ATE163288T1 - 2-amino-1,2,3,4-tetrahydronaphthalenderivate mit cardiovaskulärer wirkung - Google Patents

2-amino-1,2,3,4-tetrahydronaphthalenderivate mit cardiovaskulärer wirkung

Info

Publication number: ATE163288T1
Authority: AT; Austria
Prior art keywords: pct; hydrogen atom; group; integer; alkyl
Prior art date: 1993-09-14

Application number

AT94926245T

Other languages

English (en)

Inventor

Stefania Montanari

Paolo Cavalleri

Francesco Santangelo

Original Assignee

Zambon Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-14

Filing date

1994-09-07

Publication date

1998-03-15

1994-09-07 Application filed by Zambon Spa filed Critical Zambon Spa

1998-03-15 Application granted granted Critical

1998-03-15 Publication of ATE163288T1 publication Critical patent/ATE163288T1/de

Links

230000002526 effect on cardiovascular system Effects 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
200000000007 Arterial disease Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
208000001647 Renal Insufficiency Diseases 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Chemical group 0.000 abstract 1
208000037849 arterial hypertension Diseases 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
208000026106 cerebrovascular disease Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
201000006370 kidney failure Diseases 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
230000002093 peripheral effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
- C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/12—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT94926245T 1993-09-14 1994-09-07 2-amino-1,2,3,4-tetrahydronaphthalenderivate mit cardiovaskulärer wirkung ATE163288T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI931973A IT1271411B (it)	1993-09-14	1993-09-14	Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare

Publications (1)

Publication Number	Publication Date
ATE163288T1 true ATE163288T1 (de)	1998-03-15

Family

ID=11366895

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94926245T ATE163288T1 (de)	1993-09-14	1994-09-07	2-amino-1,2,3,4-tetrahydronaphthalenderivate mit cardiovaskulärer wirkung

Country Status (9)

Country	Link
US (2)	US5747513A (de)
EP (1)	EP0719252B1 (de)
JP (1)	JP3626191B2 (de)
AT (1)	ATE163288T1 (de)
AU (1)	AU7615794A (de)
CA (1)	CA2170619A1 (de)
DE (1)	DE69408580T2 (de)
IT (1)	IT1271411B (de)
WO (1)	WO1995007885A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1271008B (it) *	1994-09-13	1997-05-26	Zambon Spa	Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare
IT1271007B (it) *	1994-09-13	1997-05-26	Zambon Spa	Derivati del 2-ammino-1,2,3,4-tetraidronaftalene attivi sul sistema cardiovascolare
IT1271009B (it) *	1994-09-13	1997-05-26	Zambon Spa	Derivati del benzopirano e del benzotiopirano attivi sul sistema cardiovascolare
IT1289980B1 (it) *	1997-02-26	1998-10-19	Zambon Spa	Derivati idrossimetilici del 2-ammino-1,2,3,4-tetraidronaftalene attivi in campo cardiovascolare
IT1289979B1 (it) *	1997-02-26	1998-10-19	Zambon Spa	5-idrossimetil-6-idrossi-2-amminotetraline attive come agenti cardiovascolari
WO2004082567A2 (en) *	2003-03-17	2004-09-30	Bayer Healthcare Ag	Diagnostics and therapeutics for diseases associated with dopamine receptor d1a (drd1)
CA2522666A1 (en) *	2003-04-18	2004-10-28	Pharmacia & Upjohn Company Llc	Combination therapies for chronic obstructive pulmonary disease (copd)
PL3226944T5 (pl)	2014-12-03	2023-01-30	Eli Lilly And Company	Zespół ściągacza osłony igły z nasadką
CR20200225A (es)	2017-11-24	2020-07-25	H Lundbeck As	Nuevos fármacos de catecolamina para uso en el tratamiento de la enfermedad de parkinson
US11168056B2 (en)	2019-05-20	2021-11-09	H. Lundbeck A/S	Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol
US11130775B2 (en)	2019-05-20	2021-09-28	H. Lundbeck A/S	Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11104697B2 (en)	2019-05-20	2021-08-31	H. Lundbeck A/S	Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11111263B2 (en)	2019-05-20	2021-09-07	H. Lundbeck A/S	Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
JP7641234B2 (ja)	2019-05-21	2025-03-06	ハー・ルンドベック・アクチエゼルスカベット	パーキンソン病の治療に使用するための新規なカテコールアミンプロドラッグ
WO2020234277A1 (en)	2019-05-21	2020-11-26	H. Lundbeck A/S	Catecholamine carbamate prodrugs for use in the treatment of parkinson s disease
EP3972971A1 (de)	2019-05-21	2022-03-30	H. Lundbeck A/S	Neue catecholamin-prodrugs zur verwendung in der behandlung von morbus parkinson
WO2020234276A1 (en)	2019-05-21	2020-11-26	H. Lundbeck A/S	New catecholamine prodrugs for use in the treatment of parkinson's disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3263531D1 (en) *	1981-08-05	1985-06-20	Fisons Plc	Amine derivatives, processes for their production and pharmaceutical compositions containing them
EP0375668A3 (de) *	1983-10-25	1990-10-17	FISONS plc	Phenylethylamine, Verfahren zu deren Herstellung und diese enthaltende Zusammensetzungen
IT1224405B (it) *	1987-12-23	1990-10-04	Simes	Composti attivi sul sistema cardiovascolare
EP0463119A4 (en) *	1989-07-05	1992-01-22	Whitby Research Incorporated	Substituted 2-aminotetralins
US5118704A (en) *	1989-08-30	1992-06-02	Whitby Research, Inc.	Substituted 2-aminotetralins useful as dopaminergics
IT1254521B (it) *	1992-03-17	1995-09-25	Zambon Spa	Derivati della 2-ammino-tetralina attivi sul sistema cardiovascolare
IT1271007B (it) *	1994-09-13	1997-05-26	Zambon Spa	Derivati del 2-ammino-1,2,3,4-tetraidronaftalene attivi sul sistema cardiovascolare

1993
- 1993-09-14 IT ITMI931973A patent/IT1271411B/it active IP Right Grant
1994
- 1994-09-07 US US08/605,136 patent/US5747513A/en not_active Expired - Fee Related
- 1994-09-07 AU AU76157/94A patent/AU7615794A/en not_active Abandoned
- 1994-09-07 DE DE69408580T patent/DE69408580T2/de not_active Expired - Fee Related
- 1994-09-07 CA CA002170619A patent/CA2170619A1/en not_active Abandoned
- 1994-09-07 WO PCT/EP1994/002981 patent/WO1995007885A1/en not_active Ceased
- 1994-09-07 AT AT94926245T patent/ATE163288T1/de active
- 1994-09-07 JP JP50895995A patent/JP3626191B2/ja not_active Expired - Fee Related
- 1994-09-07 EP EP94926245A patent/EP0719252B1/de not_active Expired - Lifetime
1997
- 1997-10-17 US US08/954,176 patent/US6080768A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0719252B1 (de)	1998-02-18
JP3626191B2 (ja)	2005-03-02
DE69408580D1 (de)	1998-03-26
US5747513A (en)	1998-05-05
ITMI931973A0 (it)	1993-09-14
WO1995007885A1 (en)	1995-03-23
DE69408580T2 (de)	1998-06-18
US6080768A (en)	2000-06-27
AU7615794A (en)	1995-04-03
ITMI931973A1 (it)	1995-03-14
IT1271411B (it)	1997-05-28
JPH09502448A (ja)	1997-03-11
EP0719252A1 (de)	1996-07-03
CA2170619A1 (en)	1995-03-23

Publication	Publication Date	Title
ATE163288T1 (de)	1998-03-15	2-amino-1,2,3,4-tetrahydronaphthalenderivate mit cardiovaskulärer wirkung
DK0612743T3 (da)	1998-04-20	Oxazolidindionderivater, fremstilling deraf og anvendelse deraf til formindskelse af blodniveauerne for sukker og lipider
DK0415456T3 (da)	1996-07-29	Xanthinforbindelser
ATE117295T1 (de)	1995-02-15	4-oxochinolin-3-carbonsäure-derivate, ihre herstellung und ihre verwendung.
GR850126B (de)	1985-05-16
DE3876813D1 (de)	1993-02-04	3(2h)pyridazinon, verfahren zu dessen herstellung und dieses enthaltendes mittel gegen srs-a.
FI811373L (fi)	1981-11-10	Substituerade fenyletrar
PT99644A (pt)	1992-10-30	Processo para a preparacao de novos derivados de guanidina
DK0655057T3 (da)	1998-04-14	Cyanoguanidiner som kaliumkanalblokkere
DE3876536D1 (de)	1993-01-21	Oxadiazol-pyrimidinone, ihre herstellung und ihre kosmetische und dermopharmazeutische verwendung.
BG60248B1 (bg)	1994-03-24	Метод за получаване на производни на феноксиетиламина
DK599486D0 (da)	1986-12-12	1,4-dihydropyridiner, deres fremstilling af anvendelse som laegemidler
ATE44741T1 (de)	1989-08-15	2-(n-substituierte guanidino)-4heteroarylthiazole als mittel gegen geschwuere.