ATE162526T1 - 1,2-dihydro-3h-dibenzoisochinolin-1,3-dione als antitumormittel - Google Patents

1,2-dihydro-3h-dibenzoisochinolin-1,3-dione als antitumormittel

Info

Publication number: ATE162526T1
Authority: AT; Austria
Prior art keywords: lower alkyl; taken together; independently hydrogen; aryl; carbon atoms
Prior art date: 1990-06-26

Application number

AT91911663T

Other languages

English (en)

Inventor

David S Alberts

Robert T Dorr

William A Remers

Salah M Sami

Original Assignee

Res Corp Technologies Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-26

Filing date

1991-06-19

Publication date

1998-02-15

1991-06-19 Application filed by Res Corp Technologies Inc filed Critical Res Corp Technologies Inc

1998-02-15 Application granted granted Critical

1998-02-15 Publication of ATE162526T1 publication Critical patent/ATE162526T1/de

Links

239000002246 antineoplastic agent Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 6
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
125000003118 aryl group Chemical group 0.000 abstract 4
150000002431 hydrogen Chemical class 0.000 abstract 4
125000004432 carbon atom Chemical group C* 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000001589 carboacyl group Chemical group 0.000 abstract 2
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 2
-1 methoxy, hydroxy Chemical group 0.000 abstract 2
239000000126 substance Chemical group 0.000 abstract 2
BGFHMYJZJZLMHW-UHFFFAOYSA-N 4-[2-[[2-(1-benzothiophen-3-yl)-9-propan-2-ylpurin-6-yl]amino]ethyl]phenol Chemical compound N1=C(C=2C3=CC=CC=C3SC=2)N=C2N(C(C)C)C=NC2=C1NCCC1=CC=C(O)C=C1 BGFHMYJZJZLMHW-UHFFFAOYSA-N 0.000 abstract 1
125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
GRHZLQBPAJAHDM-SPRQWYLLSA-N [(3as,4r,6ar)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] n-[(2s,4s,5s)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]carbamate Chemical compound CC1=CC=CC(C)=C1OCC(=O)N[C@H]([C@@H](O)C[C@H](CC=1C=CC=CC=1)NC(=O)O[C@@H]1[C@@H]2CCO[C@@H]2OC1)CC1=CC=CC=C1 GRHZLQBPAJAHDM-SPRQWYLLSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT91911663T 1990-06-26 1991-06-19 1,2-dihydro-3h-dibenzoisochinolin-1,3-dione als antitumormittel ATE162526T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US54359690A	1990-06-26	1990-06-26

Publications (1)

Publication Number	Publication Date
ATE162526T1 true ATE162526T1 (de)	1998-02-15

Family

ID=24168698

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91911663T ATE162526T1 (de)	1990-06-26	1991-06-19	1,2-dihydro-3h-dibenzoisochinolin-1,3-dione als antitumormittel

Country Status (9)

Country	Link
EP (1)	EP0536208B1 (de)
JP (1)	JP2992769B2 (de)
AT (1)	ATE162526T1 (de)
AU (1)	AU643539B2 (de)
CA (1)	CA2085598C (de)
DE (1)	DE69128788T2 (de)
ES (1)	ES2113886T3 (de)
IE (1)	IE912200A1 (de)
WO (1)	WO1992000281A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5635506A (en) *	1990-06-26	1997-06-03	Research Corporation Technologies, Inc.	1, 2-dihydro-3H-dibenzisoquinoline-1,3-dione anticancer agents
AU5127893A (en) *	1992-09-11	1994-04-12	Research Corporation Technologies, Inc.	1,2 dihydro-3-h-dibenz(de,h) isoquinoline 1,3 dione and their use as anticancer agents
WO1995029895A1 (en) *	1994-04-28	1995-11-09	Knoll Aktiengesellschaft	Dihydrodibenzo(de,h)isoquinolines derivatives and their use as anti-cancer agents
US5703089A (en) *	1994-04-28	1997-12-30	Knoll Aktiengesellschaft	Dihydrodibenzisoquinolinediones
EP0831094B1 (de) *	1995-05-31	2004-12-08	Eisai Co., Ltd.	Verknüpfte polycyclische heterocyclische verbindungen
WO1996038446A1 (en) *	1995-05-31	1996-12-05	Eisai Co., Ltd.	Fused polycyclic heterocycle derivatives
US6291425B1 (en)	1999-09-01	2001-09-18	Guilford Pharmaceuticals Inc.	Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
EP2069308B1 (de) *	2006-09-12	2017-03-29	Government of the United States of America, Represented by the Secretary, Department of Health and Human Services	Auf tumor und krebs abzielende verbindungen aus azonafid
DE102007038422A1 (de)	2007-08-14	2009-02-19	Heinz Prof. Dr. Langhals	Aceanthren- und Anthracencarbonsäureimide

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US1253252A (en) *	1914-04-15	1918-01-15	Basf Ag	Bluish-green vat dyes and process of making them.
US3940398A (en) *	1975-01-23	1976-02-24	E. R. Squibb & Sons, Inc.	2-[[4-(Azine or diazine or triazine)-1-piperazinyl]alkyl]-1H-benz[de]isoquinoline-1,3(2H)-diones
ES459497A1 (es) *	1977-06-04	1978-04-16	Made Labor Sa	Un metodo para la preparacion industrial de naftalimidas y sus derivados.
US4665071A (en) *	1984-02-21	1987-05-12	Warner-Lambert Company	3,6-disubstituted-1,8-naphthalimides and methods for their production and use

1991
- 1991-06-19 AT AT91911663T patent/ATE162526T1/de not_active IP Right Cessation
- 1991-06-19 DE DE69128788T patent/DE69128788T2/de not_active Expired - Fee Related
- 1991-06-19 WO PCT/US1991/004364 patent/WO1992000281A1/en not_active Ceased
- 1991-06-19 AU AU80501/91A patent/AU643539B2/en not_active Ceased
- 1991-06-19 EP EP91911663A patent/EP0536208B1/de not_active Expired - Lifetime
- 1991-06-19 JP JP3511780A patent/JP2992769B2/ja not_active Expired - Fee Related
- 1991-06-19 CA CA002085598A patent/CA2085598C/en not_active Expired - Fee Related
- 1991-06-19 ES ES91911663T patent/ES2113886T3/es not_active Expired - Lifetime
- 1991-06-25 IE IE220091A patent/IE912200A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69128788D1 (de)	1998-02-26
IE912200A1 (en)	1992-01-01
AU643539B2 (en)	1993-11-18
JP2992769B2 (ja)	1999-12-20
DE69128788T2 (de)	1998-06-10
CA2085598A1 (en)	1991-12-27
EP0536208A1 (de)	1993-04-14
EP0536208A4 (en)	1993-05-05
ES2113886T3 (es)	1998-05-16
EP0536208B1 (de)	1998-01-21
WO1992000281A1 (en)	1992-01-09
AU8050191A (en)	1992-01-23
CA2085598C (en)	2002-09-17
JPH05508639A (ja)	1993-12-02

Legal Events

Date	Code	Title	Description
1998-07-15	UEP	Publication of translation of european patent specification
2010-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE184000T1 (de)	1999-09-15	2-oxindolderivate als tyrosinekinaseinhibitoren
NO890825L (no)	1985-05-20	3-amino-kinoliner.
ES8308311A1 (es)	1983-08-16	Procedimiento para la preparacion de derivados de benzazepina.
FI943646A0 (fi)	1994-08-05	Bentsosyklohepteenejä, bentsoksepiinejä bentsotiepiinejä
DK0918776T3 (da)	2004-07-12	Totalsyntese af antitumor acylfulvener
ATE162526T1 (de)	1998-02-15	1,2-dihydro-3h-dibenzoisochinolin-1,3-dione als antitumormittel
DK164554C (da)	1992-11-30	3-vinyl- og 3-ethynyl-beta-carbolinderivater og fremgangsmaade til fremstilling heraf
MY130817A (en)	2007-07-31	Herbicides
ES426135A1 (es)	1976-11-01	Procedimiento de preparacion de esteres de aril-piperazino-alcanoles.
BG104037A (en)	2001-04-30	6-pyrrolidin-2-ylpyrindine derivatives, their preparation and application in therapy
ATE136292T1 (de)	1996-04-15	Sechsbindige liganden für radiographische abbildungsagenzien
DE3175327D1 (en)	1986-10-23	Antihypertensive lactams
DK0658555T3 (da)	1997-12-22	Pyridazinonderivater, fremgangsmåder til fremstilling deraf samt anvendelse deraf
ES2001166A6 (es)	1988-05-01	Procedimiento para preparar nuevos prostadienoatos
ATE148462T1 (de)	1997-02-15	Isoxazole derivate als lichtschutzmittel
ES443519A1 (es)	1977-08-16	Procedimiento para la obtencion de derivados de benz (f) i- soindolina.
HUP9802696A2 (hu)	1999-06-28	Amino-adamantán-származékok alkalmazása immunregulátorként