ATE161835T1 - Benzoylbenzofuranderivate zur behandlung von herzarrhythmia - Google Patents

Benzoylbenzofuranderivate zur behandlung von herzarrhythmia

Info

Publication number
ATE161835T1
ATE161835T1 AT94920234T AT94920234T ATE161835T1 AT E161835 T1 ATE161835 T1 AT E161835T1 AT 94920234 T AT94920234 T AT 94920234T AT 94920234 T AT94920234 T AT 94920234T AT E161835 T1 ATE161835 T1 AT E161835T1
Authority
AT
Austria
Prior art keywords
treatment
cardiac
arhythmia
benzoylbenzofuran
derivatives
Prior art date
Application number
AT94920234T
Other languages
English (en)
Inventor
Pascal Druzgala
Original Assignee
Aryx Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aryx Therapeutics filed Critical Aryx Therapeutics
Application granted granted Critical
Publication of ATE161835T1 publication Critical patent/ATE161835T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT94920234T 1993-06-16 1994-06-16 Benzoylbenzofuranderivate zur behandlung von herzarrhythmia ATE161835T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/078,371 US5364880A (en) 1993-06-16 1993-06-16 Compound for treatment of cardiac arrhythmia, synthesis, and methods of use

Publications (1)

Publication Number Publication Date
ATE161835T1 true ATE161835T1 (de) 1998-01-15

Family

ID=22143621

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94920234T ATE161835T1 (de) 1993-06-16 1994-06-16 Benzoylbenzofuranderivate zur behandlung von herzarrhythmia

Country Status (8)

Country Link
US (4) US5364880A (de)
EP (1) EP0703910B1 (de)
JP (1) JP3435411B2 (de)
AT (1) ATE161835T1 (de)
AU (1) AU697687B2 (de)
CA (1) CA2164633C (de)
DE (1) DE69407785T2 (de)
WO (1) WO1994029289A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002038557A2 (en) * 1993-06-16 2002-05-16 Aryx Therapeutics Benzoylbenzofurane derivatives for treatment of cardiac arrhythmia
US6316487B1 (en) * 1993-06-16 2001-11-13 Aryx Therapeutics Compounds for treatment of cardiac arrhythmia synthesis, and methods of use
US5364880A (en) * 1993-06-16 1994-11-15 Advanced Therapies, Inc. Compound for treatment of cardiac arrhythmia, synthesis, and methods of use
JP2001523253A (ja) * 1997-04-30 2001-11-20 イーライ・リリー・アンド・カンパニー ベンゾ［ｂ］チオフェン類の製造のための中間体および方法
FR2764800B1 (fr) 1997-06-23 1999-09-10 Sanofi Sa Composition pharmaceutique solide contenant des derives de benzofuranne
US6221903B1 (en) * 1999-01-11 2001-04-24 University And College Of Nevada, Reno Amiodarone as an antifungal agent
DK1222180T3 (da) * 1999-10-15 2007-12-27 Aryx Therapeutics Enantiomere forbindelser til behandling af hjertearytmier og fremgangsmåde til anvendelse
US6683195B2 (en) * 1999-10-15 2004-01-27 Aryx Therapeutics Enantiomeric compounds for treatment of cardiac arrhythmias and methods of use
EP1857450A1 (de) * 1999-10-15 2007-11-21 Aryx Therapeutics Neue enantiomere Verbindungen zur Behandlung von Herzrhythmusstörungen und Verwendungsverfahren dafür
US6372783B1 (en) 1999-10-15 2002-04-16 Aryx Therapeutics Enantiomeric compounds for treatment of cardiac arrhythmias and methods of use
US7049326B2 (en) * 2000-05-12 2006-05-23 The University Of Toledo Method and compositions for temporarily incapacitating subjects
US6756047B2 (en) * 2000-05-12 2004-06-29 The University Of Toledo Method and compositions for treating persistent pulmonary hypertension using aralkyl ester soft drugs
US6750238B1 (en) 2000-05-12 2004-06-15 The University Of Toledo Aralkyl ester soft drugs
FR2813306B1 (fr) 2000-08-23 2005-10-21 Sanofi Synthelabo Aminoalkybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant
FR2813308B1 (fr) 2000-08-23 2005-07-01 Sanofi Synthelabo Aminoalkoxybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation ainsi que les compositions les contenant
FR2813307B1 (fr) * 2000-08-23 2002-11-08 Sanofi Synthelabo Aminoalkenylbenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant
AU2002211479B2 (en) * 2000-10-06 2007-08-30 Aryx Therapeutics Benzoylbenzofurane derivatives for treatment of cardiac arrhythmia
DE10129119B4 (de) * 2001-06-16 2007-10-04 Schwarz Pharma Ag Kristalline Salze von Benzoylbenzofuran-Derivaten, insbesondere von[2-(4-{1-[2-((S)-sec.-Butoxycarbonylmethyl)-benzofuran-3-carbonyl]-methanoyl}-2,6-diiod-phenoxy)-ethyl]-diethylamino und [2-(4-{1-[(3-Methyl-2-(S)-Butoxycarbonylmethyl)-benzofuran-3-carbonyl]- methanoyl}-2,6-diiodphenoxy)-ethyl]-diethylamino, deren Verwendung und Herstellung sowie diese Salze enthaltende Arzneimittel
US7236201B1 (en) * 2004-02-12 2007-06-26 The United States Of America As Represented By The Secertary Of The Navy Method of generating an image in a turbid medium
CA2469730A1 (en) * 2001-12-10 2003-06-19 Aryx Therapeutics Novel methods for treatment of cardiac arrhythmia, synthesis, and methods of use
BR0302750A (pt) * 2003-08-08 2005-03-29 Catarinense S A Lab Uso de produto compreendendo material vegetal das espécies trichilia sp. associada ou não para a reversão/combate da fibrilação ventricular; composição farmacêutica compreendendo o referido material vegetal para a reversão/combate da fibrilação ventricular; método para a reversão/combate da fibrilação ventricular usando o referido material vegetal; uso do referido material vegetal para a produção de uma composição farmacêutica para a reversão/combate da fibrilação ventricular
WO2005099684A1 (en) * 2004-04-09 2005-10-27 Aryx Therapeutics Benzofuranyl derivatives useful for the treatment of cardiac arrhythmia
AR051780A1 (es) * 2004-11-29 2007-02-07 Japan Tobacco Inc Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos
EP1904502B1 (de) * 2005-07-15 2009-10-21 Aryx Therapeutics, Inc. Antiarrhythmische vorläuferverbindungen, syntheseverfahren und verwendungsverfahren
CN100457745C (zh) * 2006-06-09 2009-02-04 浙江精进药业有限公司 2-丁基-3-(4-羟基-3，5-二碘苯甲酰)苯并呋喃的合成工艺
US20090270496A1 (en) * 2007-05-03 2009-10-29 Courchesne William E Antifungal compounds
JP5219879B2 (ja) * 2009-02-20 2013-06-26 倉敷紡績株式会社 ｌｏｇＰの決定方法、および該方法に使用される二相系溶媒
US20110136779A1 (en) * 2009-11-23 2011-06-09 Milner Peter G Methods for stroke reduction in atrial fibrillation patients
US9549912B2 (en) 2009-11-23 2017-01-24 Armetheon, Inc. Methods for treating atrial fibrillation
FR2967067A1 (fr) 2010-11-10 2012-05-11 Sanofi Aventis Composition pharmaceutique et forme galenique a base de dronedarone et son procede de preparation
CN102653529A (zh) * 2011-10-25 2012-09-05 广东医学院 一种苯并呋喃的制备工艺
WO2018039843A1 (zh) * 2016-08-29 2018-03-08 沈建美 草甘膦的制备工艺
AU2018266199A1 (en) * 2017-05-10 2019-11-07 Incarda Therapeutics, Inc. Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration
US10744087B2 (en) 2018-03-22 2020-08-18 Incarda Therapeutics, Inc. Method to slow ventricular rate
CN109988132B (zh) * 2019-04-18 2020-12-01 浙江恒康药业股份有限公司 一种盐酸胺碘酮的制备方法
US11007185B2 (en) 2019-08-01 2021-05-18 Incarda Therapeutics, Inc. Antiarrhythmic formulation
AU2020323594B2 (en) 2019-08-01 2022-02-03 Incarda Therapeutics, Inc. Antiarrhythmic formulation

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3248401A (en) * 1966-04-26 Diethylaminoe hoxybenzoyl benzofurans
GB1299247A (en) * 1970-06-22 1972-12-13 Labaz Benzofuran derivatives and process for preparing the same
US5175187A (en) * 1989-03-06 1992-12-29 Soorianarain Baligadoo Synergistic compositions for the treatment of coronary insufficiency and methods of use thereof
WO1990007329A1 (en) * 1989-01-06 1990-07-12 The Regents Of The University Of California Selection method for pharmacologically active compounds
US4962095A (en) * 1989-02-15 1990-10-09 E. R. Squibb & Sons, Inc. Method of reducing pre-and post-ischemic myocardial arrhythmias and fibrillation
US4931464A (en) * 1989-02-15 1990-06-05 E. R. Squibb & Sons, Inc. Method of reducing pre- and post-ischemic myocardial arrhythmias and fibrillation
SE9101509D0 (sv) * 1991-05-17 1991-05-17 Karobio Ab Receptor ligands
US5364880A (en) * 1993-06-16 1994-11-15 Advanced Therapies, Inc. Compound for treatment of cardiac arrhythmia, synthesis, and methods of use
NL1015686C2 (nl) * 2000-07-12 2002-01-15 Dsm Nv Werkwijze voor het met laserbestraling irreversibel aanbrengen van een voor het naakte oog onzichtbare markering op een polymeer vormdeel.

Also Published As

Publication number Publication date
US5849788A (en) 1998-12-15
DE69407785D1 (de) 1998-02-12
US6130240A (en) 2000-10-10
CA2164633A1 (en) 1994-12-22
US5440054A (en) 1995-08-08
DE69407785T2 (de) 1998-07-09
JP3435411B2 (ja) 2003-08-11
JPH08511546A (ja) 1996-12-03
EP0703910A1 (de) 1996-04-03
WO1994029289A1 (en) 1994-12-22
CA2164633C (en) 2006-11-28
US5364880A (en) 1994-11-15
AU7110294A (en) 1995-01-03
EP0703910B1 (de) 1998-01-07
AU697687B2 (en) 1998-10-15

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