ATE164076T1 - Stimulierung der stroma- und vorläuferzellen im knochenmark - Google Patents

Stimulierung der stroma- und vorläuferzellen im knochenmark

Info

Publication number
ATE164076T1
ATE164076T1 AT91913153T AT91913153T ATE164076T1 AT E164076 T1 ATE164076 T1 AT E164076T1 AT 91913153 T AT91913153 T AT 91913153T AT 91913153 T AT91913153 T AT 91913153T AT E164076 T1 ATE164076 T1 AT E164076T1
Authority
AT
Austria
Prior art keywords
bone marrow
cells
bfgf
administered
progenitor cells
Prior art date
Application number
AT91913153T
Other languages
English (en)
Inventor
E Lynette Wilson
Daniel B Rifkin
Janice Gabrilove
Original Assignee
Univ New York
Sloan Kettering Inst Cancer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York, Sloan Kettering Inst Cancer filed Critical Univ New York
Application granted granted Critical
Publication of ATE164076T1 publication Critical patent/ATE164076T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0669—Bone marrow stromal cells; Whole bone marrow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/90—Polysaccharides
    • C12N2501/91—Heparin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
AT91913153T 1990-06-08 1991-06-10 Stimulierung der stroma- und vorläuferzellen im knochenmark ATE164076T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53610890A 1990-06-08 1990-06-08

Publications (1)

Publication Number Publication Date
ATE164076T1 true ATE164076T1 (de) 1998-04-15

Family

ID=24137183

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91913153T ATE164076T1 (de) 1990-06-08 1991-06-10 Stimulierung der stroma- und vorläuferzellen im knochenmark

Country Status (5)

Country Link
EP (1) EP0535148B1 (de)
JP (1) JPH05509096A (de)
AT (1) ATE164076T1 (de)
DE (1) DE69129113T2 (de)
WO (1) WO1991018620A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69012601T2 (de) * 1989-02-02 1995-01-19 Joel S Greenberger Gentherapie durch stützgewebebezügliche Zellen.
US5612211A (en) * 1990-06-08 1997-03-18 New York University Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors
US5264358A (en) * 1992-06-24 1993-11-23 The Procter & Gamble Company Rat osteosarcoma cell line OSR9TR1
US5286645A (en) * 1992-06-24 1994-02-15 The Procter & Gamble Company Rat osteosarcoma cell line osr3tr1
US5286643A (en) * 1992-06-24 1994-02-15 The Procter & Gamble Company Rat osteosarcoma cell line OSR-8
US5292656A (en) * 1992-06-24 1994-03-08 The Procter & Gamble Company Rat osteosarcoma cell line OSR-6
US5286644A (en) * 1992-06-24 1994-02-15 The Procter & Gamble Company Rat osteosarcoma cell line OSR-2
US5288628A (en) * 1992-06-24 1994-02-22 The Procter & Gamble Company Rat osteosarcoma cell line OSR4TR1
US5405772A (en) * 1993-06-18 1995-04-11 Amgen Inc. Medium for long-term proliferation and development of cells
IL114744A0 (en) * 1994-08-18 1995-11-27 Res Dev Foundation Cytokine regulation of cellular senescence
US6991787B1 (en) 1995-12-29 2006-01-31 Alg Company Methods of preparing bone marrow stromal cells for use in gene therapy
CN1209836A (zh) * 1995-12-29 1999-03-03 阿尔格公司 骨髓基质细胞的扩展
EP0973888A1 (de) * 1997-02-06 2000-01-26 Human Genome Sciences, Inc. Von dendritischen zellen abgeleiteten wachstumsfaktor
US6093531A (en) 1997-09-29 2000-07-25 Neurospheres Holdings Ltd. Generation of hematopoietic cells from multipotent neural stem cells
EP1325953A4 (de) * 2000-09-12 2006-03-22 Yukio Kato Methode zur kultivierung von mesenchymalen stammzellen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4785079A (en) * 1984-11-09 1988-11-15 The Salk Institute For Biological Studies Isolation of fibroblast growth factor
JP2879148B2 (ja) * 1987-07-07 1999-04-05 サイオス インコーポレイテッド 組換え繊維芽細胞成長因子
US5399493A (en) * 1989-06-15 1995-03-21 The Regents Of The University Of Michigan Methods and compositions for the optimization of human hematopoietic progenitor cell cultures

Also Published As

Publication number Publication date
EP0535148B1 (de) 1998-03-18
WO1991018620A1 (en) 1991-12-12
EP0535148A4 (de) 1994-02-02
DE69129113T2 (de) 1998-10-15
EP0535148A1 (de) 1993-04-07
DE69129113D1 (de) 1998-04-23
JPH05509096A (ja) 1993-12-16

Similar Documents

Publication Publication Date Title
ATE164076T1 (de) Stimulierung der stroma- und vorläuferzellen im knochenmark
Jiang et al. Concise review: mesenchymal stem cells derived from human pluripotent cells, an unlimited and quality-controllable source for therapeutic applications
Emerson Ex vivo expansion of hematopoietic precursors, progenitors, and stem cells: the next generation of cellular therapeutics
Nakahara et al. Culture‐expanded human periosteal‐derived cells exhibit osteochondral potential in vivo
EP1100878B1 (de) Verfahren zur herstellung von genetisch modifizierten cd34-negativen, adhärent wachsenden hämatopoietischen stammzellen
US20100261152A1 (en) Method for expansion of stem cells
RU2004117523A (ru) Способы и композиции для применения стромальных клеток для поддержания эмбриональных и зрелых стволовых клеток
CN105112362B (zh) 一种胎盘间充质干细胞的无血清培养基及其制备方法
DK0455482T3 (da) En undergruppe af humane stamceller
CN113564111B (zh) 一种低氧培养脐带来源间充质干细胞的方法
KR20210093382A (ko) 3ｄ 세포 배양을 위한 방법과 시스템 및 이의 용도
Shilpa et al. Stem cells: Boon to dentistry and medicine
Ye et al. Cardiac stem cell therapy: review of the native cardiac progenitor cells and future direction
KR101753557B1 (ko) 줄기세포 증식 향상 배지 조성물 및 줄기세포의 배양방법
Bilko et al. Characterization of the interactions between stromal and haematopoietic progenitor cells in expansion cell culture models
Goan et al. The severe combined immunodeficient-human peripheral blood stem cell (SCID-huPBSC) mouse: a xenotransplant model for huPBSC-initiated hematopoiesis
JP2022521027A5 (de)
DE69230879D1 (de) Verwendung von Hepatocyten-Wachstumsfaktoren zur Herstellung eines Vermehrungssystems für Hematopoietische Stammzellen
Wang et al. Long-term culture of murine bone-marrow-derived endothelial cells
US10959425B2 (en) Method of banking stem cells
CN115067318B (zh) 一种牙髓间充质干细胞保存液及其应用
KR101570004B1 (ko) 발모촉진용 조성물
Chailakhyan et al. Transfer of bone-marrow microenvironment by clones of stromal mechanocytes
US20210371824A1 (en) Production of megakaryocytes in bioreactors
US20060233763A1 (en) Cartilaginous cell culture medium and the use thereof