ATE170867T1 - Immunsuppressive aminomethylen-peptide - Google Patents

Immunsuppressive aminomethylen-peptide

Info

Publication number: ATE170867T1
Authority: AT; Austria
Prior art keywords: aminomethylene; immunosuppressive; peptides; compounds; chem
Prior art date: 1993-02-09

Application number

AT94101262T

Other languages

English (en)

Inventor

Richard D Connell

David G Osterman

Michael E Katz

Rudolf H Hanko

Stephan Schneider

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-02-09

Filing date

1994-01-28

Publication date

1998-09-15

1994-01-28 Application filed by Bayer Ag filed Critical Bayer Ag

1998-09-15 Application granted granted Critical

1998-09-15 Publication of ATE170867T1 publication Critical patent/ATE170867T1/de

Links

-1 AMINOMETHYLENE Chemical class 0.000 title 1
230000001506 immunosuppresive effect Effects 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
210000001744 T-lymphocyte Anatomy 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Crystallography & Structural Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)
Pyrrole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT94101262T 1993-02-09 1994-01-28 Immunsuppressive aminomethylen-peptide ATE170867T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/015,688 US5385918A (en)	1993-02-09	1993-02-09	Aminomethylene-peptides as immunosuppressants

Publications (1)

Publication Number	Publication Date
ATE170867T1 true ATE170867T1 (de)	1998-09-15

Family

ID=21772959

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94101262T ATE170867T1 (de)	1993-02-09	1994-01-28	Immunsuppressive aminomethylen-peptide

Country Status (8)

Country	Link
US (1)	US5385918A (de)
EP (1)	EP0610743B1 (de)
JP (1)	JPH06234737A (de)
AT (1)	ATE170867T1 (de)
CA (1)	CA2115221A1 (de)
DE (1)	DE69413085T2 (de)
DK (1)	DK0610743T3 (de)
ES (1)	ES2119912T3 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5798355A (en) *	1995-06-07	1998-08-25	Gpi Nil Holdings, Inc.	Inhibitors of rotamase enzyme activity
EP0837875A4 (de) *	1995-03-29	1998-10-07	Merck & Co Inc	Inhibitoren der farnesyl-proteintransferase
US5696135A (en) *	1995-06-07	1997-12-09	Gpi Nil Holdings, Inc.	Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth
US5614547A (en) *	1995-06-07	1997-03-25	Guilford Pharmaceuticals Inc.	Small molecule inhibitors of rotamase enzyme
US7056935B2 (en) *	1995-06-07	2006-06-06	Gpi Nil Holdings, Inc.	Rotamase enzyme activity inhibitors
US6509477B1 (en)	1998-11-12	2003-01-21	Guilford Pharmaceuticals Inc.	Small molecule inhibitors of rotamase enzyme activity
US6291510B1 (en)	1995-06-07	2001-09-18	Gpi Nil Holdings, Inc.	Small molecule inhibitors of rotamase enzyme activity
US5859031A (en) *	1995-06-07	1999-01-12	Gpi Nil Holdings, Inc.	Small molecule inhibitors of rotamase enzyme activity
US6140305A (en)	1996-04-04	2000-10-31	Bio-Rad Laboratories, Inc.	Hereditary hemochromatosis gene products
US7026116B1 (en) *	1996-04-04	2006-04-11	Bio-Rad Laboratories, Inc.	Polymorphisms in the region of the human hemochromatosis gene
US6849399B1 (en)	1996-05-23	2005-02-01	Bio-Rad Laboratories, Inc.	Methods and compositions for diagnosis and treatment of iron misregulation diseases
US5801187A (en) *	1996-09-25	1998-09-01	Gpi-Nil Holdings, Inc.	Heterocyclic esters and amides
US6218424B1 (en)	1996-09-25	2001-04-17	Gpi Nil Holdings, Inc.	Heterocyclic ketone and thioester compounds and uses
US5786378A (en) *	1996-09-25	1998-07-28	Gpi Nil Holdings, Inc.	Heterocyclic thioesters
US5958949A (en) *	1996-12-31	1999-09-28	Gpi Nil Holdings Inc.	N-linked ureas and carbamates of piperidyl thioesters
US5935989A (en) *	1996-12-31	1999-08-10	Gpi Nil Holdings Inc.	N-linked ureas and carbamates of heterocyclic thioesters
US5846979A (en)	1997-02-28	1998-12-08	Gpi Nil Holdings, Inc.	N-oxides of heterocyclic esters, amides, thioesters, and ketones
US6187796B1 (en)	1998-06-03	2001-02-13	Gpi Nil Holdings, Inc.	Sulfone hair growth compositions and uses
US6274602B1 (en)	1998-06-03	2001-08-14	Gpi Nil Holdings, Inc.	Heterocyclic thioester and ketone hair growth compositions and uses
US6187784B1 (en)	1998-06-03	2001-02-13	Gpi Nil Holdings, Inc.	Pipecolic acid derivative hair growth compositions and uses
US5945441A (en) *	1997-06-04	1999-08-31	Gpi Nil Holdings, Inc.	Pyrrolidine carboxylate hair revitalizing agents
US6271244B1 (en)	1998-06-03	2001-08-07	Gpi Nil Holdings, Inc.	N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
US20010049381A1 (en) *	1997-06-04	2001-12-06	Gpl Nil Holdings, Inc.,	Pyrrolidine derivative hair growth compositions and uses
DE69841593D1 (de)	1997-06-13	2010-05-12	Bio Rad Laboratories	Verfahren und Zusammensetzungen für die Diagnose und die Behandlung von Krankheiten, die mit Eisenüberschuss oder Eisenmangel assoziiert sind
DE19742263A1 (de) *	1997-09-25	1999-04-01	Asta Medica Ag	Neue spezifische Immunophilin-Liganden als Antiasthmatika, Antiallergika, Antirheumatika, Immunsuppressiva, Antipsoriatika, Neuroprotektiva
US6585752B2 (en) *	1998-06-23	2003-07-01	Innercool Therapies, Inc.	Fever regulation method and apparatus
US6172087B1 (en)	1998-06-03	2001-01-09	Gpi Nil Holding, Inc.	N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6429215B1 (en)	1998-06-03	2002-08-06	Gpi Nil Holdings, Inc.	N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
WO1999062487A1 (en)	1998-06-03	1999-12-09	Gpi Nil Holdings, Inc.	Heterocyclic ester and amide hair growth compositions and uses
US6300341B1 (en)	1998-09-30	2001-10-09	The Procter & Gamble Co.	2-substituted heterocyclic sulfonamides
US6307049B1 (en)	1998-09-30	2001-10-23	The Procter & Gamble Co.	Heterocyclic 2-substituted ketoamides
AU2002322720B2 (en)	2001-07-25	2008-11-13	Raptor Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
CA2789262C (en)	2005-04-28	2016-10-04	Proteus Digital Health, Inc.	Pharma-informatics system
EP2063905B1 (de)	2006-09-18	2014-07-30	Raptor Pharmaceutical Inc	Behandlungen von lebererkrankungen durch verabreichung von konjugaten aus rezeptor-assoziierten proteinen
KR101909711B1 (ko)	2009-05-06	2018-12-19	라보라토리 스킨 케어, 인크.	활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA884504B (en) *	1987-06-29	1989-03-29	Merrell Dow Pharma	Immunosuppressant peptides
NL8801736A (nl) *	1988-07-08	1990-02-01	Bazo Staalbeheer Bv	Plankdrager.
IL90872A0 (en) *	1988-07-08	1990-02-09	Smithkline Beckman Corp	Retroviral protease binding peptides
EP0361341A3 (de) *	1988-09-28	1991-07-03	Miles Inc.	Therapeutika für AIDS auf der Basis von HIV-Protease-Inhibitoren
EP0374097A3 (de) *	1988-12-15	1991-06-12	Ciba-Geigy Ag	Verwendung von Peptidisosteren als retrovirale Proteasehemmer
DE3935371A1 (de) *	1988-12-23	1990-07-05	Merck Patent Gmbh	Stickstoffhaltige ringverbindungen
AU8305491A (en) *	1990-08-01	1992-03-02	Cytel Corporation	Novel immunosuppressant peptides
AU2468392A (en) *	1991-08-29	1993-04-05	Cytel Corporation	Novel immunosuppressants

1993
- 1993-02-09 US US08/015,688 patent/US5385918A/en not_active Expired - Fee Related
1994
- 1994-01-28 AT AT94101262T patent/ATE170867T1/de not_active IP Right Cessation
- 1994-01-28 EP EP94101262A patent/EP0610743B1/de not_active Expired - Lifetime
- 1994-01-28 DE DE69413085T patent/DE69413085T2/de not_active Expired - Fee Related
- 1994-01-28 DK DK94101262T patent/DK0610743T3/da active
- 1994-01-28 ES ES94101262T patent/ES2119912T3/es not_active Expired - Lifetime
- 1994-02-08 CA CA002115221A patent/CA2115221A1/en not_active Abandoned
- 1994-02-08 JP JP6034291A patent/JPH06234737A/ja active Pending

Also Published As

Publication number	Publication date
US5385918A (en)	1995-01-31
ES2119912T3 (es)	1998-10-16
CA2115221A1 (en)	1994-08-10
EP0610743B1 (de)	1998-09-09
DE69413085D1 (de)	1998-10-15
DE69413085T2 (de)	1999-02-04
EP0610743A1 (de)	1994-08-17
JPH06234737A (ja)	1994-08-23
DK0610743T3 (da)	1999-06-07

Legal Events

Date	Code	Title	Description
1999-01-15	UEP	Publication of translation of european patent specification
2001-10-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69413085D1 (de)	1998-10-15	Immunsuppressive Aminomethylen-Peptide
MX9800625A (es)	1998-04-30	Marcfortinas y paraherquamidas antiparasitarias.
NO910333D0 (no)	1991-01-29	Fremgangsmaate for plasmasprengning.
DE4491034T1 (de)	1996-04-25	Verschmelzungsstabilisierkammer
EP0646821A3 (de)	1995-05-17	Optisches System für Endoskope.
EP0660150A3 (de)	1997-04-02	Objektivfixationseinrichtung.
DE69414279D1 (de)	1998-12-10	Sulfonamidaminomethylenderivate als Immunsuppressiva
ZA976242B (en)	1998-03-18	Illudin analogs useful as antitumor agents.
GB2318425B (en)	1999-07-14	Interferometer with compound optics
ID16851A (id)	1997-11-13	Perintang yang ditingkatkan modulnya.
FI98970B (fi)	1997-05-30	Käsipuhelimen lisävahvistinjärjestely
FI931451L (fi)	1993-10-03	7-oxo-7h-pyrido(1,2,3-de)(1,4)bensoxazin-6-karboxylsyror och -estrar
FR2707429B1 (fr)	1995-09-01	Accessoire de raccordement.
EP0540574A4 (de)	1994-04-27
FI935060A0 (fi)	1993-11-16	Kompensaatiojärjestely
DE69312739D1 (de)	1997-09-04	Verbesserte gaslinse
FI930010A0 (fi)	1993-01-04	Madrass
FI925841A0 (fi)	1992-12-22	Järjestely hissin vaa'an virittämiseksi
FI953465L (fi)	1997-01-19	Järjestely ympärist¦n havainnointiin
FR2695976B1 (fr)	1994-12-02	Soupape de régulation compensée.
AP9300582A0 (en)	1995-04-15	An adjustable roof support.
ES1024042Y (es)	1994-04-01	Vehiculo funerario.
GB9501300D0 (en)	1995-03-15	Peptides which inhibit viruses
IT234658Y1 (it)	2000-03-13	Corpo per cassetta postale.
FI931028A0 (fi)	1993-03-09	Sokkelokammio