ATE167058T1 - Neue kombination von benzochinazolin-antifolaten und schützenden wirkstoffen - Google Patents

Neue kombination von benzochinazolin-antifolaten und schützenden wirkstoffen

Info

Publication number: ATE167058T1
Authority: AT; Austria
Prior art keywords: benzoquinazoline; antifolates; new combination; folic acid; protective ingredients
Prior art date: 1992-12-23

Application number

AT94902921T

Other languages

English (en)

Inventor

Gary Keith Smith

David Stanley Duch

Robert Ferone

Arthur Koch

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-23

Filing date

1993-12-21

Publication date

1998-06-15

1993-12-21 Application filed by Wellcome Found filed Critical Wellcome Found

1998-06-15 Application granted granted Critical

1998-06-15 Publication of ATE167058T1 publication Critical patent/ATE167058T1/de

Links

PQIUGRLKNKSKTC-UHFFFAOYSA-N benzo[h]quinazoline Chemical compound N1=CN=C2C3=CC=CC=C3C=CC2=C1 PQIUGRLKNKSKTC-UHFFFAOYSA-N 0.000 title abstract 2
229940127074 antifolate Drugs 0.000 title 1
239000004052 folic acid antagonist Substances 0.000 title 1
239000004615 ingredient Substances 0.000 title 1
230000001681 protective effect Effects 0.000 title 1
150000002224 folic acids Chemical class 0.000 abstract 3
OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 abstract 2
230000036963 noncompetitive effect Effects 0.000 abstract 2
VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 abstract 1
OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 abstract 1
229940045687 antimetabolites folic acid analogs Drugs 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
235000019152 folic acid Nutrition 0.000 abstract 1
239000011724 folic acid Substances 0.000 abstract 1
229960000304 folic acid Drugs 0.000 abstract 1
235000008191 folinic acid Nutrition 0.000 abstract 1
239000011672 folinic acid Substances 0.000 abstract 1
VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 abstract 1
229960001691 leucovorin Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000003223 protective agent Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT94902921T 1992-12-23 1993-12-21 Neue kombination von benzochinazolin-antifolaten und schützenden wirkstoffen ATE167058T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB929226842A GB9226842D0 (en)	1992-12-23	1992-12-23	Pharmaceutical compounds

Publications (1)

Publication Number	Publication Date
ATE167058T1 true ATE167058T1 (de)	1998-06-15

Family

ID=10727128

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94902921T ATE167058T1 (de)	1992-12-23	1993-12-21	Neue kombination von benzochinazolin-antifolaten und schützenden wirkstoffen

Country Status (15)

Country	Link
US (3)	US6358952B1 (de)
EP (1)	EP0675719B1 (de)
JP (1)	JP3774850B2 (de)
KR (1)	KR100296643B1 (de)
AT (1)	ATE167058T1 (de)
AU (1)	AU676252B2 (de)
CA (1)	CA2152507C (de)
DE (1)	DE69319141T2 (de)
ES (1)	ES2117245T3 (de)
GB (1)	GB9226842D0 (de)
IL (1)	IL108139A0 (de)
MX (1)	MX9400215A (de)
TW (1)	TW340044B (de)
WO (1)	WO1994014448A1 (de)
ZA (1)	ZA939633B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6762188B1 (en)	1990-06-19	2004-07-13	Smithkline Beecham Corporation	Pharmaceutically active benzoquinazoline compounds
GB9226842D0 (en) *	1992-12-23	1993-02-17	Wellcome Found	Pharmaceutical compounds
DE10062401A1 (de) *	2000-12-14	2002-06-20	Beiersdorf Ag	Verwendung von Folsäure und/oder deren Derivaten zur Herstellung kosmetischer oder dermatologischer Zubereitungen zur Prophylaxe von Schäden an der hauteigenen DNA und/oder zur Reparatur bereits eingetretener Schäden an der hauteigenen DNA
US7745930B2 (en) *	2005-04-25	2010-06-29	International Rectifier Corporation	Semiconductor device packages with substrates for redistributing semiconductor device electrodes
US8501242B2 (en) *	2009-05-29	2013-08-06	University Of Florida Research Foundation	Methods and compositions for treating neoplasia
CN101580501B (zh)	2009-06-01	2011-03-09	南京卡文迪许生物工程技术有限公司	3-(取代二氢异吲哚酮-2-基)-2,6-哌啶二酮的合成方法及其中间体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9013615D0 (en) *	1990-06-19	1990-08-08	Wellcome Found	Pharmaceutical compounds
DK0505640T4 (da)	1991-03-29	2002-12-16	Lilly Co Eli	Forbedret terapeutisk metode
US5217974A (en)	1991-03-29	1993-06-08	Eli Lilly And Company	Method for treating gar-transformylase tumors in mammals and reducing mammalian toxicity
GB9119700D0 (en)	1991-09-14	1991-10-30	Int Computers Ltd	Cryptographic facility for a data processing system
GB9226842D0 (en) *	1992-12-23	1993-02-17	Wellcome Found	Pharmaceutical compounds

1992
- 1992-12-23 GB GB929226842A patent/GB9226842D0/en active Pending
1993
- 1993-12-21 ES ES94902921T patent/ES2117245T3/es not_active Expired - Lifetime
- 1993-12-21 AT AT94902921T patent/ATE167058T1/de not_active IP Right Cessation
- 1993-12-21 DE DE69319141T patent/DE69319141T2/de not_active Expired - Fee Related
- 1993-12-21 WO PCT/GB1993/002611 patent/WO1994014448A1/en not_active Ceased
- 1993-12-21 AU AU57084/94A patent/AU676252B2/en not_active Ceased
- 1993-12-21 KR KR1019950702595A patent/KR100296643B1/ko not_active Expired - Fee Related
- 1993-12-21 CA CA002152507A patent/CA2152507C/en not_active Expired - Fee Related
- 1993-12-21 EP EP94902921A patent/EP0675719B1/de not_active Expired - Lifetime
- 1993-12-21 JP JP51493794A patent/JP3774850B2/ja not_active Expired - Fee Related
- 1993-12-21 US US08/448,393 patent/US6358952B1/en not_active Expired - Fee Related
- 1993-12-22 IL IL10813993A patent/IL108139A0/xx unknown
- 1993-12-22 ZA ZA939633A patent/ZA939633B/xx unknown
1994
- 1994-01-03 MX MX9400215A patent/MX9400215A/es unknown
- 1994-02-04 TW TW083100924A patent/TW340044B/zh active
2002
- 2002-03-18 US US10/100,582 patent/US6579877B2/en not_active Expired - Fee Related
2003
- 2003-05-07 US US10/431,016 patent/US6855712B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20020137748A1 (en)	2002-09-26
EP0675719B1 (de)	1998-06-10
US6358952B1 (en)	2002-03-19
ES2117245T3 (es)	1998-08-01
CA2152507C (en)	2005-10-18
KR950703963A (ko)	1995-11-17
EP0675719A1 (de)	1995-10-11
WO1994014448A1 (en)	1994-07-07
US6855712B2 (en)	2005-02-15
AU676252B2 (en)	1997-03-06
US6579877B2 (en)	2003-06-17
DE69319141T2 (de)	1998-10-08
TW340044B (en)	1998-09-11
IL108139A0 (en)	1994-04-12
JP3774850B2 (ja)	2006-05-17
US20030203924A1 (en)	2003-10-30
DE69319141D1 (de)	1998-07-16
JPH08504800A (ja)	1996-05-28
CA2152507A1 (en)	1994-07-07
KR100296643B1 (ko)	2001-10-22
ZA939633B (en)	1995-06-22
AU5708494A (en)	1994-07-19
MX9400215A (es)	1994-07-29
GB9226842D0 (en)	1993-02-17

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Legal Events

Date	Code	Title	Description
1998-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties