ATE160784T1 - Neue 17-hydroxyiminomethyl-5beta, 14beta- androstan-derivate, kardioaktives verfahren zu ihrer herstellung und pharmazeutische präparate davon - Google Patents

Neue 17-hydroxyiminomethyl-5beta, 14beta- androstan-derivate, kardioaktives verfahren zu ihrer herstellung und pharmazeutische präparate davon

Info

Publication number: ATE160784T1
Authority: AT; Austria
Prior art keywords: hydroxyiminomethyl; 14beta; 5beta; cardioactive; new
Prior art date: 1992-08-20

Application number

AT93110189T

Other languages

English (en)

Inventor

Alberto Cerri

Luigi Bernardi

Giuseppe Bianchi

Monica Florio

Elena Folpini

Piero Melloni

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-08-20

Filing date

1993-06-25

Publication date

1997-12-15

1993-06-25 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

1997-12-15 Application granted granted Critical

1997-12-15 Publication of ATE160784T1 publication Critical patent/ATE160784T1/de

Links

238000000034 method Methods 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
XUFBRCHFKBJRAM-MNTXRPFASA-N n-[[(5s,8r,9s,10s,13s,14r)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]methylidene]hydroxylamine Chemical class C1CCC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)C=NO)[C@H]4[C@@H]3CC[C@@H]21 XUFBRCHFKBJRAM-MNTXRPFASA-N 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
239000003814 drug Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0044—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an estrane or gonane skeleton, including 18-substituted derivatives and derivatives where position 17-beta is substituted by a carbon atom not directly bonded to another carbon atom and not being part of an amide group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Pharmacology & Pharmacy (AREA)
Heart & Thoracic Surgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT93110189T 1992-08-20 1993-06-25 Neue 17-hydroxyiminomethyl-5beta, 14beta- androstan-derivate, kardioaktives verfahren zu ihrer herstellung und pharmazeutische präparate davon ATE160784T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4227605A DE4227605C2 (de)	1992-08-20	1992-08-20	17-Hydroxyiminomethyl-14beta-hydroxy-5ß-androstan-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die dieselben enthalten

Publications (1)

Publication Number	Publication Date
ATE160784T1 true ATE160784T1 (de)	1997-12-15

Family

ID=6465986

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93110189T ATE160784T1 (de)	1992-08-20	1993-06-25	Neue 17-hydroxyiminomethyl-5beta, 14beta- androstan-derivate, kardioaktives verfahren zu ihrer herstellung und pharmazeutische präparate davon

Country Status (11)

Country	Link
US (1)	US5444055A (de)
EP (1)	EP0583579B1 (de)
JP (1)	JP3510651B2 (de)
KR (1)	KR100276527B1 (de)
AT (1)	ATE160784T1 (de)
CA (1)	CA2103825C (de)
DE (2)	DE4227605C2 (de)
DK (1)	DK0583579T3 (de)
ES (1)	ES2110030T3 (de)
GR (1)	GR3026265T3 (de)
ZA (1)	ZA935866B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4227626C2 (de) *	1992-08-20	1994-11-17	Sigma Tau Ind Farmaceuti	17-Hydrazonomethyl-14ß-hydroxy-5ß-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE4232656C2 (de) *	1992-09-29	1995-01-12	Sigma Tau Ind Farmaceuti	Cyclopentanperhydrophenanthren-17-furyl-3ß-derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutischen Zusammensetzungen
DE4420501A1 (de) *	1994-06-13	1995-12-14	Sigma Tau Ind Farmaceuti	Neue Hydrazino- und Hydroxyamino-14beta-hydroxyandrostanderivate mit Aktivität für das cardiovaskuläre System, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten
IT1279386B1 (it) *	1994-11-07	1997-12-10	Sigma Tau Ind Farmaceuti	1,5 derivati di 7a-metilperidroinden-3a-oli, attivi sul sistema cardiovascolare, procedimenti per la loro preparazione e composizioni
DE4442486A1 (de) *	1994-11-29	1996-05-30	Sigma Tau Ind Farmaceuti	Neue 17-(3-Imino-2-alkylpropylen)-5ß,14ß-androstan-Derivate, die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
IT1282286B1 (it) *	1995-05-11	1998-03-16	Sigma Tau Ind Farmaceuti	Seco-d steroidi sul sistema cardiovascolare, processi per la loro preparazione e composizioni farmaceutiche che li contengono.
IT1282289B1 (it) *	1995-06-23	1998-03-16	Sigma Tau Ind Farmaceuti	17-idrossiimminoalchil e 17-idrossiimminometilalchenil ciclopentaperidrofenantreni attivi sul sistema cardiovascolare,
DE19633376A1 (de) *	1996-08-19	1998-02-26	Sigma Tau Ind Farmaceuti	Neue Seco-D-Steroide, die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten
DE19633349A1 (de) *	1996-08-19	1998-02-26	Sigma Tau Ind Farmaceuti	Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3019242A (en) *	1960-07-01	1962-01-30	Upjohn Co	3, 20-dioximes of 11-hydroxyprogesterones

1992
- 1992-08-20 DE DE4227605A patent/DE4227605C2/de not_active Expired - Fee Related
1993
- 1993-06-25 DE DE69315501T patent/DE69315501T2/de not_active Expired - Fee Related
- 1993-06-25 ES ES93110189T patent/ES2110030T3/es not_active Expired - Lifetime
- 1993-06-25 EP EP93110189A patent/EP0583579B1/de not_active Expired - Lifetime
- 1993-06-25 AT AT93110189T patent/ATE160784T1/de not_active IP Right Cessation
- 1993-06-25 DK DK93110189.3T patent/DK0583579T3/da active
- 1993-08-11 CA CA002103825A patent/CA2103825C/en not_active Expired - Fee Related
- 1993-08-12 ZA ZA935866A patent/ZA935866B/xx unknown
- 1993-08-16 US US08/106,892 patent/US5444055A/en not_active Expired - Lifetime
- 1993-08-19 JP JP20495093A patent/JP3510651B2/ja not_active Expired - Fee Related
- 1993-08-20 KR KR1019930016224A patent/KR100276527B1/ko not_active Expired - Fee Related
1998
- 1998-02-27 GR GR980400443T patent/GR3026265T3/el unknown

Also Published As

Publication number	Publication date
DE69315501D1 (de)	1998-01-15
EP0583579A2 (de)	1994-02-23
DE4227605C2 (de)	1995-02-16
ZA935866B (en)	1994-03-09
DE69315501T2 (de)	1998-04-16
DK0583579T3 (da)	1998-04-27
EP0583579B1 (de)	1997-12-03
EP0583579A3 (de)	1995-03-22
HK1004919A1 (en)	1998-12-11
GR3026265T3 (en)	1998-05-29
CA2103825A1 (en)	1994-02-21
CA2103825C (en)	1999-01-12
KR940005661A (ko)	1994-03-22
US5444055A (en)	1995-08-22
KR100276527B1 (ko)	2001-02-01
JP3510651B2 (ja)	2004-03-29
ES2110030T3 (es)	1998-02-01
JPH06184188A (ja)	1994-07-05
DE4227605A1 (de)	1994-03-10

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Legal Events

Date	Code	Title	Description
1998-10-15	UEP	Publication of translation of european patent specification
2010-03-15	REN	Ceased due to non-payment of the annual fee