ATE165866T1 - Monoklonale antikörper gegen das mikrotubulusassoziierte tauprotein,hybridomen, die diese antikörper sezernieren, antigenerkennung durch diese monoklonalen antikörper und deren verwendung - Google Patents
Monoklonale antikörper gegen das mikrotubulusassoziierte tauprotein,hybridomen, die diese antikörper sezernieren, antigenerkennung durch diese monoklonalen antikörper und deren verwendungInfo
- Publication number
- ATE165866T1 ATE165866T1 AT94903752T AT94903752T ATE165866T1 AT E165866 T1 ATE165866 T1 AT E165866T1 AT 94903752 T AT94903752 T AT 94903752T AT 94903752 T AT94903752 T AT 94903752T AT E165866 T1 ATE165866 T1 AT E165866T1
- Authority
- AT
- Austria
- Prior art keywords
- monoclonal antibodies
- tau protein
- pct
- antibodies
- microtubulus
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP92403403 | 1992-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE165866T1 true ATE165866T1 (de) | 1998-05-15 |
Family
ID=8211736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94903752T ATE165866T1 (de) | 1992-12-14 | 1993-12-10 | Monoklonale antikörper gegen das mikrotubulusassoziierte tauprotein,hybridomen, die diese antikörper sezernieren, antigenerkennung durch diese monoklonalen antikörper und deren verwendung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5843779A (de) |
| EP (1) | EP0673418B1 (de) |
| JP (1) | JP2879975B2 (de) |
| AT (1) | ATE165866T1 (de) |
| AU (1) | AU690092B2 (de) |
| DE (1) | DE69318420T2 (de) |
| DK (1) | DK0673418T3 (de) |
| ES (1) | ES2118373T3 (de) |
| WO (1) | WO1994013795A1 (de) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5811310A (en) * | 1986-09-30 | 1998-09-22 | Albert Einstein College Of Medicine Of Yeshiva Univ. | The Alz-50 monoclonal antibody and diagnostic assay for alzheimer's disease |
| DK0610330T3 (da) * | 1991-10-25 | 1998-01-26 | Innogenetics Nv | Monoklonale antistoffer mod microtubulus-associeret protein tau |
| US6121003A (en) * | 1994-07-29 | 2000-09-19 | Innogentics N.V. | Monoclonal antibodies specific for an epitope of phosphorylated tau, and their use |
| US6797478B1 (en) * | 1998-03-05 | 2004-09-28 | University Of Cincinnati | Method of detecting axonal damage, from associated disease states using tau monoclonal antibodies |
| CN1325491A (zh) * | 1998-09-08 | 2001-12-05 | 基因创新有限公司 | 作为早期CNS损伤标记物的τ |
| CA2361013A1 (en) * | 1999-01-25 | 2000-07-27 | Minerva Biotechnologies Corporation | Rapid and sensitive detection of aberrant protein aggregation in neurodegenerative diseases |
| WO2001023894A1 (de) * | 1999-09-28 | 2001-04-05 | Evotec Oai Ag | Quantitative analyse und typisierung subzellulärer partikel |
| BR0107851A (pt) * | 2000-01-24 | 2002-10-29 | Innogenetics Nv | Diagnose de tauopatia |
| US20030162230A1 (en) | 2000-09-27 | 2003-08-28 | Reagan Kevin J. | Method for quantifying phosphokinase activity on proteins |
| WO2004081534A2 (en) * | 2003-03-12 | 2004-09-23 | Assay Designs, Inc. | Phosphokinase assay |
| CA2445420A1 (en) | 2003-07-29 | 2005-01-29 | Invitrogen Corporation | Kinase and phosphatase assays |
| US7619059B2 (en) | 2003-07-29 | 2009-11-17 | Life Technologies Corporation | Bimolecular optical probes |
| US7727752B2 (en) | 2003-07-29 | 2010-06-01 | Life Technologies Corporation | Kinase and phosphatase assays |
| WO2005080986A1 (en) * | 2004-02-18 | 2005-09-01 | University Of Iowa Research Foundation | Antibodies to phosphorylated tau, methods of making and methods of use |
| US20070178447A1 (en) * | 2006-01-31 | 2007-08-02 | Bethyl Laboratories, Inc. | Method for decreasing interference in results of immunochemical methods |
| EP3978517A1 (de) * | 2009-03-18 | 2022-04-06 | AC Immune SA | Verfahren zur therapeutischen verwendung |
| UA107571C2 (xx) | 2009-04-03 | 2015-01-26 | Фармацевтична композиція | |
| SG189174A1 (en) | 2010-10-11 | 2013-05-31 | Biogen Idec Internat Neuroscience Gmbh | Human anti-tau antibodies |
| WO2012142301A2 (en) | 2011-04-12 | 2012-10-18 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury |
| GB201111361D0 (en) * | 2011-07-04 | 2011-08-17 | Nordic Bioscience As | Biochemical markers for neurodegenerative conditions |
| EP2834270B1 (de) | 2012-04-05 | 2019-10-30 | AC Immune S.A. | Humanisierter tau-antikörper |
| DK2885010T3 (da) | 2012-08-16 | 2020-02-03 | Ipierian Inc | Fremgangsmåder til behandling med tauopati |
| US9200068B2 (en) | 2012-12-18 | 2015-12-01 | Regents Of The University Of Minnesota | Compositions and methods related to tauopathy |
| HRP20201422T1 (hr) | 2012-12-21 | 2021-02-19 | Biogen Ma Inc. | Ljudska anti-tau antitijela |
| US8980270B2 (en) | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
| MX375354B (es) | 2013-03-13 | 2025-03-06 | Prothena Biosciences Ltd | Anticuerpos que se unen a tau y usos de los mismos. |
| BR112015023262B8 (pt) | 2013-03-15 | 2024-02-06 | Ac Immune Sa | Anticorpo isolado, imunoconjugado, formulação farmacêutica e usos do anticorpo |
| JP2017512751A (ja) | 2014-02-14 | 2017-05-25 | アイピエリアン,インコーポレイティド | タウペプチド、抗タウ抗体、およびそれらの使用方法 |
| CA3022673A1 (en) | 2016-05-02 | 2017-11-09 | Prothena Biosciences Limited | Tau immunotherapy |
| CA3022515A1 (en) | 2016-05-02 | 2017-11-09 | Prothena Biosciences Limited | Antibodies recognizing tau |
| KR102784294B1 (ko) | 2017-05-02 | 2025-03-19 | 프로테나 바이오사이언시즈 리미티드 | 타우 인식 항체 |
| EA202091012A1 (ru) | 2017-10-25 | 2020-08-27 | Янссен Фармасьютикалз, Инк. | Композиции фосфорилированных тау-пептидов и их применения |
| US20220018856A1 (en) | 2018-11-22 | 2022-01-20 | Fujirebio Inc. | Antibody conjugate |
| CN113710269A (zh) | 2019-02-08 | 2021-11-26 | Ac免疫有限公司 | 磷酸化Tau肽疫苗的安全施用方法 |
| CN119371527A (zh) | 2019-03-03 | 2025-01-28 | 普罗塞纳生物科学有限公司 | 识别tau的抗体 |
| MA55902A (fr) | 2019-04-24 | 2022-03-16 | Ac Immune Sa | Administration hétérologue de vaccins tau |
| EP4040153A4 (de) * | 2019-09-30 | 2023-07-26 | Nipro Corporation | Verfahren zum nachweis von tau-protein unter verwendung einer blutprobe als probe |
| BR112022020753A2 (pt) | 2020-04-15 | 2022-12-20 | Voyager Therapeutics Inc | Compostos de ligação a tau |
| CN111349617B (zh) * | 2020-05-25 | 2020-09-22 | 苏州仁端生物医药科技有限公司 | 一种分泌抗Tau或pTau-181/231/396单克隆抗体杂交瘤细胞株及其应用 |
| JP2023554382A (ja) | 2020-12-16 | 2023-12-27 | ボイジャー セラピューティクス インコーポレイテッド | タウ結合化合物 |
| WO2022144406A1 (en) | 2020-12-29 | 2022-07-07 | Neurimmune Ag | Human anti-tau antibodies |
| CN113005096B (zh) * | 2021-01-19 | 2022-10-14 | 华中科技大学 | 分泌抗丝氨酸磷酸化tau蛋白单克隆抗体的杂交瘤细胞株 |
| CN114539400B (zh) * | 2022-02-15 | 2024-06-07 | 武汉天德生物科技有限公司 | 一种磷酸化Tau pT217蛋白单克隆抗体、ELISA试剂盒及其应用 |
| WO2023250388A1 (en) | 2022-06-22 | 2023-12-28 | Voyager Therapeutics, Inc. | Tau binding compounds |
| CN120019071A (zh) | 2022-09-15 | 2025-05-16 | 沃雅戈治疗公司 | Tau结合化合物 |
-
1993
- 1993-12-10 DK DK94903752T patent/DK0673418T3/da active
- 1993-12-10 US US08/244,951 patent/US5843779A/en not_active Expired - Lifetime
- 1993-12-10 EP EP94903752A patent/EP0673418B1/de not_active Expired - Lifetime
- 1993-12-10 DE DE69318420T patent/DE69318420T2/de not_active Expired - Lifetime
- 1993-12-10 AU AU58097/94A patent/AU690092B2/en not_active Expired
- 1993-12-10 WO PCT/EP1993/003499 patent/WO1994013795A1/en not_active Ceased
- 1993-12-10 AT AT94903752T patent/ATE165866T1/de active
- 1993-12-10 ES ES94903752T patent/ES2118373T3/es not_active Expired - Lifetime
- 1993-12-10 JP JP6513790A patent/JP2879975B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2118373T3 (es) | 1998-09-16 |
| DE69318420D1 (de) | 1998-06-10 |
| JP2879975B2 (ja) | 1999-04-05 |
| DE69318420T2 (de) | 1999-01-28 |
| US5843779A (en) | 1998-12-01 |
| AU5809794A (en) | 1994-07-04 |
| EP0673418A1 (de) | 1995-09-27 |
| AU690092B2 (en) | 1998-04-23 |
| DK0673418T3 (da) | 1999-03-01 |
| EP0673418B1 (de) | 1998-05-06 |
| JPH08502898A (ja) | 1996-04-02 |
| WO1994013795A1 (en) | 1994-06-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69318420D1 (de) | Monoklonale antikörper gegen das mikrotubulusassoziierte tauprotein,hybridomen, die diese antikörper sezernieren, antigenerkennung durch diese monoklonalen antikörper und deren verwendung | |
| ATE154642T1 (de) | Monoklonale antikörper gegen das mikrotubulusassoziierte protein tau. | |
| Hamsten et al. | Identification of galactose‐α‐1, 3‐galactose in the gastrointestinal tract of the tick I xodes ricinus; possible relationship with red meat allergy | |
| Plotz et al. | Assignment of direct and facilitated hemolytic plaques in mice to specific immunoglobulin classes | |
| Lampe et al. | Polyclonal B cell activation by the Eta-1 cytokine and the development of systemic autoimmune disease | |
| NO976122D0 (no) | AntiFasligandantistoffer og analysefremgangsmåte hvor disse anvendes | |
| ATE234324T1 (de) | Monoklonale antikörper gegen ein epitop einer gewissen unterklasse oder form von phosphoryliertem tau, hybridome die diese sezernieren,antigenerkennung durch diese antikörper und deren verwendung | |
| Guillet et al. | beta-Adrenergic agonist activity of a monoclonal anti-idiotypic antibody. | |
| ATE208820T1 (de) | Humanisierte antikoerper | |
| ATE302411T1 (de) | Diagnose, prophylaxe und behandlung von morbus crohn durch die verwendung des ompc antigens | |
| GR3025630T3 (en) | Monoclonal antibody against human IgE | |
| CY1110144T1 (el) | Αντισωματα για την ταυτοποιηση και/ή την απομονωση τουλαχιστον ενος κυτταρικου πληθυσμου ο οποιος επιλεγεται απο την ομαδα την περιλαμβανουσα αιμοποιητικα βλαστοκυτταρα, νευρικα βλαστοκυτταρα, νευρικα αρχεγονα κυτταρα, μεσεγχυματικα βλαστοκυτταρα και μεσεγχυματικα αρχεγονα κυτταρα | |
| SE9401460D0 (sv) | Antigen/antibody specificity exhanger | |
| Thomas | Antibodies specific for human T lymphocytes in cold agglutinin and lymphocytotoxic sera | |
| ATE230418T1 (de) | Monoklonaler antikörper gegen das humane mx- protein mxa | |
| NO972522L (no) | Monoklonale antistoffer med immunoundertrykkende aktivitet | |
| Quan et al. | Human amniotic IgA inhibits natural IgG autoantibodies of maternal or unrelated origin | |
| ATE77243T1 (de) | E87ag-antigen des pseudomonas aeruginosa, monoklonale antikoerper dagegen und hybridom. | |
| CA2150816A1 (en) | Monoclonal antibodies directed against the microtubule- associated protein tau, hybridomas secreting these antibodies, antigen recognition by these monoclonal antibodies and theirapplications | |
| Mudawwar et al. | Regulation of monoclonal immunoglobulin G synthesis by antiidiotypic antibody in a patient with hypogammaglobulinemia. | |
| KR890016165A (ko) | 수도모나스 아에루기노사(Pseudomonas aeruginosa)에 대한 모노클로날 항체, 이의 제조방법 및 용도 | |
| ES2061664T3 (es) | Anticuerpos monoclonales que reconocen a alfa-hanp y correspondientes hibridomas, su preparacion y uso. | |
| ATE144286T1 (de) | Monoklonale antikörper gegen den plasmin- antiplasmin komplex, verfahren zu ihrer herstellung sowie ihre verwendung | |
| van Ree et al. | A sensitive monoclonal antibody sandwich ELISA for the measurement of the major olive pollen allergen Ole e 1 | |
| Sthoeger et al. | Anticardiolipin, but not the 166 Id anti-DNA antibody induces pregnancy failure |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |