ATE169303T1 - Peptidderivate mit metallopeptidasehemmender aktivität - Google Patents

Peptidderivate mit metallopeptidasehemmender aktivität

Info

Publication number: ATE169303T1
Authority: AT; Austria
Prior art keywords: groups; carbon atoms; alkyl; alkyl moiety; mono
Prior art date: 1994-06-21

Application number

AT95921816T

Other languages

English (en)

Inventor

Franco Pellacini

Gabriele Norcini

Daniela Botta

Stefano Romagnano

Francesco Santangelo

Original Assignee

Zambon Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-21

Filing date

1995-06-02

Publication date

1998-08-15

1995-06-02 Application filed by Zambon Spa filed Critical Zambon Spa

1998-08-15 Application granted granted Critical

1998-08-15 Publication of ATE169303T1 publication Critical patent/ATE169303T1/de

Links

102000005741 Metalloproteases Human genes 0.000 title 1
108010006035 Metalloproteases Proteins 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 14
125000004432 carbon atom Chemical group C* 0.000 abstract 13
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
125000001424 substituent group Chemical group 0.000 abstract 4
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 3
125000004442 acylamino group Chemical group 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
-1 aminosulphonyl groups Chemical group 0.000 abstract 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
125000001153 fluoro group Chemical group F* 0.000 abstract 3
125000005843 halogen group Chemical group 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
125000004001 thioalkyl group Chemical group 0.000 abstract 3
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
235000010290 biphenyl Nutrition 0.000 abstract 1
239000004305 biphenyl Substances 0.000 abstract 1
125000006267 biphenyl group Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cosmetics (AREA)

AT95921816T 1994-06-21 1995-06-02 Peptidderivate mit metallopeptidasehemmender aktivität ATE169303T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI941292A IT1270261B (it)	1994-06-21	1994-06-21	Derivati peptidici ad attivita' inibitrice delle metallopeptidasi

Publications (1)

Publication Number	Publication Date
ATE169303T1 true ATE169303T1 (de)	1998-08-15

Family

ID=11369147

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95921816T ATE169303T1 (de)	1994-06-21	1995-06-02	Peptidderivate mit metallopeptidasehemmender aktivität

Country Status (7)

Country	Link
EP (1)	EP0766694B1 (de)
AT (1)	ATE169303T1 (de)
AU (1)	AU2673795A (de)
DE (1)	DE69503905T2 (de)
ES (1)	ES2122627T3 (de)
IT (1)	IT1270261B (de)
WO (1)	WO1995035307A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL2435409T3 (pl)	2009-05-28	2015-01-30	Novartis Ag	Podstawione pochodne aminopropionowe jako inhibitory neprylizyny
CA2763565A1 (en)	2009-05-28	2010-12-02	Novartis Ag	Substituted aminobutyric derivatives as neprilysin inhibitors
JO2967B1 (en)	2009-11-20	2016-03-15	نوفارتس ايه جي	Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
WO2014126972A1 (en)	2013-02-14	2014-08-21	Novartis Ag	Substituted bisphenyl butanoic acid derivatives as nep inhibitors with improved in vivo efficacy
SG11201506018PA (en)	2013-02-14	2015-08-28	Novartis Ag	Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8311286D0 (en) *	1983-04-26	1983-06-02	Searle & Co	Carboxyalkyl peptide derivatives

1994
- 1994-06-21 IT ITMI941292A patent/IT1270261B/it active IP Right Grant
1995
- 1995-06-02 EP EP95921816A patent/EP0766694B1/de not_active Expired - Lifetime
- 1995-06-02 AT AT95921816T patent/ATE169303T1/de not_active IP Right Cessation
- 1995-06-02 WO PCT/EP1995/002100 patent/WO1995035307A1/en not_active Ceased
- 1995-06-02 ES ES95921816T patent/ES2122627T3/es not_active Expired - Lifetime
- 1995-06-02 AU AU26737/95A patent/AU2673795A/en not_active Abandoned
- 1995-06-02 DE DE69503905T patent/DE69503905T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ITMI941292A1 (it)	1995-12-21
ITMI941292A0 (it)	1994-06-21
EP0766694B1 (de)	1998-08-05
IT1270261B (it)	1997-04-29
DE69503905T2 (de)	1999-04-22
AU2673795A (en)	1996-01-15
DE69503905D1 (de)	1998-09-10
ES2122627T3 (es)	1998-12-16
WO1995035307A1 (en)	1995-12-28
EP0766694A1 (de)	1997-04-09

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Legal Events

Date	Code	Title	Description
1999-07-15	UEP	Publication of translation of european patent specification
2006-03-15	REN	Ceased due to non-payment of the annual fee