ATE161535T1 - 6,11-dihydro-5h-pyrido(2,3-b)(1,5)benzodiazepin 5-one und thione und ihre verwendung für die vorbeugung oder behandlung von aids - Google Patents

6,11-dihydro-5h-pyrido(2,3-b)(1,5)benzodiazepin 5-one und thione und ihre verwendung für die vorbeugung oder behandlung von aids

Info

Publication number: ATE161535T1
Authority: AT; Austria
Prior art keywords: pyrido; dihydro; aids; treatment; phenyl
Prior art date: 1989-04-20

Application number

AT90107293T

Other languages

English (en)

Inventor

Karl D Dr Hargrave

Guenther Dr Schmidt

Original Assignee

Boehringer Ingelheim Pharma

Thomae Gmbh Dr K

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-20

Filing date

1990-04-18

Publication date

1998-01-15

1990-04-18 Application filed by Boehringer Ingelheim Pharma, Thomae Gmbh Dr K filed Critical Boehringer Ingelheim Pharma

1998-01-15 Application granted granted Critical

1998-01-15 Publication of ATE161535T1 publication Critical patent/ATE161535T1/de

Links

SFRAVXBSPHJEBZ-UHFFFAOYSA-N 6,11-dihydropyrido[3,2-c][1,5]benzodiazepin-5-one Chemical compound O=C1NC2=CC=CC=C2NC2=NC=CC=C12 SFRAVXBSPHJEBZ-UHFFFAOYSA-N 0.000 title abstract 2
208000030507 AIDS Diseases 0.000 title abstract 2
230000002265 prevention Effects 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 2
125000000304 alkynyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000005002 aryl methyl group Chemical group 0.000 abstract 2
125000001589 carboacyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000003709 fluoroalkyl group Chemical group 0.000 abstract 2
125000002541 furyl group Chemical group 0.000 abstract 2
125000001544 thienyl group Chemical group 0.000 abstract 2
-1 2-halo-propen-1-yl Chemical group 0.000 abstract 1
208000031886 HIV Infections Diseases 0.000 abstract 1
208000037357 HIV infectious disease Diseases 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000005079 alkoxycarbonylmethyl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Virology (AREA)
Immunology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT90107293T 1989-04-20 1990-04-18 6,11-dihydro-5h-pyrido(2,3-b)(1,5)benzodiazepin 5-one und thione und ihre verwendung für die vorbeugung oder behandlung von aids ATE161535T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US34097389A	1989-04-20	1989-04-20
US37273289A	1989-06-28	1989-06-28
US43857089A	1989-11-17	1989-11-17

Publications (1)

Publication Number	Publication Date
ATE161535T1 true ATE161535T1 (de)	1998-01-15

Family

ID=27407436

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90107293T ATE161535T1 (de)	1989-04-20	1990-04-18	6,11-dihydro-5h-pyrido(2,3-b)(1,5)benzodiazepin 5-one und thione und ihre verwendung für die vorbeugung oder behandlung von aids

Country Status (5)

Country	Link
EP (1)	EP0393604B1 (de)
JP (1)	JP2656133B2 (de)
AT (1)	ATE161535T1 (de)
CA (1)	CA2014885C (de)
DE (1)	DE69031845T2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5366972A (en) *	1989-04-20	1994-11-22	Boehringer Ingelheim Pharmaceuticals, Inc.	5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
CA2030056C (en) *	1989-11-17	1995-10-17	Karl D. Hargrave	5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the prevention or treatment of hiv infection
EP0475231A1 (de) *	1990-09-10	1992-03-18	F. Hoffmann-La Roche Ag	Benzodiazepine
DK0498290T3 (de) *	1991-02-07	1997-02-10	Boehringer Ingelheim Pharma
GB9109557D0 (en) *	1991-05-02	1991-06-26	Wellcome Found	Chemical compounds
US6177435B1 (en)	1992-05-13	2001-01-23	Glaxo Wellcome Inc.	Therapeutic combinations
AU5883794A (en) *	1993-01-20	1994-08-15	A. Menarini Industrie Farmaceutiche Riunite S.R.L.	Diazepin derivatives and antiviral compositions
AU3754495A (en) *	1994-10-31	1996-05-23	Yamanouchi Pharmaceutical Co., Ltd.	Novel benzodiazepinone derivative and medicinal composition thereof
US6593337B1 (en)	1999-10-19	2003-07-15	Bristol-Myers Squibb Pharma Company	Tricyclic compounds useful as HIV reverse transcriptase inhibitors
FR2850654A1 (fr) *	2003-02-03	2004-08-06	Servier Lab	Nouveaux derives d'azepines tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN107428747A (zh)	2014-11-25	2017-12-01	拜耳制药股份公司	取代的吡啶并苯并二氮杂*酮衍生物及其用途
CN110818710B (zh) *	2019-12-04	2021-02-09	石河子大学	一种苯并二氮卓类化合物及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2424811C3 (de) *	1974-05-22	1981-08-20	Dr. Karl Thomae Gmbh, 7950 Biberach	Pyrido-benzodiazepinone, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE2644121A1 (de) *	1976-09-30	1978-04-06	Thomae Gmbh Dr K	Neue pyridobenzodiazepinone, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE3818299A1 (de) *	1988-05-30	1989-12-07	Thomae Gmbh Dr K	Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

1990
- 1990-04-18 DE DE69031845T patent/DE69031845T2/de not_active Expired - Fee Related
- 1990-04-18 AT AT90107293T patent/ATE161535T1/de not_active IP Right Cessation
- 1990-04-18 EP EP90107293A patent/EP0393604B1/de not_active Expired - Lifetime
- 1990-04-19 CA CA002014885A patent/CA2014885C/en not_active Expired - Fee Related
- 1990-04-20 JP JP2105098A patent/JP2656133B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0393604B1 (de)	1997-12-29
CA2014885A1 (en)	1990-10-20
CA2014885C (en)	2000-12-26
DE69031845T2 (de)	1998-05-07
JP2656133B2 (ja)	1997-09-24
JPH0363274A (ja)	1991-03-19
EP0393604A2 (de)	1990-10-24
DE69031845D1 (de)	1998-02-05
EP0393604A3 (de)	1991-09-11

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Legal Events

Date	Code	Title	Description
1998-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties