ATE164185T1 - Produktion von hyaluronsäure - Google Patents

Produktion von hyaluronsäure

Info

Publication number
ATE164185T1
ATE164185T1 AT91918590T AT91918590T ATE164185T1 AT E164185 T1 ATE164185 T1 AT E164185T1 AT 91918590 T AT91918590 T AT 91918590T AT 91918590 T AT91918590 T AT 91918590T AT E164185 T1 ATE164185 T1 AT E164185T1
Authority
AT
Austria
Prior art keywords
pct
hyaluronic acid
production
sec
date
Prior art date
Application number
AT91918590T
Other languages
English (en)
Inventor
Derek Clifford Ellwood
Charles Gervase Thorngat Evans
Geoffrey Michael Dunn
Neil Mcinnes
Richard Grenville Yeo
Keith James Smith
Original Assignee
Fermentech Med Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fermentech Med Ltd filed Critical Fermentech Med Ltd
Application granted granted Critical
Publication of ATE164185T1 publication Critical patent/ATE164185T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/46—Streptococcus ; Enterococcus; Lactococcus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/885—Streptococcus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT91918590T 1990-11-07 1991-11-04 Produktion von hyaluronsäure ATE164185T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909024223A GB9024223D0 (en) 1990-11-07 1990-11-07 Production of hyaluronic acid

Publications (1)

Publication Number Publication Date
ATE164185T1 true ATE164185T1 (de) 1998-04-15

Family

ID=10685019

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91918590T ATE164185T1 (de) 1990-11-07 1991-11-04 Produktion von hyaluronsäure

Country Status (9)

Country Link
US (2) US5411874A (de)
EP (1) EP0556213B1 (de)
JP (1) JP3159983B2 (de)
AT (1) ATE164185T1 (de)
DE (1) DE69129118T2 (de)
DK (1) DK0556213T3 (de)
ES (1) ES2115620T3 (de)
GB (1) GB9024223D0 (de)
WO (1) WO1992008799A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9024223D0 (en) * 1990-11-07 1990-12-19 Fermentech Ltd Production of hyaluronic acid
IT1263393B (it) * 1993-07-30 1996-08-05 Fidia Advanced Biopolymers Srl Processo per la preparazione e purificazione di acido ialuronico ad alto peso molecolare
SE9401806D0 (sv) 1994-05-26 1994-05-26 Pharmacia Ab Method and means for the production of hyaluronic acid
IT1271001B (it) * 1994-07-26 1997-05-26 Poli Ind Chimica Spa Procedimento di preparazione di acido ialuronico mediante fermentazione con streptococcus
IT1295935B1 (it) 1997-10-30 1999-05-28 Acs Dobfar Spa Derivati aminotiazolici utili nella preparazione di antibiotici b -lattamici
EP1068294B1 (de) 1998-03-30 2008-02-13 Metabolix, Inc. Mikrobielle stämme und verfahren für die herstellung von biomaterialien
GB9902412D0 (en) * 1999-02-03 1999-03-24 Fermentech Med Ltd Process
GB9902652D0 (en) 1999-02-05 1999-03-31 Fermentech Med Ltd Process
CA2427765C (en) 2000-11-03 2012-01-24 Vitrolife Ab Evaluation and preservation solution
US6660853B2 (en) * 2000-12-15 2003-12-09 Al Prescott Method for purifying high molecular weight hyaluronic acid
US20040180025A1 (en) * 2003-03-12 2004-09-16 New Life Resources, Llc Therapeutic, nutraceutical and cosmetic applications for eggshell membrane and processed eggshell membrane preparations
US6946551B2 (en) * 2003-03-12 2005-09-20 New Life Resources, Llc Preparation of hyaluronic acid from eggshell membrane
US20080063677A1 (en) * 2004-03-10 2008-03-13 New Life Resources, Llc Therapeutic, nutraceutical and cosmetic applications for eggshell membrane and processed eggshell membrane preparations
AU2003901834A0 (en) * 2003-04-17 2003-05-01 Clearcoll Pty Ltd Cross-linked polysaccharide compositions
DE602004025951D1 (de) * 2003-09-11 2010-04-22 Staat Der Nederlanden Vert Doo Verfahren zur herstellung eines kapselpolysaccharids zur verwendung in konjugat-impfstoffen
US8580315B2 (en) * 2004-03-10 2013-11-12 Esm Technologies, Llc Anti-inflammatory activity of eggshell membrane and processed eggshell membrane preparations
CN1293197C (zh) * 2004-03-23 2007-01-03 中国农业大学 一种用于乳酸菌发酵的增效剂
US20050281880A1 (en) * 2004-05-20 2005-12-22 Wei Wang Methods for making injectable polymer hydrogels
ES2609105T3 (es) * 2004-05-20 2017-04-18 Mentor Worldwide Llc Método de enlance covalente de ácido hialurónico y quitosano
CN100431431C (zh) * 2004-05-25 2008-11-12 中国科学院南海海洋研究所 一种富含海洋天然牛磺酸的保健型味精及其制备方法
US7002007B2 (en) * 2004-05-28 2006-02-21 Calcigen Corporation Production of high molecular weight hyaluronates
US20080138865A1 (en) * 2006-07-06 2008-06-12 Reliance Life Sciences Pvt. Ltd. Optimisation of culture conditions for production and process of purification of high molecular weight hyaluronic acid
KR101509139B1 (ko) * 2006-11-23 2015-04-08 주식회사 엘지생명과학 히알루론산의 정제방법
US8466128B2 (en) * 2007-01-30 2013-06-18 Cypress Pharmaceuticals, Inc. Hyaluronate compositions
US8759321B2 (en) * 2007-06-13 2014-06-24 Bausch & Lomb Incorporated Ophthalmic composition with hyaluronic acid and polymeric biguanide
CN101089021B (zh) * 2007-07-12 2010-04-14 华东理工大学 从微生物发酵液中分离提取透明质酸的方法
CN101855248B (zh) * 2007-11-13 2012-08-22 生物技术通用（以色列）有限公司 用于粘弹性生物聚合物的稀释过滤灭菌方法
WO2011148116A2 (fr) 2010-05-27 2011-12-01 Laboratoire Idenov Acide hyaluronique modifie, procede de fabrication et utilisations
DE102011077393A1 (de) * 2011-06-10 2012-12-13 Johannes Reinmüller Antiinfektives Mittel
CN102504047A (zh) * 2011-11-30 2012-06-20 上海景峰制药有限公司 一种玻璃酸钠发酵液的超滤方法
CN103601814B (zh) * 2013-07-30 2016-04-13 青岛九龙生物医药有限公司 从猪皮中提取透明质酸的方法
ITMI20131654A1 (it) * 2013-10-07 2015-04-07 Rosa Mario De Downstream di purificazione di acido ialuronico da brodi di coltura microbici
CA2896038C (en) 2015-07-03 2022-08-09 Glycobiosciences Inc. Polymer matrix compositions comprising a high concentration of bio-fermented sodium hyaluronate and uses thereof
CN112553272B (zh) * 2020-12-24 2022-08-09 华熙生物科技股份有限公司 一种提高透明质酸产率的方法
WO2023030435A1 (en) 2021-09-01 2023-03-09 Shanghai Qisheng Biological Preparation Co., Ltd. Cartilage regeneration using injectable, in situ polymerizable collagen compositions containing chondrocytes or stem cells
US12304974B2 (en) 2021-12-28 2025-05-20 Shanghai Qisheng Biological Preparation Co., Ltd. Hyaluronic acid-collagen copolymer compositions and medical applications thereof
CN115215949B (zh) * 2022-06-09 2024-01-05 浙江驭远生物科技有限公司 透明质酸钠及其提纯方法
EP4512395A1 (de) 2023-08-21 2025-02-26 Bio Even Zusammensetzung mit flavin-adenin-dinucleotid (fad), l-gsh, atp und myristinsäure, allein oder mit einem arzneimittel

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4517295A (en) * 1983-02-18 1985-05-14 Diagnostic, Inc. Hyaluronic acid from bacterial culture
NO161573C (no) * 1983-11-25 1989-08-30 Miles Inc Fremgangsmaate til fremstilling av hyaluronsyre.
US5093487A (en) * 1986-01-06 1992-03-03 Mobay Corporation Low viscosity high molecular weight filter sterilizable hyaluronic acid
JPS60251898A (ja) * 1984-05-25 1985-12-12 Shiseido Co Ltd 醗酵法によるヒアルロン酸の製造方法
FR2569724B1 (fr) * 1984-09-04 1991-02-08 Chisso Corp Procede pour la preparation d'acide hyaluronique
US4780414A (en) * 1985-01-18 1988-10-25 Bio-Technology General Corp. Method of producing high molecular weight sodium hyallronate by fermentation of streptococcus
US4851521A (en) * 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
US5202431A (en) * 1985-07-08 1993-04-13 Fidia, S.P.A. Partial esters of hyaluronic acid
JPS6232893A (ja) * 1985-08-01 1987-02-12 Kyowa Hakko Kogyo Co Ltd ヒアルロン酸の製造法
US5023175A (en) * 1986-05-01 1991-06-11 Kabushiki Kaisha Yakult Honsha Novel production process of hyaluronic acid and bacterium strain therefor
US4946780A (en) * 1988-10-12 1990-08-07 Denkl Kagaku Kogyo Kabushiki Kaisha Method for producing sodium hyaluronate by fermentation method
US4897349A (en) * 1989-04-28 1990-01-30 Medchem Products, Inc. Biosynthesis of hyaluronic acid
GB9024223D0 (en) * 1990-11-07 1990-12-19 Fermentech Ltd Production of hyaluronic acid

Also Published As

Publication number Publication date
DE69129118D1 (de) 1998-04-23
JPH06505146A (ja) 1994-06-16
JP3159983B2 (ja) 2001-04-23
US5563051A (en) 1996-10-08
EP0556213B1 (de) 1998-03-18
ES2115620T3 (es) 1998-07-01
WO1992008799A1 (en) 1992-05-29
GB9024223D0 (en) 1990-12-19
US5411874A (en) 1995-05-02
DE69129118T2 (de) 1998-11-19
EP0556213A1 (de) 1993-08-25
DK0556213T3 (da) 1998-12-21

Similar Documents

Publication Publication Date Title
ATE164185T1 (de) Produktion von hyaluronsäure
KR850007983A (ko) 히알우론산 생산의 발효법
ATE250135T1 (de) Apparat und verfahren zur kontinuierlichen umwandlung von zellulotischem material zu äthanol
NZ504345A (en) Low pH lactic acid fermentation
IT1271001B (it) Procedimento di preparazione di acido ialuronico mediante fermentazione con streptococcus
AU6704196A (en) Industrial production process for a vaccine against Japanese encephalitis, and vaccine obtained
ES8606906A1 (es) Procedimiento para preparar productos que contienen oligosacaridos a partir de biomasa triturada.
FR2389673A1 (de)
ES2188708T3 (es) Metodo de produccion de acido l-lactico con alta pureza optica utilizando cepas de bacillus.
GB2021639A (en) Continuous Fermentative Process for the Production of Ethyl Alcohol
AU6460196A (en) Method for preparing pure lactic acid
Diekmann et al. Degradation of 6-aminonaphthalene-2-sulphonic acid by mixed cultures: kinetic analysis
ES2098372T3 (es) Microorganismo y procedimiento para la obtencion de acido antranilico.
ATE163677T1 (de) Anfahren eines kontinuierlichen buttersäurefermenters
AU634148B2 (en) Use of cellulase preparations in the cultivation and use of cellulose-producing microorganisms
DE60012079D1 (de) Verfahren zur Herstellung von Arabitol durch kontinuierliche Gärung
JPS6474999A (en) Production of optically active (r)-(-)-beta-hydroxylactic acid
JPS5489088A (en) Preparation of d-alpha-amino acid
FR2336476A1 (fr) Procede de preparation en continu d'une masse biologique microbienne et dispositif pour la realisation de ce procede
JPS5452791A (en) Preparation of d-alpha-amino acid
KR910018554A (ko) 발효법에 의한 d-이소구연산 (d-isocitric acid)의 제조방법
KR870004147A (ko) 케모스타트(chemostat) 배양법에 의한 히아론산 제조방법
JPS54119086A (en) Preparation of urikase by fermentation
JPS5642589A (en) Highly thermophile fumarase, its production and production of l-malic acid utilizing microorganism producing thermophile fumarase and the same
DK0522112T3 (da) Fremgangsmåde til fremstilling af dulcitol ud fra lactose

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time