ATE164185T1 - Produktion von hyaluronsäure - Google Patents

Produktion von hyaluronsäure

Info

Publication number
ATE164185T1
ATE164185T1 AT91918590T AT91918590T ATE164185T1 AT E164185 T1 ATE164185 T1 AT E164185T1 AT 91918590 T AT91918590 T AT 91918590T AT 91918590 T AT91918590 T AT 91918590T AT E164185 T1 ATE164185 T1 AT E164185T1
Authority
AT
Austria
Prior art keywords
pct
hyaluronic acid
production
sec
date
Prior art date
Application number
AT91918590T
Other languages
English (en)
Inventor
Derek Clifford Ellwood
Charles Gervase Thorngat Evans
Geoffrey Michael Dunn
Neil Mcinnes
Richard Grenville Yeo
Keith James Smith
Original Assignee
Fermentech Med Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fermentech Med Ltd filed Critical Fermentech Med Ltd
Application granted granted Critical
Publication of ATE164185T1 publication Critical patent/ATE164185T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/46—Streptococcus ; Enterococcus; Lactococcus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/885—Streptococcus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT91918590T 1990-11-07 1991-11-04 Produktion von hyaluronsäure ATE164185T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909024223A GB9024223D0 (en) 1990-11-07 1990-11-07 Production of hyaluronic acid

Publications (1)

Publication Number Publication Date
ATE164185T1 true ATE164185T1 (de) 1998-04-15

Family

ID=10685019

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91918590T ATE164185T1 (de) 1990-11-07 1991-11-04 Produktion von hyaluronsäure

Country Status (9)

Country Link
US (2) US5411874A (de)
EP (1) EP0556213B1 (de)
JP (1) JP3159983B2 (de)
AT (1) ATE164185T1 (de)
DE (1) DE69129118T2 (de)
DK (1) DK0556213T3 (de)
ES (1) ES2115620T3 (de)
GB (1) GB9024223D0 (de)
WO (1) WO1992008799A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9024223D0 (en) * 1990-11-07 1990-12-19 Fermentech Ltd Production of hyaluronic acid
IT1263393B (it) * 1993-07-30 1996-08-05 Fidia Advanced Biopolymers Srl Processo per la preparazione e purificazione di acido ialuronico ad alto peso molecolare
SE9401806D0 (sv) * 1994-05-26 1994-05-26 Pharmacia Ab Method and means for the production of hyaluronic acid
IT1271001B (it) * 1994-07-26 1997-05-26 Poli Ind Chimica Spa Procedimento di preparazione di acido ialuronico mediante fermentazione con streptococcus
IT1295935B1 (it) 1997-10-30 1999-05-28 Acs Dobfar Spa Derivati aminotiazolici utili nella preparazione di antibiotici b -lattamici
JP4298165B2 (ja) 1998-03-30 2009-07-15 メタボリックス，インコーポレイテッド 生体適合材料の製造のための微生物株およびプロセス
GB9902412D0 (en) * 1999-02-03 1999-03-24 Fermentech Med Ltd Process
GB9902652D0 (en) 1999-02-05 1999-03-31 Fermentech Med Ltd Process
ES2263674T5 (es) 2000-11-03 2011-04-01 Xvivo Perfusion Ab Disolución de evaluación y conservación .
US6660853B2 (en) * 2000-12-15 2003-12-09 Al Prescott Method for purifying high molecular weight hyaluronic acid
US6946551B2 (en) * 2003-03-12 2005-09-20 New Life Resources, Llc Preparation of hyaluronic acid from eggshell membrane
US20040180025A1 (en) * 2003-03-12 2004-09-16 New Life Resources, Llc Therapeutic, nutraceutical and cosmetic applications for eggshell membrane and processed eggshell membrane preparations
US20080063677A1 (en) * 2004-03-10 2008-03-13 New Life Resources, Llc Therapeutic, nutraceutical and cosmetic applications for eggshell membrane and processed eggshell membrane preparations
AU2003901834A0 (en) 2003-04-17 2003-05-01 Clearcoll Pty Ltd Cross-linked polysaccharide compositions
WO2005024038A2 (en) * 2003-09-11 2005-03-17 Nederlands Vaccininstituut Process for producing a capsular polysaccharide for use in conjugate vaccines
US8580315B2 (en) * 2004-03-10 2013-11-12 Esm Technologies, Llc Anti-inflammatory activity of eggshell membrane and processed eggshell membrane preparations
CN1293197C (zh) * 2004-03-23 2007-01-03 中国农业大学 一种用于乳酸菌发酵的增效剂
US20050281880A1 (en) * 2004-05-20 2005-12-22 Wei Wang Methods for making injectable polymer hydrogels
US7651702B2 (en) * 2004-05-20 2010-01-26 Mentor Corporation Crosslinking hyaluronan and chitosanic polymers
CN100431431C (zh) * 2004-05-25 2008-11-12 中国科学院南海海洋研究所 一种富含海洋天然牛磺酸的保健型味精及其制备方法
US7002007B2 (en) * 2004-05-28 2006-02-21 Calcigen Corporation Production of high molecular weight hyaluronates
ES2396955T3 (es) * 2006-07-06 2013-03-01 Reliance Life Sciences Pvt., Ltd. Procedimiento para la purificación de ácido hialurónico de elevado peso molecular
KR101509139B1 (ko) * 2006-11-23 2015-04-08 주식회사 엘지생명과학 히알루론산의 정제방법
US8466128B2 (en) 2007-01-30 2013-06-18 Cypress Pharmaceuticals, Inc. Hyaluronate compositions
US8759321B2 (en) * 2007-06-13 2014-06-24 Bausch & Lomb Incorporated Ophthalmic composition with hyaluronic acid and polymeric biguanide
CN101089021B (zh) * 2007-07-12 2010-04-14 华东理工大学 从微生物发酵液中分离提取透明质酸的方法
CA2705850C (en) * 2007-11-13 2016-07-19 Bio-Technology General (Israel) Ltd. Dilute filtration sterilization process for viscoelastic biopolymers
WO2011148116A2 (fr) 2010-05-27 2011-12-01 Laboratoire Idenov Acide hyaluronique modifie, procede de fabrication et utilisations
DE102011077393A1 (de) 2011-06-10 2012-12-13 Johannes Reinmüller Antiinfektives Mittel
CN102504047A (zh) * 2011-11-30 2012-06-20 上海景峰制药有限公司 一种玻璃酸钠发酵液的超滤方法
CN105504091A (zh) * 2013-07-30 2016-04-20 青岛九龙生物医药有限公司 从猪皮中提取透明质酸的方法
ITMI20131654A1 (it) * 2013-10-07 2015-04-07 Rosa Mario De Downstream di purificazione di acido ialuronico da brodi di coltura microbici
CA2896038C (en) * 2015-07-03 2022-08-09 Glycobiosciences Inc. Polymer matrix compositions comprising a high concentration of bio-fermented sodium hyaluronate and uses thereof
CN112553272B (zh) * 2020-12-24 2022-08-09 华熙生物科技股份有限公司 一种提高透明质酸产率的方法
EP4395796A4 (de) 2021-09-01 2024-12-25 Shanghai Qisheng Biological Preparation Co., Ltd. Knorpelregeneration mit injizierbaren, in situ polymerisierbaren collagenzusammensetzungen mit chondrozyten oder stammzellen
WO2023125689A1 (en) 2021-12-28 2023-07-06 Shanghai Qisheng Biological Preparation Co., Ltd. Hyaluronic acid-collagen copolymer compositions and medical applications thereof
CN115215949B (zh) * 2022-06-09 2024-01-05 浙江驭远生物科技有限公司 透明质酸钠及其提纯方法
EP4512395A1 (de) 2023-08-21 2025-02-26 Bio Even Zusammensetzung mit flavin-adenin-dinucleotid (fad), l-gsh, atp und myristinsäure, allein oder mit einem arzneimittel

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4517295A (en) * 1983-02-18 1985-05-14 Diagnostic, Inc. Hyaluronic acid from bacterial culture
US5093487A (en) * 1986-01-06 1992-03-03 Mobay Corporation Low viscosity high molecular weight filter sterilizable hyaluronic acid
NO161573C (no) * 1983-11-25 1989-08-30 Miles Inc Fremgangsmaate til fremstilling av hyaluronsyre.
JPS60251898A (ja) * 1984-05-25 1985-12-12 Shiseido Co Ltd 醗酵法によるヒアルロン酸の製造方法
DE3531612A1 (de) * 1984-09-04 1986-03-27 Chisso Corp., Osaka Verfahren zur herstellung von hyaluronsaeure
US4780414A (en) * 1985-01-18 1988-10-25 Bio-Technology General Corp. Method of producing high molecular weight sodium hyallronate by fermentation of streptococcus
US5202431A (en) * 1985-07-08 1993-04-13 Fidia, S.P.A. Partial esters of hyaluronic acid
US4851521A (en) * 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
JPS6232893A (ja) * 1985-08-01 1987-02-12 Kyowa Hakko Kogyo Co Ltd ヒアルロン酸の製造法
US5023175A (en) * 1986-05-01 1991-06-11 Kabushiki Kaisha Yakult Honsha Novel production process of hyaluronic acid and bacterium strain therefor
US4946780A (en) * 1988-10-12 1990-08-07 Denkl Kagaku Kogyo Kabushiki Kaisha Method for producing sodium hyaluronate by fermentation method
US4897349A (en) * 1989-04-28 1990-01-30 Medchem Products, Inc. Biosynthesis of hyaluronic acid
GB9024223D0 (en) * 1990-11-07 1990-12-19 Fermentech Ltd Production of hyaluronic acid

Also Published As

Publication number Publication date
US5563051A (en) 1996-10-08
DE69129118T2 (de) 1998-11-19
EP0556213B1 (de) 1998-03-18
JPH06505146A (ja) 1994-06-16
US5411874A (en) 1995-05-02
DE69129118D1 (de) 1998-04-23
EP0556213A1 (de) 1993-08-25
DK0556213T3 (da) 1998-12-21
GB9024223D0 (en) 1990-12-19
ES2115620T3 (es) 1998-07-01
JP3159983B2 (ja) 2001-04-23
WO1992008799A1 (en) 1992-05-29

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time