ATE169896T1 - Formylierungsverfahren für aromatische aldehyde - Google Patents

Formylierungsverfahren für aromatische aldehyde

Info

Publication number: ATE169896T1
Authority: AT; Austria
Prior art keywords: methoxy; substituted; compound; cis; useful
Prior art date: 1993-04-20

Application number

AT94906619T

Other languages

English (en)

Inventor

Dennis M Godek

William M Snyder

Andrew M Stewart

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-20

Filing date

1994-01-26

Publication date

1998-09-15

1994-01-26 Application filed by Pfizer filed Critical Pfizer

1998-09-15 Application granted granted Critical

1998-09-15 Publication of ATE169896T1 publication Critical patent/ATE169896T1/de

Links

238000006170 formylation reaction Methods 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
150000003934 aromatic aldehydes Chemical class 0.000 title 1
230000022244 formylation Effects 0.000 title 1
-1 5-substituted-2-methoxybenzaldehyde compounds Chemical class 0.000 abstract 5
DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 2
VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 abstract 2
ATRDCTRZAJKDPL-UHFFFAOYSA-N 2-methoxy-5-(trifluoromethoxy)benzaldehyde Chemical compound COC1=CC=C(OC(F)(F)F)C=C1C=O ATRDCTRZAJKDPL-UHFFFAOYSA-N 0.000 abstract 1
FPZHOBMVPBJNKL-UHFFFAOYSA-N 2-methoxy-5-propan-2-ylbenzaldehyde Chemical compound COC1=CC=C(C(C)C)C=C1C=O FPZHOBMVPBJNKL-UHFFFAOYSA-N 0.000 abstract 1
102000002002 Neurokinin-1 Receptors Human genes 0.000 abstract 1
108010040718 Neurokinin-1 Receptors Proteins 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
IEJIGPNLZYLLBP-UHFFFAOYSA-N dimethyl carbonate Chemical compound COC(=O)OC IEJIGPNLZYLLBP-UHFFFAOYSA-N 0.000 abstract 1
235000010299 hexamethylene tetramine Nutrition 0.000 abstract 1
239000004312 hexamethylene tetramine Substances 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000013067 intermediate product Substances 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000000047 product Substances 0.000 abstract 1
239000002464 receptor antagonist Substances 0.000 abstract 1
229940044551 receptor antagonist Drugs 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
150000003512 tertiary amines Chemical class 0.000 abstract 1
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
238000007039 two-step reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/16—Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/34—Separation; Purification; Stabilisation; Use of additives
- C07C41/36—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/562—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom
- C07C45/565—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom by reaction with hexamethylene-tetramine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT94906619T 1993-04-20 1994-01-26 Formylierungsverfahren für aromatische aldehyde ATE169896T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/049,904 US5294744A (en)	1993-04-20	1993-04-20	Formylation process for aromatic aldehydes

Publications (1)

Publication Number	Publication Date
ATE169896T1 true ATE169896T1 (de)	1998-09-15

Family

ID=21962370

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94906619T ATE169896T1 (de)	1993-04-20	1994-01-26	Formylierungsverfahren für aromatische aldehyde

Country Status (10)

Country	Link
US (1)	US5294744A (de)
EP (1)	EP0690835B1 (de)
JP (1)	JP2745163B2 (de)
AT (1)	ATE169896T1 (de)
CA (1)	CA2160686C (de)
DE (1)	DE69412598T2 (de)
DK (1)	DK0690835T3 (de)
ES (1)	ES2119171T3 (de)
FI (1)	FI109789B (de)
WO (1)	WO1994024081A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL109646A0 (en) *	1993-05-19	1994-08-26	Pfizer	Heteroatom substituted alkyl benzylamino-quinuclidines
EP0655246A1 (de) *	1993-11-30	1995-05-31	Pfizer Inc.	Substanz P Antagonisten zur Behandlung von durch Helicobacter Pylori oder andere spirale Urease-positive Gram-negative Bakterien verursachten Krankheiten
US5804690A (en) *	1995-12-14	1998-09-08	Mobil Oil Corporation	Selective monomethylation of aromatics with dimethylcarbonate
DK1095939T3 (da) *	1999-10-18	2004-04-13	Pfizer Prod Inc	Fremgangsmåde til fremstilling af cykliske piperidinylaminomethyltrifluormethyletherforbindelser
US6686507B2 (en)	2002-03-06	2004-02-03	Pfizer Inc	Purification of 2-methoxy-5-trifluoromethoxybenzaldehyde
DE10257357A1 (de) *	2002-12-09	2004-06-24	Bayer Ag	Fluorhaltige Benzaldehyde
US7122700B2 (en) *	2004-07-30	2006-10-17	Xerox Corporation	Arylamine processes
JP2006137691A (ja) *	2004-11-11	2006-06-01	Toyo Kasei Kogyo Co Ltd	２−アルコキシ−５−テトラゾリル−ベンズアルデヒド化合物の製造方法
CN112439454B (zh) *	2019-09-05	2023-04-07	中国石油化工股份有限公司	一种rt培司缩合催化剂及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3833660A (en) *	1972-04-26	1974-09-03	Gen Electric	Process for making aromatic aldehydes
US4192949A (en) *	1977-06-28	1980-03-11	Basf Aktiengesellschaft	Preparation of aralkyl phenyl ethers and alkyl phenyl ethers
IT1099572B (it) *	1978-07-21	1985-09-18	Snam Progetti	Procedimento per la preparazione di eteri fenclici
US4515987A (en) *	1982-06-04	1985-05-07	International Flavors & Fragrances Inc.	Process for preparing a methoxybenzaldehyde from the corresponding phenolic benzaldehyde
DE3304202A1 (de) *	1983-02-08	1984-08-09	Bayer Ag, 5090 Leverkusen	Verfahren zur herstellung von aromatischen aldehyden
SK284565B6 (sk) *	1991-03-26	2005-06-02	Pfizer Inc.	Spôsob prípravy substituovaných piperidínov

1993
- 1993-04-20 US US08/049,904 patent/US5294744A/en not_active Expired - Fee Related
1994
- 1994-01-26 DE DE69412598T patent/DE69412598T2/de not_active Expired - Fee Related
- 1994-01-26 CA CA002160686A patent/CA2160686C/en not_active Expired - Fee Related
- 1994-01-26 AT AT94906619T patent/ATE169896T1/de not_active IP Right Cessation
- 1994-01-26 ES ES94906619T patent/ES2119171T3/es not_active Expired - Lifetime
- 1994-01-26 DK DK94906619T patent/DK0690835T3/da active
- 1994-01-26 EP EP94906619A patent/EP0690835B1/de not_active Expired - Lifetime
- 1994-01-26 WO PCT/US1994/000445 patent/WO1994024081A1/en not_active Ceased
- 1994-01-26 JP JP6523111A patent/JP2745163B2/ja not_active Expired - Fee Related
- 1994-04-19 FI FI941808A patent/FI109789B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK0690835T3 (da)	1999-02-08
DE69412598T2 (de)	1998-12-24
FI941808A0 (fi)	1994-04-19
CA2160686A1 (en)	1994-10-27
EP0690835A1 (de)	1996-01-10
WO1994024081A1 (en)	1994-10-27
EP0690835B1 (de)	1998-08-19
JPH08505399A (ja)	1996-06-11
JP2745163B2 (ja)	1998-04-28
FI941808A7 (fi)	1994-10-21
CA2160686C (en)	1998-01-06
FI109789B (fi)	2002-10-15
DE69412598D1 (de)	1998-09-24
US5294744A (en)	1994-03-15
ES2119171T3 (es)	1998-10-01

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Legal Events

Date	Code	Title	Description
1999-01-15	UEP	Publication of translation of european patent specification
2004-10-15	REN	Ceased due to non-payment of the annual fee