ATE171705T1 - Cephalosporine und ihre homologen, verfahren zu ihrer herstellung und pharmazeutische präparate - Google Patents
Cephalosporine und ihre homologen, verfahren zu ihrer herstellung und pharmazeutische präparateInfo
- Publication number
- ATE171705T1 ATE171705T1 AT90303177T AT90303177T ATE171705T1 AT E171705 T1 ATE171705 T1 AT E171705T1 AT 90303177 T AT90303177 T AT 90303177T AT 90303177 T AT90303177 T AT 90303177T AT E171705 T1 ATE171705 T1 AT E171705T1
- Authority
- AT
- Austria
- Prior art keywords
- optionally
- cephalosporins
- homologues
- production
- substituted
- Prior art date
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 2
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- HOKIDJSKDBPKTQ-GLXFQSAKSA-N cephalosporin C Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- -1 beta -Lactam compounds Chemical class 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000000457 gamma-lactone group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898907171A GB8907171D0 (en) | 1989-03-30 | 1989-03-30 | Novel compounds |
| GB898920791A GB8920791D0 (en) | 1989-09-14 | 1989-09-14 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE171705T1 true ATE171705T1 (de) | 1998-10-15 |
Family
ID=26295148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90303177T ATE171705T1 (de) | 1989-03-30 | 1990-03-26 | Cephalosporine und ihre homologen, verfahren zu ihrer herstellung und pharmazeutische präparate |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5246926A (de) |
| EP (1) | EP0395219B1 (de) |
| JP (1) | JP2979235B2 (de) |
| KR (1) | KR900014403A (de) |
| AT (1) | ATE171705T1 (de) |
| AU (1) | AU625844B2 (de) |
| CA (1) | CA2013391A1 (de) |
| DE (1) | DE69032681T2 (de) |
| DK (1) | DK0395219T3 (de) |
| ES (1) | ES2121745T3 (de) |
| PT (1) | PT93602A (de) |
| ZA (1) | ZA902378B (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0432042B1 (de) * | 1989-12-07 | 1996-08-28 | Meiji Seika Kaisha Ltd. | Cephalosporinderivate, ihre Herstellung und Anwendungen |
| MY106399A (en) * | 1990-07-24 | 1995-05-30 | Pfizer | Cephalosporins and homologeus, preparation and pharmaceutical composition |
| US6020329A (en) * | 1990-07-24 | 2000-02-01 | Pzifer Inc. | Cephaloporins and homologues, preparations and pharmaceutical compositions |
| US6001997A (en) * | 1990-07-24 | 1999-12-14 | Bateson; John Hargreaves | Cephalosporins and homologues, preparations and pharmaceutical compositions |
| GB9019743D0 (en) * | 1990-09-10 | 1990-10-24 | Beecham Group Plc | Novel compounds |
| DE4037841A1 (de) * | 1990-11-28 | 1992-06-04 | Bayer Ag | Neue 3-substituierte cephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| IT1251643B (it) * | 1991-10-29 | 1995-05-17 | Mini Ricerca Scient Tecnolog | Derivati maleimmidici contenenti residui acrilici |
| GB9125645D0 (en) * | 1991-12-03 | 1992-01-29 | Smithkline Beecham Plc | Novel compounds |
| US5302711A (en) * | 1992-02-18 | 1994-04-12 | Eli Lilly And Company | Ester cleavage process for use with β-lactams |
| GB9212609D0 (en) * | 1992-06-13 | 1992-07-29 | Smithkline Beecham Plc | Novel compounds |
| GB9213567D0 (en) * | 1992-06-26 | 1992-08-12 | Smithkline Beecham Plc | Novel compounds |
| US5604222A (en) | 1993-12-27 | 1997-02-18 | Lupin Laboratories, Ltd. | Method for the preparation of 2-chloro sulfinyl azetidinones |
| US5578721A (en) | 1994-07-11 | 1996-11-26 | Lupin Laboratories Limited | Process for preparation of 3-exomethylene cepham sulfoxide esters |
| GB9424847D0 (en) * | 1994-12-09 | 1995-02-08 | Smithkline Beecham Plc | Novel process |
| IT1277048B1 (it) * | 1995-12-06 | 1997-11-04 | 3 Exo S R L | Procedimento per la preparazione di cefalosporine attraverso ciclizzazione riduttiva dicarbonilica per trattamento con |
| JP2005524611A (ja) * | 2001-12-21 | 2005-08-18 | ファイザー・プロダクツ・インク | イヌ及びネコにおける細菌感染の治療方法 |
| US20040002600A1 (en) * | 2002-06-20 | 2004-01-01 | Orchid Chemicals And Pharmaceuticals Limited | Process for the conversion of penam ring system to cepham ring system |
| BRPI0816412A2 (pt) * | 2007-09-21 | 2017-05-16 | Forest Laboratories Holdings Ltd | forma de dosagem, e, método para tratar uma infecção bacteriana |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0182633A3 (de) * | 1984-11-20 | 1987-09-02 | Ici Pharma | Cephalosporinderivate |
| GB8821797D0 (en) * | 1988-09-16 | 1988-10-19 | Beecham Group Plc | Novel compounds |
-
1990
- 1990-03-26 ES ES90303177T patent/ES2121745T3/es not_active Expired - Lifetime
- 1990-03-26 DE DE69032681T patent/DE69032681T2/de not_active Expired - Fee Related
- 1990-03-26 AT AT90303177T patent/ATE171705T1/de not_active IP Right Cessation
- 1990-03-26 EP EP90303177A patent/EP0395219B1/de not_active Expired - Lifetime
- 1990-03-26 DK DK90303177T patent/DK0395219T3/da active
- 1990-03-28 ZA ZA902378A patent/ZA902378B/xx unknown
- 1990-03-28 CA CA002013391A patent/CA2013391A1/en not_active Abandoned
- 1990-03-28 AU AU52321/90A patent/AU625844B2/en not_active Ceased
- 1990-03-28 US US07/500,397 patent/US5246926A/en not_active Expired - Lifetime
- 1990-03-29 PT PT93602A patent/PT93602A/pt not_active Application Discontinuation
- 1990-03-29 KR KR1019900004244A patent/KR900014403A/ko not_active Withdrawn
- 1990-03-30 JP JP2081481A patent/JP2979235B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU625844B2 (en) | 1992-07-16 |
| ZA902378B (en) | 1991-06-26 |
| KR900014403A (ko) | 1990-10-23 |
| PT93602A (pt) | 1990-11-20 |
| ES2121745T3 (es) | 1998-12-16 |
| AU5232190A (en) | 1990-10-04 |
| DE69032681T2 (de) | 1999-02-25 |
| JPH02286680A (ja) | 1990-11-26 |
| DK0395219T3 (da) | 1999-02-15 |
| JP2979235B2 (ja) | 1999-11-15 |
| US5246926A (en) | 1993-09-21 |
| DE69032681D1 (de) | 1998-11-05 |
| EP0395219A2 (de) | 1990-10-31 |
| CA2013391A1 (en) | 1990-09-30 |
| EP0395219A3 (de) | 1992-04-01 |
| EP0395219B1 (de) | 1998-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |