ATE169499T1 - Topische antiglaukoma zusammensetzungen, enthaltend karbonhydrasehemmer und beta-blocker - Google Patents

Topische antiglaukoma zusammensetzungen, enthaltend karbonhydrasehemmer und beta-blocker

Info

Publication number: ATE169499T1
Authority: AT; Austria
Prior art keywords: hydrase; inhibitors; compositions containing; containing carbon; compositions
Prior art date: 1992-02-21

Application number

AT93906084T

Other languages

English (en)

Inventor

Thomas Robert Dean

Louis Desantis Jr

Original Assignee

Alcon Lab Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-21

Filing date

1993-02-19

Publication date

1998-08-15

1993-02-19 Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc

1998-08-15 Application granted granted Critical

1998-08-15 Publication of ATE169499T1 publication Critical patent/ATE169499T1/de

Links

239000000203 mixture Substances 0.000 title abstract 4
239000002876 beta blocker Substances 0.000 title abstract 2
229940097320 beta blocking agent Drugs 0.000 title abstract 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 title 1
102000004867 Hydro-Lyases Human genes 0.000 title 1
108090001042 Hydro-Lyases Proteins 0.000 title 1
230000001384 anti-glaucoma Effects 0.000 title 1
229910052799 carbon Inorganic materials 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
230000000699 topical effect Effects 0.000 title 1
230000004406 elevated intraocular pressure Effects 0.000 abstract 2
229940122072 Carbonic anhydrase inhibitor Drugs 0.000 abstract 1
206010018307 Glaucoma and ocular hypertension Diseases 0.000 abstract 1
229920006318 anionic polymer Polymers 0.000 abstract 1
210000001742 aqueous humor Anatomy 0.000 abstract 1
239000003489 carbonate dehydratase inhibitor Substances 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000758 substrate Substances 0.000 abstract 1
239000000725 suspension Substances 0.000 abstract 1
238000013268 sustained release Methods 0.000 abstract 1
239000012730 sustained-release form Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Ophthalmology & Optometry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT93906084T 1992-02-21 1993-02-19 Topische antiglaukoma zusammensetzungen, enthaltend karbonhydrasehemmer und beta-blocker ATE169499T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US83986992A	1992-02-21	1992-02-21

Publications (1)

Publication Number	Publication Date
ATE169499T1 true ATE169499T1 (de)	1998-08-15

Family

ID=25280847

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93906084T ATE169499T1 (de)	1992-02-21	1993-02-19	Topische antiglaukoma zusammensetzungen, enthaltend karbonhydrasehemmer und beta-blocker

Country Status (9)

Country	Link
EP (1)	EP0625903B1 (de)
JP (2)	JP2965267B2 (de)
AT (1)	ATE169499T1 (de)
AU (1)	AU677577B2 (de)
CA (1)	CA2129037C (de)
DE (1)	DE69320329T2 (de)
DK (1)	DK0625903T3 (de)
ES (1)	ES2118941T3 (de)
WO (1)	WO1993016701A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SG84487A1 (en)	1991-04-17	2001-11-20	Merck & Co Inc	Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a b-adrenergic antagonist
US6316443B1 (en)	1994-08-04	2001-11-13	Merck & Co., Inc.	Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a β-adrenergic antagonist
US6071904A (en) *	1996-12-11	2000-06-06	Alcon Laboratories, Inc.	Process for manufacturing ophthalmic suspensions
JP2002506461A (ja) *	1997-06-26	2002-02-26	メルクエンドカンパニーインコーポレーテッド	網膜及び視神経の健康の最適化方法
ATE311880T1 (de) *	1998-01-23	2005-12-15	Einar Stefansson	Carbonische anhydrase inhibitor zur steigerung des sauerstoffdrucks im sehnerv und retina
US6291506B1 (en)	1998-08-04	2001-09-18	Wisconsin Alumni Research Foundation	Method of reducing retinal ganglion cell degeneration
TWI290470B (en)	1999-12-01	2007-12-01	Sankyo Co	The composition for treating glaucoma
AU2003280812A1 (en) *	2002-11-18	2004-06-15	Santen Pharmaceutical Co., Ltd.	REMEDY FOR GLAUCOMA COMPRISING Rho KINASE INHIBITOR AND Beta-BLOCKER
US9649300B2 (en) *	2013-08-28	2017-05-16	University of Pittsburgh—of the Commonwealth System of Higher Education	Inhibition of WNT, TGF beta and Hippo signaling pathways to treat cancer, organ fibrosis and metabolic disorders
US10040804B2 (en)	2016-12-21	2018-08-07	Biotheryx, Inc.	Compounds targeting proteins, compositions, methods, and uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3655663A (en) *	1969-04-21	1972-04-11	Burton K Wasson	4-(3-secondary amino-2-hydroxy-proxy) 1 2 5-thiadiazoles
US4911920A (en) *	1986-07-30	1990-03-27	Alcon Laboratories, Inc.	Sustained release, comfort formulation for glaucoma therapy
US4797413A (en) *	1986-05-14	1989-01-10	Merck & Co., Inc.	Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use
DE3568431D1 (en) *	1984-12-12	1989-04-06	Merck & Co Inc	Substituted aromatic sulfonamides, their preparation and ophthalmic compositions containing them
US4863922A (en) *	1984-12-12	1989-09-05	Merck & Co., Inc.	Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use
US4731368A (en) *	1986-12-08	1988-03-15	Merck & Co., Inc.	Thienopyridine sulfonamides and their ophthalmological formulation
EP0309028A3 (de) *	1987-09-16	1990-06-27	Merck & Co. Inc.	Substituierte Thieno[2,3-b]furan-2-sulfonamide als Antiglaukommittel
US4751231A (en) *	1987-09-16	1988-06-14	Merck & Co., Inc.	Substituted thieno[2,3-b]pyrrole-5-sulfonamides as antiglaucoma agents
US4946859A (en) *	1989-07-31	1990-08-07	Merck & Co., Inc.	4-(2-methyl-2-hydroxypropylamino)-5,6-dihydrothieno-[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide
US5153192A (en) *	1990-04-09	1992-10-06	Alcon Laboratories, Inc.	Thiophene sulfonamides useful as carbonic anhydrase inhibitors
IE911192A1 (en) *	1990-04-12	1991-10-23	Merck & Co Inc	Substituted aromatic sulfonamides as antiglaucoma agents
JP2594486B2 (ja) *	1991-01-15	1997-03-26	アルコンラボラトリーズインコーポレイテッド	局所的眼薬組成物
CA2064160C (en) *	1991-03-27	1998-08-11	Paul J. T. Missel	Use of combinations of gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
RO113612B1 (ro) *	1991-04-17	1998-09-30	Merck & Co Inc	Compozitie oftalmica

1993
- 1993-02-19 WO PCT/US1993/001487 patent/WO1993016701A2/en not_active Ceased
- 1993-02-19 EP EP93906084A patent/EP0625903B1/de not_active Expired - Lifetime
- 1993-02-19 ES ES93906084T patent/ES2118941T3/es not_active Expired - Lifetime
- 1993-02-19 AT AT93906084T patent/ATE169499T1/de not_active IP Right Cessation
- 1993-02-19 DE DE69320329T patent/DE69320329T2/de not_active Expired - Fee Related
- 1993-02-19 CA CA002129037A patent/CA2129037C/en not_active Expired - Fee Related
- 1993-02-19 JP JP5514967A patent/JP2965267B2/ja not_active Expired - Fee Related
- 1993-02-19 AU AU37257/93A patent/AU677577B2/en not_active Ceased
- 1993-02-19 DK DK93906084T patent/DK0625903T3/da active
1998
- 1998-02-25 JP JP10044090A patent/JPH10324640A/ja active Pending

Also Published As

Publication number	Publication date
JPH07504899A (ja)	1995-06-01
DE69320329T2 (de)	1998-12-24
JPH10324640A (ja)	1998-12-08
CA2129037A1 (en)	1993-09-02
CA2129037C (en)	1998-03-24
DE69320329D1 (de)	1998-09-17
EP0625903B1 (de)	1998-08-12
WO1993016701A3 (en)	1994-01-06
AU677577B2 (en)	1997-05-01
DK0625903T3 (da)	1999-05-10
WO1993016701A2 (en)	1993-09-02
JP2965267B2 (ja)	1999-10-18
AU3725793A (en)	1993-09-13
EP0625903A1 (de)	1994-11-30
HK1009941A1 (en)	1999-06-11
ES2118941T3 (es)	1998-10-01

Legal Events

Date	Code	Title	Description
2003-11-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
AU1387088A (en)	1988-10-06	Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocularpressure
PT639563E (pt)	2005-05-31	Utilizacao de ester de isopropilo de fluprostenol para a producao de um medicamento para o tratamento do glaucoma e hipertensao ocular
EP0308021A3 (de)	1990-11-28	Substituierte Thieno[2,3-b]pyrrol-5-sulfonamide als Antiglaukommittel
ATE169499T1 (de)	1998-08-15	Topische antiglaukoma zusammensetzungen, enthaltend karbonhydrasehemmer und beta-blocker
FI902258A0 (fi)	1990-05-04	Menetelmä farmakologisesti aktiivisten 13,14-dihydro-17-fenyyli-18,19,20-trinor-PGF2 -alkyyliestereiden valmistamiseksi
AU1838788A (en)	1989-01-05	Substituted aromatic sulfonamides as antiglaucoma agents
IE811654L (en)	1982-02-01	Ophthalmic composition
NO179612C (no)	1996-11-13	Analogifremgangsmåte for fremstilling av 3-arylkarbonyl-1-aminoalkyl-1H-indol-forbindelser
ATE223200T1 (de)	2002-09-15	Einen carboanhydrase-hemmer und xanthangummi enthaltendes augenarzneimittel
PT87620A (pt)	1988-06-01	Process for preparing thiophene sulfonamide antiglaucoma agents
ES2095975T3 (es)	1997-03-01	Uso de combinaciones de polisacaridos gelificantes y substratos portadores de medicamento, finamente divididos, para composiciones oftalmicas de uso topico.
DE3167999D1 (en)	1985-02-14	Ophthalmic compositions of carbonic anhydrase inhibitors for topical application in the treatment of elevated intraocular pressure
WO1992000287A3 (en)	1992-03-19	Analogs of carbonic anhydrase inhibitors and their use as topical iop inhibitors
AU2001285958A1 (en)	2002-03-22	Method for obtaining 4-(n-alkylamine)-5, 6-dihydro-4h-thieno-(2,3-b)-thiopyran-2-sulfamide-7, 7-dioxides and intermediate products
ATE102618T1 (de)	1994-03-15	Mit einem heterocyclischen ring substituierte cycloalkano(b>dihydroindole und indolsulfonamide.
AU3386299A (en)	1999-10-25	N-aryloxyethylamine derivatives for the treatment of depression
JPS6450886A (en)	1989-02-27	Substituted thieno(2,3-b)thiophene-2-sulfonamides as antiglaucoma
AU584176B2 (en)	1989-05-18	Eye-drop mirror
ID22073A (id)	1999-09-02	Turunan-turunan nitrometil tiobenzena sebagai bahan penghambat aldosa reduktase
EP0309028A3 (de)	1990-06-27	Substituierte Thieno[2,3-b]furan-2-sulfonamide als Antiglaukommittel
EP0527748A4 (en)	1993-03-10	Use of prostaglandin f 3 alpha as an ocular hypotensive agent
NO923642L (no)	1992-09-18	Anvendelse av 5-trans-prostaglandin f2alfa som et okulart hypotensivt middel