ATE166655T1 - 1,5-anhydrohexitolnukleosidanaloge und pharmazeutische verwendung davon - Google Patents

1,5-anhydrohexitolnukleosidanaloge und pharmazeutische verwendung davon

Info

Publication number: ATE166655T1
Authority: AT; Austria
Prior art keywords: group; unsubstituted; substituted; hydrogen; virus
Prior art date: 1992-06-18

Application number

AT93912478T

Other languages

English (en)

Inventor

Clercq Erik Desire Alice De

Piet Andre Maurits Herdewijn

Aerschot Arthur Albert Edg Van

Original Assignee

Stichting Rega V Z W

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-18

Filing date

1993-06-18

Publication date

1998-06-15

1993-06-18 Application filed by Stichting Rega V Z W filed Critical Stichting Rega V Z W

1998-06-15 Application granted granted Critical

1998-06-15 Publication of ATE166655T1 publication Critical patent/ATE166655T1/de

Links

MPCAJMNYNOGXPB-UHFFFAOYSA-N 1,5-Anhydro-mannit Natural products OCC1OCC(O)C(O)C1O MPCAJMNYNOGXPB-UHFFFAOYSA-N 0.000 title abstract 3
-1 1,5-ANHYDROHEXITOL NUCLEOSIDE Chemical class 0.000 title abstract 2
239000002777 nucleoside Substances 0.000 title 1
KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical group N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
229940127073 nucleoside analogue Drugs 0.000 abstract 2
241000701085 Human alphaherpesvirus 3 Species 0.000 abstract 1
241000700584 Simplexvirus Species 0.000 abstract 1
241000700605 Viruses Species 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
125000003435 aroyl group Chemical group 0.000 abstract 1
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
FBPFZTCFMRRESA-UHFFFAOYSA-N hexane-1,2,3,4,5,6-hexol Chemical compound OCC(O)C(O)C(O)C(O)CO FBPFZTCFMRRESA-UHFFFAOYSA-N 0.000 abstract 1
LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Virology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT93912478T 1992-06-18 1993-06-18 1,5-anhydrohexitolnukleosidanaloge und pharmazeutische verwendung davon ATE166655T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP92201803		1992-06-18

Publications (1)

Publication Number	Publication Date
ATE166655T1 true ATE166655T1 (de)	1998-06-15

Family

ID=8210706

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93912478T ATE166655T1 (de)	1992-06-18	1993-06-18	1,5-anhydrohexitolnukleosidanaloge und pharmazeutische verwendung davon

Country Status (12)

Country	Link
US (2)	US5607922A (de)
EP (1)	EP0646125B1 (de)
JP (1)	JPH08501071A (de)
AT (1)	ATE166655T1 (de)
AU (1)	AU671129B2 (de)
CA (1)	CA2138415A1 (de)
DE (1)	DE69318836T2 (de)
DK (1)	DK0646125T3 (de)
ES (1)	ES2117134T3 (de)
GR (1)	GR3027651T3 (de)
NL (1)	NL9300058A (de)
WO (1)	WO1993025565A1 (de)

Families Citing this family (42)

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JPH06263793A (ja) *	1993-03-04	1994-09-20	Asahi Breweries Ltd	ピラノース型ヌクレオシド誘導体
NZ292140A (en) *	1994-08-17	1998-02-26	Stichting Rega V Z W	Oligomers consisting of 1,5-anhydrohexitol nucleosides, antisence techniques.
FI971413L (fi) *	1994-10-05	1997-04-04	Chiroscience Ltd	Puriini- ja guaniiniyhdisteet PNP:n estäjinä
AU1874397A (en) *	1996-02-16	1997-09-02	Stichting Rega Vzw	Hexitol containing oligonucleotides and their use in antisense strategies
US20040161777A1 (en) *	1996-06-06	2004-08-19	Baker Brenda F.	Modified oligonucleotides for use in RNA interference
US20050118605A9 (en) *	1996-06-06	2005-06-02	Baker Brenda F.	Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation
US20040171028A1 (en) *	1996-06-06	2004-09-02	Baker Brenda F.	Phosphorous-linked oligomeric compounds and their use in gene modulation
US20050042647A1 (en) *	1996-06-06	2005-02-24	Baker Brenda F.	Phosphorous-linked oligomeric compounds and their use in gene modulation
US20040266706A1 (en) *	2002-11-05	2004-12-30	Muthiah Manoharan	Cross-linked oligomeric compounds and their use in gene modulation
US20040161844A1 (en) *	1996-06-06	2004-08-19	Baker Brenda F.	Sugar and backbone-surrogate-containing oligomeric compounds and compositions for use in gene modulation
US7812149B2 (en) *	1996-06-06	2010-10-12	Isis Pharmaceuticals, Inc.	2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
US20080119427A1 (en) *	1996-06-06	2008-05-22	Isis Pharmaceuticals, Inc.	Double Strand Compositions Comprising Differentially Modified Strands for Use in Gene Modulation
US20040171032A1 (en) *	1996-06-06	2004-09-02	Baker Brenda F.	Non-phosphorous-linked oligomeric compounds and their use in gene modulation
US20050053976A1 (en) *	1996-06-06	2005-03-10	Baker Brenda F.	Chimeric oligomeric compounds and their use in gene modulation
US5898031A (en) *	1996-06-06	1999-04-27	Isis Pharmaceuticals, Inc.	Oligoribonucleotides for cleaving RNA
US9096636B2 (en) *	1996-06-06	2015-08-04	Isis Pharmaceuticals, Inc.	Chimeric oligomeric compounds and their use in gene modulation
US20040203024A1 (en) *	1996-06-06	2004-10-14	Baker Brenda F.	Modified oligonucleotides for use in RNA interference
US20040171030A1 (en) *	1996-06-06	2004-09-02	Baker Brenda F.	Oligomeric compounds having modified bases for binding to cytosine and uracil or thymine and their use in gene modulation
JP2003508533A (ja) *	1999-09-10	2003-03-04	スティヒティング・レガ・ヴェー・ゼット・ウェー	炭素環式ヌクレオシドとその製造方法
US7138531B2 (en) *	2001-10-15	2006-11-21	Kemin Pharma B.V.B.A.	Preparation and use of carbohydrate-based bicyclic ring structures with antimicrobial and cytostatic activity
WO2004041889A2 (en) *	2002-11-05	2004-05-21	Isis Pharmaceuticals, Inc.	Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
US9150606B2 (en) *	2002-11-05	2015-10-06	Isis Pharmaceuticals, Inc.	Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
US9150605B2 (en)	2002-11-05	2015-10-06	Isis Pharmaceuticals, Inc.	Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
AU2003291755A1 (en) *	2002-11-05	2004-06-07	Isis Pharmaceuticals, Inc.	Oligomers comprising modified bases for binding cytosine and uracil or thymine and their use
US7560231B2 (en)	2002-12-20	2009-07-14	Roche Molecular Systems, Inc.	Mannitol and glucitol derivatives
CA2463719A1 (en) *	2003-04-05	2004-10-05	F. Hoffmann-La Roche Ag	Nucleotide analogs with six membered rings
EP1636342A4 (de) *	2003-06-20	2008-10-08	Isis Pharmaceuticals Inc	Oligomere verbindungen zur verwendung bei der modulation von genen
US8569474B2 (en) *	2004-03-09	2013-10-29	Isis Pharmaceuticals, Inc.	Double stranded constructs comprising one or more short strands hybridized to a longer strand
US8394947B2 (en) *	2004-06-03	2013-03-12	Isis Pharmaceuticals, Inc.	Positionally modified siRNA constructs
US7884086B2 (en) *	2004-09-08	2011-02-08	Isis Pharmaceuticals, Inc.	Conjugates for use in hepatocyte free uptake assays
WO2007090071A2 (en)	2006-01-27	2007-08-09	Isis Pharmaceuticals, Inc.	6-modified bicyclic nucleic acid analogs
JP2009536222A (ja)	2006-05-05	2009-10-08	アイシスファーマシューティカルズ，インコーポレーテッド	Ｐｃｓｋ９の発現を調節するための化合物および方法
AU2007249349B2 (en) *	2006-05-11	2012-03-08	Isis Pharmaceuticals, Inc.	5'-Modified bicyclic nucleic acid analogs
US7666854B2 (en) *	2006-05-11	2010-02-23	Isis Pharmaceuticals, Inc.	Bis-modified bicyclic nucleic acid analogs
KR101654007B1 (ko)	2007-08-15	2016-09-05	아이오니스 파마수티컬즈, 인코포레이티드	테트라하이드로피란 핵산 유사체
WO2009100320A2 (en) *	2008-02-07	2009-08-13	Isis Pharmaceuticals, Inc.	Bicyclic cyclohexitol nucleic acid analogs
US20120021515A1 (en)	2009-02-06	2012-01-26	Swayze Eric E	Oligomeric compounds and methods
US8536320B2 (en)	2009-02-06	2013-09-17	Isis Pharmaceuticals, Inc.	Tetrahydropyran nucleic acid analogs
US8496917B2 (en) *	2009-11-13	2013-07-30	Sytheon Ltd	Compositions and methods for improving skin appearance
EP2601204B1 (de)	2010-04-28	2016-09-07	Ionis Pharmaceuticals, Inc.	Modifizierte nukleoside und daraus hergestellte oligomere verbindungen
AU2012308320C1 (en)	2011-09-14	2018-08-23	Translate Bio Ma, Inc.	Multimeric oligonucleotide compounds
WO2015168172A1 (en)	2014-04-28	2015-11-05	Isis Pharmaceuticals, Inc.	Linkage modified oligomeric compounds

Family Cites Families (4)

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Publication number	Priority date	Publication date	Assignee	Title
DE3650741T2 (de) *	1985-09-17	2000-10-12	The Wellcome Foundation Ltd., Greenford	Kombination therapeutische Nukleoside mit weiteren therapeutisch wirksamen Komponenten.
US4997926A (en) *	1987-11-18	1991-03-05	Scripps Clinic And Research Foundation	Deaminase-stable anti-retroviral 2-halo-2',3'-dideoxy
SE8802687D0 (sv) *	1988-07-20	1988-07-20	Astra Ab	Nucleoside derivatives
DD293498A5 (de) *	1989-07-20	1991-09-05	Zi Fuer Molekularbiologie Der Adw,De	Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier

1993
- 1993-01-12 NL NL9300058A patent/NL9300058A/nl not_active Application Discontinuation
- 1993-06-18 AT AT93912478T patent/ATE166655T1/de not_active IP Right Cessation
- 1993-06-18 CA CA002138415A patent/CA2138415A1/en not_active Abandoned
- 1993-06-18 ES ES93912478T patent/ES2117134T3/es not_active Expired - Lifetime
- 1993-06-18 AU AU43013/93A patent/AU671129B2/en not_active Ceased
- 1993-06-18 WO PCT/BE1993/000036 patent/WO1993025565A1/en not_active Ceased
- 1993-06-18 DE DE69318836T patent/DE69318836T2/de not_active Expired - Fee Related
- 1993-06-18 DK DK93912478T patent/DK0646125T3/da active
- 1993-06-18 EP EP93912478A patent/EP0646125B1/de not_active Expired - Lifetime
- 1993-06-18 JP JP6500978A patent/JPH08501071A/ja active Pending
- 1993-12-17 US US08/170,117 patent/US5607922A/en not_active Expired - Fee Related
1995
- 1995-06-07 US US08/482,823 patent/US5668113A/en not_active Expired - Fee Related
1998
- 1998-08-14 GR GR980401826T patent/GR3027651T3/el unknown

Also Published As

Publication number	Publication date
US5607922A (en)	1997-03-04
DE69318836T2 (de)	1999-01-28
US5668113A (en)	1997-09-16
ES2117134T3 (es)	1998-08-01
WO1993025565A1 (en)	1993-12-23
AU671129B2 (en)	1996-08-15
EP0646125B1 (de)	1998-05-27
DK0646125T3 (da)	1999-03-22
CA2138415A1 (en)	1993-12-23
EP0646125A1 (de)	1995-04-05
NL9300058A (nl)	1994-01-17
JPH08501071A (ja)	1996-02-06
DE69318836D1 (de)	1998-07-02
GR3027651T3 (en)	1998-11-30
AU4301393A (en)	1994-01-04

Legal Events

Date	Code	Title	Description
1998-11-15	UEP	Publication of translation of european patent specification
2000-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE166655T1 (de)	1998-06-15	1,5-anhydrohexitolnukleosidanaloge und pharmazeutische verwendung davon
NO885768L (no)	1989-06-29	Fremgangsmaate for fremstilling av antivirale purinyl- og pyrimidinyl-cyklobutaner.
ATE295849T1 (de)	2005-06-15	Aryl-ester phosphoramidatderivate von 2',3'- didehydronukleoside
ATE67768T1 (de)	1991-10-15	Nukleosid-derivate und ihre verwendung in der oligonukleosid-synthese.
ES455979A1 (es)	1978-01-16	Un procedimiento para preparar una purina sustituida.
GR3025395T3 (en)	1998-02-27	Hydroxymethyl(methylenecyclopentyl)Purines and Pyrimidines
DE69110854D1 (de)	1995-08-03	Antivirusderivate von (Phosphonmethoxy)Methoxy Purin/Pyrimidin.
ATE170846T1 (de)	1998-09-15	Antivirale nukleosidanaloge
CA2366624A1 (en)	2000-09-14	2-hydroxy methylcyclopro pylidenemethyl purines and -pyrimidines as antiviral agents
ATE207077T1 (de)	2001-11-15	Nucleosid-derivate mit photolabilen schutzgruppen
ATE160340T1 (de)	1997-12-15	Konformationell festgelegte nukleosidanaloge
EP0391411A3 (de)	1991-04-10	In 3'-substituierte 3-Methylnukleoside an antivirale Agenzien
NO911322L (no)	1991-06-04	Nukleosid-derivater.
Winkelmann et al.	1988	New prodrugs of acyclic nucleosides with antiviral activity
DE68901443D1 (de)	1992-06-11	Derivate von nukleosiden.
AR003454A1 (es)	1998-08-05	Derivados de nucleosido de pirimidina, un procedimiento para su preparación y el uso de los mismos como agentes antivirales.
IT1146724B (it)	1986-11-19	Composti di purina e di piramidina loro uso come agenti antivirali e composizioni contenenti tali composti
ES8800908A1 (es)	1987-12-01	Un procedimiento para la preparacion de derivados de 6-amino-4-amino (sustituido)-1,2-dihidro-1-hidroxi-2-iminopirimidina o sus tautomeros