ATE170332T1 - Mikroelektrosprühverfahren und - vorrichtung - Google Patents

Mikroelektrosprühverfahren und - vorrichtung

Info

Publication number
ATE170332T1
ATE170332T1 AT92912552T AT92912552T ATE170332T1 AT E170332 T1 ATE170332 T1 AT E170332T1 AT 92912552 T AT92912552 T AT 92912552T AT 92912552 T AT92912552 T AT 92912552T AT E170332 T1 ATE170332 T1 AT E170332T1
Authority
AT
Austria
Prior art keywords
solution
terminal portion
capillary tube
electrospraying
electrospray
Prior art date
Application number
AT92912552T
Other languages
English (en)
Inventor
James W Jorgenson
Daniel M Dohmeier
Original Assignee
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina filed Critical Univ North Carolina
Application granted granted Critical
Publication of ATE170332T1 publication Critical patent/ATE170332T1/de

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plasma & Fusion (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Optical Measuring Cells (AREA)
AT92912552T 1991-05-15 1992-05-14 Mikroelektrosprühverfahren und - vorrichtung ATE170332T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/700,572 US5115131A (en) 1991-05-15 1991-05-15 Microelectrospray method and apparatus

Publications (1)

Publication Number Publication Date
ATE170332T1 true ATE170332T1 (de) 1998-09-15

Family

ID=24814024

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92912552T ATE170332T1 (de) 1991-05-15 1992-05-14 Mikroelektrosprühverfahren und - vorrichtung

Country Status (7)

Country Link
US (1) US5115131A (de)
EP (1) EP0586543B1 (de)
JP (1) JP3350547B2 (de)
AT (1) ATE170332T1 (de)
CA (1) CA2102431C (de)
DE (1) DE69226773T2 (de)
WO (1) WO1992020437A1 (de)

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JP2603868Y2 (ja) 1993-09-30 2000-03-27 株式会社島津製作所 キャピラリー電気泳動装置
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US20060277017A1 (en) * 1993-11-04 2006-12-07 Sproch Norman K Method for the characterization of the three-dimensional structure of proteins employing mass spectrometric analysis and computational feedback modeling
US7047171B1 (en) 1995-12-08 2006-05-16 Sproch Norman K Method for the characterization of the three-dimensional structure of proteins employing mass spectrometric analysis and computational feedback modeling
DE4408032A1 (de) * 1994-03-10 1995-09-14 Bruker Franzen Analytik Gmbh Verfahren zur Ionisierung von gelösten Atomen oder Molekülen aus Flüssigkeiten durch elektrisches Versprühen
US5608217A (en) * 1994-03-10 1997-03-04 Bruker-Franzen Analytik Gmbh Electrospraying method for mass spectrometric analysis
DE4444229C2 (de) * 1994-03-10 1996-07-25 Bruker Franzen Analytik Gmbh Verfahren und Vorrichtungen zur Elektrosprüh-Ionisierung für speichernde Massenspektometer
DE4415480C2 (de) * 1994-05-02 1999-09-02 Bruker Daltonik Gmbh Vorrichtung und Verfahren zur massenspektrometrischen Untersuchung von Substanzgemischen durch Kopplung kapillarelektrophoretischer Separation (CE) mit Elektrospray-Ionisierung (ESI)
IT1270203B (it) * 1994-06-09 1997-04-29 Fisons Instr Spa Procedimento e dispositivo per l'introduzione di liquidi in spettrometri di massa mediante nebulizzazione elettrostatica
US5750988A (en) * 1994-07-11 1998-05-12 Hewlett-Packard Company Orthogonal ion sampling for APCI mass spectrometry
US5495108A (en) * 1994-07-11 1996-02-27 Hewlett-Packard Company Orthogonal ion sampling for electrospray LC/MS
US5572023A (en) * 1995-05-30 1996-11-05 Board Of Regents, The University Of Texas System Electrospray methods and apparatus for trace analysis
US6278111B1 (en) 1995-08-21 2001-08-21 Waters Investments Limited Electrospray for chemical analysis
US5838002A (en) * 1996-08-21 1998-11-17 Chem-Space Associates, Inc Method and apparatus for improved electrospray analysis
US6068749A (en) * 1996-01-19 2000-05-30 Northeastern University Subatmospheric, variable pressure sample delivery chamber for electrospray ionization/mass spectrometry and other applications
US5868322A (en) * 1996-01-31 1999-02-09 Hewlett-Packard Company Apparatus for forming liquid droplets having a mechanically fixed inner microtube
US5788166A (en) * 1996-08-27 1998-08-04 Cornell Research Foundation, Inc. Electrospray ionization source and method of using the same
US6070779A (en) * 1997-02-06 2000-06-06 U.S. Philips Corporation Liquid dosing device
US5828062A (en) * 1997-03-03 1998-10-27 Waters Investments Limited Ionization electrospray apparatus for mass spectrometry
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US6127680A (en) * 1997-03-15 2000-10-03 Analytica Of Branford, Inc. Disposable microtip probe for low flow electrospray
US6207955B1 (en) * 1998-09-28 2001-03-27 Varian, Inc. Pneumatically assisted electrospray device with alternating pressure gradients for mass spectrometry
US6586731B1 (en) 1999-04-12 2003-07-01 Mds Inc. High intensity ion source apparatus for mass spectrometry
US6407382B1 (en) 1999-06-04 2002-06-18 Technispan Llc Discharge ionization source
EP1099484B1 (de) 1999-11-11 2006-06-07 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Vorrichtung und Verfahren zur Verabreichung von Tropfen
US6670607B2 (en) * 2000-01-05 2003-12-30 The Research Foundation Of State University Of New York Conductive polymer coated nano-electrospray emitter
US6768119B2 (en) * 2000-04-06 2004-07-27 De La Mora Juan F. Method and apparatus to produce ions and nanodrops from Taylor cones at reduced pressure
SE0004233D0 (sv) * 2000-06-08 2000-11-17 Jonas Bergquist Jonas Electrospray emitter
US6525313B1 (en) * 2000-08-16 2003-02-25 Brucker Daltonics Inc. Method and apparatus for an electrospray needle for use in mass spectrometry
US6653625B2 (en) * 2001-03-19 2003-11-25 Gyros Ab Microfluidic system (MS)
US20040099310A1 (en) * 2001-01-05 2004-05-27 Per Andersson Microfluidic device
US6717136B2 (en) 2001-03-19 2004-04-06 Gyros Ab Microfludic system (EDI)
WO2002075775A1 (en) 2001-03-19 2002-09-26 Gyros Ab A microfluidic system (edi)
CA2441206A1 (en) 2001-03-19 2002-09-26 Gyros Ab Characterization of reaction variables
US20020168297A1 (en) * 2001-05-11 2002-11-14 Igor Shvets Method and device for dispensing of droplets
US6744046B2 (en) 2001-05-24 2004-06-01 New Objective, Inc. Method and apparatus for feedback controlled electrospray
US6803568B2 (en) 2001-09-19 2004-10-12 Predicant Biosciences, Inc. Multi-channel microfluidic chip for electrospray ionization
WO2003031931A2 (en) * 2001-10-05 2003-04-17 Yale University Method and apparatus to produce ions and nanodrops from taylor cones of volatile liquids at reduced pressures
EP1588398A2 (de) * 2002-12-18 2005-10-26 Brigham Young University Verfahren und einrichtung zur aerodynamischen ionenfokussierung
SE0300454D0 (sv) * 2003-02-19 2003-02-19 Aamic Ab Nozzles for electrospray ionization and methods of fabricating them
US7007710B2 (en) * 2003-04-21 2006-03-07 Predicant Biosciences, Inc. Microfluidic devices and methods
US6870154B1 (en) 2004-02-27 2005-03-22 The University Of Western Ontario Capillary mixer with adjustable reaction chamber volume for mass spectrometry
US20060022130A1 (en) * 2004-07-29 2006-02-02 Predicant Biosciences, Inc., A Delaware Corporation Microfluidic devices and methods with integrated electrical contact
US20060060769A1 (en) 2004-09-21 2006-03-23 Predicant Biosciences, Inc. Electrospray apparatus with an integrated electrode
US20090218481A1 (en) * 2004-10-07 2009-09-03 Dewalch Norman Binz High-Speed Molecular Analyzer System and Method
US20090084979A1 (en) * 2004-10-07 2009-04-02 Dewalch Norman Binz High-speed molecular analyzer system and method
CA2597321A1 (en) * 2005-02-11 2006-08-17 Battelle Memorial Institute Ehd aerosol dispensing device and spraying method
US20060208186A1 (en) * 2005-03-15 2006-09-21 Goodley Paul C Nanospray ion source with multiple spray emitters
GB0524979D0 (en) * 2005-12-07 2006-01-18 Queen Mary & Westfield College An electrospray device and a method of electrospraying
US7880140B2 (en) * 2007-05-02 2011-02-01 Dh Technologies Development Pte. Ltd Multipole mass filter having improved mass resolution
GB0709517D0 (en) * 2007-05-17 2007-06-27 Queen Mary & Westfield College An electrostatic spraying device and a method of electrostatic spraying
US8205558B2 (en) * 2007-07-09 2012-06-26 Middlesex General Industries, Inc. System and method of improving throughput and vehicle utilization of monorail factory transport systems
US7671344B2 (en) * 2007-08-31 2010-03-02 Battelle Memorial Institute Low pressure electrospray ionization system and process for effective transmission of ions
US8173960B2 (en) * 2007-08-31 2012-05-08 Battelle Memorial Institute Low pressure electrospray ionization system and process for effective transmission of ions
GB2471520B (en) 2009-07-03 2013-08-21 Microsaic Systems Plc An electrospray pneumatic nebuliser ionisation source
CN102221576B (zh) 2010-04-15 2015-09-16 岛津分析技术研发（上海）有限公司 一种产生、分析离子的方法与装置
JP6601819B2 (ja) * 2013-08-29 2019-11-06 ユニヴァーシティー オブ ノートル ダム デュ ラック 高感度エレクトロスプレーインターフェース
US9711341B2 (en) * 2014-06-10 2017-07-18 The University Of North Carolina At Chapel Hill Mass spectrometry systems with convective flow of buffer gas for enhanced signals and related methods
CN115295394A (zh) * 2015-05-12 2022-11-04 北卡罗来纳-查佩尔山大学 高压质谱测定的电喷射离子化接口和相关方法
US9406492B1 (en) * 2015-05-12 2016-08-02 The University Of North Carolina At Chapel Hill Electrospray ionization interface to high pressure mass spectrometry and related methods
EP3391405B1 (de) * 2015-12-18 2021-04-07 DH Technologies Development Pte. Ltd. System zur minimierung der elektrischen entladung während des esi-betriebs
CN105575752B (zh) * 2016-03-04 2017-09-22 北京工业大学 一种双功能等内径皮流质谱喷针及制备方法
US10763095B2 (en) * 2016-06-02 2020-09-01 Shimadzu Corporation Ionizer and mass spectrometer system

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US4542293A (en) * 1983-04-20 1985-09-17 Yale University Process and apparatus for changing the energy of charged particles contained in a gaseous medium
US4531056A (en) * 1983-04-20 1985-07-23 Yale University Method and apparatus for the mass spectrometric analysis of solutions
US4885076A (en) * 1987-04-06 1989-12-05 Battelle Memorial Institute Combined electrophoresis-electrospray interface and method
US4842701A (en) * 1987-04-06 1989-06-27 Battelle Memorial Institute Combined electrophoretic-separation and electrospray method and system
US4935624A (en) * 1987-09-30 1990-06-19 Cornell Research Foundation, Inc. Thermal-assisted electrospray interface (TAESI) for LC/MS
US4861988A (en) * 1987-09-30 1989-08-29 Cornell Research Foundation, Inc. Ion spray apparatus and method
US4994165A (en) * 1989-02-16 1991-02-19 Cornell Research Foundation, Inc. Liquid junction coupling for capillary zone electrophoresis/ion spray spectrometry
US4977320A (en) * 1990-01-22 1990-12-11 The Rockefeller University Electrospray ionization mass spectrometer with new features
US5015845A (en) * 1990-06-01 1991-05-14 Vestec Corporation Electrospray method for mass spectrometry

Also Published As

Publication number Publication date
EP0586543A1 (de) 1994-03-16
EP0586543B1 (de) 1998-08-26
EP0586543A4 (en) 1995-12-20
US5115131A (en) 1992-05-19
JP3350547B2 (ja) 2002-11-25
JPH06507997A (ja) 1994-09-08
CA2102431C (en) 2000-04-25
DE69226773D1 (de) 1998-10-01
CA2102431A1 (en) 1992-11-16
WO1992020437A1 (en) 1992-11-26
DE69226773T2 (de) 1999-04-29

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