ATE167865T1 - Furo(3,2b>pyridine und thieno(3,2b>pyridine als inhibitoren der leukotrienbiosynthese - Google Patents

Furo(3,2b>pyridine und thieno(3,2b>pyridine als inhibitoren der leukotrienbiosynthese

Info

Publication number: ATE167865T1
Authority: AT; Austria
Prior art keywords: pyridines; inhibitors; biosynthesis; leukotrien; furo
Prior art date: 1993-03-29

Application number

AT94908907T

Other languages

English (en)

Inventor

Serge Leger

John H Hutchinson

Original Assignee

Merck Frosst Canada Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-29

Filing date

1994-03-10

Publication date

1998-07-15

1994-03-10 Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc

1998-07-15 Application granted granted Critical

1998-07-15 Publication of ATE167865T1 publication Critical patent/ATE167865T1/de

Links

230000015572 biosynthetic process Effects 0.000 title abstract 3
239000003112 inhibitor Substances 0.000 title abstract 2
RQMWVVBHJMUJNZ-UHFFFAOYSA-N 4-chloropyridin-2-amine Chemical compound NC1=CC(Cl)=CC=N1 RQMWVVBHJMUJNZ-UHFFFAOYSA-N 0.000 title 2
150000001875 compounds Chemical class 0.000 abstract 2
206010002383 Angina Pectoris Diseases 0.000 abstract 1
208000037260 Atherosclerotic Plaque Diseases 0.000 abstract 1
208000037487 Endotoxemia Diseases 0.000 abstract 1
208000005392 Spasm Diseases 0.000 abstract 1
206010046851 Uveitis Diseases 0.000 abstract 1
230000003266 anti-allergic effect Effects 0.000 abstract 1
230000001088 anti-asthma Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
239000000924 antiasthmatic agent Substances 0.000 abstract 1
230000002490 cerebral effect Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
230000001120 cytoprotective effect Effects 0.000 abstract 1
208000006454 hepatitis Diseases 0.000 abstract 1
231100000283 hepatitis Toxicity 0.000 abstract 1
150000002617 leukotrienes Chemical class 0.000 abstract 1
201000008383 nephritis Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT94908907T 1993-03-29 1994-03-10 Furo(3,2b>pyridine und thieno(3,2b>pyridine als inhibitoren der leukotrienbiosynthese ATE167865T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/037,862 US5374635A (en)	1993-03-29	1993-03-29	Furo[3,2-b]pyridines and thieno[3,2-b]pyridines as inhibitors of leukotriene biosynthesis

Publications (1)

Publication Number	Publication Date
ATE167865T1 true ATE167865T1 (de)	1998-07-15

Family

ID=21896774

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94908907T ATE167865T1 (de)	1993-03-29	1994-03-10	Furo(3,2b>pyridine und thieno(3,2b>pyridine als inhibitoren der leukotrienbiosynthese

Country Status (9)

Country	Link
US (1)	US5374635A (de)
EP (1)	EP0691972B1 (de)
JP (1)	JPH08510723A (de)
AT (1)	ATE167865T1 (de)
AU (1)	AU683451B2 (de)
CA (1)	CA2156262A1 (de)
DE (1)	DE69411375T2 (de)
ES (1)	ES2119176T3 (de)
WO (1)	WO1994022869A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20070219206A1 (en) *	2005-11-04	2007-09-20	Amira Pharmaceuticals, Inc.	5-lipoxygenase-activating protein (flap) inhibitors
GB2431927B (en) *	2005-11-04	2010-03-17	Amira Pharmaceuticals Inc	5-Lipoxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) *	2005-11-04	2013-03-19	Panmira Pharmaceuticals, Llc	5-lipoxygenase-activating protein (FLAP) inhibitors
US20070244128A1 (en) *	2005-11-04	2007-10-18	Amira Pharmaceuticals, Inc.	5-lipoxygenase-activating protein (flap) inhibitors
US7977359B2 (en)	2005-11-04	2011-07-12	Amira Pharmaceuticals, Inc.	5-lipdxygenase-activating protein (FLAP) inhibitors
TW200920369A (en) *	2007-10-26	2009-05-16	Amira Pharmaceuticals Inc	5-lipoxygenase activating protein (flap) inhibitor
MX2010012814A (es) *	2008-05-23	2010-12-20	Amira Pharmaceuticals Inc	Inhibidor de proteina activadora de 5-lipoxigenasa.
US8546431B2 (en)	2008-10-01	2013-10-01	Panmira Pharmaceuticals, Llc	5-lipoxygenase-activating protein (FLAP) inhibitors

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH498831A (fr) *	1967-12-27	1970-11-15	Lodzkie Zaklady Farma	Procédé pour la préparation d'acides indolyl-3 acétiques
IT1171624B (it) *	1980-11-12	1987-06-10	Thomae Gmbh Dr K	Indolinoni dotati di proprieta' farmaceutiche e procedimento per la loro produzione
CA1241660A (en) *	1984-06-25	1988-09-06	Yvan Guindon	Indole-2-alkanoic acids
NZ213986A (en) *	1984-10-30	1989-07-27	Usv Pharma Corp	Heterocyclic or aromatic compounds, and pharmaceutical compositions containing such
US4839369A (en) *	1985-04-16	1989-06-13	Rorer Pharmaceutical Corporation	Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
NZ222878A (en) *	1986-12-17	1991-02-26	Merck Frosst Canada Inc	3-hetero-substituted-n-benzyl-indole derivatives, and pharmaceutical compositions
ES2059408T3 (es) *	1987-02-10	1994-11-16	Abbott Lab	Un proceso para la preparacion de un compuesto.
US5034403A (en) *	1989-06-28	1991-07-23	Hoechst-Roussel Pharmaceuticals Inc.	Heteroarylamino-and heteroaryloxypyridinamines and related compounds
NZ234883A (en) *	1989-08-22	1995-01-27	Merck Frosst Canada Inc	Quinolin-2-ylmethoxy indole derivatives, preparation and pharmaceutical compositions thereof
PT95690A (pt) *	1989-10-27	1991-09-13	American Home Prod	Processo para a preparacao de derivados substituidos de acidos benzoilbenzo-, bifenil- e 2-oxazol-alcanoicos, uteis como inibidores de pla2 e da lipoxigenase
PT95692A (pt) *	1989-10-27	1991-09-13	American Home Prod	Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
US5021576A (en) *	1989-10-27	1991-06-04	American Home Products Corporation	2-Anilino phenylacetic acid derivatives
US5095031A (en) *	1990-08-20	1992-03-10	Abbott Laboratories	Indole derivatives which inhibit leukotriene biosynthesis
JPH0764841B2 (ja) *	1990-10-03	1995-07-12	ファイザー製薬株式会社	インドール誘導体およびその用途
US5308850A (en) *	1991-09-30	1994-05-03	Merck Frosst Canada, Inc.	(Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5190968A (en) *	1991-09-30	1993-03-02	Merck Frosst Canada, Inc.	(Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis

1993
- 1993-03-29 US US08/037,862 patent/US5374635A/en not_active Expired - Fee Related
1994
- 1994-03-10 AU AU61787/94A patent/AU683451B2/en not_active Ceased
- 1994-03-10 CA CA002156262A patent/CA2156262A1/en not_active Abandoned
- 1994-03-10 DE DE69411375T patent/DE69411375T2/de not_active Expired - Fee Related
- 1994-03-10 JP JP6521482A patent/JPH08510723A/ja active Pending
- 1994-03-10 AT AT94908907T patent/ATE167865T1/de not_active IP Right Cessation
- 1994-03-10 WO PCT/CA1994/000134 patent/WO1994022869A1/en not_active Ceased
- 1994-03-10 EP EP94908907A patent/EP0691972B1/de not_active Expired - Lifetime
- 1994-03-10 ES ES94908907T patent/ES2119176T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2156262A1 (en)	1994-10-13
EP0691972A1 (de)	1996-01-17
AU683451B2 (en)	1997-11-13
EP0691972B1 (de)	1998-07-01
DE69411375T2 (de)	1999-02-25
WO1994022869A1 (en)	1994-10-13
US5374635A (en)	1994-12-20
ES2119176T3 (es)	1998-10-01
JPH08510723A (ja)	1996-11-12
AU6178794A (en)	1994-10-24
DE69411375D1 (de)	1998-08-06

Legal Events

Date	Code	Title	Description
1999-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69319482D1 (de)	1998-08-13	Chinolinderivate als Leukotrien-Antagoniste
LV12187A (lv)	1998-12-20	Nepiesatinatas hidroksialkiletas hinolina rindas karbonskabes
ES2156961T3 (es)	2001-08-01	Derivados de bisarilcarbinol como inhibidores de la biosintesis de los leucotrienos.
CA2125824A1 (en)	1994-12-24	Heteroaryl coumarins as inhibitors of leukotriene biosynthesis
ATE167865T1 (de)	1998-07-15	Furo(3,2b>pyridine und thieno(3,2b>pyridine als inhibitoren der leukotrienbiosynthese
FI920734A0 (fi)	1992-02-20	Ketosyror innehaollande kinoliner med leukotrienantagonisteffekt.
PL309408A1 (en)	1995-10-02	Diaryl-5,6-condensed heterocyclic acids as leucotrenic antagonistic substances
CA2125830A1 (en)	1994-12-24	Heteroaryl cinnamic acids as inhibitors of leukotriene biosynthesis
FI914795A0 (fi)	1991-10-11	Hydroxialkylkinolinetersyror som leukotrienantagonister.
CA2063955A1 (en)	1992-09-29	Pyrrolo(1,2-a)indole hydroxylamine derivatives as inhibitors of leukotriene biosynthesis
CA2163244A1 (en)	1994-12-08	Quinoline derivatives as leukotriene antagonists
CA2061706A1 (en)	1992-08-29	Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis
EP0712407A1 (de)	1996-05-22	Aza-5,5-fusierte heterocyclische säure und ihre verwendung als leukotriene-antagonisten
MY107767A (en)	1996-06-15	Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists