ATE170185T1 - Kristaliner polymorph von terazosin und dies enthaltende pharmazeutische zusammensetzungen - Google Patents
Kristaliner polymorph von terazosin und dies enthaltende pharmazeutische zusammensetzungenInfo
- Publication number
- ATE170185T1 ATE170185T1 AT96307027T AT96307027T ATE170185T1 AT E170185 T1 ATE170185 T1 AT E170185T1 AT 96307027 T AT96307027 T AT 96307027T AT 96307027 T AT96307027 T AT 96307027T AT E170185 T1 ATE170185 T1 AT E170185T1
- Authority
- AT
- Austria
- Prior art keywords
- crystalline polymorph
- terazosine
- pharmaceutical compositions
- compositions containing
- containing same
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- VCKUSRYTPJJLNI-UHFFFAOYSA-N terazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1CCCO1 VCKUSRYTPJJLNI-UHFFFAOYSA-N 0.000 title 1
- 229960001693 terazosin Drugs 0.000 title 1
- OIUZTIHPMCTAMF-UHFFFAOYSA-N oxolan-2-yl-(4-quinazolin-2-ylpiperazin-1-yl)methanone hydrate hydrochloride Chemical group C1CC(OC1)C(=O)N2CCN(CC2)C3=NC4=CC=CC=C4C=N3.O.Cl OIUZTIHPMCTAMF-UHFFFAOYSA-N 0.000 abstract 1
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/547,209 US5587377A (en) | 1995-10-24 | 1995-10-24 | Terazosin crystalline polymorph and pharmaceutical compositions thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE170185T1 true ATE170185T1 (de) | 1998-09-15 |
Family
ID=24183758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96307027T ATE170185T1 (de) | 1995-10-24 | 1996-09-26 | Kristaliner polymorph von terazosin und dies enthaltende pharmazeutische zusammensetzungen |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5587377A (de) |
| EP (1) | EP0770612B1 (de) |
| JP (1) | JPH09124644A (de) |
| AT (1) | ATE170185T1 (de) |
| DE (1) | DE69600565T2 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19546573A1 (de) * | 1995-12-13 | 1997-06-19 | Uetikon Chemie Gmbh | Kristallines Polymorph von Terazosin-Hydrochlorid, sowie Verfahren zu seiner Herstellung |
| US5952003A (en) * | 1996-08-01 | 1999-09-14 | Novartis Corporation | Terazosin capsules |
| IT1286790B1 (it) * | 1996-11-29 | 1998-07-17 | Alfa Chem Ital | Processo per la produzione della forma i del terazosin monocloridrato anidro |
| EP0849265A1 (de) * | 1996-12-20 | 1998-06-24 | HEUMANN PHARMA GmbH | Neue polymorphe Form von Doxazosin-Mesylat (Form II) |
| US6248888B1 (en) | 1997-11-14 | 2001-06-19 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of terazosin hydrochloride dihydrate |
| US7521793B2 (en) * | 2005-09-26 | 2009-04-21 | Temic Automotive Of North America, Inc. | Integrated circuit mounting for thermal stress relief useable in a multi-chip module |
| US11224572B1 (en) | 2020-08-17 | 2022-01-18 | Novitium Pharma LLC | Stable oral liquid composition of terazosin |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4026894A (en) * | 1975-10-14 | 1977-05-31 | Abbott Laboratories | Antihypertensive agents |
| GB1591490A (en) * | 1977-08-04 | 1981-06-24 | Abbott Lab | 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate |
| EP0237608B1 (de) * | 1986-03-21 | 1992-01-29 | HEUMANN PHARMA GMBH & CO | Kristalline, wasserfreie Sigma -Form von 2-[4-(2-Furoyl-(2-piperazin)-1-yl]-4-amino-6,7-dimethoxychinazolinhydrochlorid und Verfahren zu ihrer Herstellung |
| US5212176A (en) * | 1990-06-29 | 1993-05-18 | Abbott Laboratories | R(+)-terazosin |
| JP2652272B2 (ja) * | 1990-12-31 | 1997-09-10 | 住化ファインケム株式会社 | １−（４−アミノ−６，７−ジメトキシ−２−キナゾリニル）−４−（２−テトラヒドロフロイル）ピペラジン塩酸塩の新規な結晶体および該結晶体の製造方法 |
| US5294615A (en) * | 1993-04-29 | 1994-03-15 | Abbott Laboratories | Terazosin polymorph and pharmaceutical composition |
| US5412095A (en) * | 1993-04-29 | 1995-05-02 | Abbott Laboratories | Terazosin monohydrochloride and processes and intermediate for its production |
| US5504207A (en) * | 1994-10-18 | 1996-04-02 | Abbott Laboratories | Process and intermediate for the preparation of terazosin hydrochloride dihydrate |
-
1995
- 1995-10-24 US US08/547,209 patent/US5587377A/en not_active Expired - Fee Related
-
1996
- 1996-09-26 EP EP96307027A patent/EP0770612B1/de not_active Expired - Lifetime
- 1996-09-26 AT AT96307027T patent/ATE170185T1/de active
- 1996-09-26 DE DE69600565T patent/DE69600565T2/de not_active Expired - Fee Related
- 1996-10-11 JP JP8287360A patent/JPH09124644A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JPH09124644A (ja) | 1997-05-13 |
| EP0770612A1 (de) | 1997-05-02 |
| DE69600565D1 (de) | 1998-10-01 |
| EP0770612B1 (de) | 1998-08-26 |
| US5587377A (en) | 1996-12-24 |
| DE69600565T2 (de) | 1999-05-12 |
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