ATE164582T1 - 1-methylcarbapenemderivate und verfahren zu ihrer herstellung - Google Patents
1-methylcarbapenemderivate und verfahren zu ihrer herstellungInfo
- Publication number
- ATE164582T1 ATE164582T1 AT91115083T AT91115083T ATE164582T1 AT E164582 T1 ATE164582 T1 AT E164582T1 AT 91115083 T AT91115083 T AT 91115083T AT 91115083 T AT91115083 T AT 91115083T AT E164582 T1 ATE164582 T1 AT E164582T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- hydrogen atom
- methylcarbapenem derivatives
- methylcarbapenem
- derivatives
- Prior art date
Links
- YKMONJZIUAOVEM-GDVGLLTNSA-N (5S)-4-methyl-1-azabicyclo[3.2.0]hept-2-en-7-one Chemical class CC1C=CN2[C@H]1CC2=O YKMONJZIUAOVEM-GDVGLLTNSA-N 0.000 title abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23842090 | 1990-09-07 | ||
| JP7028591 | 1991-01-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE164582T1 true ATE164582T1 (de) | 1998-04-15 |
Family
ID=26411452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91115083T ATE164582T1 (de) | 1990-09-07 | 1991-09-06 | 1-methylcarbapenemderivate und verfahren zu ihrer herstellung |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5153187A (de) |
| EP (1) | EP0474243B1 (de) |
| JP (1) | JPH0745500B2 (de) |
| KR (1) | KR0148379B1 (de) |
| CN (1) | CN1033455C (de) |
| AT (1) | ATE164582T1 (de) |
| AU (1) | AU630574B2 (de) |
| CA (1) | CA2050255C (de) |
| DE (1) | DE69129175T2 (de) |
| DK (1) | DK0474243T3 (de) |
| ES (1) | ES2115600T3 (de) |
| FI (2) | FI95470C (de) |
| HU (2) | HU211122B (de) |
| IE (1) | IE913065A1 (de) |
| IL (1) | IL99399A0 (de) |
| SG (1) | SG49607A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU644008B2 (en) * | 1990-08-10 | 1993-12-02 | Sumitomo Pharmaceuticals Company, Limited | Beta-lactam compounds, and their production and use |
| JP2569455B2 (ja) * | 1992-03-06 | 1997-01-08 | 田辺製薬株式会社 | β−ラクタム誘導体の製法 |
| EP0937725A3 (de) | 1992-04-28 | 2004-12-01 | Tanabe Seiyaku Co., Ltd. | Verfahren, um eine geschützte HO-Gruppe freizumachen |
| US5587474A (en) * | 1992-06-18 | 1996-12-24 | Tanabe Seiyaku Co., Ltd. | Method for removing the protecting group for carboxyl group |
| US5442055A (en) * | 1992-11-13 | 1995-08-15 | Tanabe Seiyaku Co., Ltd. | Azetidinone compound and process for preparation thereof |
| US5631363A (en) * | 1992-11-13 | 1997-05-20 | Tanabe Seiyaku Co., Ltd. | Azetidinone compound and process for preparation thereof |
| US6011150A (en) * | 1992-11-13 | 2000-01-04 | Tanabe Seiyaku Co., Ltd. | Azetidinone compound and process for preparation thereof |
| US5495012A (en) * | 1992-12-28 | 1996-02-27 | Tanabe Seiyaku Co., Ltd. | Process for preparing optically active 4-mercapto-2-pyrrolidone derivative and intermediate therefor |
| JP2701685B2 (ja) * | 1992-12-28 | 1998-01-21 | 田辺製薬株式会社 | 光学活性４−メルカプト−２−ピロリドン誘導体及びその合成中間体の製法 |
| EP0704446A4 (de) * | 1993-06-16 | 1996-06-12 | Sumitomo Pharma | Neue beta-lactamverbindung und ein verfahren zu ihrer herstellung |
| US5550229A (en) * | 1993-06-23 | 1996-08-27 | Tanabe Seiyaku Co., Ltd. | Alkylation process for preparing azetidinone compound and starting compound therefor |
| WO1996007655A1 (en) * | 1994-09-06 | 1996-03-14 | Banyu Pharmaceutical Co., Ltd. | Novel carbapenem derivative |
| JP2969616B2 (ja) | 1994-11-24 | 1999-11-02 | 田辺製薬株式会社 | ４−メルカプトピロリジン化合物の製法 |
| WO1997041853A1 (en) | 1996-05-09 | 1997-11-13 | Sankyo Company, Limited | Anti-helicobacter pylori compositions containing 1-methylcarbapenem derivatives as the active ingredient |
| JPH1077285A (ja) | 1996-09-04 | 1998-03-24 | Sumitomo Pharmaceut Co Ltd | 新規なβ−ラクタム化合物およびその製造法 |
| KR100377448B1 (ko) | 2000-08-10 | 2003-03-26 | 동화약품공업주식회사 | 카바페넴 항생물질의 중간체 및 그의 제조방법 |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| JP4377231B2 (ja) | 2001-11-05 | 2009-12-02 | 大日本住友製薬株式会社 | 新規なカルバペネム化合物 |
| WO2004089954A1 (ja) | 2003-04-08 | 2004-10-21 | Sumitomo Pharmaceuticals Co., Ltd. | 新規なカルバペネム化合物 |
| CA2577924A1 (en) * | 2004-09-03 | 2006-03-09 | Dainippon Sumitomo Pharma Co., Ltd. | Novel carbapenem compound |
| JPWO2006103999A1 (ja) * | 2005-03-25 | 2008-09-04 | 大日本住友製薬株式会社 | 新規なカルバペネム化合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60202886A (ja) * | 1984-03-27 | 1985-10-14 | Sankyo Co Ltd | １―置換カルバペネム―３―カルボン酸誘導体 |
| KR880006244A (ko) * | 1986-11-24 | 1988-07-22 | 후지사와 도모 기찌 로 | 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법 |
| DE68919508T2 (de) * | 1988-04-01 | 1995-07-20 | Sankyo Co | 2-(Heterocyclylthio)carbapenemderivate, deren Herstellung und deren Verwendung als Antibiotika. |
-
1991
- 1991-08-29 CA CA002050255A patent/CA2050255C/en not_active Expired - Fee Related
- 1991-08-30 AU AU83479/91A patent/AU630574B2/en not_active Ceased
- 1991-08-30 IE IE306591A patent/IE913065A1/en not_active Application Discontinuation
- 1991-09-04 IL IL99399A patent/IL99399A0/xx unknown
- 1991-09-05 FI FI914187A patent/FI95470C/fi active
- 1991-09-05 JP JP3305725A patent/JPH0745500B2/ja not_active Expired - Lifetime
- 1991-09-06 ES ES91115083T patent/ES2115600T3/es not_active Expired - Lifetime
- 1991-09-06 SG SG1996000874A patent/SG49607A1/en unknown
- 1991-09-06 HU HU912884A patent/HU211122B/hu not_active IP Right Cessation
- 1991-09-06 DK DK91115083T patent/DK0474243T3/da active
- 1991-09-06 US US07/755,884 patent/US5153187A/en not_active Expired - Lifetime
- 1991-09-06 EP EP91115083A patent/EP0474243B1/de not_active Expired - Lifetime
- 1991-09-06 DE DE69129175T patent/DE69129175T2/de not_active Expired - Fee Related
- 1991-09-06 AT AT91115083T patent/ATE164582T1/de not_active IP Right Cessation
- 1991-09-07 CN CN91108869A patent/CN1033455C/zh not_active Expired - Fee Related
- 1991-09-07 KR KR1019910015637A patent/KR0148379B1/ko not_active Expired - Fee Related
-
1995
- 1995-05-03 FI FI952101A patent/FI100399B/fi active
- 1995-06-28 HU HU95P/P00516P patent/HU211892A9/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69129175D1 (de) | 1998-05-07 |
| DK0474243T3 (da) | 1998-12-07 |
| EP0474243A1 (de) | 1992-03-11 |
| KR920006358A (ko) | 1992-04-27 |
| SG49607A1 (en) | 1998-06-15 |
| CA2050255A1 (en) | 1992-03-08 |
| CN1033455C (zh) | 1996-12-04 |
| FI914187L (fi) | 1992-03-08 |
| FI95470B (fi) | 1995-10-31 |
| EP0474243B1 (de) | 1998-04-01 |
| CA2050255C (en) | 1997-02-04 |
| FI100399B (fi) | 1997-11-28 |
| AU8347991A (en) | 1992-03-12 |
| FI952101L (fi) | 1995-05-03 |
| KR0148379B1 (ko) | 1998-11-02 |
| JPH0745500B2 (ja) | 1995-05-17 |
| CN1060093A (zh) | 1992-04-08 |
| HUT59410A (en) | 1992-05-28 |
| FI952101A0 (fi) | 1995-05-03 |
| HU211122B (en) | 1995-10-30 |
| FI914187A0 (fi) | 1991-09-05 |
| AU630574B2 (en) | 1992-10-29 |
| US5153187A (en) | 1992-10-06 |
| HU211892A9 (en) | 1995-12-28 |
| ES2115600T3 (es) | 1998-07-01 |
| FI95470C (fi) | 1996-02-12 |
| IL99399A0 (en) | 1992-08-18 |
| IE913065A1 (en) | 1992-03-11 |
| JPH04279588A (ja) | 1992-10-05 |
| DE69129175T2 (de) | 1998-09-03 |
| HU912884D0 (en) | 1992-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |