ATE161727T1 - Zyklische gnrh-antagonisten - Google Patents

Zyklische gnrh-antagonisten

Info

Publication number: ATE161727T1
Authority: AT; Austria
Prior art keywords: residues; linkage; positions; peptides; chain
Prior art date: 1990-02-06

Application number

AT91904673T

Other languages

English (en)

Inventor

Jean E F Rivier

Catherine L Rivier

Wylie W Vale Jr

Steven C Koerber

Arnold T Hagler

Original Assignee

Salk Inst For Biological Studi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-06

Filing date

1991-02-05

Publication date

1998-01-15

1991-02-05 Application filed by Salk Inst For Biological Studi filed Critical Salk Inst For Biological Studi

1998-01-15 Application granted granted Critical

1998-01-15 Publication of ATE161727T1 publication Critical patent/ATE161727T1/de

Links

229940121381 gonadotrophin releasing hormone (gnrh) antagonists Drugs 0.000 title abstract 2
102000004196 processed proteins & peptides Human genes 0.000 abstract 3
108090000765 processed proteins & peptides Proteins 0.000 abstract 3
150000003431 steroids Chemical class 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
210000002149 gonad Anatomy 0.000 abstract 2
206010006187 Breast cancer Diseases 0.000 abstract 1
BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 abstract 1
NMJREATYWWNIKX-UHFFFAOYSA-N GnRH Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CC(C)C)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 NMJREATYWWNIKX-UHFFFAOYSA-N 0.000 abstract 1
102000006771 Gonadotropins Human genes 0.000 abstract 1
108010086677 Gonadotropins Proteins 0.000 abstract 1
206010062767 Hypophysitis Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
235000013601 eggs Nutrition 0.000 abstract 1
239000002622 gonadotropin Substances 0.000 abstract 1
229940094892 gonadotropins Drugs 0.000 abstract 1
230000016087 ovulation Effects 0.000 abstract 1
210000003635 pituitary gland Anatomy 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1
125000003396 thiol group Chemical group [H]S* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT91904673T 1990-02-06 1991-02-05 Zyklische gnrh-antagonisten ATE161727T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/475,767 US5064939A (en)	1990-02-06	1990-02-06	Cyclic gnrh antagonists

Publications (1)

Publication Number	Publication Date
ATE161727T1 true ATE161727T1 (de)	1998-01-15

Family

ID=23889046

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91904673T ATE161727T1 (de)	1990-02-06	1991-02-05	Zyklische gnrh-antagonisten

Country Status (12)

Country	Link
US (1)	US5064939A (de)
EP (1)	EP0514475B1 (de)
JP (1)	JPH05503529A (de)
AT (1)	ATE161727T1 (de)
AU (1)	AU639310B2 (de)
CA (1)	CA2073766A1 (de)
DE (1)	DE69128617D1 (de)
HU (1)	HUT62015A (de)
IE (1)	IE69981B1 (de)
PT (1)	PT96688B (de)
WO (1)	WO1991012013A1 (de)
ZA (1)	ZA91854B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5985583A (en) *	1992-06-23	1999-11-16	Mount Sinai School Of Medicine Of The City University Of New York	Cloning and expression of gonadotropin-releasing hormone receptor
US5371070A (en) *	1992-11-09	1994-12-06	The Salk Institute For Biological Studies	Bicyclic GnRH antagonists and a method for regulating the secretion of gonadotropins
US6008058A (en) *	1993-06-18	1999-12-28	University Of Louisville	Cyclic peptide mixtures via side chain or backbone attachment and solid phase synthesis
US5508383A (en) *	1994-03-09	1996-04-16	Tap Holdings Inc.	Cyclic peptide LHRH antagonists
US5824771A (en) *	1994-12-12	1998-10-20	The Salk Institute For Biological Studies	Cyclic CRF agonists
US5663292A (en) *	1994-12-12	1997-09-02	The Salk Institute For Biological Studies	Cyclic CRF analogs
US5777073A (en) *	1994-12-12	1998-07-07	The Salk Institute For Biological Studies	Cyclic CRF antagonist peptides
US5843901A (en)	1995-06-07	1998-12-01	Advanced Research & Technology Institute	LHRH antagonist peptides
WO1998014474A1 (en) *	1996-09-30	1998-04-09	Kyowa Hakko Kogyo Co., Ltd.	E2f activity inhibitory compounds
US5889147A (en) *	1997-01-17	1999-03-30	University Of Utah Research Foundation	Bromo-tryptophan conopeptides
US5821230A (en) *	1997-04-11	1998-10-13	Ferring Bv	GnRH antagonist decapeptides
EP1093458A4 (de) *	1998-04-15	2001-07-18	Aventis Pharm Prod Inc	Verfahren für die herstellung von harzgebundenen zyklischen peptiden
US6455499B1 (en)	1999-02-23	2002-09-24	Indiana University Foundation	Methods for treating disorders associated with LHRH activity
NZ534836A (en) *	1999-09-23	2007-07-27	Zentaris Gmbh	Method for the therapeutic management of extrauterine proliferatoin of endometrial tissue, chronic pelvic pain and fallopian tube obstruction
US6598784B2 (en) *	2000-12-20	2003-07-29	Meadwestvaco Packaging Syatens, Llc	Beverage carton with strap type carrying handle
GB0307777D0 (en) *	2003-04-04	2003-05-07	Medical Res Council	Conjugate compounds
AU2011348220B2 (en)	2010-12-22	2017-09-07	The Salk Institute For Biological Studies	Cyclic CRF antagonist peptides
EP3128036B1 (de) *	2014-03-31	2020-07-01	Furukawa Electric Co. Ltd.	Gewalzte kupferfolie, verfahren zur herstellung einer gewalzten kupferfolie, flexibles flachkabel und verfahren zur herstellung eines flachkabels
WO2023056368A1 (en) *	2021-09-30	2023-04-06	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Cyclic peptides as non-hormonal male contraceptive agents and methods of use thereof
WO2025128794A1 (en)	2023-12-15	2025-06-19	Neurocrine Biosciences, Inc.	Fatty acid conjugated cyclic peptides

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4161521A (en) *	1975-08-08	1979-07-17	Merck & Co., Inc.	Somatostatin analogs
US4191754A (en) *	1979-02-28	1980-03-04	Merck & Co., Inc.	Bicyclic somatostatin analogs
US4619914A (en) *	1983-03-10	1986-10-28	The Salk Institute For Biological Studies	GNRH antagonists IIIB
DE3467173D1 (en) *	1983-08-16	1987-12-10	Akzo Nv	Lh- rh antagonists
US4569927A (en) *	1984-02-23	1986-02-11	The Salk Institute For Biological Studies	GnRH Antagonists IV
US4652550A (en) *	1984-05-21	1987-03-24	The Salk Institute For Biological Studies	GnRH antagonists VII
US4565804A (en) *	1984-09-07	1986-01-21	The Salk Institute For Biological Studies	GnRH Antagonists VI
JPS61112099A (ja) *	1984-11-06	1986-05-30	Mitsubishi Petrochem Co Ltd	新規ポリペプチド及びその製造法
US4690916A (en) *	1984-11-13	1987-09-01	Syntex (U.S.A.) Inc.	Nona and decapeptide analogs of LHRH useful as LHRH antagonists
US4740500A (en) *	1985-01-31	1988-04-26	The Salk Institute For Biological Studies	GnRH antagonists VIII
US4659691A (en) *	1985-02-08	1987-04-21	Merck & Co., Inc.	Novel cyclic Hexapeptide LHRH antagonists
US4611054A (en) *	1985-04-29	1986-09-09	Merck & Co., Inc.	Cyclic hexapeptide somatostatin analogs
US4661472A (en) *	1985-05-09	1987-04-28	The Salk Institute For Biological Studies	GnRH antagonists IX
US4705778A (en) *	1985-10-22	1987-11-10	Sri International	Orally active LHRH analogs
US4801577A (en) *	1987-02-05	1989-01-31	Syntex (U.S.A.) Inc.	Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
US4800191A (en) *	1987-07-17	1989-01-24	Schally Andrew Victor	LHRH antagonists

1990
- 1990-02-06 US US07/475,767 patent/US5064939A/en not_active Expired - Fee Related
1991
- 1991-02-05 ZA ZA91854A patent/ZA91854B/xx unknown
- 1991-02-05 CA CA002073766A patent/CA2073766A1/en not_active Abandoned
- 1991-02-05 DE DE69128617T patent/DE69128617D1/de not_active Expired - Lifetime
- 1991-02-05 AU AU73047/91A patent/AU639310B2/en not_active Ceased
- 1991-02-05 JP JP3504526A patent/JPH05503529A/ja active Pending
- 1991-02-05 EP EP91904673A patent/EP0514475B1/de not_active Expired - Lifetime
- 1991-02-05 AT AT91904673T patent/ATE161727T1/de not_active IP Right Cessation
- 1991-02-05 WO PCT/US1991/000774 patent/WO1991012013A1/en not_active Ceased
- 1991-02-05 IE IE38091A patent/IE69981B1/en not_active IP Right Cessation
- 1991-02-05 HU HU9202569A patent/HUT62015A/hu unknown
- 1991-02-06 PT PT96688A patent/PT96688B/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU639310B2 (en)	1993-07-22
EP0514475A1 (de)	1992-11-25
IE69981B1 (en)	1996-10-16
EP0514475B1 (de)	1998-01-07
PT96688B (pt)	1998-07-31
WO1991012013A1 (en)	1991-08-22
EP0514475A4 (en)	1993-10-13
DE69128617D1 (de)	1998-02-12
PT96688A (pt)	1991-11-29
ZA91854B (en)	1991-11-27
HUT62015A (en)	1993-03-29
US5064939A (en)	1991-11-12
AU7304791A (en)	1991-09-03
IE910380A1 (en)	1991-08-14
JPH05503529A (ja)	1993-06-10
CA2073766A1 (en)	1991-08-07

Legal Events

Date	Code	Title	Description
1998-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69128617D1 (de)	1998-02-12	Zyklische gnrh-antagonisten
DE3684170D1 (de)	1992-04-16	Gnrh-antagonisten.
ATE33252T1 (de)	1988-04-15	Gnrh-antagonisten.
AU571595B2 (en)	1988-04-21	Gnrh antagonists
ES8504110A1 (es)	1985-04-16	"procedimiento para preparar nonapeptidos y decapeptidos analogos a lhrh"
IL101648A0 (en)	1992-12-30	Bradykinin antagonist peptides
ES2123556T3 (es)	1999-01-16	Peptidos de tipo bradiquinina.
DE69229722D1 (de)	1999-09-09	GnRH Analoge
SE9002384D0 (sv)	1990-07-09	Derivat av baklobshormoner
WO2001024765A3 (en)	2001-10-25	Antigenic modification of polypeptides