknown

Also Published As

Publication number	Publication date
US5149804A (en)	1992-09-22
EP0559838B1 (de)	1997-10-08
JP3098029B2 (ja)	2000-10-10
DK0559838T3 (da)	1998-05-18
GR3025837T3 (en)	1998-04-30
ES2111631T3 (es)	1998-03-16
EP0559838A1 (de)	1993-09-15
WO1992009607A1 (en)	1992-06-11
DE69127905D1 (de)	1997-11-13
AU9176491A (en)	1992-06-25
AU650829B2 (en)	1994-06-30
EP0559838A4 (en)	1994-06-29
DE69127905T2 (de)	1998-05-28
JPH06503579A (ja)	1994-04-21

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Legal Events

Date	Code	Title	Description
1998-06-15	UEP	Publication of translation of european patent specification
2012-02-15	EELA	Cancelled due to lapse of time