ATE169915T1 - Pyrimidindionderivate, deren herstellung und verwendung - Google Patents

Pyrimidindionderivate, deren herstellung und verwendung

Info

Publication number: ATE169915T1
Authority: AT; Austria
Prior art keywords: hydrogen; substituted; residue; hydrocarbon residue; diseases
Prior art date: 1990-02-15

Application number

AT91102020T

Other languages

English (en)

Inventor

Takehiko Naka

Kohei Nishikawa

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-15

Filing date

1991-02-13

Publication date

1998-09-15

1991-02-13 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

1998-09-15 Application granted granted Critical

1998-09-15 Publication of ATE169915T1 publication Critical patent/ATE169915T1/de

Links

150000008512 pyrimidinediones Chemical class 0.000 title abstract 2
125000001183 hydrocarbyl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
150000001450 anions Chemical class 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
125000006850 spacer group Chemical group 0.000 abstract 2
102000005862 Angiotensin II Human genes 0.000 abstract 1
101800000733 Angiotensin-2 Proteins 0.000 abstract 1
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 abstract 1
208000006011 Stroke Diseases 0.000 abstract 1
-1 amino, formyl Chemical group 0.000 abstract 1
229950006323 angiotensin ii Drugs 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
208000019622 heart disease Diseases 0.000 abstract 1
230000001077 hypotensive effect Effects 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT91102020T 1990-02-15 1991-02-13 Pyrimidindionderivate, deren herstellung und verwendung ATE169915T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP3491990		1990-02-15

Publications (1)

Publication Number	Publication Date
ATE169915T1 true ATE169915T1 (de)	1998-09-15

Family

ID=12427624

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91102020T ATE169915T1 (de)	1990-02-15	1991-02-13	Pyrimidindionderivate, deren herstellung und verwendung

Country Status (5)

Country	Link
US (1)	US5162326A (de)
EP (1)	EP0442473B1 (de)
AT (1)	ATE169915T1 (de)
CA (1)	CA2036304C (de)
DE (1)	DE69129998T2 (de)

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US5250548A (en) *	1990-09-10	1993-10-05	Abbott Laboratories	Angiotensin II receptor antagonists
US5182288A (en) *	1991-11-13	1993-01-26	Ortho Pharmaceutical Corporation	Substituted n-biphenylyl lactams
TW284688B (de) *	1991-11-20	1996-09-01	Takeda Pharm Industry Co Ltd
US5350752A (en) *	1991-12-16	1994-09-27	E. R. Squibb & Sons, Inc.	Dihydropyrimidine derivatives
DE4227773A1 (de) *	1992-08-23	1994-02-24	Merck Patent Gmbh	Di- bzw. Triazindione
CA2115985A1 (en) *	1993-02-25	1994-08-26	Kohei Nishikawa	Vascular hypertrophy suppressor
JP3810020B2 (ja) *	1993-04-22	2006-08-16	武田薬品工業株式会社	腎疾患の予防または治療剤
US5721263A (en) *	1993-06-07	1998-02-24	Takeda Chemical Industries, Ltd.	Pharmaceutical composition for angiotensin II-mediated diseases
CZ154994A3 (en) *	1993-07-02	1995-09-13	Senju Pharma Co	Visual hypotensive agent
US5391541A (en) *	1993-08-11	1995-02-21	Fmc Corporation	Herbicidal 3-(substituted-benzyl)-1-methyl-6-trifluoromethyluracils
KR0151811B1 (ko) *	1993-12-21	1998-10-15	강박광	신규한 항바이러스성 2,4-피리미딘디온 유도체 및 그의 제조방법
WO1999044590A1 (en)	1998-03-04	1999-09-10	Takeda Chemical Industries, Ltd.	Sustained-release preparation for aii antagonist, production and use thereof
SE9903028D0 (sv)	1999-08-27	1999-08-27	Astra Ab	New use
US6613469B2 (en) *	2000-12-22	2003-09-02	Delphi Technologies, Inc.	Fluid distribution surface for solid oxide fuel cells
AU2002344813A1 (en) *	2001-06-15	2003-01-02	University Of Massachusetts	Methods for synthesizing substituted pyrimidines
EP1444988A4 (de)	2001-11-13	2007-04-25	Takeda Pharmaceutical	Krebsmittel
US7232828B2 (en) *	2002-08-10	2007-06-19	Bethesda Pharmaceuticals, Inc.	PPAR Ligands that do not cause fluid retention, edema or congestive heart failure
US20040242568A1 (en)	2003-03-25	2004-12-02	Syrrx, Inc.	Dipeptidyl peptidase inhibitors
CN102079743B (zh) *	2004-03-15	2020-08-25	武田药品工业株式会社	二肽基肽酶抑制剂
WO2007035629A2 (en)	2005-09-16	2007-03-29	Takeda Pharmaceutical Company Limited	Process for the preparation of pyrimidinedione derivatives
WO2008016522A2 (en) *	2006-07-24	2008-02-07	Gilead Sciences, Inc.	Hiv reverse transcriptase inhibitors
EA200970510A1 (ru)	2006-11-24	2009-12-30	Такеда Фармасьютикал Компани Лимитед	Гетеромоноциклическое соединение и его применение
US7803940B2 (en) *	2006-11-24	2010-09-28	Takeda Pharmaceutical Company Limited	Heteromonocyclic compound or a salt thereof having strong antihypertensive action, insulin sensitizing activity and the like production thereof and use thereof for prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases
TW200838536A (en)	2006-11-29	2008-10-01	Takeda Pharmaceutical	Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
EP2151440A4 (de) *	2007-05-21	2010-10-20	Takeda Pharmaceutical	Heterocyclische verbindung und ihre verwendung
WO2008151257A2 (en)	2007-06-04	2008-12-11	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US8354421B2 (en) *	2007-06-29	2013-01-15	Korea Research Insitute Of Chemical Technology	HIV reverse transcriptase inhibitors
CN101784532B (zh) *	2007-06-29	2014-10-22	韩国化学研究院	Hiv逆转录酶抑制剂
HRP20110632T1 (hr) *	2007-09-17	2011-10-31	Abbott Laboratories	N-fenil-diokso-hidropirimidini korisni kao inhibitori virusa hepatitisa c (hcv)
WO2009039134A1 (en)	2007-09-17	2009-03-26	Abbott Laboratories	Anti-infective pyrimidines and uses thereof
AR070027A1 (es)	2007-09-17	2010-03-10	Abbott Lab	Agentes anti-infecciosos contra el virus hcv
US8119800B2 (en) *	2007-12-21	2012-02-21	Korea Research Institute Of Chemical Technology	Processes for preparing HIV reverse transcriptase inhibitors
ES2627848T3 (es)	2008-06-04	2017-07-31	Synergy Pharmaceuticals Inc.	Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
ES2624828T3 (es)	2008-07-16	2017-07-17	Synergy Pharmaceuticals Inc.	Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9216952B2 (en)	2010-03-23	2015-12-22	Abbvie Inc.	Process for preparing antiviral compound
US8841487B2 (en)	2010-07-16	2014-09-23	Abbvie Inc.	Phosphine ligands for catalytic reactions
US8975443B2 (en)	2010-07-16	2015-03-10	Abbvie Inc.	Phosphine ligands for catalytic reactions
NZ705225A (en)	2010-07-16	2016-11-25	Abbvie Bahamas Ltd	Process for preparing antiviral compounds
US9255074B2 (en)	2010-07-16	2016-02-09	Abbvie Inc.	Process for preparing antiviral compounds
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
US9708367B2 (en)	2013-03-15	2017-07-18	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase and their uses
EP2968439A2 (de)	2013-03-15	2016-01-20	Synergy Pharmaceuticals Inc.	Zusammensetzungen zur behandlung von magen-darm-störungen
PL3004138T3 (pl)	2013-06-05	2024-07-29	Bausch Health Ireland Limited	Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie
LT4122926T (lt)	2021-04-14	2025-07-25	Shionogi & Co., Ltd.	Triazino dariniai, turintys virusų replikaciją slopinantį poveikį, ir juos apimanti farmacinė kompozicija

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Publication number	Priority date	Publication date	Assignee	Title
JPS5671073A (en) *	1979-11-12	1981-06-13	Takeda Chem Ind Ltd	Imidazole derivative
JPS5671074A (en) *	1979-11-12	1981-06-13	Takeda Chem Ind Ltd	1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
US4812462A (en) *	1986-04-01	1989-03-14	Warner-Lambert Company	4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity
CA1334092C (en) *	1986-07-11	1995-01-24	David John Carini	Angiotensin ii receptor blocking imidazoles
US4820843A (en) *	1987-05-22	1989-04-11	E. I. Du Pont De Nemours And Company	Tetrazole intermediates to antihypertensive compounds
US4880804A (en) *	1988-01-07	1989-11-14	E. I. Du Pont De Nemours And Company	Angiotensin II receptor blocking benzimidazoles
US5015651A (en) *	1988-01-07	1991-05-14	E. I. Du Pont De Nemours And Company	Treatment of hypertension with 1,2,4-angiotensin II antagonists

1991
- 1991-02-13 DE DE69129998T patent/DE69129998T2/de not_active Expired - Fee Related
- 1991-02-13 EP EP91102020A patent/EP0442473B1/de not_active Expired - Lifetime
- 1991-02-13 AT AT91102020T patent/ATE169915T1/de not_active IP Right Cessation
- 1991-02-13 CA CA002036304A patent/CA2036304C/en not_active Expired - Fee Related
- 1991-02-13 US US07/654,490 patent/US5162326A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2036304A1 (en)	1991-08-16
EP0442473B1 (de)	1998-08-19
CA2036304C (en)	2001-04-17
DE69129998D1 (de)	1998-09-24
DE69129998T2 (de)	1998-12-24
EP0442473A1 (de)	1991-08-21
US5162326A (en)	1992-11-10

Legal Events

Date	Code	Title	Description
1999-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69129998D1 (de)	1998-09-24	Pyrimidindionderivate, deren Herstellung und Verwendung
DE69120100D1 (de)	1996-07-18	Annelierte Thiophen-Derivate, ihre Herstellung und Verwendung
DE69110320D1 (de)	1995-07-20	Stickstoff enthaltende heterozyklische Verbindungen, ihre Herstellung und Verwendung.
DE68920654D1 (de)	1995-03-02	4-Oxochinolin-3-carbonsäure-Derivate, ihre Herstellung und ihre Verwendung.
KR900700465A (ko)	1990-08-13	화합물
ATE105554T1 (de)	1994-05-15	Benzazol-derivate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
EP0262399A3 (en)	1989-04-26	Cyclic enol derivatives, production and use thereof
PH25859A (en)	1991-12-02	Composition for treatment of ischemic disorder
ATE134633T1 (de)	1996-03-15	Thienoimidazolderivate, ihre herstellung und verwendung
AR002761A1 (es)	1998-04-29	Un compuesto derivado del triazol, su uso, una composicion farmaceutica que lo contiene, un metodo de tratamiento o prevencion de una infeccion fungica enun paciente humano mediante dicho compuesto o composicion, y procedimiento y compuestos intermedios para prepararlo.
DK0648760T3 (da)	1999-09-13	Triazinderivat og dets fremstilling og anvendelse
NO934741L (no)	1994-06-24	Fremgangsmåte for minimalisering og kontroll av ischemiske og reperfusjonsskade
AU590748B2 (en)	1989-11-16	Benzo(C)-1,5-naphthyridines, a process and intermediates for their preparation and their use as medicaments
DE3675431D1 (de)	1990-12-13	1,3-oxathianderivate.
DE69002217D1 (de)	1993-08-19	Dibenzodioxazecin- und dibenzodioxaazacycloundecin-derivate.